ORCID Profile
0000-0003-4962-7587
Current Organisation
Queensland University of Technology
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Biomaterials | Biomedical engineering not elsewhere classified | Biomedical engineering | Manufacturing Engineering | Manufacturing Processes and Technologies (excl. Textiles) | Machine learning not elsewhere classified | Petroleum and Reservoir Engineering | Timber, Pulp and Paper | Approximation theory and asymptotic methods | Numerical analysis | Image processing | Numerical and computational mathematics
ANZSRC Socio-Economic Objective (SEO)
Oil and Gas Extraction | Wood, Wood Products and Paper not elsewhere classified | Fabricated Metal Products not elsewhere classified |
Related Links
Publications
Synthesis, application and evaluation of non-sintered zeolite porous filter (ZPF) as novel filter media in biological aerated filters (BAFs)
Publisher: Elsevier BV
Date: 09-2016
Transducer impulse response correction for a deconvolution derived ultrasound transit time spectrum
Publisher: IOP Publishing
Date: 30-08-2018
Abstract: Propagation of ultrasound through a complex composite s le may exhibit phase interference between two or more sonic-rays if differences in transit time are less than the pulse length. The transit time spectrum of a test s le, equivalent to its impulse response, was derived through active-set deconvolution of ultrasound signals with, and without, the test s le. The aim of this study was to test the hypothesis that in cases where only the transmit ultrasound transducer's digitally-coded excitation signal is available, hence not the input ultrasound signal without the test s le, incorporation of the transducer impulse response may increase both accuracy and precision of ultrasound transit time spectroscopy. A digital 1 MHz sinusoid signal was used to create an ultrasound pulse that was propagated through a 5 step-wedge acrylic s le immersed in water. Transit time spectra were obtained through deconvolution utilising an ultrasound input signal, along with a digital input signal, with and without incorporation of the transducer impulse response. Incorporation of the transducer impulse response reduced a quantitative measure of noise-to-signal ratio by a factor of 12. The paper has demonstrated the potential for increased accuracy and precision of transit time spectroscopy when the transducer impulse response is incorporated within active-set deconvolution analysis.
Mechanical and geometrical study of 3D printed Voronoi scaffold design for large bone defects
Publisher: Elsevier BV
Date: 12-2021
A deconvolution method for deriving the transit time spectrum for ultrasound propagation through cancellous bone replica models
Publisher: SAGE Publications
Date: 05-03-2014
Abstract: The acceptance of broadband ultrasound attenuation for the assessment of osteoporosis suffers from a limited understanding of ultrasound wave propagation through cancellous bone. It has recently been proposed that the ultrasound wave propagation can be described by a concept of parallel sonic rays. This concept approximates the detected transmission signal to be the superposition of all sonic rays that travel directly from transmitting to receiving transducer. The transit time of each ray is defined by the proportion of bone and marrow propagated. An ultrasound transit time spectrum describes the proportion of sonic rays having a particular transit time, effectively describing lateral inhomogeneity of transit times over the surface of the receiving ultrasound transducer. The aim of this study was to provide a proof of concept that a transit time spectrum may be derived from digital deconvolution of input and output ultrasound signals. We have applied the active-set method deconvolution algorithm to determine the ultrasound transit time spectra in the three orthogonal directions of four cancellous bone replica s les and have compared experimental data with the prediction from the computer simulation. The agreement between experimental and predicted ultrasound transit time spectrum analyses derived from Bland–Altman analysis ranged from 92% to 99%, thereby supporting the concept of parallel sonic rays for ultrasound propagation in cancellous bone. In addition to further validation of the parallel sonic ray concept, this technique offers the opportunity to consider quantitative characterisation of the material and structural properties of cancellous bone, not previously available utilising ultrasound.
Convergence of scaffold-guided bone regeneration principles and microvascular tissue transfer surgery
Publisher: American Association for the Advancement of Science (AAAS)
Date: 05-05-2023
Abstract: A preclinical evaluation using a regenerative medicine methodology comprising an additively manufactured medical-grade ε-polycaprolactone β-tricalcium phosphate (mPCL-TCP) scaffold with a corticoperiosteal flap was undertaken in eight sheep with a tibial critical-size segmental bone defect (9.5 cm 3 , M size) using the regenerative matching axial vascularization (RMAV) approach. Biomechanical, radiological, histological, and immunohistochemical analysis confirmed functional bone regeneration comparable to a clinical gold standard control (autologous bone graft) and was superior to a scaffold control group (mPCL-TCP only). Affirmative bone regeneration results from a pilot study using an XL size defect volume (19 cm 3 ) subsequently supported clinical translation. A 27-year-old adult male underwent reconstruction of a 36-cm near-total intercalary tibial defect secondary to osteomyelitis using the RMAV approach. Robust bone regeneration led to complete independent weight bearing within 24 months. This article demonstrates the widely advocated and seldomly accomplished concept of “bench-to-bedside” research and has weighty implications for reconstructive surgery and regenerative medicine more generally.
Pulse-echo ultrasound transit time spectroscopy: A comparison of experimental measurement and simulation prediction
Publisher: SAGE Publications
Date: 18-11-2015
Abstract: Considering ultrasound propagation through complex composite media as an array of parallel sonic rays, a comparison of computer-simulated prediction with experimental data has previously been reported for transmission mode (where one transducer serves as transmitter, the other as receiver) in a series of 10 acrylic step-wedge s les, immersed in water, exhibiting varying degrees of transit time inhomogeneity. In this study, the same s les were used but in pulse-echo mode, where the same ultrasound transducer served as both transmitter and receiver, detecting both ‘primary’ (internal s le interface) and ‘secondary’ (external s le interface) echoes. A transit time spectrum was derived, describing the proportion of sonic rays with a particular transit time. A computer simulation was performed to predict the transit time and litude of various echoes created, and compared with experimental data. Applying an litude-tolerance analysis, 91.7% ± 3.7% of the simulated data were within ±1 standard deviation of the experimentally measured litude-time data. Correlation of predicted and experimental transit time spectra provided coefficients of determination (R 2 %) ranging from 100.0% to 96.8% for the various s les tested. The results acquired from this study provide good evidence for the concept of parallel sonic rays. Furthermore, deconvolution of experimental input and output signals has been shown to provide an effective method to identify echoes otherwise lost due to phase cancellation. Potential applications of pulse-echo ultrasound transit time spectroscopy include improvement of ultrasound image fidelity by improving spatial resolution and reducing phase interference artefacts.
Melt Electrospinning Writing of Highly Ordered Large Volume Scaffold Architectures
Publisher: Wiley
Date: 10-04-2018
Abstract: The additive manufacturing of highly ordered, micrometer-scale scaffolds is at the forefront of tissue engineering and regenerative medicine research. The fabrication of scaffolds for the regeneration of larger tissue volumes, in particular, remains a major challenge. A technology at the convergence of additive manufacturing and electrospinning-melt electrospinning writing (MEW)-is also limited in thickness/volume due to the accumulation of excess charge from the deposited material repelling and hence, distorting scaffold architectures. The underlying physical principles are studied that constrain MEW of thick, large volume scaffolds. Through computational modeling, numerical values variable working distances are established respectively, which maintain the electrostatic force at a constant level during the printing process. Based on the computational simulations, three voltage profiles are applied to determine the maximum height (exceeding 7 mm) of a highly ordered large volume scaffold. These thick MEW scaffolds have fully interconnected pores and allow cells to migrate and proliferate. To the best of the authors knowledge, this is the first study to report that z-axis adjustment and increasing the voltage during the MEW process allows for the fabrication of high-volume scaffolds with uniform morphologies and fiber diameters.
Application of ultrasound transit time spectroscopy to human cancellous bone for derivation of bone volume fraction in-vitro
Publisher: Acoustical Society of America (ASA)
Date: 04-2015
DOI: 10.1121/1.4920339
Abstract: We have previously demonstrated that ultrasound propagation in complex composite media may be described as an array of parallel sonic rays. The transit time of each sonic ray is determined by the proportion of solid (bone) and fluid (marrow) traversed, the received ultrasound signal being a superposition of all sonic rays. An Ultrasound Transit Time Spectrum (UTTS) for a test s le may be obtained via digital deconvolution of input and output ultrasound signals, describing the proportion of sonic rays having a particular transit time, from which the bone volume fraction (BVF) of the s le may be estimated. In a recent in-vitro study, 21 cancellous bone s les, extracted from 5 human femoral heads following total hip replacement, were measured with microCT to derive the true BVF value. Transmission ultrasound signals of 1 MHz were recorded and UTTS-derived BVF calculated. A coefficient of determination (R2) of 82% was achieved between ultrasound and microCT derived BVF values. Current work is clinically implementing UTTS, noting its potential to estimate bone mineral density, and hence, a means to diagnose osteopenia and osteoporosis using WHO T-score criteria.
Microenvironment engineering of osteoblastic bone metastases reveals osteomimicry of patient-derived prostate cancer xenografts
Publisher: Elsevier BV
Date: 11-2019
DOI: 10.1016/J.BIOMATERIALS.2019.119402
Abstract: Representative in vitro models that mimic the native bone tumor microenvironment are warranted to support the development of more successful treatments for bone metastases. Here, we have developed a primary cell 3D model consisting of a human osteoblast-derived tissue-engineered construct (hOTEC) indirectly co-cultured with patient-derived prostate cancer xenografts (PDXs), in order to study molecular interactions in a patient-derived microenvironment context. The engineered biomimetic microenvironment had high mineralization and embedded osteocytes, and supported a high degree of cancer cell osteomimicry at the gene, protein and mineralization levels when co-cultured with prostate cancer PDXs from a lymph node metastasis (LuCaP35) and bone metastasis (BM18) from patients with primary prostate cancer. This fully patient-derived model is a promising tool for the assessment of new molecular mechanisms and as a personalized pre-clinical platform for therapy testing for patients with prostate cancer bone metastases.
4D Ultrasound-Based Knee Joint Atlas for Robotic Knee Arthroscopy: A Feasibility Study
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2020
Potential for ultrasound transit time spectroscopy to improve axial resolution
Publisher: Elsevier BV
Date: 04-2018
The application of metal artifact reduction methods on computed tomography scans for radiotherapy applications: A literature review
Publisher: Wiley
Date: 03-05-2021
DOI: 10.1002/ACM2.13255
Abstract: Metal artifact reduction (MAR) methods are used to reduce artifacts from metals or metal components in computed tomography (CT). In radiotherapy (RT), CT is the most used imaging modality for planning, whose quality is often affected by metal artifacts. The aim of this study is to systematically review the impact of MAR methods on CT Hounsfield Unit values, contouring of regions of interest, and dose calculation for RT applications. This systematic review is performed in accordance with the PRISMA guidelines the PubMed and Web of Science databases were searched using the main keywords “metal artifact reduction”, “computed tomography” and “radiotherapy”. A total of 382 publications were identified, of which 40 (including one review article) met the inclusion criteria and were included in this review. The selected publications (except for the review article) were grouped into two main categories: commercial MAR methods and research‐based MAR methods. Conclusion: The application of MAR methods on CT scans can improve treatment planning quality in RT. However, none of the investigated or proposed MAR methods was completely satisfactory for RT applications because of limitations such as the introduction of other errors (e.g., other artifacts) or image quality degradation (e.g., blurring), and further research is still necessary to overcome these challenges.
A performance evaluation of a new iron oxide-based porous ceramsite (IPC) in biological aerated filters
Publisher: Informa UK Limited
Date: 03-08-2016
DOI: 10.1080/09593330.2016.1213769
Abstract: A novel medium containing iron oxide-based porous ceramsite (IPC) and commercial ceramsite (CC) was used in two laboratory-scale upflow biological aerated filters (BAFs) to treat city wastewater to compare their efficacy in wastewater treatment. The IPC BAF and CC BAF were operated in water at 20-26°C, an air/water (A/W) ratio of: 3:1 and hydraulic retention times (HRTs) of 7, 3.5, 1.75, and 0.5 h and the removal of ammonia nitrogen (NH
In vitro engineering of a bone metastases model allows for study of the effects of antiandrogen therapies in advanced prostate cancer
Publisher: American Association for the Advancement of Science (AAAS)
Date: 02-07-2021
Abstract: In vitro engineering of a bone metastases model allows us to study the effects of antiandrogens in advanced prostate cancer.
The development of a modular design workflow for 3D printable bioresorbable patient-specific bone scaffolds to facilitate clinical translation
Publisher: Informa UK Limited
Date: 05-09-2023
Preparation of iron oxide-based porous ceramsite from goethite and application for city wastewater treatment in biological aerated filters
Publisher: Informa UK Limited
Date: 15-10-2015
A 3D-printed passive ultrasound phase-interference compensator for reduced wave degradation in cancellous bone – an experimental study in replica models
Publisher: SAGE Publications
Date: 2018
Abstract: The current ‘active’ solution to overcome the impediment of ultrasound wave degradation associated with transit-time variation in complex tissue structures, such as the skull, is to vary the transmission delay of ultrasound pulses from in idual transducer elements. This article considers a novel ‘passive’ solution in which constant transit time is achieved by propagating through an additional material layer positioned between the ultrasound transducer and the test s le. To test the concept, replica models based on four cancellous bone natural tissue s les and their corresponding passive ultrasound phase-interference compensator were 3D-printed. Normalised broadband ultrasound attenuation was used as a quantitative measure of wave degradation, performed in transmission mode at a frequency of 1 MHz and yielding a reduction ranging from 57% to 74% when the ultrasound phase-interference compensator was incorporated. It is suggested that the passive compensator offers a broad utility and, hence, it may be applied to any ultrasound transducer, of any complexity (single element or array), frequency and dimension.
Synthesis, application, and evaluation of palygorskite porous ceramsite as filter media in biological aerated filters
Publisher: Desalination Publications
Date: 2017
Synthesis and performance of iron oxide-based porous ceramsite in a biological aerated filter for the simultaneous removal of nitrogen and phosphorus from domestic wastewater
Publisher: Elsevier BV
Date: 07-2016
Production of zeolite composite filters using waste paper pulp as slow release carbon source and performance investigation in a biological aerated filter
Publisher: Elsevier BV
Date: 02-2016
Advanced wastewater treatment with autoclaved aerated concrete particles in biological aerated filters
Publisher: Elsevier BV
Date: 02-2016
3D printed lattices as an activation and expansion platform for T cell therapy
Publisher: Elsevier BV
Date: 09-2017
DOI: 10.1016/J.BIOMATERIALS.2017.05.009
Abstract: One of the most significant hurdles to the affordable, accessible delivery of cell therapy is the cost and difficulty of expanding cells to clinically relevant numbers. Immunotherapy to prevent autoimmune disease, tolerate organ transplants or target cancer critically relies on the expansion of specialized T cell populations. We have designed 3D-printed cell culture lattices with highly organized micron-scale architectures, functionalized via plasma polymerization to bind monoclonal antibodies that trigger cell proliferation. This 3D technology platform facilitate the expansion of therapeutic human T cell subsets, including regulatory, effector, and cytotoxic T cells while maintaining the correct phenotype. Lentiviral gene delivery to T cells is enhanced in the presence of the lattices. Incorporation of the lattice format into existing cell culture vessels such as the G-Rex system is feasible. This cell expansion platform is user-friendly and expedites cell recovery and scale-up, making it ideal for translating T cell therapies from bench to bedside.
Bone Regeneration Exploiting Corticoperiosteal Tissue Transfer for Scaffold-Guided Bone Regeneration
Publisher: Mary Ann Liebert Inc
Date: 05-2022
Solid volume fraction estimation of bone:marrow replica models using ultrasound transit time spectroscopy.
Publisher: Elsevier BV
Date: 02-2016
DOI: 10.1016/J.ULTRAS.2015.09.009
Abstract: The acceptance of broadband ultrasound attenuation (BUA) for the assessment of osteoporosis suffers from a limited understanding of both ultrasound wave propagation through cancellous bone and its exact dependence upon the material and structural properties. It has recently been proposed that ultrasound wave propagation in cancellous bone may be described by a concept of parallel sonic rays the transit time of each ray defined by the proportion of bone and marrow propagated. A Transit Time Spectrum (TTS) describes the proportion of sonic rays having a particular transit time, effectively describing the lateral inhomogeneity of transit times over the surface aperture of the receive ultrasound transducer. The aim of this study was to test the hypothesis that the solid volume fraction (SVF) of simplified bone:marrow replica models may be reliably estimated from the corresponding ultrasound transit time spectrum. Transit time spectra were derived via digital deconvolution of the experimentally measured input and output ultrasonic signals, and compared to predicted TTS based on the parallel sonic ray concept, demonstrating agreement in both position and litude of spectral peaks. Solid volume fraction was calculated from the TTS agreement between true (geometric calculation) with predicted (computer simulation) and experimentally-derived values were R(2)=99.9% and R(2)=97.3% respectively. It is therefore envisaged that ultrasound transit time spectroscopy (UTTS) offers the potential to reliably estimate bone mineral density and hence the established T-score parameter for clinical osteoporosis assessment.
Bayesian CNN for Segmentation Uncertainty Inference on 4D Ultrasound Images of the Femoral Cartilage for Guidance in Robotic Knee Arthroscopy
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2020
Sub-transducer element spatial resolution ultrasound wavefront modification using passive twin-layer compensators
Publisher: Elsevier BV
Date: 02-2018
Improvement of B-scan spatial resolution by pulse-echo ultrasound transit time spectroscopy
Publisher: Elsevier BV
Date: 02-2019
Experimental and computer simulation validation of ultrasound phase interference created by lateral inhomogeneity of transit time in replica bone: marrow composite models
Publisher: SAGE Publications
Date: 26-04-2013
Abstract: The measurement of broadband ultrasound attenuation in cancellous bone for the assessment of osteoporosis follows a parabolic-type dependence with bone volume fraction, having minima values corresponding to both entire bone and entire marrow. Langton has recently proposed that the primary attenuation mechanism is phase interference due to variations in propagation transit time through the test s le as detected over the phase-sensitive surface of the receive ultrasound transducer. This fundamentally simple concept assumes that the propagation may be considered as an array of parallel ‘sonic rays’. The transit time of each ray is defined by the proportion of bone and marrow propagated, being a minimum (t min ) solely through bone and a maximum (t max ) solely through marrow, from which a transit time spectrum, may be defined describing the proportion of sonic rays having a particular transit time. The aim of this study was to test the hypothesis that there is a dependence of phase interference upon the lateral inhomogeneity of transit time by comparing experimental measurements and computer simulation predictions of ultrasound propagation through a range of relatively simplistic solid:liquid models. From qualitative and quantitative comparison of the experimental and computer simulation results, there is an extremely high degree of agreement of 94.2%–99.0% between the two approaches. This combined experimental and computer simulation study has successfully demonstrated that lateral inhomogeneity of transit time has significant potential for phase interference to occur if a phase-sensitive receive ultrasound transducer is implemented as in most commercial ultrasound bone analysis devices.
Frequency Independence of Ultrasound Transit Time Spectroscopy
Publisher: Springer International Publishing
Date: 2015
Pectus excavatum camouflage: a new technique using a tissue engineered scaffold
Publisher: Springer Science and Business Media LLC
Date: 19-11-2022
Combining Ultrasound Pulse-Echo and Transmission Computed Tomography for Quantitative Imaging the Cortical Shell of Long-Bone Replicas
Publisher: Frontiers Media SA
Date: 29-11-2017
Histomorphometric Evaluation of Critical-Sized Bone Defects Using Osteomeasure and Aperio Image Analysis Systems
Publisher: Mary Ann Liebert Inc
Date: 12-2019
Performance and characterization of a non-sintered zeolite porous filter for the simultaneous removal of nitrogen and phosphorus in a biological aerated filter (BAF)
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6RA05417J
Abstract: A novel non-sintered zeolite porous filter (ZPF) and commercially available ceramsite (CAC) are used to investigate the simultaneous removal of nitrogen and phosphorus from city wastewater treated by biological aerated filter (BAF) reactors.
Trajectory fluctuations accompanying the manipulation of spherical nanoparticles
Publisher: American Physical Society (APS)
Date: 10-11-2009
Bone volume fraction and structural parameters for estimation of mechanical stiffness and failure load of human cancellous bone samples; in-vitro comparison of ultrasound transit time spectroscopy and
Publisher: Elsevier BV
Date: 02-2018
DOI: 10.1016/J.BONE.2017.11.021
Abstract: Conventional mechanical testing is the 'gold standard' for assessing the stiffness (N mm
Regenerative matching axial vascularisation of absorbable 3D-printed scaffold for large bone defects: A first in human series
Publisher: Elsevier BV
Date: 07-2022
Ultrasound-triggered release from metal shell microcapsules
Publisher: Elsevier BV
Date: 10-2019
DOI: 10.1016/J.JCIS.2019.07.020
Abstract: Metal shell microcapsules have been shown to completely retain their core until its release is triggered, making them a promising candidate for use as a controllable drug delivery vehicle due to their superior retention properties as compared to polymer shell microcapsules. Focused ultrasound (FUS) has been successfully utilised to trigger release of lipophilic drugs from polymer microcapsules, and in this work the response of gold shell microcapsules with and without an inner polymeric shell, to FUS and standard ultrasound is explored. The results show that gold shell microcapsules with an inner polymer shell rupture when exposed to standard ultrasound and that there is a linear correlation between the gold shell thickness and the extent of shell rupture. When FUS is applied to these microcapsules, powers as low as 0.16 W delivered in bursts of 10 ms/s over a period of 120 s are sufficient to cause rupture of 53 nm gold shell microcapsules. Additional findings suggest that gold shell microcapsules without the polymer layer dispersed in a hydrogel matrix, as opposed to aqueous media, rupture more efficiently when exposed to FUS, and that thicker gold shells are more responsive to ultrasound-triggered rupture regardless of the external environment. Release of dye from all successfully ruptured capsules was sustained over a period of between 7 and 35 days. These findings suggest that emulsion-templated gold shell microcapsules embedded in a hydrogel matrix would be suitable for use as an implantable drug delivery vehicle with FUS used to externally trigger release.
Soft-tissue thickness compensation for ultrasound transit time spectroscopy estimated bone volume fraction—an experimental replication study
Publisher: IOP Publishing
Date: 07-07-2017
Estimation of mechanical stiffness by finite element analysis of ultrasound computed tomography (UCT-FEA); a comparison with X-ray µCT based FEA in cancellous bone replica models
Publisher: Elsevier BV
Date: 04-2018
A New Automated Histomorphometric MATLAB Algorithm for Immunohistochemistry Analysis Using Whole Slide Imaging
Publisher: Mary Ann Liebert Inc
Date: 09-2020
Comparison of active-set method deconvolution and matched-filtering for derivation of an ultrasound transit time spectrum
Publisher: IOP Publishing
Date: 05-06-2015
The dependence of broadband ultrasound attenuation on phase interference in thin plates of variable thickness and curvature: a comparison of experimental measurement and computer simulation
Publisher: SAGE Publications
Date: 28-03-2018
Abstract: The measurement of broadband ultrasound attenuation describes the linear increase in ultrasound attenuation with frequency (dB/MHz) this is generally performed at the calcaneus, consisting of a high proportion of metabolically active cancellous bone. Although broadband ultrasound attenuation is not routinely implemented within clinical management since it cannot provide a reliable estimation of bone mineral density and hence clinical definition of osteopenia and osteoporosis, it offers a reliable means to predict osteoporotic fracture risk. One of the potential factors that can influence the accuracy of broadband ultrasound attenuation measurement is the effect of cortical end plates. This study aimed to explore this, performing a comparison of experimental study and computer simulation prediction. A total of three categories of thin discs were three-dimensional (3D) printed to replicate cortical shells of (1) variable constant thickness (planar), (2) variable constant thickness (curved), and (3) variable thickness. A through-transmission technique was used, where two single-element, unfocused, 1 MHz broadband transducers, as utilised clinically, were positioned coaxially in a cylindrical holder and immersed in water. Both quantitative and qualitative analyses demonstrated that broadband ultrasound attenuation measurements of the ‘planar’ and ‘curved’ discs were not statistically different (p-values 0.01). A cyclic relationship between broadband ultrasound attenuation and disc thickness was observed this was replicated within a computer simulation of phase interference created by a double-reflection echo within each disc (R 2 = 97.0%). Variable-thickness discs provided broadband ultrasound attenuation measurements ranging between 31.6 ± 0.1 and 40.60 ± 0.1 dB/MHz. Again applying the double-reflection echo simulation, a high level of agreement between experimental and simulation was recorded (R 2 = 93.4%). This study indicates that the cortical end plate can significantly affect the broadband ultrasound attenuation measurement of cancellous bone as a result of phase interference and, therefore, warrants further investigation to minimise its effect on clinical assessment.
Clinical translation of a patient-specific scaffold-guided bone regeneration concept in four cases with large long bone defects
Publisher: Elsevier BV
Date: 05-2022
Feasibility of 3D printing for customized radiotherapeutic models to be used in superficial skin cancer therapy
Publisher: Transactions on Additive Manufacturing Meets Medicine
Date: 2019
Changes in placental elastography in the third trimester - Analysis using a linear mixed effect model
Publisher: Elsevier BV
Date: 10-2021
DOI: 10.1016/J.PLACENTA.2021.09.001
Abstract: Research into the role of ultrasound elastography to assess compromised placental tissue is ongoing. There is particular interest in evaluating its potential in the investigation of changes associated with uteroplacental dysfunction. To date, there is limited data on how different maternal and fetal considerations, such as advancing gestational age, amniotic fluid Index (AFI) and maternal body mass index (BMI) may influence shear wave velocity (SWV) measurements. This study aimed to evaluate longitudinal changes in SWV throughout gestation and model these changes with other developing fetal and maternal physiological and biological characteristics. The study utilised 238 singleton pregnancies and collected longitudinal data at repeated intervals in the 3rd trimester representing 629 in idual data points. Linear mixed model regression analysis was used to identify significant predictors for SWV. From a total of ten variables selected for modelling, only gestational age, AFI, BMI, and s le depth were found to be significant predictors of placental SWV, and gestational age and AFI were found to have only a minimal impact on SWV. Sophisticated statistical modelling demonstrates that many of the expected maternal and fetal changes in the 3rd trimester have no or minimal impact on placental SWV. Understanding which factors influence placental SWV is essential to ascertain the technique's utility in managing pregnancies complicated by placental dysfunction in the future.
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