ORCID Profile
0000-0002-4400-2732
Current Organisations
Aalborg University
,
Region Nordjylland
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Publisher: The Endocrine Society
Date: 19-07-2018
Abstract: Little is known about long-term excess mortality following fragility nonhip fractures. The study aimed to determine which fracture was associated with excess mortality and for how long the postfracture excess mortality persisted. This nationwide registry-based follow-up study included all in iduals in Denmark aged 50+ years who first experienced fragility fractures in 2001 and were followed up for up to 10 years for their mortality risk. The contribution of fracture to mortality at precise postfracture time intervals was examined using relative survival analysis, accounting for time-related mortality changes in the background population. There were 21,123 women (aged 72 ± 13 years) and 9481 men (aged 67 ± 12 years) with an incident fragility fracture in 2001, followed by 10,668 and 4745 deaths, respectively. Excess mortality was observed following all proximal and lower leg fractures. The majority of deaths occurred within the first year after fracture, and thereafter excess mortality gradually declined. Hip fractures were associated with the highest excess mortality (33% and 20% at 1 year after fracture in men and women, respectively). One-year excess mortality after fracture of a femur or pelvis was 20% to 25% vertebrae, 10% humerus, rib, or clavicle, 5% to 10% and lower leg, 3%. A significant although smaller excess mortality was still observed until 10 years for hip fractures and ~5 years after femur, other proximal, and lower leg fractures. This study highlights the important contribution of a wide variety of fragility fractures to long-term excess mortality and thus the potential for benefit from early intervention.
Publisher: eLife Sciences Publications, Ltd
Date: 16-05-2023
DOI: 10.7554/ELIFE.83888
Abstract: Fragility fracture is associated with an increased risk of mortality, but mortality is not part of doctor-patient communication. Here, we introduce a new concept called ‘Skeletal Age’ as the age of an in idual’s skeleton resulting from a fragility fracture to convey the combined risk of fracture and fracture-associated mortality for an in idual. We used the Danish National Hospital Discharge Register which includes the whole-country data of 1,667,339 adults in Denmark born on or before January 1, 1950, who were followed up to December 31, 2016 for incident low-trauma fracture and mortality. Skeletal age is defined as the sum of chronological age and the number of years of life lost (YLL) associated with a fracture. Cox’s proportional hazards model was employed to determine the hazard of mortality associated with a specific fracture for a given risk profile, and the hazard was then transformed into YLL using the Gompertz law of mortality. During the median follow-up period of 16 years, there had been 307,870 fractures and 122,744 post-fracture deaths. A fracture was associated with between 1 and 7 years of life lost, with the loss being greater in men than women. Hip fractures incurred the greatest loss of life years. For instance, a 60-year-old in idual with a hip fracture is estimated to have a skeletal age of 66 for men and 65 for women. Skeletal Age was estimated for each age and fracture site stratified by gender. We propose ‘Skeletal Age’ as a new metric to assess the impact of a fragility fracture on an in idual’s life expectancy. This approach will enhance doctor-patient risk communication about the risks associated with osteoporosis. National Health and Medical Research Council in Australia and Amgen Competitive Grant Program 2019.
Publisher: Wiley
Date: 12-2019
DOI: 10.1002/JBMR.3936
Location: Denmark
No related grants have been discovered for Louise Hansen.