ORCID Profile
0000-0003-0599-0739
Current Organisation
Universidade de São Paulo
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Publisher: Wiley
Date: 05-03-2017
DOI: 10.1002/UOG.17347
Publisher: Elsevier BV
Date: 2010
DOI: 10.1590/S0104-42302010000600017
Abstract: To describe chromosomal abnormalities in spontaneous abortion material. A retrospective compilation of karyotype analysis of slides stained with Band G was carried out by optical microscopy with materials of 428 abortion products referred for study. There were 145 normal results (33.9%) and 237 abnormal results (55.4%). In 46 s les there was no cell growth (10.7%). Numerical abnormalities were the most frequent, especially trisomy 16 (41 cases), triplodia (27 cases), monosomy X (26 cases), tetraploidy (13 cases) and trisomy 15 (13 cases). Cytogenetic alterations are an important cause of pregnancy loss and their detection helps the genetic counseling to the couple. Trisomy 16 is the most often found change.
Publisher: Springer Science and Business Media LLC
Date: 13-06-2018
Publisher: FapUNIFESP (SciELO)
Date: 09-2013
DOI: 10.1590/S0100-72032013000900003
Abstract: To investigate the usefulness of the measurement of cervical length and of the test for phosphorylated insulin-like growth factor binding protein-1 (phIGFBP-1) performed sequentially in the prediction of preterm birth and the correlation between tests. We analyzed data from 101 asymptomatic pregnant women with a history of premature delivery. The ultrasound measurement of cervical length and phIGFBP-1 test were performed in parallel every three weeks, between 24 and 34 week. The best cutoff value for each cervical evaluation was established by the ROC curve, and the two tests were compared using nonparametric tests. We determined the sensitivity, specificity and predictive values of each test and of the association of the exams for the occurrence of delivery before the 37th weeks. There were 25 preterm births (24.8%). The cervix length showed the highest sensitivity and was able to predict preterm birth in all evaluations, with similar accuracy at different gestational ages. The test for phIGFBP-1 was not helpful at 24 weeks, but was able to predict prematurity when performed at 27, 30 and 33 weeks. The combination of tests increased the sensitivity (81.8%) and negative predictive value (93.7%) when compared to the separate use of each test. The mean cervical length was lower in women with a positive test. Both cervical length and the test for phIGFBP-1 were able to predict premature delivery, and sequential combination of both tests showed a high sensitivity and high negative predictive value.
Publisher: Georg Thieme Verlag KG
Date: 04-2021
No related grants have been discovered for Mario Henrique Burlacchini de Carvalho.