ORCID Profile
0000-0003-0528-2396
Current Organisation
Dalian Institute of Chemical Physics
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: MDPI AG
Date: 16-12-2016
DOI: 10.3390/S16122165
Publisher: Elsevier BV
Date: 03-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0NJ02762F
Abstract: Recent advances in the development of “dual-key-and-lock” responsive probes for accurate detection of various biomolecules are reviewed.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0TB01628D
Abstract: Resorufin has been widely used in the design of responsive probes for various bioactive species due to its excellent properties. This work summarized the advances in the development of resorufin-based probes for fluorescent and colorimetric analysis.
Publisher: American Chemical Society (ACS)
Date: 13-03-2019
Abstract: The development of new methods for rapid and effective detection of bisulfite (HSO
Publisher: MDPI AG
Date: 04-07-2019
DOI: 10.3390/MOLECULES24132455
Abstract: We report the development of a new colorimetric probe (L-ol) for investigations of the redox process regulated by hypochlorous acid (HOCl) and glutathione (GSH). The HOCl/GSH redox-switching cycle process was investigated in detail by UV-vis absorption spectroscopy, colorimetric analysis assay and high-resolution mass spectrometry (HRMS). The switchable absorbance responses were attributed to the HOCl-induced oxidation of the p-methoxyphenol unit to the benzoquinone derivative (L-one) and sequential reduction of L-one to hydroquinone (L-ol’) by GSH. In phosphate-buffered saline (PBS) buffer, the absorbance of L-ol at 619 nm underwent a remarkable bathochromic-shift, accompanied by a color change from pale yellow to blue in the presence of HOCl. With further addition of GSH, the absorbance of L-one exclusively recovered to the original level. Meanwhile, the blue-colored solution returned to the naive pale yellow color in the presence of GSH. The detection limits for HOCl and GSH were calculated to be 6.3 and 96 nM according to the IUPAC criteria. Furthermore, L-ol-loaded chromatography plates have been prepared and successfully applied to visualize and quantitatively analyze HOCl in several natural waters.
Publisher: Wiley
Date: 06-08-2018
Abstract: The development of effective bioanalytical methods for rapid, sensitive and specific detection of HOCl in vitro and in vivo plays a key role for better understanding the roles of this molecule in normal and diseased conditions, but remains challenging due to the highly reactive nature of HOCl and the complicated biological conditions. In this work, a new fluorescence probe, PQI, was developed for monitoring of the HOCl level in biological s les. PQI was easily synthesized by a one-step condensation reaction. Upon addition of HOCl, significant changes in the absorption spectra and the color of the solution were noticed, facilitating the "naked eye" detection of HOCl in PBS buffer. The fluorescence of PQI was found to be significantly increased within a few seconds, leading to "OFF-ON" fluorescence response towards HOCl. The sensing mechanism, oxidation of thioether by HOCl, was confirmed by HRMS titration analysis. PQI features a large Stokes shift, high sensitivity and selectivity, and rapid fluorescence response towards HOCl. Quantitative detection of HOCl in single live cells was demonstrated through fluorescence imaging and flow cytometry analysis. PQI was then successfully used in visualisation of HOCl in live zebrafish and nude mice.
Publisher: American Chemical Society (ACS)
Date: 03-03-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6TB02384C
Abstract: The present work reports a bimodal probe for the fluorescence and magnetic resonance detection of fluoride ion (F − ) in aqueous medium and in vivo .
Publisher: MDPI AG
Date: 29-02-2020
DOI: 10.3390/S20051331
Abstract: Quick and effective detection of biothiols in biological fluids has gained increasing attention due to its vital biological functions. In this paper, a novel reversible fluorescence chemosensor (L-Cu2+) based on a benzocoumarin-Cu2+ ensemble has been developed for the detection of biothiols (Cys, Hcy and GSH) in human urine. The chemosensing ensemble (L-Cu2+) contains a 2:1 stoichiometry structure between fluorescent ligand L and paramagnetic Cu2+. L was found to exclusively bond with Cu2+ ions accompanied with a dramatic fluorescence quenching maximum at 443 nm and an increase of an absorbance band centered at 378 nm. Then, the in situ generated fluorescence sluggish ensemble, L-Cu2+, was successfully used as a chemosensor for the detection of biothiols with a fluorescence “OFF-ON” response modality. Upon the addition of biothiols, the decomplexation of L-Cu2+ led to the liberation of the fluorescent ligand, L, resulting in the recovery of fluorescence and absorbance spectra. Studies revealed that L-Cu2+ possesses simple synthesis, excellent stability, high sensitivity, reliability at a broad pH range and desired renewability (at least 5 times). The practical application of L-Cu2+ was then demonstrated by the detection of biothiols in human urine s le.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TB00551J
Abstract: We report the development of a new chromogenic and fluorogenic probe for the detection of HOCl in zebrafish, mice with arthritis and environmental water s les.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8NJ03809K
Abstract: A coumarin–Cu 2+ ensemble based fluorescent chemosensor was developed for the selective detection of cysteine in aqueous media and live cells.
Publisher: Elsevier BV
Date: 09-2017
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8OB00036K
Abstract: The features of DNPH-NA , including its high sensitivity, selectivity, and reliability at physiological pH, together with a rapid response, enable its successful application in the detection of endogenous HOCl in vitro and in vivo .
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C7NJ01983A
Abstract: A new activatable fluorescence probe has been designed and synthesized for inorganic phosphate detection in buffer and live cells.
Publisher: Wiley
Date: 07-06-2018
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7NJ04107A
Abstract: A glucosamine-linked Cu 2+ ensemble has been successfully developed for detection of pyrophosphate (PPi) in aqueous medium and in live MD-AMB-231 cells.
No related grants have been discovered for Huan Feng.