ARDC Research Link Australia

ORCID Profile
Orcid icon. 0000-0003-0750-0553

Current Organisations
Kobenhavns Universitet Niels Bohr Institutet , Københavns Universitet

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Publications

Publication

Dynamics of encapsulated hepatitis B surface antigen

Publisher: Springer Science and Business Media LLC

Date: 03-2019

DOI: 10.1140/EPJST/E2019-700103-X

Publication

Raman and neutron scattering study of partially deuterated l-alanine: Evidence of a solid-solid phase transition

Publisher: Wiley

Date: 10-12-2009

DOI: 10.1002/CPHC.200900482

Abstract: Raman and neutron experiments using specific isotope labeling were combined in order to study the dynamics and structure of L-alanine. Inelastic neutron and Raman scattering data of C(2)H(4)(ND(2))CO(2)D are discussed in relation to the doubling of the lattice parameter a observed by means of neutron powder diffraction in C(2)D(4) (NH(2))CO(2)H. The major changes accompanying the phase transition are found in the vibrational frequencies involving the torsional vibration tau(CO(2)(-)), which is clearly affected by the hydrogen bonds between the protons of the ammonium group and the oxygen atoms of the carboxylate group. At lower temperatures the rearrangement of identifiable hydrogen bonds induces changes in the bending vibration delta(ND(3)), confirming some orientational disorder.

Publication

3D visualisation of hepatitis B vaccine in the oral delivery vehicle SBA-15

Publisher: Springer Science and Business Media LLC

Date: 15-04-2019

DOI: 10.1038/S41598-019-42645-5

Abstract: Developing a technology that enables oral vaccines to work efficiently remains a considerable effort since a number of difficulties must be addressed. The key objective being to ensure the safe passage through the harsh conditions within the gastrointestinal tract, promoting delivery that induces enhanced immune response. In the particular case of hepatitis B, the oral formulation in the nanostructured silica SBA-15 is a viable approach. As a result of its porous structure, low toxicity and structural stability, SBA-15 is capable to protect and release the hepatitis B surface antigen (HBsAg), used in the vaccination scheme, at the desired destination. Furthermore, when compared to the currently used injection based delivery method, better or similar antibody response has been observed. However, information about the organisation of the antigen protein remains unknown. For instance, HBsAg is too large to enter the 10 nm ordered mesopores of SBA-15 and has a tendency to agglomerate when protected by the delivery system. Here we report on the pH dependence of HBsAg aggregation in saline solution investigated using small angle X-rays scattering that resulted in an optimisation of the encapsulation conditions. Additionally, X-ray microscopy combined with neutron and X-ray tomography provided full 3D information of the HBsAg clustering (i.e. agglomeration) inside the SBA-15 macropores. This method enables the visualisation of the organisation of the antigen in the interior of the delivery system, where agglomerated HBsAg coexists with its immunological effective uniformly distributed counterpart. This new approach, to be taken into account while preparing the formulation, can greatly help in the understanding of clinical studies and advance new formulations.

Publication

The instrument suite of the European Spallation Source

Publisher: Elsevier BV

Date: 03-2020

DOI: 10.1016/J.NIMA.2020.163402

Publication

Electric Field Induced Polarization Effects Measured by in Situ Neutron Spectroscopy

Publisher: American Chemical Society (ACS)

Date: 13-10-2017

DOI: 10.1021/ACS.JPCC.7B08769

Publication

Neutron scattering quantification of unfrozen pore water in frozen mud

Publisher: Elsevier BV

Date: 09-2021

DOI: 10.1016/J.MICROMESO.2021.111267

Publication

Optimization of the Guide Design of MIRACLES, the Neutron Time-of-Flight Backscattering Spectrometer at the European Spallation Source

Publisher: MDPI AG

Date: 31-12-2021

DOI: 10.3390/QUBS6010003

Abstract: To boost the science case of MIRACLES, the time-of-flight backscattering spectrometer at the European Spallation Source (ESS), an optimized neutron guide system, is proposed. This systematic study resulted in an enhancement in the transport of cold neutrons, compared with the previous conceptual design, with wavelengths ranging from λ = 2 Å to 20 Å along the 162.5-m distance from source to s le. This maintained the undisturbed main focus of the instrument, viz, to carry out quasielastic and inelastic neutron scattering (QENS and INS) experiments on a large dynamic range and for both energy-gain and energy-loss sides. To improve the collection of cold neutrons from the source and direct them to the s le position, the vertical geometry was adjusted to an adapted version of a ballistic elliptical profile. Its horizontal geometry was conceived to: (i) keep the high-resolution performance of the instrument, and (ii) minimize the background originating from fast and thermal neutrons. To comply with the first requirement, a narrow guide section at the pulse shaping chopper position has been implemented. To fulfil the second, a curved guide segment has been chosen to suppress neutrons with wavelengths λ 2 Å. Subsequent tailoring of the phase space provided an efficient transport of cold neutrons along the beamline to reach a 3 × 3 cm2 s le. Finally, additional calculations were performed to present a potential upgrade, with the exchange of the final segment, to focus on s les of approximately 1 × 1 cm2 the proposal anticipates a flux increase of 70% in this 1 cm2 s le area.

Publication