ORCID Profile
0000-0002-4392-3572
Current Organisation
University of Oxford
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Publisher: Springer Science and Business Media LLC
Date: 07-07-2021
Publisher: Wiley
Date: 25-04-2018
DOI: 10.1111/DDI.12758
Publisher: MDPI AG
Date: 28-03-2023
DOI: 10.3390/IJMS24076381
Abstract: Sigma-2 receptor (S2R) is a S2R ligand-binding site historically associated with reportedly 21.5 kDa proteins that have been linked to several diseases, such as cancer, Alzheimer’s disease, and schizophrenia. The S2R is highly expressed in various tumors, where it correlates with the proliferative status of the malignant cells. Recently, S2R was reported to be the transmembrane protein TMEM97. Prior to that, we had been investigating the translocator protein (TSPO) as a potential 21.5 kDa S2R candidate protein with reported heme and sterol associations. Here, we investigate the contributions of TMEM97 and TSPO to S2R activity in MCF7 breast adenocarcinoma and MIA PaCa-2 (MP) pancreatic carcinoma cells. Additionally, the role of the reported S2R-interacting partner PGRMC1 was also elucidated. Proximity ligation assays and co-immunoprecipitation show a functional association between S2R and TSPO. Moreover, a close physical colocalization of TMEM97 and TSPO was found in MP cells. In MCF7 cells, co-immunoprecipitation only occurred with TMEM97 but not with PGRMC1, which was further confirmed by confocal microscopy experiments. Treatment with the TMEM97 ligand 20-(S)-hydroxycholesterol reduced co-immunoprecipitation of both TMEM97 and PGRMC1 in immune pellets of immunoprecipitated TSPO in MP cells. To the best of our knowledge, this is the first suggestion of a (functional) interaction between TSPO and TMEM97 that can be affected by S2R ligands.
Publisher: Elsevier BV
Date: 02-2021
Publisher: Springer Science and Business Media LLC
Date: 06-2013
DOI: 10.1038/S41586-019-1444-4
Abstract: Effective ocean management and the conservation of highly migratory species depend on resolving the overlap between animal movements and distributions, and fishing effort. However, this information is lacking at a global scale. Here we show, using a big-data approach that combines satellite-tracked movements of pelagic sharks and global fishing fleets, that 24% of the mean monthly space used by sharks falls under the footprint of pelagic longline fisheries. Space-use hotspots of commercially valuable sharks and of internationally protected species had the highest overlap with longlines (up to 76% and 64%, respectively), and were also associated with significant increases in fishing effort. We conclude that pelagic sharks have limited spatial refuge from current levels of fishing effort in marine areas beyond national jurisdictions (the high seas). Our results demonstrate an urgent need for conservation and management measures at high-seas hotspots of shark space use, and highlight the potential of simultaneous satellite surveillance of megafauna and fishers as a tool for near-real-time, dynamic management.
Publisher: Springer Science and Business Media LLC
Date: 07-07-2021
Publisher: CRC Press
Date: 10-12-2020
Publisher: American Association for the Advancement of Science (AAAS)
Date: 19-08-2022
Abstract: Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements.
Publisher: Springer Science and Business Media LLC
Date: 26-10-2020
DOI: 10.1007/S10980-020-01146-X
Abstract: Effective planning for protected areas and wildlife population management requires a firm understanding of the location of the species’ core habitat patches, the dispersal corridors connecting them, and the risk they face from key threats, notably deforestation. To quantify and map core habitat patches and dispersal corridors for Sunda clouded leopard ( Neofelis diardi diardi ), Asiatic golden cat ( Catopuma temminckii ) and marbled cat ( Pardofelis marmorata ) across the 16,000 km 2 tropical rainforest Kerinci Seblat landscape, Sumatra. Also, to model future forest loss and fragmentation and its effect on landscape connectivity for populations of these threatened species. Using data from camera trap (671 sites/55,856 trap nights), and occupancy modelling, we developed habitat use maps and converted these into species-specific landscape resistance layers. We applied cumulative resistant kernels to map core areas and we used factorial least-cost paths to define dispersal corridors. A 17-year deforestation dataset was used to predict deforestation risk towards the integrity of corridors and core areas. The occupancy estimates of the three cats were similar (0.18–0.29), with preference shown for habitats with dense tree cover, medium elevation and low human disturbance. The overlap between core areas and corridors across the three species was moderate, 7–11% and 10%, respectively. We predicted future loss of 1052 km 2 of forest in the landscape, of which 2–4% and 5% in highly importance core areas and corridors. This study provides a valuable guidance for identifying priority areas in need of urgent protection within and outside the protected area network, and where infrastructure development planning can incorporate wildlife conservation goals.
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Lara L. Sousa.