ORCID Profile
0000-0002-0031-526X
Current Organisations
University of Agriculture Faisalabad
,
Universiteit Hasselt
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Publisher: Elsevier BV
Date: 06-2018
DOI: 10.1016/J.MICPATH.2018.04.020
Abstract: Classical swine fever virus (CSFV) infection causes mild to severe diseases among pigs, depending on the age and immune status of the host and viral strains. CSFV targets various cells, including macrophages and conventional and plasmacytoid dendritic cells. Classical swine fever is one of the most devastating diseases of pigs which leads to high morbidity and mortality, and causes significant economic loss worldwide. In response to infection with CSFV, host innate immune system eliminates the virus by recognizing specific viral molecules via distinct cellular pattern recognition receptors. These receptors trigger downstream intracellular signaling pathways, which regulate the translocation and activation of transcription factors that control the production of cytokines and interferons (IFNs). In turn, these IFNs activate JAK-STAT signaling that governs the transcription of IFN-stimulated genes (ISGs) that play critical roles in antiviral immunity. However, CSFV has evolved different strategies to evade innate immune signaling and can establish persistent infection without being recognized by immune surveillance. In this review, we discuss the current understanding of host innate response to CSFV infection. We also summarize how CSFV evades innate immunity to establish its chronic infection.
Publisher: Elsevier BV
Date: 08-2013
Publisher: Frontiers Media SA
Date: 2010
Publisher: Frontiers Media SA
Date: 09-01-2018
Publisher: Frontiers Media SA
Date: 2009
Publisher: Springer Science and Business Media LLC
Date: 13-06-2014
DOI: 10.1038/CDD.2014.75
Publisher: Wiley
Date: 30-06-2020
DOI: 10.1111/BPH.15136
Publisher: Elsevier BV
Date: 05-2018
DOI: 10.1016/J.CELREP.2018.04.083
Abstract: The protein p27
Location: China
No related grants have been discovered for Jean-Michel Rigo.