ORCID Profile
0000-0002-5005-0124
Current Organisation
Oak Ridge National Laboratory
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Publisher: Elsevier BV
Date: 02-2005
Publisher: Elsevier BV
Date: 03-2020
Publisher: IEEE
Date: 10-2013
Publisher: Crossref
Date: 2007
Publisher: Elsevier BV
Date: 11-2006
Publisher: Elsevier BV
Date: 11-2012
Publisher: Springer Science and Business Media LLC
Date: 16-02-2005
DOI: 10.1007/S00775-004-0617-1
Abstract: Chromium(VI) is a human carcinogen, primarily affecting the respiratory tract probably via active transport into cells, followed by the reduction to Cr(III) with the formation of DNA-damaging intermediates. Distribution of Cr and endogenous elements within A549 human lung adenocarcinoma epithelial cells, following treatment with Cr(VI) (100 microM, 20 min or 4 h) were studied by synchrotron-radiation-induced X-ray emission (SRIXE) of single freeze-dried cells. After the 20-min treatment, Cr was confined to a small area of the cytoplasm and strongly co-localized with S, Cl, K, and Ca. After the 4-h treatment, Cr was distributed throughout the cell, with higher concentrations in the nucleus and the cytoplasmic membrane. This time-dependence corresponded to approximately 100% or 0% clonogenic survival of the cells following the 20-min or 4-h treatments, respectively, and could potentially be explained by a new cellular protective mechanism. Such processes may also be important in reducing the potential hazards of Cr(III) dietary supplements, for which there is emerging evidence that they exert their anti-diabetic effects via biological oxidation to Cr(VI). The predominance of Cr(III) was confirmed by micro-XANES spectroscopy of intracellular Cr hotspots. X-ray absorption spectroscopy (XANES and EXAFS, using freeze-dried cells after the 0-4-h treatments) was used to gain insight into the chemical structures of Cr(III) complexes formed during the intracellular reduction of Cr(VI). The polynuclear nature of such complexes (probably with a combination of carboxylato and hydroxo bridging groups and O-donor atoms of small peptides or proteins) was established by XAFS data analyses.
Publisher: Elsevier BV
Date: 11-2006
Publisher: Elsevier BV
Date: 08-2013
Publisher: AIP Publishing
Date: 09-2013
DOI: 10.1063/1.4819739
Abstract: The technique of longitudinal (“xyz”) polarization analysis has been used successfully for many years to study disordered magnetic materials in thermal and cold neutron diffraction experiments. The technique allows the simultaneous and unambiguous separation of the nuclear, magnetic, and nuclear spin-incoherent contributions to the scattering. The technical advances seen in recent years, such as the availability of polarized 3He analyzer cells to cover a large detector solid angle, the ability to detect out-of-plane scattering in a multi-detector, and a significant increase of the usable beam ergence, call for a generalization of the method. A general treatment of the formalism for carrying out neutron polarization analysis will be given in this paper, which describes a possible method of usage at a future, modern diffractometer or inelastic spectrometer with large area multi-detector coverage.
Publisher: International Union of Crystallography (IUCr)
Date: 11-09-2013
DOI: 10.1107/S0021889813022826
Abstract: Errors in the paper by Kanaki, Jackson, Hall-Wilton, Piscitelli, Kirstein & Andersen [ J. Appl. Cryst. (2013), 46 , 1031–1037] are corrected.
Publisher: Elsevier BV
Date: 03-2000
Publisher: Elsevier BV
Date: 03-2000
Publisher: Springer Science and Business Media LLC
Date: 12-2002
Publisher: Elsevier BV
Date: 04-2011
Publisher: International Union of Crystallography (IUCr)
Date: 03-2018
DOI: 10.1107/S160057671800239X
Abstract: The vertical s le-plane reflectometer D17 at the Institut Laue–Langevin in Grenoble, France, has undergone several major upgrades since its commissioning, which are summarized in this article. The three major improvements are (i) a new focusing guide, increasing the usable flux on the s le by a factor of 2.5 (ii) a new beam polarizer and new spin flippers, allowing for the use of polarized neutrons in time-of-flight mode and (iii) a new detector with a particularly uniform response under homogeneous exposure, improved stability and state-of-the-art detector electronics. The combination of these factors has paved the road to new possibilities in fast kinetic measurements, magnetism and off-specular scattering. Ex les and scientific references for the new capabilities are presented.
Publisher: International Union of Crystallography (IUCr)
Date: 04-07-2013
DOI: 10.1107/S0021889813011862
Abstract: A novel 2π detector geometry for small-angle neutron scattering (SANS) applications is presented and its theoretical performance evaluated. Such a novel geometry is ideally suited for a SANS instrument at the European Spallation Source (ESS). Motivated by the low availability and high price of 3 He, the new concept utilizes gaseous detectors with 10 B as the neutron converter. The shape of the detector is inspired by an optimization process based on the properties of the conversion material. Advantages over the detector geometry traditionally used on SANS instruments are discussed. The angular and time resolutions of the proposed detector concept are shown to satisfy the requirements of the particular SANS instrument.
Publisher: Elsevier BV
Date: 02-2018
Publisher: IEEE
Date: 10-2012
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Ken Andersen.