ORCID Profile
0009-0005-2129-4348
Current Organisation
Extracting the Ocean (ARC Discovery Project, Elspeth Probyn, (University of Sydney))
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Publisher: Springer Science and Business Media LLC
Date: 17-03-2020
Publisher: Duke University Press
Date: 31-12-2020
Publisher: Routledge
Date: 03-08-2022
Publisher: Wiley
Date: 22-05-2013
DOI: 10.1111/JGH.12157
Abstract: TRIM28 is a multi-domain nuclear protein with pleotropic effects in both normal and tumor cells. In this study, TRIM28 expression in epithelial and stromal tumor microenvironment and its prognostic role in colorectal cancer were investigated. Immunohistological staining of TRIM28 was evaluated in tissue microarrays constructed from 137 colorectal cancer patients. The correlations of TRIM28 expression with clinicopathological features and p53 expression were studied. Kaplan-Meier analysis and Cox proportional hazard modeling were used to assess overall survival (OS) and recurrence-free survival (RFS). Strong epithelial TRIM28 expression was found in 42% of colorectal cancer tissues. TRIM28 expression correlated significantly with p53 expression in matched cases (P=0.0168, Spearman rank test). A high epithelial to stromal TRIM28 expression ratio was associated with shorter OS (P=0.033 log-rank test) and RFS (P=0.043 log-rank test). Multivariate analysis showed that the epithelial to stromal TRIM28 expression ratio was an independent predictor of OS (hazard ratio=2.136 95% confidence interval 1.015-4.498, P=0.046) and RFS (hazard ratio=2.100 confidence interval 1.052-4.191, P=0.035). A high TRIM28 expression ratio between stromal and epithelial compartments in colorectal cancer tissue is an independent predictor of poor prognosis. The pathophysiological role of TRIM28 in carcinogenesis may be dependent on expression levels and cell type within the tumor microenvironment.
Publisher: Duke University Press
Date: 03-2023
DOI: 10.1215/17432197-10232516
Abstract: The continued c aign of violence by extractivists against multibeing relations, embodied beings, and ecological living is bewildering. Coded by mastery, and as a carrier of its values, international laws of the sea facilitate these c aigns by legitimating ecological abuse. As such, responding to the ocean's declining conditions with more laws and regulations alone misses how underlying cultural values contribute to the production of ecological harm. This article considers how the imaginary of mastery underpinning dominant ocean governance regimes enables the production and distribution of vulnerability. Thinking with the ocean reveals how anthropogenic harms manifest and proliferate both materially and through the discursive networks of ocean governance. Though material vulnerability is a condition that brings us into being interconnectedly with other worlds, it also (unevenly) implicates us in ocean harm. This article draws on feminist posthumanist, legal, and marine scientific work to examine these issues in the context of an emerging concept of ocean justice, in which the conditions for cohabiting well with the seas might be imagined and activated.
Publisher: SAGE Publications
Date: 03-2022
Location: Australia
No related grants have been discovered for Susan Reid.