ORCID Profile
0000-0003-4445-6686
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Publisher: Wiley
Date: 07-2022
DOI: 10.1111/ANS.17892
Publisher: Wiley
Date: 29-07-2022
DOI: 10.1111/ANS.17100
Publisher: Wiley
Date: 04-08-2020
DOI: 10.1111/ANS.16176
Publisher: Wiley
Date: 02-08-2023
DOI: 10.1111/ANS.18637
Abstract: Accurate staging of colon cancer is imperative in directing treatment and prognostication. Existing literature on pre‐operative accuracy of FDG‐PET/CT in detecting lymph node disease often combines colon and rectal cancer, examines rectal cancers alone, and rarely assesses colon cancer in isolation. Our aim was to assess pre‐operative utility of FDG‐PET/CT in detecting lymph node disease in colon cancer. A retrospective cohort analysis was performed at a single Australian institution between 2017 and 2022 to identify treatment naive primary colonic tumours. Primary outcome was sensitivity and specificity using formal surgical histopathology as gold standard. Secondary outcomes were patient and tumour factors predictive of FDG‐PET/CT positive disease including pre‐operative CEA, mismatch repair status, duration to surgery, and tumour T‐stage. Three hundred and thirty‐nine patients were identified. Thirty‐four had pre‐operative FDG‐PET/CT without neoadjuvant therapy. The mean surgical lymph node harvest was 18 nodes. Twenty‐five patients had moderately differentiated tumours. The median duration between FDG‐PET/CT and operation was 17 days. Pre‐operative FDG‐PET/CT suggested positive lymph node involvement in 12 patients. Compared to final lymph node histopathology, FDG‐PET/CT had a sensitivity of 53%, specificity of 82%, positive predictive value of 75%, negative predictive value of 64% and accuracy of 68%. There was no significant difference between groups for secondary outcomes. FDG‐PET/CT has moderate specificity but poor sensitivity in the detection of lymph node involvement in colon cancer. Its utility should likely remain isolated to investigating equivocal lesions or follow up of known PET avid disease.
Publisher: Wiley
Date: 28-01-2019
DOI: 10.1111/ANS.14915
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 11-2019
Publisher: Future Medicine Ltd
Date: 08-2021
Abstract: Aim: Quantum dots (QDs) are nanoparticles that have an emerging application as theranostic agents in several neurodegenerative diseases. The advantage of QDs as nanomedicine is due to their unique optical properties that provide high sensitivity, stability and selectivity at a nanoscale range. Objective: To offer renewed insight into current QD research and elucidate its promising application in Alzheimer's disease (AD) diagnosis and therapy. Methods: A comprehensive literature search was conducted in PubMed and Google Scholar databases that included the following search terms: ‘quantum dots’, ‘blood–brain barrier’, ‘cytotoxicity’, ‘toxicity’ and ‘Alzheimer's disease’ PRISMA guidelines were adhered to. Results: Thirty-four publications were selected to evaluate the ability of QDs to cross the blood–brain barrier, potential toxicity and current AD diagnostic and therapeutic applications. Conclusion: QD's unique optical properties and versatility to conjugate to various biomolecules, while maintaining a nanoscale size, render them a promising theranostic tool in AD.
Publisher: Wiley
Date: 18-09-2019
DOI: 10.1111/ANS.14147
Publisher: Elsevier BV
Date: 04-2022
DOI: 10.1016/J.JAMDA.2022.01.080
Abstract: With increasing age, there is greater need for right-sided colonic resections than its left-sided counterparts. Older age is associated with limited physical and functional status, which carries greater operative risk. Improvements in robotic surgery questions its role, especially in older adults, compared with laparoscopy. The objective is to investigate whether robotic right hemicolectomy (RRH) is as safe and effective as laparoscopic right hemicolectomy (LHR) in octogenarians (age >80 years). Retrospective cross-sectional analysis. Octogenarians who underwent elective RRH and LRH by the Tweed Colorectal Group over 5 years. Complications within 30 days, age, gender, smoking status, immunocompromised status, presence of diabetes, American Society of Anesthesiologists (ASA) physical status score, preoperative Eastern Cooperative Oncology Group (ECOG) performance status, mFI-5 (modified frailty index), operative time, method of anastomosis, postoperative length of stay (LOS), need for rehabilitation, and short-term oncologic data using the TNM criteria were compared using univariate and multivariate analysis. Seventy-eight elective patients were included. LRH and RRH groups had similar median ages, gender distribution, and comorbidities. Across the entire cohort, 61.5% had no 30-day complications. RRH had nonsignificantly shorter operative time but significantly shorter LOS (5 vs 8 days) and fewer minor complications (24.5% vs 34.5%). Major complications and overall complications were not significantly different between the groups. Lower ASA and ECOG status were associated with lower complication rates across both groups. Oncologic resection outcomes were similar for both approaches. RRH does not confer an increased risk of complications compared to LRH in the octogenarians and may be a viable alternative in the field of minimally invasive surgery for older patients. Future research should focus on intracorporeal anastomoses, as it is a potential confounder leading to the shorter inpatient LOS shown in our robotic group.
Publisher: Wiley
Date: 08-05-2019
DOI: 10.1111/ANS.14463
Publisher: Wiley
Date: 08-05-2020
DOI: 10.1111/ANS.15211
Publisher: Wiley
Date: 20-04-2023
DOI: 10.1111/ANS.18370
Abstract: Diverticular disease of the colon occurs commonly in developed countries. Immunosuppressed patients are thought to be more at risk of developing acute erticulitis, worse disease, and higher complications secondary to therapy. This study aimed to assess outcomes for immunosuppressed patients with acute erticulitis. A retrospective single‐centre review was conducted of all patients presenting with acute erticulitis at a major tertiary Australian hospital from 2006 to 2018. A total of 751 patients, comprising of 46 immunosuppressed patients, were included. Immunosuppressed patients were found to be older (62.25 versus 55.96, p = 0.016), have more comorbidities (median Charlson Index 3 versus 1, P 0.001), and undergo more operative management (13.3% versus 5.1%, P = 0.020). Immunosuppressed patients with paracolic elvic abscesses (Modified Hinchey 1b/2) were more likely to undergo surgery (56% versus 24%, P = 0.046), while in patients with uncomplicated erticulitis, there was no difference in immunosuppressed patients undergoing surgery (6.1% versus 5.1% P = 0.815). Immunosuppressed patients were more likely to have Grade III‐IV Clavien‐Dindo complication ( P 0.001). Immunosuppressed patients with uncomplicated erticulitis can be treated safely with non‐operative management. Immunosuppressed patients were more likely to have operative management for Hinchey 1b/II and more likely to have grade III/IV complications.
Publisher: Wiley
Date: 15-10-2021
DOI: 10.1111/ANS.17261
No related grants have been discovered for Tae Jun Kim.