ORCID Profile
0000-0002-6034-0942
Current Organisations
IT University of Copenhagen
,
Queensland University of Technology
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Macromolecular and Materials Chemistry | Synthesis Of Macromolecules | Characterisation Of Macromolecules | Synthesis of Materials | Polymerisation Mechanisms | Physical Chemistry Of Macromolecules | Chemical Characterisation of Materials | Macromolecular materials | Chemical engineering not elsewhere classified | Free Radical Chemistry | Separation Science | Organic Chemical Synthesis | Nanochemistry and Supramolecular Chemistry | Biologically Active Molecules | Macromolecular and materials chemistry |
ANZSRC Socio-Economic Objective (SEO)
Polymeric materials (e.g. paints) | Expanding Knowledge in the Chemical Sciences | Plastic products (incl. Construction materials) | Structural glass and glass products | Plastics in primary forms | Expanding Knowledge in Technology | Rubber and Synthetic Resins | Hearing, vision, speech and their disorders | Industrial Chemicals and Related Products not elsewhere classified | Scientific Instruments | Diagnostics | Treatments (e.g. chemicals, antibiotics)
Related Links
Publications
Probing solid-liquid interfaces using radiotracer technology: Characterization of functionalized microspheres
Publisher: American Chemical Society (ACS)
Date: 30-07-2008
DOI: 10.1021/CM800248S
An in-depth analysis approach enabling precision single chain nanoparticle design
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0PY01045F
Abstract: The synthesis of single chain nanoparticles (SCNPs) is a vibrant field in macromolecular science. However, to achieve an in-depth understanding of the nature of intramolecular polymer folding, a step-change in the methodologies for SCNP analysis is required.
Reversible addition–fragmentation chain transfer polymerization initiated with γ-radiation at ambient temperature: an overview
Publisher: Elsevier BV
Date: 03-2003
Photo-Induced Macromolecular Functionalization of Cellulose via Nitroxide Spin Trapping
Publisher: American Chemical Society (ACS)
Date: 26-04-2012
DOI: 10.1021/BM3001364
Reversible addition-fragmentation chain-transfer graft polymerization of styrene
Publisher: Wiley
Date: 15-10-2002
DOI: 10.1002/POLA.10513
Dynamic Nitroxide Functional Materials.
Publisher: Wiley
Date: 16-11-2018
Abstract: A substrate-independent and versatile coating platform for (spatially resolved) surface functionalization, based on nitroxide radical coupling (NRC) reactions and the formation of thermo-labile alkoxyamine functional groups, was introduced. Nitroxide-decorated poly(glycidyl methacrylate) (PGMA) microspheres, obtained through bioinspired copolymer surface deposition using dopamine and a nitroxide functional dopamine derivative as monomers, were conjugated with small functional groups in a rewritable process. Reversible coding of the nitroxide functional microspheres by NRC and decoding through thermal alkoxyamine fission were monitored and characterized by electron paramagnetic resonance (EPR) spectroscopy and X-ray photoelectron spectroscopy (XPS). In addition, this nitroxide coating system was exploited in "grafting-to" polymer surface ligations of poly(methyl methacrylate) (PMMA) and poly(2,2,2-trifluoroethyl methacrylate) (PTFEMA) in spatially confined areas. Polymer strands terminated with an Irgacure 2959 (2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone) photoinitiator were obtained through chain-transfer polymerization, and subsequently coupled to nitroxide-immobilized poly(dopamine) (PDA)-coated silicon substrates by using rapid photoclick NRC reactions. Light-driven polymer surface coding was visualized by time-of-flight secondary ion mass spectrometry (ToF-SIMS) and XPS imaging.
Analysis of the Local Mobility of RAFT Mediated Poly(acrylic acid) Networks via Low Field 1 H‐NMR Techniques for Investigation of the Network Topology
Publisher: Wiley
Date: 09-12-2019
Free-radical copolymerization of styrene and m-isopropenyl-alpha,alpha '-dimethylbenzyl isocyanate studied by H-1 NMR kinetic experiments
Publisher: Wiley
Date: 27-02-2002
DOI: 10.1002/POLA.10195
A Photochemical Ligation System Enabling Solid‐Phase Chemiluminescence Read‐Out
Publisher: Wiley
Date: 09-07-2019
Abstract: The peroxyoxalate chemiluminescence (PO-CL) reaction is among the most powerful and versatile techniques for the detection of hydrogen peroxide (H
Controlled growth of protein resistant PHEMA brushes via S-RAFT polymerization
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3TB20880J
Synthesis and On‐Demand Gelation of Multifunctional Poly(ethylene glycol)‐Based Polymers
Publisher: Wiley
Date: 13-02-2014
Abstract: The synthesis of a novel photoreactive poly(ethylene glycol) (PEG)-based polymer with caged carbonyl groups is reported. We further demonstrate its use for the on-demand fabrication of hydrogels. For rapid gelation, a hydrazide-functionalized PEG is used as the second component for the hydrogel preparation. The photoreactive PEG-based polymer is designed for controlled cleavage of the protecting groups upon exposure to UV light releases free aldehyde moieties, which readily react with hydrazide groups in situ. This hydrogel system may find applications in controlled release drug delivery applications, when combined with in situ gelation. Furthermore, the possibility of forming gels specifically upon UV irradiation gives an opportunity for 3D fabrication of degradable scaffolds.
Grafting of n-butyl acrylate and N,N '-dimethyl acrylamide from poly(divinylbenzene) microspheres by RAFT polymerization
Publisher: CSIRO Publishing
Date: 2005
DOI: 10.1071/CH05057
Abstract: N,N´-Dimethyl acrylamide and n-butyl acrylate have been grafted from crosslinked poly( inylbenzene) core microspheres by both reversible addition–fragmentation chain transfer (RAFT) polymerization and conventional free radical polymerization. The microspheres were prepared by precipitation polymerization utilizing 55 and 80 wt. % inylbenzene (DVB), respectively. The RAFT agent cumyl dithiobenzoate (CDB) was utilized and grafting was performed in toluene at 80°C with 2,2´-azoisobutyronitrile (AIBN) as thermal initiator. Particle weights increased up to 6% for poly(n-butyl acrylate) and up to 15% for poly(N,N´-dimethyl acrylamide). Grafting from poly(DVB-55) microspheres results in a higher particle weight increase than grafting from poly(DVB-80) microspheres while using the same RAFT agent concentrations. The particle weight increase is approximately higher by a factor of two. The grafted microspheres were characterized by attenuated total reflection (ATR) IR spectroscopy and scanning electron microscopy.
Quantifying Solvent Effects on Polymer Surface Grafting
Publisher: American Chemical Society (ACS)
Date: 18-06-2019
DOI: 10.1021/ACSMACROLETT.9B00336
Abstract: When grafting polymers onto surfaces, the reaction conditions critically influence the resulting interface properties, including the grafting density and molar mass distribution (MMD) on the surface. Herein, we show theoretically and experimentally that the application of poor solvents is beneficial for the "grafting-to" approach. We demonstrate the effect by grafting poly(methyl methacrylate) chains on silica nanoparticles in different solvents and compare the MMD of the polymer in solution before and after grafting via size exclusion chromatography (SEC). The shorter polymer chains are preferentially grafted onto the surface, leading to a distortion effect between the MMD in solution and on surfaces. The molecular weight distortion effect is significantly higher for ethyl acetate (good solvent quality, difference in
RDM+PM Checklist: Towards a Measure of Your Institution’s Preparedness for the Effective Planning of Research Data Management
Publisher: Ubiquity Press, Ltd.
Date: 2023
DOI: 10.5334/DSJ-2023-036
Self‐Propagated para ‐Fluoro‐Thiol Reaction
Publisher: Wiley
Date: 08-07-2019
Abstract: We introduce a protecting-group-free concept for the powerful para-fluoro-thiol reaction (PFTR) employing a source of fluoride ions as base. The reaction is shown to be self-propagating, with under-stoichiometric amounts of base, thus effectively foregoing the need for high base concentrations. Careful tuning of the solvent-thiol combination allows for quantitative conversion, in some cases within a short timeframe, when only minimal amounts of base are used, allowing the PFTR reaction to essentially proceed base-free.
An In-Depth Analysis Approach Enabling Precision Single Chain Nanoparticle Design
Publisher: American Chemical Society (ACS)
Date: 25-08-2020
DOI: 10.26434/CHEMRXIV.12854636
Abstract: The formation of single chain nanoparticles (SCNPs) is typically characterized by a shift towards higher elution volumes in SEC due to size decrease upon folding. However, a step-change in SCNP analysis is required for understanding of the nature of intramolecular SCNP folding. Herein, we exploit a unique combination of SANS, 19F NMR spectroscopy, and multidetection SEC to generate a systematic view of the folded morphology of poly(butyl acrylate) based-SCNPs as a function of their reactive group density and molar mass. In addition to detailed morphological insights, we establish that the primary factor dictating the compaction of SCNPs is their reactive group density, which is ineffective below 5 mol%, reaching maximum compaction close to 30 mol%. Above 20 kDa the molar mass of the precursor polymers has a minor impact on how an SCNP compacts.
Photostationary State in Dynamic Covalent Networks
Publisher: American Chemical Society (ACS)
Date: 31-03-2022
DOI: 10.1021/ACSMACROLETT.2C00097
Abstract: We explore a cross-linked polymer network based on a visible light photodynamic [2 + 2] cycloaddition driven by styrylpyrene chemistry. Based on a polymer backbone with pendent styrylpyrene units, the network can be formed by using λ = 450 nm irradiation. Upon irradiation with λ = 340 nm, a photostationary state is generated within the network with ∼17% of the styrylpyrene units open compared to close to 2% in the visible light cured state. The limited fraction of open [2 + 2] couples is caused by their proximity and is in sharp contrast to solution experiments on the photoreactive moiety. Thus, the polymer network retains its mechanical properties even at the photostationary point. We hypothesize that the application of an additional stimulus could serve as a second gate for inducing network disintegration by spacing the [2 + 2] units during ultraviolet irradiation.
Modular design of glyco-microspheres via mild pericyclic reactions and their quantitative analysis
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2PY20369C
Critical Assessment of the Application of Multidetection SEC and AF4 for the Separation of Single-Chain Nanoparticles
Publisher: American Chemical Society (ACS)
Date: 20-10-2020
DOI: 10.1021/ACSMACROLETT.0C00519
Abstract: The intramolecular chain collapse of linear precursors with systematic variation of molar mass and ligation group density (5, 15, and 30 mol %) into single-chain nanoparticles (SCNPs) was studied by two different separation approaches. The efficiency of size exclusion chromatography with quadruple detection (SEC-D4) was compared to asymmetrical field flow fractionation hyphenated to quintuple detection (AF4-D5) in organic solvent. The application of the unique combination of advanced detection to different separation principles opens up the opportunity to critically evaluate the determination of molar masses and different types of radii for an in-depth understanding of the structural properties affected by the internal folding process. This is achieved by a detailed comparison of assets, drawbacks, and limitations of these approaches based on the systematical screening of different chain lengths and sizes of the precursors and the SCNPs. Furthermore, an alternative strategy for quantitative determination of intramolecular ligation density by a combination of AF4 and UV detection is introduced.
Reversible addition–fragmentation chain‐transfer polymerization: Unambiguous end‐group assignment via electrospray ionization mass spectrometry
Publisher: Wiley
Date: 03-10-2002
DOI: 10.1002/POLA.10500
Synthesis of core-shell poly(divinylbenzene) microspheres via reversible addition fragmentation chain transfer graft polymerization of styrene
Publisher: Wiley
Date: 07-09-2004
DOI: 10.1002/POLA.20328
Size-controlled synthesis of bioinspired polyserotonin nanoparticles with free radical scavenging activity
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0TB02383C
Abstract: Shortest synthetic route for polyserotonin nanoparticles as a new class of bioinspired nanomaterial with demonstrated therapeutic potential for future clinical applications.
Living free radical polymerisation under a constant source of gamma radiation - An example of reversible addition-fragmentation chain transfer or reversible termination?
Publisher: Wiley
Date: 08-2002
DOI: 10.1002/1521-3927(20020801)23:12<717::AID-MARC717>3.0.CO;2-I
The long and the short of polymer grafting
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8PY01470A
Abstract: Polymer chains are grafted depending on their size onto solid interfaces, leading to a distortion of the surface grafted size distribution. We herein predict and quanitify this distortion effect, which has critical consequences for functional polymer interface design.
Investigation of the Porosity of Poly(sodium methacrylate) Hydrogels by 1H‐NMR T2‐Relaxation and Inverse Size‐Exclusion Chromatography
Publisher: Wiley
Date: 09-12-2020
Self-Reporting Fluorescent Step-Growth RAFT Polymers Based on Nitrile Imine-Mediated Tetrazole-ene Cycloaddition Chemistry
Publisher: American Chemical Society (ACS)
Date: 17-02-2017
Oxidative polymerization of catecholamines: structural access by high-resolution mass spectrometry
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7PY00506G
Abstract: We introduce an avenue for the structural elucidation of bio-inspired functional poly(catecholamines) via high-resolution electrospray ionization mass spectrometry.
Polymers with Well-Defined End Groups via RAFT - Synthesis, Applications and Postmodifications
Publisher: Wiley
Date: 23-01-2008
Universal mass spectrometric analysis of poly(ionic liquid)s
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6SC01347C
Abstract: We introduce a universal tool for the mass spectrometric analysis of a wide range of various types of poly(ionic liquids).
Unplugging DI-DIV and DII-DIII lateral fenestrations of NALCN reveals unexpected pharmacology
Publisher: Cold Spring Harbor Laboratory
Date: 13-04-2023
DOI: 10.1101/2023.04.12.536537
Abstract: The sodium (Na + ) leak channel (NALCN) is a member of the four-domain voltage-gated cation channel family that includes the prototypical voltage-gated sodium and calcium channels (Na V s and Ca V s, respectively). Unlike Na V s and Ca V s, which have four intramembrane fenestrations that serve as routes for lipophilic compounds to enter the central cavity to modulate channel function, NALCN has bulky residues (W311, L588, M1145 and Y1436) that block these openings. Structural data suggest that occluded lateral fenestrations underlie the pharmacological resistance of NALCN, but functional evidence is lacking. To test this hypothesis, we unplugged the fenestrations of NALCN by substituting the four aforementioned residues with alanine (AAAA) and compared the effects of Na V , Ca V and NALCN blockers on both wild-type (WT) and AAAA channels. Most compounds behaved in a similar manner on both channels, but phenytoin and 2-aminoethoxydiphenyl borate (2-APB) elicited additional, distinct responses on AAAA channels, highlighting the existence of drug binding sites beyond the occluded fenestrations of NALCN. Further experiments using single alanine mutants revealed that phenytoin and 2-APB access their putative binding sites through distinct fenestrations, implying structural specificity to their modes of access. Intrigued by the activity of 2-APB and its analogues, we tested more compounds containing the diphenylmethane/amine moiety on WT channels. We identified novel compounds that exhibited erse activity, thus expanding the pharmacological toolbox for NALCN. While the low potencies of active compounds reiterate the resistance of NALCN to pharmacological targeting, our findings lay the foundation for rational drug design to develop NALCN modulators with refined properties.
Controlled radical polymerization and in-depth mass-spectrometric characterization of poly(ionic liquid)s and their photopatterning on surfaces
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C5PY01320H
Abstract: Poly(ionic liquid)s (PILs) bearing a polystyrene backbone prepared via RAFT polymerization and their photolithographic patterning on silicon wafers is reported.
pH‐Responsive Aminomethyl Functionalized Poly( p ‐xylylene) Coatings by Chemical Vapor Deposition Polymerization
Publisher: Wiley
Date: 21-02-2017
Synthesis of polymers with phosphorus containing side chains via modular conjugation
Publisher: Royal Society of Chemistry (RSC)
Date: 2013
DOI: 10.1039/C3PY00103B
Hyperbranched polymers as scaffolds for multifunctional reversible addition-fragmentation chain-transfer agents
Publisher: Wiley
Date: 23-10-2003
DOI: 10.1002/POLA.10976
The Link that Lasts: A New Frontier in Supramolecular Block Copolymer Design
Publisher: Wiley
Date: 03-09-2015
Abstract: Lasting link: A supramolecular linkage between two parts of an hiphilic block copolymer was developed that is sufficiently strong to allow phase-separation-driven nanopatterning as well as chromatographic characterization. The link can also be severed in response to a solvent trigger signal. This powerful approach will open new avenues for the production of self-healing materials, triggered-release systems, and reversible surface designs.
Design for Recycling Strategies Based on the Life Cycle Assessment and End of Life Options of Plastics in a Circular Economy
Publisher: Wiley
Date: 03-05-2022
Abstract: The plastic economy, despite offering unique properties in fulfilling the functions of products in different industrial sectors over decades, has so far been mainly linear, that is, “take‐make and dispose” with only a small fraction of plastics being recycled worldwide. With ever‐increasing circular economy initiatives and the urge to conserve resources and prevent plastic pollution from affecting ecosystems, more emphasis on the resource recovery of plastic products after its use has been made over the last few years. It is necessary for manufacturers to understand the value chain as early as the design phase while manufacturing and distributing plastic products across the world. The current study provides an overview of the status quo of plastic waste management and analyzes the Life Cycle Assessment (LCA) studies of different End‐of‐Life (EoL) options for plastics. Based on the LCA studies, a preliminary, country‐specific Circular Footprint (CF) is calculated and Design for Recycling (DfR) strategies are identified. Results show that the environmental impacts of different EoL options differ significantly for different plastics. The CF highlights the lack of data regarding the composition and recovery of plastics in different countries thus showing the necessity to consider the whole lifecycle when quantifying the environmental impacts of plastics.
Dual-Gated Microparticles for Switchable Antibody Release
Publisher: American Chemical Society (ACS)
Date: 20-12-2017
Abstract: We pioneer the design of dual-gated microparticles, both responsive to changes in temperature and pH, for stimuli-responsive chromatography targeted at the efficient separation of antibodies. Dual-gated microspheres were synthesized by introducing RAFT-based thiol-terminal block copolymers of poly(N-isopropylacrylamide-b-4-vinylpyridine) (P(NIPAM-b-4VP, 4800 ≤ M
Acid-cleavable polymeric core–shell particles for delivery of hydrophobic drugs
Publisher: Elsevier BV
Date: 10-2006
DOI: 10.1016/J.JCONREL.2006.07.025
Abstract: Here we describe the combined use of acid-labile microgel approach and RAFT-mediated seeded dispersion polymerization technique to prepare an acid-cleavable core-shell like polymeric colloidal system for the delivery of hydrophobic drugs at slightly acidic sites. A new bisacrylate acetal crosslinker was copolymerized with n-butyl acrylate (BA) in the presence of a RAFT agent using a dispersion polymerization technique, which yielded crosslinked spherical particles with the size ranging between 150 and 500 nm. The particles were cleaved in a pH-dependent manner similar to the acid-labile hydrolysis behaviour of the crosslinker. In order to mask the hydrophobic surface of the particles, polyethylene glycol acrylate (PEG-A) was grafted onto poly(BA) seed particles via the RAFT agent groups on the particle surface. The acidic-site selective delivery potential of the poly(BA)-g-poly(PEG-A) particles was assessed in-vitro using a lipophilic fluorescent dye as a model hydrophobic drug. Ca. 73% and 34% of the total dye loaded in the particles was found to be released at pH 5.0 and 7.4 in 24 h, respectively. The growth of human neuroblastoma cells was not affected by the incubation with the core-shell particles and their cleavage by-products up to 3 mg/ml concentration. The physicochemical and the functional features support the potential value of the acid-cleavable poly(BA) core-poly(PEG-A) shell particles as carriers for the delivery of hydrophobic drugs at acidic sites.
Synthesis of microspheres as versatile functional scaffolds for materials science applications
Publisher: Wiley
Date: 18-06-2009
Industry 4.0 as an enabler in transitioning to circular business models: A systematic literature review
Publisher: Elsevier BV
Date: 03-2023
The para-fluoro-thiol reaction as a powerful tool for precision network synthesis
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7PY00812K
Abstract: We introduce the regioselective para -fluoro-thiol reaction (PFTR) as a novel strategy for precision network formation evidenced by XPS and ToF-SIMS.
The para-fluoro-thiol reaction as an efficient tool in polymer chemistry
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8PY00287H
Abstract: The current literature describing the application of the para -fluoro–thiol reaction in the realm of macromolecular chemistry and the future of this coupling strategy are discussed.
Synthesis of water-soluble homo- and block-copolymers by RAFT polymerization under γ-irradiation in aqueous media
Publisher: Elsevier BV
Date: 09-2010
A Synthetic Route to Sulfobetaine Methacrylates with Varying Charge Distance
Publisher: Wiley
Date: 05-11-2014
Structural architecture of the human NALCN channelosome
Publisher: Springer Science and Business Media LLC
Date: 20-12-2021
DOI: 10.1038/S41586-021-04313-5
Abstract: Depolarizing sodium (Na
Linear and nonlinear rheological behavior and crystallization of semicrystalline poly(styrene)–poly(l-lactide) block copolymers
Publisher: Elsevier BV
Date: 09-2013
Polymer on Top: Current Limits and Future Perspectives of Quantitatively Evaluating Surface Grafting
Publisher: Wiley
Date: 07-03-2018
Abstract: Well-defined polymer strands covalently tethered onto solid substrates determine the properties of the resulting functional interface. Herein, the current approaches to determine quantitative grafting densities are assessed. Based on a brief introduction into the key theories describing polymer brush regimes, a user's guide is provided to estimating maximum chain coverage and-importantly-examine the most frequently employed approaches for determining grafting densities, i.e., dry thickness measurements, gravimetric assessment, and swelling experiments. An estimation of the reliability of these determination methods is provided via carefully evaluating their assumptions and assessing the stability of the underpinning equations. A practical access guide for comparatively and quantitatively evaluating the reliability of a given approach is thus provided, enabling the field to critically judge experimentally determined grafting densities and to avoid the reporting of grafting densities that fall outside the physically realistic parameter space. The assessment is concluded with a perspective on the development of advanced approaches for determination of grafting density, in particular, on single-chain methodologies.
Mapping Photochemical Reactivity Profiles on Surfaces
Publisher: American Chemical Society (ACS)
Date: 18-12-2020
DOI: 10.1021/JACS.0C11485
Surface Modification of Poly(divinylbenzene) Microspheres via Thiol−Ene Chemistry and Alkyne−Azide Click Reactions
Publisher: American Chemical Society (ACS)
Date: 27-04-2009
DOI: 10.1021/MA900332D
A kinetic study on the para-fluoro-thiol reaction in view of its use in materials design
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9PY00435A
Abstract: A detailed kinetic study on the para -fluoro-thiol reaction (PFTR) using experimental analysis and kinetic Monte Carlo modeling is introduced, covering the difference in reactivity of a selected variety of structurally different thiols, uniquely including polymeric thiols.
Ambient temperature synthesis of well-defined microspheres via precipitation polymerization initiated by UV-irradiation
Publisher: Wiley
Date: 19-06-2007
DOI: 10.1002/POLA.22132
Chemiluminescent Read-Out of Degradable Fluorescent Polymer Particles
Publisher: American Chemical Society (ACS)
Date: 06-07-2020
Engineering Nitroxide Functional Surfaces Using Bioinspired Adhesion
Publisher: American Chemical Society (ACS)
Date: 14-02-2018
DOI: 10.1021/ACS.LANGMUIR.7B03755
Abstract: We pioneer a versatile surface modification strategy based on mussel-inspired oxidative catecholamine polymerization for the design of nitroxide-containing thin polymer films. A 3,4-dihydroxy-l-phenylalanine (l-DOPA) monomer equipped with a 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-derived oxidation-labile hydroxylamine functional group is employed as a universal coating agent to generate polymer scaffolds with persistent radical character. Various types of materials including silicon, titanium, ceramic alumina, and inert poly(tetrafluoroethylene) (PTFE) were successfully coated with poly(DOPA-TEMPO) thin films in a one-step dip-coating procedure under aerobic, slightly alkaline (pH 8.5) conditions. Steadily growing polymer films (∼1.1 nm h
Conceptualizing the Transnational Regulation of Plastics: Moving Towards a Preventative and Just Agenda for Plastics
Publisher: Cambridge University Press (CUP)
Date: 02-09-2022
DOI: 10.1017/S2047102521000261
Abstract: This article categorizes and evaluates how regulatory regimes conceptualize plastics, and how such conceptualizations affect the production, consumption, and disposal of plastics. Taking a doctrinal and policy-oriented approach, it identifies four ‘frames’ – that is, four distinct and coherent sets of meanings attributed to plastics within transnational regulation – namely, plastics as waste to be managed a material to be prevented a good (or waste) to be traded freely and inputs or outputs in production-consumption systems. Based on this analysis, three significant deficiencies in the transnational regulation of plastics are identified: the failure to frame plastics in terms of environmental justice and human rights issues insufficient focus on plastics prevention (rather than management) and the role of law in reinforcing its production and consumption.
RAFT Polymerization of N‐Isopropylacrylamide and Acrylic Acid under γ‐Irradiation in Aqueous Media
Publisher: Wiley
Date: 22-05-2006
Efficient Surface Modification of Divinylbenzene Microspheres via a Combination of RAFT and Hetero Diels-Alder Chemistry
Publisher: Wiley
Date: 25-08-2008
An In-Depth Analysis Approach Enabling Precision Single Chain Nanoparticle Design
Publisher: American Chemical Society (ACS)
Date: 25-08-2020
DOI: 10.26434/CHEMRXIV.12854636.V1
Abstract: The formation of single chain nanoparticles (SCNPs) is typically characterized by a shift towards higher elution volumes in SEC due to size decrease upon folding. However, a step-change in SCNP analysis is required for understanding of the nature of intramolecular SCNP folding. Herein, we exploit a unique combination of SANS, 19F NMR spectroscopy, and multidetection SEC to generate a systematic view of the folded morphology of poly(butyl acrylate) based-SCNPs as a function of their reactive group density and molar mass. In addition to detailed morphological insights, we establish that the primary factor dictating the compaction of SCNPs is their reactive group density, which is ineffective below 5 mol%, reaching maximum compaction close to 30 mol%. Above 20 kDa the molar mass of the precursor polymers has a minor impact on how an SCNP compacts.
Synthesis of in situ functionalized iron oxide nanoparticles presenting alkyne groups via a continuous process using near-critical and supercritical water
Publisher: Elsevier BV
Date: 10-2013
Surface-initiated RAFT polymerization from vapor-based polymer coatings
Publisher: Elsevier BV
Date: 08-2018
Depropagation kinetics of sterically demanding monomers: A pulsed laser size exclusion chromatography study
Publisher: American Chemical Society (ACS)
Date: 15-06-2005
DOI: 10.1021/MA050444L
Complex molecular architecture polymers via RAFT
Publisher: CSIRO Publishing
Date: 2004
DOI: 10.1071/CH03232
Mild and Modular Surface Modification of Cellulose via Hetero Diels−Alder (HDA) Cycloaddition
Publisher: American Chemical Society (ACS)
Date: 02-03-2011
DOI: 10.1021/BM101461H
Abstract: A combination of reversible addition-fragmentation chain transfer (RAFT) polymerization and hetero Diels-Alder (HDA) cycloaddition was used to effect, under mild (T ≈ 20 °C), fast, and modular conditions, the grafting of poly(isobornyl acrylate) (M(n) = 9800 g mol(-1), PDI = 1.19) onto a solid cellulose substrate. The active hydroxyl groups expressed on the cellulose fibers were converted to tosylate leaving groups, which were subsequently substituted by a highly reactive cyclopentadienyl functionality (Cp). By employing the reactive Cp-functionality as a diene, thiocarbonyl thio-capped poly(isobornyl acrylate) synthesized via RAFT polymerization (mediated by benzyl pyridine-2-yldithioformiate (BPDF)) was attached to the surface under ambient conditions by an HDA cycloaddition (reaction time: 15 h). The surface-modified cellulose s les were analyzed in-depth by X-ray photoelectron spectroscopy, scanning electron microscopy, elemental analysis, Fourier transform infrared (FT-IR) spectroscopy as well as Fourier transform infrared microscopy employing a focal plane array detector for imaging purposes. The analytical results provide strong evidence that the reaction of suitable dienophiles with Cp-functional cellulose proceeds under mild reaction conditions (T ≈ 20 °C) in an efficient fashion. In particular, the visualization of in idual modified cellulose fibers via high-resolution FT-IR microscopy corroborates the homogeneous distribution of the polymer film on the cellulose fibers.
Reversible addition-fragmentation chain transfer graft copolymerization of styrene and m-isopropenyl-alpha,alpha '-dimethylbenzyl isocyanate from polypropylene lanterns: Solid phases for scavenging applications
Publisher: Wiley
Date: 02-12-2006
DOI: 10.1002/POLA.21216
Challenges and opportunities for innovation in bioinformed sustainable materials
Publisher: Springer Science and Business Media LLC
Date: 04-10-2023
Recodable surfaces based on switchable hydrogen bonds
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6CC03612K
Abstract: We introduce recodable surfaces solely based on reversible artificial hydrogen bonding interactions.
Synergy of Advanced Experimental and Modeling Tools to Underpin the Synthesis of Static Step-Growth-Based Networks Involving Polymeric Precursor Building Blocks
Publisher: American Chemical Society (ACS)
Date: 13-10-2021
Two Grapes Short of a Fruit Salad: Raspberry-, Strawberry-, and Seedpod-Like Organic Microspheres via Colloidal Nanotemplating
Publisher: American Chemical Society (ACS)
Date: 23-11-2020
Thermally responsive core–shell microparticles and cross-linked networks based on nitrone chemistry
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2PY20272G
Abstract: Complex cross-linked soluble architectures are generated using nitrone mediated chemistry and are subsequently cleaved into network fragments. Nitrone mediated reactions are additionally applied for the synthesis of stimuli-responsive microspheres.
The application of ionizing radiation in reversible addition-fragmentation chain transfer (RAFT) polymerization: Renaissance of a key synthetic and kinetic tool
Publisher: Elsevier BV
Date: 10-2007
RAFT-mediated polymerization and grafting of sodium 4-styrenesulfonate from cellulose initiated via gamma-radiation
Publisher: Elsevier BV
Date: 02-2009
The bright and the dark side of the sphere: light-stabilized microparticles
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0PY01456G
Abstract: We introduce degradable microparticles, synthesized from prepolymers in a precipitation-like polymerization. The narrow disperse particles are stabilized with continuous irradiation of green light and can be spontaneously degraded in the dark.
Complex macromolecular architectures by reversible addition fragmentation chain transfer chemistry: Theory and practice
Publisher: Wiley
Date: 03-2007
With polymer photoclicks to fluorescent microspheres
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8MH01078A
Abstract: A new method of additive-free particle synthesis facilitates the rapid preparation of inherently fluorescent microspheres via photoactive prepolymers.
Teaching an Old Dog New Tricks: Sustainable Polymers
Publisher: Wiley
Date: 07-2022
Suppressing Pseudomonas aeruginosa adhesion via non-fouling polymer brushes
Publisher: Royal Society of Chemistry (RSC)
Date: 2014
DOI: 10.1039/C4RA12663G
Abstract: In the current study, well-defined polymer brushes are shown as an effective surface modification to resist biofilm formation from opportunistic pathogens.
Cover Feature: A Photochemical Ligation System Enabling Solid‐Phase Chemiluminescence Read‐Out (Chem. Eur. J. 54/2019)
Publisher: Wiley
Date: 02-08-2019
An Access Route to Polyferrocenes via Modular Conjugation
Publisher: Wiley
Date: 17-02-2011
A Facile Route to Boronic Acid Functional Polymeric Microspheres via Epoxide Ring Opening
Publisher: Wiley
Date: 27-04-2012
Abstract: Boronic acid-functionalized microspheres are prepared for the first time via mild epoxide ring opening based on porous cross-linked polymeric microspheres (diameter ≈ 10 μm, porosity ≈ 1000 Å). Quantitative chemical analysis by XPS and EA evidences that there is a greater functionalization with boronic acid when employing a sequential synthetic method [1.7 atom% boron (XPS) 1.12 wt% nitrogen (EA)] versus a one-pot synthetic method [0.2 atom% boron (XPS) 0.60 wt% nitrogen (EA)] yielding grafting densities ranging from approximately 2.5 molecules of boronic acid per nm(2) to 1 molecule of boronic acid per nm(2), respectively. Furthermore, the boronic acid-functionalized microspheres are conjugated with a novel fluorescent glucose molecule demonstrating a homogeneous spatial distribution of boronic acid.
Access to Intrinsically Glucoside‐Based Microspheres with Boron Affinity
Publisher: Wiley
Date: 27-03-2013
Abstract: Intrinsically glucoside-based microspheres are prepared in olive oil via a water in oil inverse suspension polymerization. The microspheres are characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) microscopy, and X-ray photoelectron spectroscopy (XPS), evidencing the intrinsic glucose character of the spheres. A novel boronic acid fluorescent molecule was subsequently conjugated to the microspheres in an aqueous environment, exhibiting the spatial and uniform distribution of glucoside as well as the affinity of the microspheres to bind with boron, evidenced via fluorescence spectroscopy measurements.
Orthogonal ligation to spherical polymeric microparticles: Modular approaches for surface tailoring
Publisher: Elsevier BV
Date: 07-2012
Reversible addition - Fragmentation chain transfer polymerization initiated with ultraviolet radiation
Publisher: American Chemical Society (ACS)
Date: 27-08-2002
DOI: 10.1021/MA0204296
Controlling biofilm formation with nitroxide functional surfaces
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9PY00690G
Abstract: Nitroxide functional polymer coatings with inherent antibiofilm activity are introduced as an avenue to combat bacterial biofilm contamination of medical devices.
Accessing Quantitative Degrees of Functionalization on Solid Substrates via Solid-State NMR Spectroscopy
Publisher: American Chemical Society (ACS)
Date: 16-03-2010
DOI: 10.1021/MA100149P
Plastics and the Environment—Current Status and Challenges in Germany and Australia
Publisher: Wiley
Date: 09-2020
Counting the Clicks in Fluorescent Polymer Networks
Publisher: Wiley
Date: 14-04-2018
Abstract: We introduce a fluorescence-based methodology enabling the quantification of ligation points in photochemically prepared polymer networks. Well-defined α,ω-tetrazole-capped polymer strands prepared via RAFT polymerization are crosslinked under UV irradiation by a trimaleimide via nitrile imine mediated tetrazole-ene cycloaddition. Thus, for each linkage point a fluorescent pyrazoline ring is formed, resulting in fluorescent networks, which are degradable by aminolysis of the trithiocarbonate functionalities, leading to soluble fragments. The fluorescence emission of the soluble network fragments correlates directly with the number of pyrazoline moieties originally present in the network, thus providing a direct measure of the number of ligation points constituting the network. The herein introduced strategy based on a fluorescence readout is a powerful yet simple approach to quantify network formation processes applicable to a wide class of polymers accessible via RAFT.
Quantification of Grafting Densities Achieved via Modular Grafting-to Approaches onto Divinylbenzene Microspheres
Publisher: Wiley
Date: 22-06-2010
On-demand acid-gated fluorescence switch-on in photo-generated nanospheres
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0CC01557A
Abstract: Polymer particles are synthesized using a photo-active ortho -methyl benzaldehyde with a terminal alkyne for cross-linking. The reactive 1,4-dihydronaphthalene at every cross-linking point undergoes aromatisation to a fluorescent naphthalene upon exposure to acid.
Verification of controlled grafting of styrene from cellulose via radiation-induced RAFT polymerization
Publisher: American Chemical Society (ACS)
Date: 08-09-2007
DOI: 10.1021/MA070825U
Getting the Terms Right: Green, Sustainable, or Circular Chemistry?
Publisher: Wiley
Date: 03-06-2022
Abstract: Green chemistry, sustainable chemistry, and circular chemistry are important concepts for the modern lifestyle, current research directions, and worldwide industries. These three concepts are closely related and interconnected but cannot be used synonymously. In addition, they are addressing two different economic models, i.e., linear economy and circular economy. The current contribution focuses on the importance of these decisive chemistries for the development of a sustainable future and their role in the realm of circular economy and the planetary boundaries framework—especially for the planetary boundary of “novel entities.” Researchers active in the field of polymer chemistry play an important role as plastic pollution and resource in addition to environmental depletion, caused by the still increasing production of polymers and plastics, become more and more pronounced. It is also reported that multi‐ and interdisciplinary approaches are needed to develop solutions for a sustainable future.
Precisely Controlled Microsphere Design via Visible‐Light Cross‐Linking of Functional Prepolymers
Publisher: Wiley
Date: 30-09-2019
Ambient temperature RAFT polymerization of acrylic acid initiated with ultraviolet radiation in aqueous solution
Publisher: American Chemical Society (ACS)
Date: 03-04-2007
DOI: 10.1021/MA0703094
Living free-radical polymerization of styrene under a constant source of γ radiation
Publisher: Wiley
Date: 06-11-2002
DOI: 10.1002/POLA.10086
Direct Mapping of RAFT Controlled Macromolecular Growth on Surfaces via Single Molecule Force Spectroscopy
Publisher: American Chemical Society (ACS)
Date: 30-03-2016
DOI: 10.1021/ACSMACROLETT.6B00106
Abstract: Single molecule force spectroscopy (SMFS) is employed to gain insight into reversible addition-fragmentation chain transfer (RAFT) polymerization processes with living characteristics on glass surfaces. Surface-initiated (SI)-RAFT was selected to grow poly(hydroxyethyl methacrylate) (PHEMA). After aminolysis of the RAFT chain termini, thiol moieties serve as anchoring points for the gold tip of an atomic force microscope. The results allow to directly monitor the macromolecular growth of the surface-initiated polymerization. The obtained SMFS-based molecular weight distribution data of the polymers present on the surface indicate that the RAFT chain extension proceeds linearly with time up to high conversions. The current study thus adds SMFS as a valuable tool for the investigation of SI-RAFT polymerizations.
Continuous Hydrothermal Synthesis of In Situ Functionalized Iron Oxide Nanoparticles: A General Strategy to Produce Metal Oxide Nanoparticles With Clickable Anchors
Publisher: Wiley
Date: 07-02-2013
Surface Grafting via the Reversible Addition-Fragmentation Chain-Transfer (RAFT) Process
Publisher: CSIRO Publishing
Date: 2003
DOI: 10.1071/CH03142
TEMPO Driven Mild and Modular Route to Functionalized Microparticles
Publisher: Wiley
Date: 11-05-2018
Abstract: The synthesis of crosslinked polymeric microspheres (3.8-15.0 µm) via (2,2,6,6-tetramethylpiperidin-1-yl)oxyl (TEMPO) initiated thiol-ene dispersion polymerization under ambient conditions is reported for the first time. The initiating ability of TEMPO for the thiol-ene reaction is validated by electron paramagnetic resonance (EPR) and
Chemiluminescent read-out of para-fluoro-thiol reaction events
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0CC06356H
Abstract: We exploit the fluoride that is released via the para -fluoro-thiol reaction (PFTR) to cleave silyl ethers, turning the PFTR into an effective self-reporting chemiluminescence (CL) probe.
Direct access to biocompatible nitroxide containing polymers
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8PY00089A
Abstract: Ring-opening copolymerization of a nitroxide containing cyclic carbonate and d / l -lactide was used to directly access well-defined biocompatible polymers.
Applications of Lawesson's reagent in organic and organometallic syntheses
Publisher: Georg Thieme Verlag KG
Date: 2003
DOI: 10.1055/S-2003-41447
Bestimmung der Verknüpfungspunkte in fluoreszenten Polymernetzwerken
Publisher: Wiley
Date: 14-04-2018
Facile Access to Hydroxy‐Functional Core–Shell Microspheres via Grafting of Ethylene Oxide by Anionic Ring‐Opening Polymerization
Publisher: Wiley
Date: 12-06-2009
Abstract: We present a facile access route to hydroxy-functional narrow disperse microspheres of well-defined grafting density (GD). Ethylene oxide has been grafted from highly crosslinked poly( inyl benzene) microspheres by anionic ring-opening polymerization using sec-butyllithium as activator together with the phosphazene base t-BuP(4) . Initially, core microspheres have been prepared by precipitation polymerization utilizing inyl benzene (DVB, 80 wt.-%). The grafting of poly(ethylene oxide) (PEO) from the surface resulted in the formation of functional core-shell microspheres with hydroxy-terminal end groups. The number average particle diameter of the grafted microspheres was 3.6 µm and the particle weight increased by 5.7%. The microspheres were characterized by SEM, FT-IR spectroscopy, elemental analysis, and fluorescence microscopy. The surface GD (determined via two methods) was 1.65 ± 0.06 and 2.09 ± 0.08 chains · nm(-2) , respectively.
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