ORCID Profile
0000-0001-9225-7900
Current Organisation
Australian Nuclear Science and Technology Organisation
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Colloid and Surface Chemistry | Physical Chemistry (Incl. Structural)
Industrial Chemicals and Related Products not elsewhere classified |
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3CP02619A
Abstract: Structure formation of the binary system of silica nanoparticle–BSA protein in presence of salt (below and above the critical salt concentration (CSC)) as a function of SDS concentration.
Publisher: Wiley
Date: 16-04-2020
Publisher: American Chemical Society (ACS)
Date: 02-12-2009
DOI: 10.1021/LA802865Z
Publisher: Wiley
Date: 30-08-2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1MA00835H
Abstract: Targeted and sustained release of doxorubicin was achieved through a self-healable and injectable ionic hydrogel.
Publisher: Elsevier BV
Date: 2022
Publisher: Informa UK Limited
Date: 19-09-2008
Publisher: Elsevier BV
Date: 2023
DOI: 10.1016/J.JCIS.2022.10.029
Abstract: Hydrogels made with semi-interpenetrating networks of the oligomerized polyphenol tannic acid, and poly(acrylamide), exhibit high stiffness and toughness. However, the structure property relationships that give rise to enhanced mechanical properties is not well understood. Herein, we systematically investigate the hydrogels using small angle X-ray scattering and small and Ultra-small angle neutron scattering within a wide length scale range (1 nm to 20 µm), polarized optical microscopy, and rheology. Small angle X-ray and neutron scattering reveal the presence of micron sized hydrogen bonded clusters in the hydrogels. Breaking of hydrogen bonded clusters above a critical solution temperature was clearly observed in the small angle neutron scattering data. Polarized optical microscopy show enhanced anisotropy for the gels with oligomerized tannic acid incorporated - when compared to gels with monomeric tannic acid. Rheological studies at varying temperatures nicely corroborate the structural changes observed at high temperatures and reveal a self-healing behavior of the gels. The knowledge gained from this study will aid in rational design of hydrogels for biomedical applications.
Publisher: Elsevier BV
Date: 05-2011
Publisher: Geochemical Society
Date: 2020
Publisher: Elsevier BV
Date: 05-2020
Publisher: Elsevier BV
Date: 2022
Publisher: Springer Science and Business Media LLC
Date: 11-08-2023
Publisher: Research Square Platform LLC
Date: 24-08-2022
DOI: 10.21203/RS.3.RS-1929196/V1
Abstract: Fibrin is commonly used as a natural hydrogel for three-dimensional (3D) cell culture but is poorly defined. We demonstrate a novel snake venom-controlled fibrin system with tunable architectural and mechanical properties. Employing the snake venom-derived protein ecarin, which rapidly activates the thrombin precursor prothrombin, we establish a tunable fibrin system with a broader range of pore sizes, compared to the existing thrombin-initiated system. By controlling the coagulation factor XIII (FXIII)-induced crosslinking, the mechanical properties are precisely tuned. This fibrin system allows independent control of pore size (1–13 μm) and stiffness (0.2–1 kPa), providing a defined platform for biophysical studies. We show that fibrin architecture influences fibroblast survival, spreading phenotype, and differentiation. A fine fibrin architecture is a key prerequisite for fibroblast differentiation, whilst a coarse architecture induces cell loss and disengages fibroblast’s sensitivity towards TGF-β1. These results have biophysical and translational implications for regenerative medicine and tissue engineering.
Publisher: European Association of Geochemistry
Date: 2022
Publisher: MDPI AG
Date: 09-07-2020
DOI: 10.3390/MA13143066
Publisher: Elsevier BV
Date: 11-2022
DOI: 10.1016/J.CARBPOL.2022.119871
Abstract: To elucidate starch structural features underlying resistant starch formation, wheat starch granules with three (A-, B- and C- type) crystalline polymorphisms and a range of amylose contents were digested in vitro. The changes in multi-level structure of digestion residues were compared. In the residues of A- and C-type starches, the molecular fine structure (distributions of chain length and whole molecular size), as analyzed by size exclusion chromatography (SEC), remained similar during digestion. In contrast, B-type high amylose wheat starch (HAWS) showed distinct changes in multi-level structures of digestion-resistant fractions: (1) the peak of longer amylopectin branches shifted to a lower degree of polymerization (40 DP) (2) production of α-limit dextrin (~2 nm hydrodynamic radius) in the residues (3) a small increase of double helix content during digestion, in contrast to 6 % reduction for the A-type starch (4) a decrease (6 °C lower) in the melting temperature of amylose-lipid complexes. The comparison suggests that elongated branches in B-type starch contribute to the formation of resistant fraction (including α-limit dextrin) against α-amylase. The amorphous packing of starch polymers with elongated branches together with the absence of surface pores and channels is proposed to be the basis for the enzymatic resistance of granular HAWS.
Publisher: Elsevier BV
Date: 03-2021
Publisher: American Chemical Society (ACS)
Date: 11-01-2023
Publisher: Elsevier BV
Date: 04-2016
DOI: 10.1016/J.FOODCHEM.2015.10.104
Abstract: Two main classes of interaction between soluble dietary fibres (SDFs), such as (1,3:1,4)-β-D-glucan (βG) and arabinoxylan (AX) and bile salt (BS) or diluted porcine bile, were identified by (13)C NMR and small angle X-ray scattering (SAXS). Small chemical shift differences of BS NMR resonances were consistent with effective local concentration or dilution of BS micelles mostly by βG, suggesting dynamic interactions whilst the reduced line widths/intensities observed were mostly caused by wheat AX and the highest molecular size and concentrations of βG. SAXS showed evidence of changes in βG but not AX in the presence of BS micelles, at >13 nm length scale consistent with molecular level interactions. Thus intermolecular interactions between SDF and BS depend on both SDF source and its molecular weight and may occur alone or in combination.
Publisher: American Chemical Society (ACS)
Date: 23-01-2020
Publisher: Elsevier BV
Date: 12-2005
Publisher: Elsevier BV
Date: 11-2008
Publisher: American Chemical Society (ACS)
Date: 30-08-2021
Publisher: Springer International Publishing
Date: 2022
Publisher: Elsevier BV
Date: 07-2017
Publisher: American Chemical Society (ACS)
Date: 22-04-2019
Publisher: Elsevier BV
Date: 08-2022
Publisher: Elsevier BV
Date: 02-2021
Publisher: Informa UK Limited
Date: 06-2006
Publisher: American Chemical Society (ACS)
Date: 07-2018
DOI: 10.1021/ACS.LANGMUIR.8B00434
Abstract: This work systematically explores the biomineralization of calcium phosphate (CaP) and carbonate (CaCO
Publisher: Elsevier BV
Date: 2022
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9SM00932A
Abstract: Explaining antimicrobial battacin lipopeptides by investigating the solution structure – the propensity to aggregate may have a role in a declined antimicrobial activity.
Publisher: Elsevier BV
Date: 02-2023
Publisher: Elsevier BV
Date: 06-2023
Publisher: Springer US
Date: 15-11-2012
Publisher: American Chemical Society (ACS)
Date: 28-06-2016
Abstract: In this study, we explore the overall structural ensembles and transitions of a biomimetic, multi-stimuli-responsive, intrinsically disordered protein (IDP), Rec1-resilin. The structural transition of Rec1-resilin with change in molecular crowding and environment is evaluated using small-angle neutron scattering and small-angle X-ray scattering. The quantitative analyses of the experimental scattering data using a combination of computational models allowed comprehensive description of the structural evolution, organization, and conformational ensembles of Rec1-resilin in response to the changes in concentration, pH, and temperature. Rec1-resilin in uncrowded solutions demonstrates the equilibrium intrinsic structure quality of an IDP with radius of gyration Rg ∼ 5 nm, and a scattering function for the triaxial ellipsoidal model best fit the experimental dataset. On crowding (increase in concentration >10 wt %), Rec1-resilin molecules exert intermolecular repulsive force of interaction, the Rg value reduces with a progressive increase in concentration, and molecular chains transform from a Gaussian coil to a fully swollen coil. It is also revealed that the structural organization of Rec1-resilin dynamically transforms from a rod (pH 2) to coil (pH 4.8) and to globular (pH 12) as a function of pH. The findings further support the temperature-triggered dual-phase-transition behavior of Rec1-resilin, exhibiting rod-shaped structural organization below the upper critical solution temperature (∼4 °C) and a large but compact structure above the lower critical solution temperature (∼75 °C). This work attempted to correlate unusual responsiveness of Rec1-resilin to the evolution of conformational ensembles.
Publisher: American Chemical Society (ACS)
Date: 02-05-2019
Abstract: The motivation for designing low-molecular-weight gelators with self-healing characteristics originates from elegant ex les in biology such as vines of the genus Aristolochia whose internal secondary growth exhibits rapid self-healing in their stems. In the present work, we had explored the stimuli-responsive dual gelation characteristics for the ester-functionalized surfactant (4-(2-(hexadecyloxy)-2-oxoethyl)-4-methylmorpholin-4-ium bromide, C
Publisher: MDPI AG
Date: 12-05-2022
Abstract: In recent years, significant attention has been paid towards the study and application of mixed matrix nanofibrous membranes for water treatment. The focus of this study is to develop and characterize functional polysulfone (PSf)-based composite nanofiltration (NF) membranes comprising two different oxides, such as graphene oxide (GO) and zinc oxide (ZnO) for arsenic removal from water. PSf/GO- and PSf/ZnO-mixed matrix NF membranes were fabricated using the electrospinning technique, and subsequently examined for their physicochemical properties and evaluated for their performance for arsenite–As(III) and arsenate–As(V) rejection. The effect of GO and ZnO on the morphology, hierarchical structure, and hydrophilicity of fabricated membranes was studied using a scanning electron microscope (SEM), small and ultra-small angle neutron scattering (USANS and SANS), contact angle, zeta potential, and BET (Brunauer, Emmett and Teller) surface area analysis. Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) were used to study the elemental compositions and polymer-oxide interaction in the membranes. The incorporation of GO and ZnO in PSf matrix reduced the fiber diameter but increased the porosity, hydrophilicity, and surface negative charge of the membranes. Among five membrane systems, PSf with 1% ZnO has the highest water permeability of 13, 13 and 11 L h−1 m−2 bar−1 for pure water, As(III), and As(V)-contaminated water, respectively. The composite NF membranes of PSf and ZnO exhibited enhanced (more than twice) arsenite removal (at 5 bar pressure) of 71% as compared to pristine PSf membranes, at 43%, whereas both membranes showed only a 27% removal for arsenate.
Publisher: Elsevier BV
Date: 2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3CP00029J
Abstract: This work illustrates how the copper substrate for anodes in lithium-ion batteries are used to make copper-carboxylates via reactions with dicarboxylic acids. The resulting electrode performance can be tuned by controlling the reaction conditions.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7TB02140B
Abstract: N-terminal capped tripeptides self-assemble into hydrogels with tuneable properties depending on gelation trigger, giving differences in structure, stiffness and biocompatibility.
Publisher: Elsevier BV
Date: 11-2023
Publisher: Research Square Platform LLC
Date: 08-11-2022
DOI: 10.21203/RS.3.RS-2197445/V1
Abstract: Pepsin is an aspartic acid protease and the first protease that proteins encounter in the gastrointestinal tract. In vitro digestion assays on proteins including those found in food, or as oral protein and peptide drugs, often involve different solvents or pH conditions where the activity of the digestive enzyme may not be optimal. To improve the accuracy of these assays it is, therefore, important to understand the effect of common experimental conditions, such as solvent, on enzymes such as pepsin. Herein we investigate the activity and structure of porcine pepsin in H 2 O and D 2 O at pH values between 1–8. When dissolved in D 2 O, the enzyme activity of pepsin between pH 1–3 decreased to 60% of the activity in H2O. However, the relative change in activity with pH was similar in D 2 O and H 2 O. CD measurements demonstrated that changing the pH and solvent did not influence the secondary structure of the pepsin enzyme. SAXS analysis revealed that structural changes to pepsin did not occur until a pH value between pH 7 and 8, at which point it was denatured and adopted an extended state. Therefore, changes in the pepsin enzymatic activity with pH and solvent change were found to be related to the solubility of pepsin but not to the structure of the protein. In digestion studies, pepsin activity is determined based on its measured activity in H 2 O at pH 3, regardless of the dynamic pH conditions in digestion or the local environment of the pepsin. This research has therefore significant applicability in improved setups for future digestion and drug bioavailability experiments, as well as future neutron scattering, NMR, and FTIR experiments for enzyme studies in D 2 O.
Publisher: Elsevier BV
Date: 05-2005
Publisher: Springer Science and Business Media LLC
Date: 23-02-2023
DOI: 10.1038/S41467-023-36437-9
Abstract: Fibrin is the provisional matrix formed after injury, setting the trajectory for the subsequent stages of wound healing. It is commonly used as a wound sealant and a natural hydrogel for three-dimensional (3D) biophysical studies. However, the traditional thrombin-driven fibrin systems are poorly controlled. Therefore, the precise roles of fibrin’s biophysical properties on fibroblast functions, which underlie healing outcomes, are unknown. Here, we establish a snake venom-controlled fibrin system with precisely and independently tuned architectural and mechanical properties. Employing this defined system, we show that fibrin architecture influences fibroblast survival, spreading phenotype, and differentiation. A fine fibrin architecture is a key prerequisite for fibroblast differentiation, while a coarse architecture induces cell loss and disengages fibroblast’s sensitivity towards TGF-β1. Our results demonstrate that snake venom-controlled fibrin can precisely control fibroblast differentiation. Applying these biophysical principles to fibrin sealants has translational significance in regenerative medicine and tissue engineering.
Publisher: Elsevier BV
Date: 02-2013
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6SM02660E
Abstract: We have simplified the structural heterogeneity of protein-polysaccharide binding by investigating protein binding to oligosaccharides. The interactions between bovine beta-lactoglobulin A (βLgA) and oligo-galacturonic acids (OGAs) with various numbers of sugar residues have been investigated with a range of biophysical techniques. We show that the βLgA-OGA interaction is critically dependent on the length of the oligosaccharide. Isothermal titration calorimetry results suggest that a minimum length of 7 or 8 sugar residues is required in order to exhibit appreciable exothermic interactions with βLgA - shorter oligosaccharides show no enthalpic interactions at any concentration ratio. When titrating βLgA into OGAs with more than 7-8 sugar residues the s le solution also became turbid with increasing amounts of βLgA, indicating the formation of macroscopic assemblies. Circular dichroism, thioflavin T fluorescence and small angle X-ray/neutron scattering experiments revealed two structural regimes during the titration. When OGAs were in excess, βLgA formed discrete assemblies upon OGA binding, and no subsequent aggregation was observed. However, when βLgA was present in excess, multi-scale structures were formed and this eventually led to the separation of the solution into two liquid-phases.
Publisher: Elsevier BV
Date: 02-2022
Publisher: American Chemical Society (ACS)
Date: 13-02-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3MA00286A
Abstract: Holistic investigations into the various mechanisms of battery electrodes are essential for the development of competitive and sustainable novel battery materials.
Publisher: Informa UK Limited
Date: 23-10-2009
Publisher: Elsevier BV
Date: 05-2006
Publisher: Elsevier BV
Date: 12-2018
Publisher: Springer Science and Business Media LLC
Date: 19-02-2021
Publisher: European Association of Geoscientists & Engineers
Date: 2019
Publisher: Geochemical Society
Date: 2020
DOI: 10.46427/GOLD2020.17
Publisher: American Chemical Society (ACS)
Date: 10-07-2018
DOI: 10.1021/ACS.LANGMUIR.8B01141
Abstract: The development of protein-based hydrogels for tissue engineering applications is often limited by their mechanical properties. Herein, we present the facile fabrication of tough regenerated silk fibroin (RSF)/graphene oxide (GO) nanocomposite hydrogels by a photochemical cross-linking method. The RSF/GO composite hydrogels demonstrated soft and adhesive properties during initial stages of photocrosslinking (<2 min), which is not observed for the pristine RSF hydrogel, and rendered a tough and nonadhesive hydrogel upon complete cross-linking (10 min). The composite hydrogels exhibited superior tensile mechanical properties, increased β-sheet content, and decreased chain mobility compared to that of the pristine RSF hydrogels. The composite hydrogels demonstrated Young's modulus as high as ∼8 MPa, which is significantly higher than native cartilage (∼1.5 MPa), and tensile toughness as high as ∼2.4 MJ/m
Publisher: International Union of Crystallography (IUCr)
Date: 25-03-2022
DOI: 10.1107/S1600576722002084
Abstract: Ultra-small-angle neutron scattering (USANS) and small-angle neutron scattering (SANS) measurements, covering length scales from micrometres to nanometres, were made to investigate the structure of nanodiamonds (NDs) and their suspensions. These nanodiamonds were produced by two different techniques, namely by the detonation method and by the laser ablation of a carbon–hydrocarbon mixture. The (U)SANS results indicated the presence of structures four orders of magnitude larger than the dimensions of a single ND particle, consisting of aggregations of ND particles. This aggregation of the ND particles was studied by employing the contrast variation technique. Two different solvents, namely H 2 O and dimethyl sulfoxide (and their deuterated counterparts), were used to understand the role of hydrogen in the shape and size of the aggregates. The analysis of experimental data from SANS measurements also reveals the ND particles to have an ellipsoidal structure. Using a defined shape model and the SANS contrast variation technique, it was possible to characterize the non-diamond outer shell of the particles and determine the outer layer thickness. This clarification of the structure of the NDs will allow better preparation of suspensions/s les for various applications. Understanding the structure of NDs at multiple length scales also provides crucial knowledge of particle–particle interaction and its effect on the aggregation structures.
Publisher: Elsevier BV
Date: 07-2023
Publisher: Springer Science and Business Media LLC
Date: 20-03-2023
DOI: 10.1038/S41598-023-30757-Y
Abstract: The microstructure of minerals and rocks can significantly alter reaction rates. This study focuses on identifying transport paths in low porosity rocks based on the hypothesis that grain boundary widening accelerates reactions in which one mineral is replaced by another (replacement reaction). We conducted a time series of replacement experiments of three limestones (CaCO 3 ) of different microstructures and solid impurity contents using FeCl 2 . Reacted solids were analyzed using chemical imaging, small angle X-ray and neutron scattering and Raman spectroscopy. In high porosity limestones replacement is reaction controlled and complete replacement was observed within 2 days. In low porosity limestones that contain 1–2% dolomite impurities and are dominated by grain boundaries, a reaction rim was observed whose width did not change with reaction time. Siderite (FeCO 3 ) nucleation was observed in all parts of the rock cores indicating the percolation of the solution throughout the complete core. Dolomite impurities were identified to act as nucleation sites leading to growth of crystals that exert force on the CaCO 3 grains. Widening of grain boundaries beyond what is expected based on dissolution and thermal grain expansion was observed in the low porosity marble containing dolomite impurities. This leads to a self-perpetuating cycle of grain boundary widening and reaction acceleration instead of reaction front propagation.
Publisher: Springer Science and Business Media LLC
Date: 29-04-2023
DOI: 10.1038/S41526-023-00280-5
Abstract: We conducted a charge–charge clustering experiment of positively and negatively charged colloidal particles in aqueous media under a microgravity environment at the International Space Station. A special setup was used to mix the colloid particles in microgravity and then these structures were immobilized in gel cured using ultraviolet (UV) light. The s les returned to the ground were observed by optical microscopy. The space s le of polystyrene particles with a specific gravity ρ (=1.05) close to the medium had an average association number of ~50% larger than the ground control and better structural symmetry. The effect of electrostatic interactions on the clustering was also confirmed for titania particles ( ρ ~ 3), whose association structures were only possible in the microgravity environment without any sedimentation they generally suffer on the ground. This study suggests that even slight sedimentation and convection on the ground significantly affect the structure formation of colloids. Knowledge from this study will help us to develop a model which will be used to design photonic materials and better drugs.
Publisher: Elsevier BV
Date: 07-2018
DOI: 10.1016/J.IJBIOMAC.2018.03.044
Abstract: Regenerated Bombyx mori silk fibroin (RSF) is a widely recognized protein for biomedical applications however, its hierarchical gel structure is poorly understood. In this paper, the hierarchical structure of photocrosslinked RSF and RSF-based hybrid hydrogel systems: (i) RSF/Rec1-resilin and (ii) RSF oly(N-vinylcaprolactam (PVCL) is reported for the first time using small-angle scattering (SAS) techniques. The structure of RSF in dilute to concentrated solution to fabricated hydrogels were characterized using small angle X-ray scattering (SAXS), small angle neutron scattering (SANS) and ultra-small angle neutron scattering (USANS) techniques. The RSF hydrogel exhibited three distinctive structural characteristics: (i) a Porod region in the length scale of 2 to 3nm due to hydrophobic domains (containing β-sheets) which exhibits sharp interfaces with the amorphous matrix of the hydrogel and the solvent, (ii) a Guinier region in the length scale of 4 to 20nm due to hydrophilic domains (containing turns and random coil), and (iii) a Porod-like region in the length scale of few micrometers due to water pores/channels exhibiting fractal-like characteristics. Addition of Rec1-resilin or PVCL to RSF and subsequent crosslinking systematically increased the nanoscale size of hydrophobic and hydrophilic domains, whereas decreased the homogeneity of pore size distribution in the microscale. The presented results have implications on the fundamental understanding of the structure-property relationship of RSF-based hydrogels.
Publisher: Springer Science and Business Media LLC
Date: 23-10-2023
Publisher: Elsevier BV
Date: 07-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1SM01340H
Abstract: Tuning of silica nanoparticles–lysozyme protein complexes in presence of SDS surfactant, have been investigated by small-angle neutron scattering (SANS) and dynamic light scattering (DLS).
Publisher: Springer Science and Business Media LLC
Date: 02-08-2021
Publisher: Elsevier BV
Date: 04-2018
Publisher: American Vacuum Society
Date: 07-2021
DOI: 10.1116/6.0001124
Abstract: Plastic waste is ubiquitously spread across the world and its smaller analogs-microplastics and nanoplastics-raise particular health concerns. While biological impacts of microplastics and nanoplastics have been actively studied, the chemical and biological bases for the adverse effects are sought after. This work explores contributory factors by combining results from in vitro and model mammalian membrane experimentation to assess the outcome of cell/nanoplastic interactions in molecular detail, inspecting the in idual contribution of nanoplastics and different types of protein coronae. The in vitro study showed mild cytotoxicity and cellular uptake of polystyrene (PS) nanoplastics, with no clear trend based on nanoplastic size (20 and 200 nm) or surface charge. In contrast, a nanoplastic size-dependency on bilayer disruption was observed in the model system. This suggests that membrane disruption resulting from direct interaction with PS nanoplastics has little correlation with cytotoxicity. Furthermore, the level of bilayer disruption was found to be limited to the hydrophilic headgroup, indicating that transmembrane diffusion was an unlikely pathway for cellular uptake-endocytosis is the viable mechanism. In rare cases, small PS nanoplastics (20 nm) were found in the vicinity of chromosomes without a nuclear membrane surrounding them however, this was not observed for larger PS nanoplastics (200 nm). We hypothesize that the nanoplastics can interact with chromosomes prior to nuclear membrane formation. Overall, precoating PS particles with protein coronae reduced the cytotoxicity, irrespective of the corona type. When comparing the two types, the extent of reduction was more apparent with soft than hard corona.
Publisher: American Association for Cancer Research (AACR)
Date: 31-03-2023
DOI: 10.1158/1078-0432.22476902
Abstract: Selected datasets of GSEA between paired comparisons
Publisher: Elsevier BV
Date: 10-2004
Publisher: Elsevier BV
Date: 07-2006
Publisher: Elsevier BV
Date: 10-2021
Publisher: Elsevier BV
Date: 09-2021
Publisher: Elsevier BV
Date: 07-2021
Publisher: American Chemical Society (ACS)
Date: 29-12-2021
Publisher: Elsevier BV
Date: 06-2021
Publisher: Elsevier BV
Date: 2022
DOI: 10.2139/SSRN.4169539
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7CP02585H
Abstract: Bicelles can be formulated by a simple one-step process using a polyglyceryl dialkyl ether that has asymmetric tails.
Publisher: American Chemical Society (ACS)
Date: 14-02-2019
Abstract: The electrocatalyst layer (ECL) of the proton-exchange membrane fuel cell (PEMFC) is commonly fabricated from colloidal catalyst ink containing carbon-supported catalyst nanoparticles (NPs), ionomer stabilizer, and dispersion medium (DM). The structure, stability, and aggregate size distribution of fuel cell catalyst ink are critically dependent on the quality of DM. However, understanding of the influence of the quality of DM on the hierarchical structure of the ECL is lacking. This work presents a systematic investigation of the effects of reducing alcohol content in isopropyl alcohol/water (IPA/H
Publisher: Elsevier BV
Date: 11-2006
Publisher: Elsevier BV
Date: 05-2016
Publisher: Elsevier BV
Date: 04-2008
Publisher: American Chemical Society (ACS)
Date: 04-06-2018
Publisher: Wiley
Date: 22-11-2019
Publisher: Public Library of Science (PLoS)
Date: 19-06-2019
Publisher: International Union of Crystallography (IUCr)
Date: 20-03-2018
DOI: 10.1107/S1600576718002534
Abstract: QUOKKA is a 40 m pinhole small-angle neutron scattering instrument in routine user operation at the OPAL research reactor at the Australian Nuclear Science and Technology Organisation. Operating with a neutron velocity selector enabling variable wavelength, QUOKKA has an adjustable collimation system providing source–s le distances of up to 20 m. Following the large-area s le position, a two-dimensional 1 m 2 position-sensitive detector measures neutrons scattered from the s le over a secondary flight path of up to 20 m. Also offering incident beam polarization and analysis capability as well as lens focusing optics, QUOKKA has been designed as a general purpose SANS instrument to conduct research across a broad range of scientific disciplines, from structural biology to magnetism. As it has recently generated its first 100 publications through serving the needs of the domestic and international user communities, it is timely to detail a description of its as-built design, performance and operation as well as its scientific highlights. Scientific ex les presented here reflect the Australian context, as do the industrial applications, many combined with innovative and unique s le environments.
Publisher: European Association of Geoscientists & Engineers
Date: 2019
Publisher: American Vacuum Society
Date: 09-2020
DOI: 10.1116/6.0000404
Abstract: A major challenge in understanding nanoplastic toxicity (or nanoparticles in general) lies in establishing the causal relationships between its physical properties and biological impact. This difficulty can be attributed to surface alterations that follow the formation of a biological complex around the nanoplastic, as exemplified by protein coronae. The protein corona is known to be responsible for the biological response elicited, although its own structure and attributes remain unknown. We approach this knowledge gap by independently studying the structure of soft and hard coronae using neutron scattering techniques. We investigated the formation and the structure of corona proteins (human serum albumin and lysozyme) and the resulting protein corona complexes with polystyrene nanoplastics of different sizes (20 and 200 nm) and charges. Soft corona complexes (regardless of protein type) adopted a structure where the nanoplastics were surrounded by a loose protein layer (∼2–3 protein molecules thick). Hard corona complexes formed fractal-like aggregates, and the morphology of which is known to be harmful to cellular membranes. In most cases, hard-corona coated nanoplastics also formed fractal-like aggregates in solution. Nanoplastic size affected the structures of both the protein corona and the intrinsic protein: more significant conformational change was observed in the hard corona proteins around smaller nanoparticles compared to larger ones, as the self-association forces holding the nanoplastic rotein complex together were stronger. This also implies that protein-dependent biochemical processes are more likely to be disrupted by smaller polystyrene nanoplastics, rather than larger ones.
Publisher: Elsevier BV
Date: 04-2005
Publisher: Elsevier BV
Date: 08-2020
Publisher: Elsevier BV
Date: 03-2022
Publisher: Elsevier BV
Date: 09-2017
Publisher: Elsevier BV
Date: 09-2004
Publisher: Elsevier BV
Date: 06-2005
Publisher: Elsevier BV
Date: 07-2021
Publisher: Elsevier BV
Date: 05-2010
Publisher: Elsevier BV
Date: 07-2020
Publisher: Elsevier BV
Date: 09-2017
Publisher: Informa UK Limited
Date: 03-04-2023
Publisher: American Chemical Society (ACS)
Date: 24-11-2020
Abstract: Resilin-like polypeptides (RLPs) are an important class of intrinsically disordered multistimuli-responsive bioelastomers. The nanostructure of RLPs in solution has been extensively studied in the past few years, from dilute to molecular crowding conditions, and with the addition of rigid biopolymers. Modification of the hierarchical network structure of RLP hydrogels using graphene oxide (GO) as an additive is a burgeoning prospect for their application in the bioelectronic and biomedical fields. In this work, we systemically study the influence of incorporating GO into RLP (Rec1) hydrogels for tuning their physicochemical properties and understanding the gel-cell interactions. The nature of GO interaction with the Rec1 hydrogel is deduced from the change in structure and properties. Contrast-matching small-angle and ultra-small-angle neutron-scattering techniques were used to investigate the network structure of the Rec1 hydrogel and how this structure is modified in the presence of GO. Incorporation of GO in the Rec1 hydrogel matrix results in an increase in the micromechanical resilience, equilibrium water swelling ratio, micropore size, cross-linked domain size with a decrease in the cross-link density, mass fractal cluster size, local compressive elastic modulus, and cell inert characteristics. These property combinations achieved with the addition of GO further open up the available structure-property design window for RLP applications.
Publisher: Elsevier BV
Date: 09-2020
Publisher: Elsevier BV
Date: 07-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3CP02030D
Abstract: Batteries play an increasingly critical role in the functioning of contemporary society. This work illustrates a new family of electrode materials and an alternative method to produce the electrode for applications.
Publisher: American Chemical Society
Date: 2018
Publisher: Scientific Societies
Date: 13-10-2012
Publisher: American Chemical Society (ACS)
Date: 06-07-2016
Publisher: Wiley
Date: 04-05-2018
Publisher: Elsevier BV
Date: 03-2021
Publisher: Research Square Platform LLC
Date: 18-10-2022
DOI: 10.21203/RS.3.RS-2013176/V1
Abstract: We conducted a charge-charge clustering experiment of positively and negatively charged colloidal particles in aqueous media under a microgravity environment at the International Space Station. A special setup was used to mix the colloid particles in microgravity and then immobilize these structures in gel cured using UV light. The s les returned to the ground were observed by optical microscopy. The space s le of polystyrene particles with a specific gravity d (=1.05) close to the medium had an average association number of approximately 50% larger than the ground control and better structural symmetry. The effect of electrostatic interactions on the clustering was also confirmed for titania particles (d~3), whose association structures were only possible in the microgravity environment without any sedimentation they generally suffer on the ground. This study suggests that even slight sedimentation and convection on the ground significantly affect the structure formation of colloids. Knowledge from this study will help us to develop a model which will be used to design photonic materials and better drugs.
Publisher: Elsevier BV
Date: 12-2023
Publisher: Elsevier BV
Date: 06-2022
Publisher: Informa UK Limited
Date: 04-2008
Publisher: Springer Science and Business Media LLC
Date: 13-01-2020
Publisher: Vilnius Gediminas Technical University
Date: 24-02-2022
Abstract: To explore the law of megaproject social responsibility behavior (MSRB) among internal organizations under institutional pressure, this paper presents a theoretical and empirical study to investigate how institutional pressure affects MSRB through the mediating role of organizational social responsibility cognition and the mediating roles of the communication mechanism and relationship strength based on new institutional sociology. Based on a total of 147 responses from a broad questionnaire survey, structural equation modelling (SEM) was used to test the proposed hypotheses. The research results show that institutional pressure has a promoting effect on MSRB, and organizational social responsibility cognition mediates the relationship between institutional pressure and MSRB. Additionally, the communication mechanism and relationship strength have no effect on the relationship between institutional pressures and MSRB. The research results provide a new theoretical foundation for the analysis of MSRB and practical suggestions for policymakers on the governance of MSRB.
Publisher: Elsevier BV
Date: 12-2021
Publisher: Informa UK Limited
Date: 10-2007
Publisher: Elsevier BV
Date: 12-2018
Publisher: American Chemical Society (ACS)
Date: 03-2019
DOI: 10.1021/ACS.BIOCONJCHEM.9B00015
Abstract: Upon contact with biological fluids, the surface of nanoparticles is surrounded by many types of proteins, forming a so-called "protein corona". The physicochemical properties of the nanoparticle/corona complex depend predominantly on the nature of the protein corona. An understanding of the structure of the corona and the resulting complex provides insight into the structure-activity relationship. Here, we structurally evaluate the soft and hard components of the protein corona, formed from polystyrene (PS) nanoplastics and human serum albumin (HSA). Using circular dichroism spectroscopy to elucidate the structure of HSA within the complex, we establish the effect of nanoparticle size and pH on the nature of the protein corona formed- whether hard or soft. Despite the weak interaction between PS and the HSA corona, small angle neutron scattering revealed the formation of a complex structure that enhanced the intermolecular interactions between HSA proteins, PS particles, and the HS/PSA complexes. Fractal formation occurred under conditions where the interaction between PS and HSA was strong, and increasing HSA concentrations suppressed the degree of aggregation. The size of the nanoparticles directly influenced the nature of the protein corona, with larger particles favoring the formation of a soft corona, due to the decreased PS-HSA attraction.
Publisher: Springer Science and Business Media LLC
Date: 27-01-2022
DOI: 10.1038/S41528-022-00138-Y
Abstract: In this work, a polymer and ionic liquid (IL) hybrid with superior thermoelectric performance is prepared via a system design of the chemical composition, molar ratio of the constituent molecules and manipulating the structure in solution and dried films. The solution-casted hybrid film, consisting of poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) and 1-ethyl-3-methylimidazolium tricyanomethanide (EMIM:TCM), shows the highest power factor of 175 μW m −1 K −2 in the polymer hybrid prepared by a post-treatment-free method. With a set of complementary structure characterization methods, it is found that EMIM:TCM can induce the structure reorganization of PEDOT:PSS in solution from a core-shell model to a rod-like model, during which PEDOT partially separates from PSS that eases the conductive network formation. In addition, the oxidation level of PEDOT:PSS is reduced by adding EMIM:TCM. Based on which, the PEDOT:PSS/IL hybrid shows the best performance in optimizing the conductivity (1163 S cm −1 ) and Seebeck coefficient (38.8 μV K −1 ) simultaneously.
Publisher: Elsevier BV
Date: 2021
Publisher: American Association for the Advancement of Science (AAAS)
Date: 21-12-2022
Abstract: The consequences of crowding on the dynamic conformational ensembles of intrinsically disordered proteins (IDPs) remain unresolved because of their ultrafast motion. Here, we report crowder-induced interactions and conformational dynamics of a prototypical multistimuli-responsive IDP, Rec1-resilin. The effects of a range of crowders of varying sizes, forms, topologies, and concentrations were examined using spectroscopic, spectrofluorimetric, and contrast-matching small- and ultrasmall-angle neutron scattering investigation. To achieve sufficient neutron contrast against the crowders, deuterium-labeled Rec1-resilin was biosynthesized successfully. Moreover, the ab initio “shape reconstruction” approach was used to obtain three-dimensional models of the conformational assemblies. The IDP revealed crowder-specific systematic extension and compaction with the level of macromolecular crowding. Last, a robust extension-contraction model has been postulated to capture the fundamental phenomena governing the observed behavior of IDPs. The study provides insights and fresh perspectives for understanding the interactions and structural dynamics of IDPs in crowded states.
Publisher: American Chemical Society (ACS)
Date: 13-10-2017
Publisher: Wiley
Date: 10-10-2023
Publisher: Springer Science and Business Media LLC
Date: 21-10-2019
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SM00777B
Abstract: We investigate the effect of side chain length on the chain shape and thin film behaviour of conjugated graft copolymers.
Location: Australia
Start Date: 2020
End Date: 2020
Funder: Australian Research Council
View Funded ActivityStart Date: 02-2021
End Date: 02-2022
Amount: $320,000.00
Funder: Australian Research Council
View Funded Activity