ORCID Profile
0000-0003-0248-3627
Current Organisations
Beckman Research Institute, City of Hope
,
Lawrence Livermore National Laboratory
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Publisher: AIP Publishing
Date: 31-03-2010
DOI: 10.1063/1.3358144
Abstract: The equation of state (EOS) of polystyrene and polypropylene were measured using laser-driven shock waves with pressures from 1 to 10 Mbar. Precision data resulting from the use of α-quartz as an impedance-matching (IM) standard tightly constrains the EOS of these hydrocarbons, even with the inclusion of systematic errors inherent to IM. The temperature at these high pressures was measured, which, combined with kinematic measurements, provide a complete shock EOS. Both hydrocarbons were observed to reach similar compressions and temperatures as a function of pressure. The materials were observed to transition from transparent insulators to reflecting conductors at pressures of 1 to 2 Mbar.
Publisher: American Physical Society (APS)
Date: 05-08-2013
Publisher: AIP Publishing
Date: 2019
DOI: 10.1063/1.5053994
Abstract: Many experimental studies, spanning several decades of research and using various dynamic compression schemes, have been conducted to investigate cryogenic liquid deuterium under strong shock compression. The consensus emerging from these studies is that of a progressive dissociation of the D2 molecules into an electrically conducting, atomic plasma, when subjected to shock pressures exceeding ∼50 GPa. While state-of-the-art numerical simulations based on density-functional-theory or quantum Monte-Carlo techniques capture this behavior quite well, subtle differences subsist between these simulations and the available experimental data regarding the pressure-density compressibility. Here, leveraging a recently developed analysis method for high-resolution Doppler interferometric velocity data, we present Eulerian sound speed measurements in compressed deuterium to shock pressures between 50 and 200 GPa. These results, extracted from laser-driven shockwave experiments, are found to agree with several of the most accurate equation of state models for deuterium at those conditions up to ∼150 GPa. However, the data indicate that these models fail to reproduce the experimentally observed sound speed at higher pressures, approaching 200 GPa. In particular, we unveil a discrepancy between the experimental results and the equation of state model that is most commonly used in inertial confinement fusion at the National Ignition Facility.
Publisher: Elsevier BV
Date: 08-2017
Publisher: AIP Publishing
Date: 09-2011
DOI: 10.1063/1.3640805
Publisher: Elsevier BV
Date: 08-2019
Publisher: Cold Spring Harbor Laboratory
Date: 28-06-2019
DOI: 10.1101/680462
Abstract: NAD + is modulated by conditions of metabolic stress and has been reported to decline with aging, but human data are sparse. Nicotinamide riboside (NR) supplementation ameliorates metabolic dysfunction in rodents. We aimed to establish whether oral NR supplementation in aged participants can increase the skeletal muscle NAD + metabolome, and questioned if tissue NAD + levels are depressed with aging. We supplemented 12 aged men with NR 1g per day for 21-days in a placebo-controlled, randomized, double-blind, crossover trial. Targeted metabolomics showed that NR elevated the muscle NAD + metabolome, evident by increased nicotinic acid adenine dinucleotide and nicotinamide clearance products. Muscle RNA sequencing revealed NR-mediated downregulation of energy metabolism and mitochondria pathways. NR also depressed levels of circulating inflammatory cytokines. In an additional study, 31 P magnetic resonance spectroscopy-based NAD + measurement in muscle and brain showed no difference between young and aged in iduals. Our data establish that oral NR is available to aged human muscle and identify anti-inflammatory effects of NR, while suggesting that NAD + decline is not associated with chronological aging per se in human muscle or brain.
Publisher: MDPI AG
Date: 23-07-2018
DOI: 10.3390/BIOENGINEERING5030057
Abstract: Cell culture and cell scaffold engineering have previously developed in two directions. First can be ‘static into dynamic’, with proven effects that dynamic cultures have benefits over static ones. Researches in this direction have used several mechanical means, like external vibrators or shakers, to approximate the dynamic environments in real tissue, though such approaches could only partly address the issue. Second, can be ‘2D into 3D’, that is, artificially created three-dimensional (3D) passive (also called ‘static’) scaffolds have been utilized for 3D cell culture, helping external culturing conditions mimic real tissue 3D environments in a better way as compared with traditional two-dimensional (2D) culturing. In terms of the fabrication of 3D scaffolds, 3D printing (3DP) has witnessed its high popularity in recent years with ascending applicability, and this tendency might continue to grow along with the rapid development in scaffold engineering. In this review, we first introduce cell culturing, then focus 3D cell culture scaffold, vibration stimulation for dynamic culture, and 3DP technologies fabricating 3D scaffold. Potential interconnection of these realms will be analyzed, as well as the limitations of current 3D scaffold and vibration mechanisms. In the recommendation part, further discussion on future scaffold engineering regarding 3D vibratory scaffold will be addressed, indicating 3DP as a positive bridging technology for future scaffold with integrated and localized vibratory functions.
Publisher: AIP Publishing
Date: 05-2012
DOI: 10.1063/1.4712050
Abstract: A large uncertainty in the design of ignition capsules for use in the National Ignition C aign (NIC) is the ablator equation of state. In this article, we report equation-of-state measurements for two candidate NIC ablator materials, glow-discharge polymer (GDP), and germanium-doped GDP. These materials were driven to pressures of 1 to 12 Mbar using laser-driven shock waves. Hugoniot measurements were obtained using the impedance matching technique with an α-quartz standard. This article presents the first kinematic measurements in the high-pressure fluid regime for these materials, which show to be in close agreement with Livermore equation-of-state model predictions.
Publisher: American Physical Society (APS)
Date: 09-01-2017
Publisher: Elsevier BV
Date: 03-2012
Publisher: AIP Publishing
Date: 10-2011
DOI: 10.1063/1.3646554
Abstract: The instantaneous scaling of ablation pressure to laser intensity is directly inferred for r compression of diamond targets irradiated by 351-nm light. Continuously increasing pressure profiles from 100 to 970 GPa are produced by direct-drive laser ablation at intensities up to 7 × 1013 W/cm2. The free-surface velocity on the rear of the target is used to directly infer the instantaneous ablation-pressure profile at the front of the target. The laser intensity on target is determined by laser power measurements and fully characterized laser spots. The ablation pressure is found to depend on the laser intensity as P(GPa)=42(±3)[I(TW/cm2)]0.71(±0.01).
Publisher: AIP Publishing
Date: 16-11-2015
DOI: 10.1063/1.4935295
Abstract: Megabar (1 Mbar = 100 GPa) laser shocks on precompressed s les allow reaching unprecedented high densities and moderately high ∼103–104 K temperatures. We describe here a complete analysis framework for the velocimetry (VISAR) and pyrometry (SOP) data produced in these experiments. Since the precompression increases the initial density of both the s le of interest and the quartz reference for pressure-density, reflectivity, and temperature measurements, we describe analytical corrections based on available experimental data on warm dense silica and density-functional-theory based molecular dynamics computer simulations. Using our improved analysis framework, we report a re-analysis of previously published data on warm dense hydrogen and helium, compare the newly inferred pressure, density, and temperature data with most advanced equation of state models and provide updated reflectivity values.
Publisher: Springer Science and Business Media LLC
Date: 16-11-2018
DOI: 10.1038/S41598-018-35260-3
Abstract: Bismuth has long been a prototypical system for investigating phase transformations and melting at high pressure. Despite decades of experimental study, however, the lattice-level response of Bi to rapid (shock) compression and the relationship between structures occurring dynamically and those observed during slow (static) compression, are still not clearly understood. We have determined the structural response of shock-compressed Bi to 68 GPa using femtosecond X-ray diffraction, thereby revealing the phase transition sequence and equation-of-state in unprecedented detail for the first time. We show that shocked-Bi exhibits a marked departure from equilibrium behavior - the incommensurate Bi-III phase is not observed, but rather a new metastable phase, and the Bi-V phase is formed at significantly lower pressures compared to static compression studies. We also directly measure structural changes in a shocked liquid for the first time. These observations reveal new behaviour in the solid and liquid phases of a shocked material and give important insights into the validity of comparing static and dynamic datasets.
Publisher: AIP Publishing
Date: 15-06-2011
DOI: 10.1063/1.3599884
Abstract: We report the highest pressure under which a transparent insulator has been observed. The refractive index of r -compressed lithium fluoride (LiF) is measured up to a pressure of 800 GPa and is observed to maintain its linear dependence on density. An effective single-oscillator model infers that the bandgap monotonically closes with increasing density, indicating that metallization of LiF should occur at pressures above 4000 GPa, and that LiF should remain transparent at extremely high pressures.
Location: United States of America
Location: United States of America
Location: United States of America
No related grants have been discovered for Dayne Fratanduono.