ORCID Profile
0000-0003-2189-4368
Current Organisation
Vanderbilt University Medical Center
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Publisher: American Society for Clinical Investigation
Date: 09-2021
DOI: 10.1172/JCI150143
Publisher: Elsevier BV
Date: 12-2020
Publisher: American Association for the Advancement of Science (AAAS)
Date: 14-12-2018
DOI: 10.1126/SCIIMMUNOL.AAU6759
Abstract: Human IFN-γ–dependent immunity to mycobacteria is less compromised in IL-12Rβ2 or IL-23R deficiency than IL-12Rβ1 deficiency.
Publisher: American Association for the Advancement of Science (AAAS)
Date: 14-12-2018
DOI: 10.1126/SCIIMMUNOL.AAU8714
Abstract: Homozygosity for the P1104A missense variant of the TYK2 Janus kinase is common monogenic etiology of primary tuberculosis.
Publisher: Springer Science and Business Media LLC
Date: 20-08-2018
Publisher: American Association for the Advancement of Science (AAAS)
Date: 07-08-2015
Abstract: The immune system needs its full array of soldiers—including cells and the molecules they secrete—to optimally protect the host. When this isn't the case, minor infections can become chronic or even deadly. Markle et al. report the discovery of seven in iduals carrying loss-of-function mutations in RORC, which encodes the transcription factors RORγ and RORγT. These in iduals lacked immune cells that produce the cytokine interleukin-17, causing them to suffer from chronic candidiasis. RORC-deficient in iduals also exhibited impaired immunity to mycobacterium, probably due to reduced production of the cytokine interferon-γ, a molecule not known to require RORC for its induction. Science , this issue p. 606
Location: United States of America
Location: United States of America
No related grants have been discovered for Janet Markle.