ORCID Profile
0000-0002-9827-5496
Current Organisation
Monash University
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Research Topics
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Top 5 Research Topics
ANZSRC Field of Research (FoR)
Computer Software | Software Engineering | Software Engineering | Information Systems Management | Computer Software Not Elsewhere Classified | Medical Devices | Health Information Systems (incl. Surveillance) | Pattern Recognition and Data Mining
ANZSRC Socio-Economic Objective (SEO)
Application tools and system utilities | Information processing services | Computer software and services not elsewhere classified | Application Software Packages (excl. Computer Games) | Information Processing Services (incl. Data Entry and Capture) | Application Tools and System Utilities | Behaviour and Health | Internet Hosting Services (incl. Application Hosting Services) | Integrated Circuits and Devices |
Related Links
Publications
R-gram: Inferring message formats of service protocols with relative positional n-grams
Publisher: Elsevier BV
Date: 12-2021
Probabilistic Critical Path identification for cost-effective monitoring of Service-based Web Applications
Publisher: ACM
Date: 16-04-2012
A case study on optimizing web service monitoring configurations
Publisher: Springer Berlin Heidelberg
Date: 2011
Rapid Inflammation in Mice Lacking Both SOCS1 and SOCS3 in Hematopoietic Cells
Publisher: Public Library of Science (PLoS)
Date: 09-2016
Prosurvival Bcl-2 family members reveal a distinct apoptotic identity between conventional and plasmacytoid dendritic cells
Publisher: Proceedings of the National Academy of Sciences
Date: 16-03-2015
Abstract: Dendritic cells (DCs) are pivotal for immune responses as they present antigens to T cells. Different DC subsets have different functions and are associated with different diseases. For ex le, plasmacytoid DCs (pDCs) produce type 1 interferons and are associated with the autoimmune disease, systemic lupus erythematosus. Understanding control of survival/apoptosis in different DC subsets may not only provide a molecular basis for their homeostasis but also guide therapeutic intervention of immunopathology. We revealed that two major DC subsets (pDCs and conventional DCs) express distinct BCL-2 family proteins at different levels and this correlated with their survival requirements. Accordingly, clinically applicable antagonist drugs killed the appropriate DC subsets, informing on the future use of these compounds for treating immune-mediated damage.
Targeting CLEC9A delivers antigen to human CD141+ DC for CD4+ and CD8+T cell recognition
Publisher: American Society for Clinical Investigation
Date: 19-05-2016
Emulation of cloud-scale environments for scalability testing
Publisher: IEEE
Date: 08-2012
DOI: 10.1109/QSIC.2012.57
A role for the mitochondrial protein Mrpl44 in maintaining OXPHOS capacity
Publisher: Public Library of Science (PLoS)
Date: 29-07-2015
Quokka: visualising interactions of enterprise software environment emulators
Publisher: ACM
Date: 03-09-2012
Reac2o: A runtime for enterprise system models
Publisher: ACM
Date: 20-09-2010
Plasmacytoid dendritic cells are short-lived: Reappraising the influence of migration, genetic factors and activation on estimation of lifespan
Publisher: Springer Science and Business Media LLC
Date: 26-04-2016
DOI: 10.1038/SREP25060
Abstract: Plasmacytoid dendritic cells (pDCs) play an important role in immunity to certain pathogens and immunopathology in some autoimmune diseases. They are thought to have a longer lifespan than conventional DCs (cDCs), largely based on a slower rate of BrdU labeling by splenic pDCs. Here we demonstrated that pDC expansion and therefore BrdU labeling by pDCs occurs in bone marrow (BM). The rate of labeling was similar between BM pDCs and spleen cDCs. Therefore, slower BrdU labeling of spleen pDCs likely reflects the “migration time” (∼2 days) for BrdU labeled pDCs to traffic to the spleen, not necessarily reflecting longer life span. Tracking the decay of differentiated DCs showed that splenic pDCs and cDCs decayed at a similar rate. We suggest that spleen pDCs have a shorter in vivo lifespan than estimated utilizing some of the previous approaches. Nevertheless, pDC lifespan varies between mouse strains. pDCs from lupus-prone NZB mice survived longer than C57BL/6 pDCs. We also demonstrated that activation either positively or negatively impacted on the survival of pDCs via different cell-death mechanisms. Thus, pDCs are also short-lived. However, the pDC lifespan is regulated by genetic and environmental factors that may have pathological consequence.
A virtual deployment testing environment for enterprise software systems
Publisher: ACM
Date: 25-06-2012
The inevitable stability of software change
Publisher: IEEE
Date: 10-2007
Assessing the performance impact of service monitoring
Publisher: IEEE
Date: 2010
A form-based meta-model for software composition
Publisher: Elsevier BV
Date: 04-2005
Agile practices in software development - experiences from student projects
Publisher: IEEE
Date: 2006
DOI: 10.1109/ASWEC.2006.9
Automated analysis of performance and energy consumption for cloud applications
Publisher: ACM
Date: 22-03-2014
Towards Dynamic Matching of Business-Level Protocols in Adaptive Service Compositions
Publisher: Springer Berlin Heidelberg
Date: 2008
Measuring the Energy and Performance of Scientific Workflows on Low-Power Clusters
Publisher: MDPI AG
Date: 06-06-2022
DOI: 10.3390/ELECTRONICS11111801
Abstract: Scientific problems can be formulated as workflows to allow them to take advantage of cluster computing resources. Generally, the assumption is that the greater the resources dedicated to completing these tasks the better. This assumption does not take into account the energy cost of performing the computation and the specific characteristics of each workflow. In this paper, we present a unique approach to evaluating the energy consumption of scientific workflows on compute clusters. Two workflows from different domains, Astronomy and Bioinformatics, are presented and their execution is analyzed on a cluster of low powered small board computers. The paper presents a theoretical analysis of an energy-aware execution of workflows that can reduce the energy consumption of workflows by up to 68% compared to normal execution. We demonstrate that there are limitations to the benefits of increasing cluster sizes and there are trade-offs when considering energy vs. performance of the workflows and that the performance and energy consumption of any scientific workflow is heavily dependent on its underlying structure. The study concludes that the energy consumption of workflows can be optimized to improve both aspects of the workflow and motivates the development of an energy-aware scheduler.
A preliminary analysis of vocabulary in mobile app user reviews
Publisher: ACM
Date: 26-11-2012
Energy Efficient Node Selection in Edge-Fog-Cloud Layered IoT Architecture
Publisher: MDPI AG
Date: 29-06-2023
DOI: 10.3390/S23136039
Abstract: Internet of Things (IoT) architectures generally focus on providing consistent performance and reliable communications. The convergence of IoT, edge, fog, and cloud aims to improve the quality of service of applications, which does not typically emphasize energy efficiency. Considering energy in IoT architectures would reduce the energy impact from billions of IoT devices. The research presented in this paper proposes an optimization framework that considers energy consumption of nodes when selecting a node for processing an IoT request in edge-fog-cloud layered architecture. The IoT use cases considered in this paper include smart grid, autonomous vehicles, and eHealth. The proposed framework is evaluated using CPLEX simulations. The results provide insights into mechanisms that can be used to select nodes energy-efficiently whilst meeting the application requirements and other network constraints in multi-layered IoT architectures.
Metric selection and anomaly detection for cloud operations using log and metric correlation analysis
Publisher: Elsevier BV
Date: 03-2018
Automating Performance and Energy Consumption Analysis for Cloud Applications
Publisher: IEEE
Date: 06-2015
Curriculum Development in Educating Undergraduate Software Engineers — Are Students Being Prepared for the Profession?
Publisher: IEEE
Date: 2005
Formulating Cost-Effective Monitoring Strategies for Service-Based Systems
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2014
DOI: 10.1109/TSE.2013.48
SPINET: A Parallel Computing Approach to Spine Simulations
Publisher: Hindawi Limited
Date: 1996
DOI: 10.1155/1996/607139
Abstract: Research in scientitic programming enables us to realize more and more complex applications, and on the other hand, application-driven demands on computing methods and power are continuously growing. Therefore, interdisciplinary approaches become more widely used. The interdisciplinary SPINET project presented in this article applies modern scientific computing tools to biomechanical simulations: parallel computing and symbolic and modern functional programming. The target application is the human spine. Simulations of the spine help us to investigate and better understand the mechanisms of back pain and spinal injury. Two approaches have been used: the first uses the finite element method for high-performance simulations of static biomechanical models, and the second generates a simulation developmenttool for experimenting with different dynamic models. A finite element program for static analysis has been parallelized for the MUSIC machine. To solve the sparse system of linear equations, a conjugate gradient solver (iterative method) and a frontal solver (direct method) have been implemented. The preprocessor required for the frontal solver is written in the modern functional programming language SML, the solver itself in C, thus exploiting the characteristic advantages of both functional and imperative programming. The speedup analysis of both solvers show very satisfactory results for this irregular problem. A mixed symbolic-numeric environment for rigid body system simulations is presented. It automatically generates C code from a problem specification expressed by the Lagrange formalism using Maple.
Oct4-GFP expression during transformation of gonocytes into spermatogonial stem cells in the perinatal mouse testis
Publisher: Elsevier BV
Date: 12-2015
A petri-net-based virtual deployment testing environment for enterprise software systems
Publisher: Oxford University Press (OUP)
Date: 22-08-2017
Opaque service virtualisation
Publisher: ACM
Date: 14-05-2016
App reviews: Breaking the user and developer language barrier
Publisher: Springer International Publishing
Date: 22-10-2016
Experience report: Anomaly detection of cloud application operations using log and cloud metric correlation analysis
Publisher: IEEE
Date: 11-2015
What influences usability defect reporting? - A survey of software development practitioners
Publisher: IEEE
Date: 2017
Cognitive Service Virtualisation: A New Machine Learning-Based Virtualisation to Generate Numeric Values
Publisher: MDPI AG
Date: 03-10-2020
DOI: 10.3390/S20195664
Abstract: Continuous delivery has gained increased popularity in industry as a development approach to develop, test, and deploy enhancements to software components in short development cycles. In order for continuous delivery to be effectively adopted, the services that a component depends upon must be readily available to software engineers in order to systematically apply quality assurance techniques. However, this may not always be possible as (i) these requisite services may have limited access and (ii) defects that are introduced in a component under development may cause ripple effects in real deployment environments. Service virtualisation (SV) has been introduced as an approach to address these challenges, but existing approaches to SV still fall short of delivering the required accuracy and/or ease-of-use to virtualise services for adoption in continuous delivery. In this work, we propose a novel machine learning based approach to predict numeric fields in virtualised responses, extending existing research that has provided a way to produce values for categorical fields. The SV approach introduced here uses machine learning techniques to derive values of numeric fields that are based on a variable number of pertinent historic messages. Our empirical evaluation demonstrates that the Cognitive SV approach can produce responses with the appropriate fields and accurately predict values of numeric fields across three data sets, some of them based on stateful protocols.
Do metrics help to identify refactoring?
Publisher: ACM
Date: 20-09-2010
An object oriented approach towards dynamic data flow analysis
Publisher: IEEE
Date: 08-2008
DOI: 10.1109/QSIC.2008.18
An energy consumption model and analysis tool for Cloud computing environments
Publisher: IEEE
Date: 06-2012
Hyper-parameter optimization in classification: To-do or not-to-do
Publisher: Elsevier BV
Date: 07-2020
Modelling enterprise system protocols and trace conformance
Publisher: IEEE
Date: 2010
Optimizing the configuration of web service monitors
Publisher: Springer Berlin Heidelberg
Date: 2010
Detecting structural changes in object oriented software systems
Publisher: IEEE
Date: 2005
Probabilistic Critical Path Identification for Cost-Effective Monitoring of Service-Based Systems
Publisher: IEEE
Date: 06-2012
DOI: 10.1109/SCC.2012.39
Partitioning of Java applications to support dynamic updates
Publisher: IEEE
Date: 2004
Detection of endogenous SOCS1 and SOCS3 proteins by immunoprecipitation and western blot analysis
Publisher: Humana Press
Date: 04-11-2013
The polycomb repressive complex 2 governs life and death of peripheral T cells
Publisher: American Society of Hematology
Date: 31-07-2014
DOI: 10.1182/BLOOD-2013-12-544106
Abstract: Ezh2 represses Ifng, Gata3, and Il10 loci in naïve CD4+T cells, and its deficiency leads to Th1 skewing and IL-10 overproduction in Th2 cells. Ezh2 deficiency activates multiple death pathways in differentiated effector Th cells.
eXtreme Programming––helpful or harmful in educating undergraduates?
Publisher: Elsevier BV
Date: 2005
A conceptual framework for unified and comprehensive SOA management
Publisher: Springer Berlin Heidelberg
Date: 2009
Idea: A reference platform for systematic information security management tool support
Publisher: Springer Berlin Heidelberg
Date: 2011
Correction for Zhang et al., The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.
Publisher: Proceedings of the National Academy of Sciences
Date: 08-05-2015
Mining processes with multi-instantiation
Publisher: ACM
Date: 13-04-2015
HSP90 activity is required for MLKL oligomerisation and membrane translocation and the induction of necroptotic cell death
Publisher: Springer Science and Business Media LLC
Date: 14-01-2016
Abstract: Necroptosis is a caspase-independent form of regulated cell death that has been implicated in the development of a range of inflammatory, autoimmune and neurodegenerative diseases. The pseudokinase, Mixed Lineage Kinase Domain-Like (MLKL), is the most terminal known obligatory effector in the necroptosis pathway, and is activated following phosphorylation by Receptor Interacting Protein Kinase-3 (RIPK3). Activated MLKL translocates to membranes, leading to membrane destabilisation and subsequent cell death. However, the molecular interactions governing the processes downstream of RIPK3 activation remain poorly defined. Using a phenotypic screen, we identified seven heat-shock protein 90 (HSP90) inhibitors that inhibited necroptosis in both wild-type fibroblasts and fibroblasts expressing an activated mutant of MLKL. We observed a modest reduction in MLKL protein levels in human and murine cells following HSP90 inhibition, which was only apparent after 15 h of treatment. The delayed reduction in MLKL protein abundance was unlikely to completely account for defective necroptosis, and, consistent with this, we also found inhibition of HSP90 blocked membrane translocation of activated MLKL. Together, these findings implicate HSP90 as a modulator of necroptosis at the level of MLKL, a function that complements HSP90’s previously demonstrated modulation of the upstream necroptosis effector kinases, RIPK1 and RIPK3.
Mutually exclusive regulation of T cell survival by IL-7R and antigen receptor-induced signals
Publisher: Springer Science and Business Media LLC
Date: 16-04-2013
DOI: 10.1038/NCOMMS2719
StressCloud: A Tool for Analysing Performance and Energy Consumption of Cloud Applications
Publisher: IEEE
Date: 05-2015
LRIG1 Extracellular Domain: Structure and Function Analysis
Publisher: Elsevier BV
Date: 05-2015
DOI: 10.1016/J.JMB.2015.03.001
Abstract: We have expressed and purified three soluble fragments of the human LRIG1-ECD (extracellular domain): the LRIG1-LRR (leucine-rich repeat) domain, the LRIG1-3Ig (immunoglobulin-like) domain, and the LRIG1-LRR-1Ig fragment using baculovirus vectors in insect cells. The two LRIG1 domains crystallised so that we have been able to determine the three-dimensional structures at 2.3Å resolution. We developed a three-dimensional structure for the LRIG1-ECD using homology modelling based on the LINGO-1 structure. The LRIG1-LRR domain and the LRIG1-LRR-1Ig fragment are monomers in solution, whereas the LRIG1-3Ig domain appears to be dimeric. We could not detect any binding of the LRIG1 domains or the LRIG1-LRR-1Ig fragment to the EGF receptor (EGFR), either in solution using biosensor analysis or when the EGFR was expressed on the cell surface. The FLAG-tagged LRIG1-LRR-1Ig fragment binds weakly to colon cancer cells regardless of the presence of EGFRs. Similarly, neither the soluble LRIG1-LRR nor the LRIG1-3Ig domains nor the full-length LRIG1 co-expressed in HEK293 cells inhibited ligand-stimulated activation of cell-surface EGFR.
A positional keyword-based approach to inferring fine-grained message formats
Publisher: Elsevier BV
Date: 2020
The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism
Publisher: Elsevier BV
Date: 09-2013
DOI: 10.1016/J.IMMUNI.2013.06.018
Abstract: Mixed lineage kinase domain-like (MLKL) is a component of the "necrosome," the multiprotein complex that triggers tumor necrosis factor (TNF)-induced cell death by necroptosis. To define the specific role and molecular mechanism of MLKL action, we generated MLKL-deficient mice and solved the crystal structure of MLKL. Although MLKL-deficient mice were viable and displayed no hematopoietic anomalies or other obvious pathology, cells derived from these animals were resistant to TNF-induced necroptosis unless MLKL expression was restored. Structurally, MLKL comprises a four-helical bundle tethered to the pseudokinase domain, which contains an unusual pseudoactive site. Although the pseudokinase domain binds ATP, it is catalytically inactive and its essential nonenzymatic role in necroptotic signaling is induced by receptor-interacting serine-threonine kinase 3 (RIPK3)-mediated phosphorylation. Structure-guided mutation of the MLKL pseudoactive site resulted in constitutive, RIPK3-independent necroptosis, demonstrating that modification of MLKL is essential for propagation of the necroptosis pathway downstream of RIPK3.
Generating service models by trace subsequence substitution
Publisher: ACM
Date: 17-06-2013
Experimental analysis of task-based energy consumption in cloud computing systems
Publisher: ACM
Date: 21-04-2013
Enhanced playback of automated service emulation models using entropy analysis
Publisher: ACM
Date: 14-05-2016
Bcl-2 antagonists kill plasmacytoid dendritic cells from lupus-prone mice and dampen interferon-α production
Publisher: Wiley
Date: 25-02-2015
DOI: 10.1002/ART.38966
Abstract: Interferon-α (IFNα)-producing plasmacytoid dendritic cells (PDCs) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). IFNα-related genes are highlighted among SLE susceptibility alleles and are characteristically expressed in the blood of patients with SLE, while in mouse models of lupus, PDC numbers and IFNα production are increased. This study was undertaken to investigate the effects of inhibitors that selectively target different antiapoptotic molecules on the survival of PDCs. PDC numbers, in vitro survival, and expression of antiapoptotic molecules were evaluated in lupus-prone (NZB × NZW)F1 (NZB/NZW) mice. The impact of Bcl-2 antagonists and glucocorticoids on PDCs was evaluated in vitro and in vivo. IFNα production by NZB/NZW mice was evaluated before and after treatment with Bcl-2 antagonists. PDCs, but not lymphoid tissue-resident conventional DCs, largely relied on the antiapoptotic protein Bcl-2 for survival. The enlarged PDC compartment in NZB/NZW mice was associated with selectively prolonged survival and increased Bcl-2 transcription. Functionally, this resulted in enhanced production of IFNα. Bcl-2 inhibitors selectively killed mouse and human PDCs, including PDCs from SLE patients, but not conventional DCs, d ened IFNα production by PDCs, and synergized with glucocorticoids to kill activated PDCs. Enhanced PDC survival is a likely contributing factor to enhanced IFNα production by lupus PDCs. Bcl-2 antagonists potently and selectively kill PDCs and reduce IFNα production. Thus, we believe that they are attractive candidates for treating PDC-associated diseases.
Fas regulates neutrophil lifespan during viral and bacterial infection
Publisher: Oxford University Press (OUP)
Date: 03-12-2015
DOI: 10.1189/JLB.3AB1113-594RR
Abstract: Neutrophils use Toll-like receptor and IL-18 signaling to reprogram Fas-induced death. The regulation of neutrophil lifespan is critical for a circumscribed immune response. Neutrophils are sensitive to Fas/CD95 death receptor signaling in vitro, but it is unknown if Fas regulates neutrophil lifespan in vivo. We hypothesized that FasL-expressing CD8+ T cells, which kill antigen-stimulated T cells during chronic viral infection, can also induce neutrophil death in tissues during infection. With the use of LysM-Cre Fasfl/fl mice, which lack Fas expression in macrophages and neutrophils, we show that Fas regulates neutrophil lifespan during lymphocytic choriomeningitis virus (LCMV) infection in the lung, peripheral blood, and spleen. Fas also contributed to the regulation of neutrophil numbers in the colon of Citrobacter rodentium-infected mice. To examine the effects of infection on Fas activation in neutrophils, we primed neutrophils with TLR ligands or IL-18, resulting in ablation of Fas death receptor signaling. These data provide the first in vivo genetic evidence that neutrophil lifespan is controlled by death receptor signaling and provide a mechanism to account for neutrophil resistance to Fas stimulation during infection.
Tackling the loss of control: Standards-based conjoint management of security requirements for cloud services
Publisher: IEEE
Date: 07-2011
Adaptive application-specific middleware
Publisher: ACM
Date: 27-11-2006
A Survey of Policy-Based Management Approaches for Service Oriented Systems
Publisher: IEEE
Date: 03-2008
Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia
Publisher: Informa UK Limited
Date: 20-01-2014
DOI: 10.3109/08977194.2013.874347
Abstract: Activation of the cell surface receptor, c-Mpl, by the cytokine, thrombopoietin (TPO), underpins megakaryocyte and platelet production in mammals. In humans, mutations in c-Mpl have been identified as the molecular basis of Congenital Amegakaryocytic Thrombocytopenia (CAMT). Here, we show that CAMT-associated mutations in c-Mpl principally lead to defective receptor presentation on the cell surface. In contrast, one CAMT mutant c-Mpl, F104S, was expressed on the cell surface, but showed defective TPO binding and receptor activation. Using mutational analyses, we examined which residues adjacent to F104 within the membrane-distal cytokine receptor homology module (CRM) of c-Mpl comprise the TPO-binding epitope, revealing residues within the predicted Domain 1 E-F and A-B loops and Domain 2 F'-G' loop as key TPO-binding determinants. These studies underscore the importance of the c-Mpl membrane-distal CRM to TPO-binding and suggest that mutations within this CRM that perturb TPO binding could give rise to CAMT.
The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15
Publisher: Elsevier BV
Date: 2016
DOI: 10.1016/J.IMMUNI.2015.12.007
Abstract: The inhibitor of DNA binding 2 (Id2) is essential for natural killer (NK) cell development with its canonical role being to antagonize E-protein function and alternate lineage fate. Here we have identified a key role for Id2 in regulating interleukin-15 (IL-15) receptor signaling and homeostasis of NK cells by repressing multiple E-protein target genes including Socs3. Id2 deletion in mature NK cells was incompatible with their homeostasis due to impaired IL-15 receptor signaling and metabolic function and this could be rescued by strong IL-15 receptor stimulation or genetic ablation of Socs3. During NK cell maturation, we observed an inverse correlation between E-protein target genes and Id2. These results shift the current paradigm on the role of ID2, indicating that it is required not only to antagonize E-proteins during NK cell commitment, but constantly required to titrate E-protein activity to regulate NK cell fitness and responsiveness to IL-15.
Run-time management and optimization of web service monitoring systems
Publisher: IEEE
Date: 12-2011
Is matrix metalloproteinase required in postnatal testicular tubules for germ cell maturation?
Publisher: Elsevier BV
Date: 07-2012
DOI: 10.1016/J.JPEDSURG.2012.03.062
Abstract: Cryptorchidism may cause infertility by failed transformation of neonatal gonocytes into adult dark spermatogonia, the putative stem cells for spermatogenesis. Gonocytes migrate centrifugally to the tubular basement membrane to become adult dark spermatogonia. Regulation of this transformation remains unknown. We aimed to investigate neonatal rodent testis matrix metalloproteinase (MMP) production to see whether MMPs loosen extracellular matrix between Sertoli cells to facilitate gonocyte movement. Sprague-Dawley rat testes (n = 4-6 per group) were collected at embryonic day 19 (E19) and postnatal (P) days P0 to 10 for immunohistochemistry. Immunofluorescent confocal images were captured for presence of membrane type 1 MMP (MT1-MMP), matrix metalloproteinase 2 (MMP2), tissue inhibitor of metalloproteinase 2 (TIMP2), mouse VASA homologue, anti-Müllerian hormone, and androgen receptor in tissue sections. Testicular proteins were analyzed by immunoblotting. Membrane type 1 MMP was strongly present in gonocytes at E19 then decreased, whereas it increased in testicular somatic cells from P0 to P10. Testicular protein levels of MT1-MMP, MMP2, and androgen receptor were constant from E19 to P10. Anti-Müllerian hormone protein sharply decreased after P2, whereas TIMP2 gradually increased from E19 to P10. Gonocytes migrated to basement membrane at P2 to P6. Membrane type 1 MMP, MMP2, and TIMP2 were present in testis from E19 to P10 during gonocyte migration and transformation into spermatogenic stem cells. Increased knowledge about germ cell development may aid efforts to improve fertility in cryptorchidism.
Dynamic Protocol Aggregation and Adaptation for Service-Oriented Computing
Publisher: IEEE
Date: 04-2007
Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation
Publisher: Proceedings of the National Academy of Sciences
Date: 07-04-2014
Abstract: Blood platelets, the small circulating cells that coordinate hemostasis, are produced by specialized bone marrow cells called megakaryocytes. The cytokine thrombopoietin (TPO) is a key regulator of platelet production acting via its specific cell receptor, Mpl. Via genetic modification of the Mpl allele in mice, we precisely define the bone marrow cells that express Mpl and, by genetically removing Mpl from megakaryocytes and platelets, we show TPO signaling via Mpl is not required in megakaryocytes for their expansion, maturation, or platelet production. Rather, Mpl expression on megakaryocytes is essential for regulating TPO availability in the bone marrow microenvironment to prevent myeloproliferation, a model we suggest is important for human disease.
Verifying student identity in oral assessments with deep speaker
Publisher: Elsevier BV
Date: 2022
Scalable Emulation of Enterprise Systems
Publisher: IEEE
Date: 2009
Murine Oncostatin M Acts via Leukemia Inhibitory Factor Receptor to Phosphorylate Signal Transducer and Activator of Transcription 3 (STAT3) but Not STAT1, an Effect That Protects Bone Mass
Publisher: Elsevier BV
Date: 10-2016
Minimising Cycle Time in Assembly Lines: A Novel Ant Colony Optimisation Approach
Publisher: Springer International Publishing
Date: 2020
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Related Funding Activities
Linkage Projects - Grant ID: LP100100622
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End Date: 12-2014
Amount: $470,000.00
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View Funded ActivityLinkage Projects - Grant ID: LP0775188
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View Funded ActivityIndustrial Transformation Research Hubs - Grant ID: IH170100013
Start Date: 03-2018
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Amount: $2,962,655.00
Funder: Australian Research Council
View Funded Activity