ORCID Profile
0000-0003-1101-5614
Current Organisations
University of Queensland
,
Monash Institute of Pharmaceutical Sciences
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: Wiley
Date: 08-12-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0NH00548G
Abstract: Impactful research in nanomedicine depends upon the adequate use of cellular and animal models. Here we systematically review and evaluate the in vitro and in vivo models which have enabled the development of anti-amyloidosis nanomedicines.
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5TB01258A
Abstract: Lecithin-drug hybrid nanocarriers (NCs) are demonstrated to enhance oral bioavailability and anti-parasitic potential for poorly water-soluble drugs.
Publisher: Elsevier BV
Date: 03-2019
DOI: 10.1016/J.BIOORG.2018.11.039
Abstract: We have carried out a docking inspired synthesis and screening of a library of diazenyl-derivatives of pyridazinylpyrazolone molecules for their ability to modulate the amyloidogenic self-assembly of human islet amyloid polypeptide (hIAPP). hIAPP is a 37-residue peptide which is involved in glycemic control along with insulin. Its extracellular fibrillar assemblies in pancreatic β-cells are responsible for type 2 diabetes. A three-step synthetic scheme was used to prepare these novel compounds using 2-(6-chloropyridazin-3-yl)-5-methyl-2,4-dihydro-3H-pyrazol-3-one as a key intermediate that was reacted with various diazo electrophiles to generate a library of compounds with yields ranging from 64 to 85%. The effect of the compounds on hIAPP amyloid fibril formation was evaluated with a thioflavin T (ThT) fluorescence-based kinetic assay. Furthermore, TEM imaging was carried out to corroborate the interactions of the compounds with hIAPP and subsequent hIAPP inhibition at the different level of fibrillization. The CD spectroscopy showed that upon incubation with SSE15314 for 12 h, the percentage of α-helices was maintained to a level of hIAPP at 0 h. The current study presents identification and characterization of SSE15314 as the hit, which completely inhibited the fibril formation and can be further optimized into a lead compound.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7NR05216B
Abstract: Thermoresponsive lipid nanoparticles were formulated to transition into a liquid phase to pass the blood brain barrier to treat numerous brain disorders.
Publisher: Oxford University Press (OUP)
Date: 2017
DOI: 10.1039/C7TX00146K
Abstract: Polymeric nanomaterials, hybridized with lipid components, e.g. phosphocholine or fatty acids, are currently being explored for efficient nano-platforms for hydrophobic drugs.
Publisher: American Chemical Society (ACS)
Date: 10-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8TB01634H
Abstract: The protein corona is a concept central to a range of disciplines exploiting the bio–nano interface.
Publisher: Wiley
Date: 11-08-2020
DOI: 10.1002/DDR.21728
Publisher: American Chemical Society (ACS)
Date: 02-11-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8NR00835C
Abstract: Human plasma proteome associations with nGO grafted with stealth polymers PEG and PEtOx.
Publisher: Springer Science and Business Media LLC
Date: 22-08-2019
DOI: 10.1038/S41467-019-11762-0
Abstract: Alzheimer’s disease (AD) is the most prevalent form of neurodegenerative disorders, yet no major breakthroughs have been made in AD human trials and the disease remains a paramount challenge and a stigma in medicine. Here we eliminate the toxicity of amyloid beta (Aβ) in a facile, high-throughput zebrafish ( Danio rerio ) model using casein coated-gold nanoparticles (βCas AuNPs). βCas AuNPs in systemic circulation translocate across the blood brain barrier of zebrafish larvae and sequester intracerebral Aβ 42 and its elicited toxicity in a nonspecific, chaperone-like manner. This is evidenced by behavioral pathology, reactive oxygen species and neuronal dysfunction biomarkers assays, complemented by brain histology and inductively coupled plasma-mass spectroscopy. We further demonstrate the capacity of βCas AuNPs in recovering the mobility and cognitive function of adult zebrafish exposed to Aβ. This potent, safe-to-use, and easy-to-apply nanomedicine may find broad use for eradicating toxic amyloid proteins implicated in a range of human diseases.
Publisher: American Chemical Society (ACS)
Date: 03-08-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8NR07180B
Abstract: Graphene quantum dots are biocompatible zero-dimensional nanostructures, which displayed a potency in rescuing zebrafish embryos from the toxicity of human islet amyloid polypeptide.
Publisher: American Chemical Society (ACS)
Date: 05-12-2018
Publisher: Wiley
Date: 18-08-2023
Abstract: Alzheimer's disease (AD) is a leading form of dementia where the presence of extra‐neuronal plaques of Amyloid‐β (Aβ) is a pathological hallmark. However, Aβ peptide is also observed in the intestinal tissues of AD patients and animal models. In this study, it is reported that Aβ monomers can target and disintegrate microbial amyloids of FapC and CsgA formed by opportunistic gut pathogens, Pseudomonas aeruginosa and Escherichia coli , explaining a potential role of Aβ in the gut‐brain axis. Employing a zebrafish‐based transparent in vivo system and whole‐mount live‐imaging, Aβ is observed to diffuse into the vasculature and subsequently localize with FapC or CsgA fibrils that were injected into the tail muscles of the fish. FapC aggregates, produced after Aβ treatment (Faβ), present selective toxicity to SH‐SY5Y neuronal cells while the intestinal Caco‐2 cells are shown to phagocytose Faβ in a non‐toxic cellular process. After remodeling by Aβ, microbial fibrils lose their native function of cell adhesion with intestinal Caco‐2 cells and Aβ dissolves and detachs the microbial fibrils already attached to the cell membrane. Taken together, this study strongly indicates an anti‐biofilm role for Aβ monomers that can help aid in the future development of selective anti‐Alzheimer's and anti‐infective medicine.
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7CS00372B
Abstract: We highlight the role of molecular self-assembly in eliciting the mesoscopic and pathological properties of amyloid proteins. This knowledge is pivotal for the development of theranostics against amyloid diseases.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6TB01348A
Abstract: Folate grafted and thiolated chitosan coated nanoliposomes were evaluated to improve the oral absorption and targeted pharmacological activity of docetaxel.
Publisher: Oxford University Press (OUP)
Date: 2018
DOI: 10.1039/C8TX00108A
Abstract: Sulfanilamide based nonionic surfactant can self-assemble into haemocompatible and non-toxic niosomes that are promising for drug delivery.
Publisher: Springer Science and Business Media LLC
Date: 26-01-2019
Publisher: Springer Science and Business Media LLC
Date: 05-08-2016
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0NR02710C
Abstract: CQDs were potent in inhibiting IAPP and Aβ amyloidosis, allowing hatching of zebrafish embryos into healthy larvae.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6RA11799F
Abstract: Water insoluble drugs with a short plasma half-life face the pharmacokinetic (PK) barriers of low oral absorption from the gastrointestinal route of drug administration and rapid clearance from systemic circulation.
Publisher: American Chemical Society (ACS)
Date: 14-11-2017
Publisher: American Chemical Society (ACS)
Date: 21-01-2019
Abstract: The use of nanomaterials has recently become an emerging strategy against protein amyloidosis associated with a range of metabolic and brain diseases. To facilitate research in this area, here we first demonstrated the use of hyperspectral imaging (HSI) and COMSOL simulations for reporting the aggregation of human islet amyloid polypeptides (IAPPs), a hallmark of type 2 diabetes, as well as the physical interactions between the peptide and gold nanoparticles (AuNPs) grafted with citrate and poly(ethylene glycol) (PEG
Publisher: American Chemical Society (ACS)
Date: 08-08-2018
DOI: 10.1021/ACS.NANOLETT.8B02446
Abstract: Amyloid diseases are global epidemics with no cure available. Herein, we report a first demonstration of in vivo mitigation of amyloidogenesis using biomimetic nanotechnology. Specifically, the amyloid fragments (b
Publisher: American Chemical Society (ACS)
Date: 24-04-2019
Publisher: American Chemical Society (ACS)
Date: 28-08-2019
Publisher: American Chemical Society (ACS)
Date: 07-01-2020
Publisher: American Chemical Society (ACS)
Date: 16-01-2020
No related grants have been discovered for Ibrahim Javed.