ORCID Profile
0000-0002-5907-9257
Current Organisation
The University of Auckland
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Publisher: American Association for Cancer Research (AACR)
Date: 04-04-2023
DOI: 10.1158/2326-6066.22543495.V1
Abstract: Supplementary Figures 1-6 and Tables 1-7
Publisher: American Association for Cancer Research (AACR)
Date: 04-04-2023
DOI: 10.1158/2326-6066.C.6550291.V1
Abstract: Abstract Metastasis of human tumors to lymph nodes (LN) is a universally negative prognostic factor. LN stromal cells (SC) play a crucial role in enabling T-cell responses, and because tumor metastases modulate their structure and function, this interaction may suppress immune responses to tumor antigens. The SC subpopulations that respond to infiltration of malignant cells into human LNs have not been defined. Here, we identify distinctive subpopulations of CD90 sup + /sup SCs present in melanoma-infiltrated LNs and compare them with their counterparts in normal LNs. The first population (CD90 sup + /sup podoplanin sup + /sup CD105 sup + /sup CD146 sup + /sup CD271 sup + /sup VCAM-1 sup + /sup ICAM-1 sup + /sup α-SMA sup + /sup ) corresponds to fibroblastic reticular cells that express various T-cell modulating cytokines, chemokines, and adhesion molecules. The second (CD90 sup + /sup CD34 sup + /sup CD105 sup + /sup CD271 sup + /sup ) represents a novel population of CD34 sup + /sup SCs embedded in collagenous structures, such as the capsule and trabeculae, that predominantly produce extracellular matrix. We also demonstrated that these two SC subpopulations are distinct from two subsets of human LN pericytes, CD90 sup + /sup CD146 sup + /sup CD36 sup + /sup NG2 sup − /sup pericytes in the walls of high endothelial venules and other small vessels, and CD90 sup + /sup CD146 sup + /sup NG2 sup + /sup CD36 sup − /sup pericytes in the walls of larger vessels. Distinguishing between these CD90 sup + /sup SC subpopulations in human LNs allows for further study of their respective impact on T-cell responses to tumor antigens and clinical outcomes. /
Publisher: American Association for Cancer Research (AACR)
Date: 08-2020
DOI: 10.1158/2326-6066.CIR-19-0796
Abstract: Metastasis of human tumors to lymph nodes (LN) is a universally negative prognostic factor. LN stromal cells (SC) play a crucial role in enabling T-cell responses, and because tumor metastases modulate their structure and function, this interaction may suppress immune responses to tumor antigens. The SC subpopulations that respond to infiltration of malignant cells into human LNs have not been defined. Here, we identify distinctive subpopulations of CD90+ SCs present in melanoma-infiltrated LNs and compare them with their counterparts in normal LNs. The first population (CD90+ podoplanin+ CD105+ CD146+ CD271+ VCAM-1+ ICAM-1+ α-SMA+) corresponds to fibroblastic reticular cells that express various T-cell modulating cytokines, chemokines, and adhesion molecules. The second (CD90+ CD34+ CD105+ CD271+) represents a novel population of CD34+ SCs embedded in collagenous structures, such as the capsule and trabeculae, that predominantly produce extracellular matrix. We also demonstrated that these two SC subpopulations are distinct from two subsets of human LN pericytes, CD90+ CD146+ CD36+ NG2− pericytes in the walls of high endothelial venules and other small vessels, and CD90+ CD146+ NG2+ CD36− pericytes in the walls of larger vessels. Distinguishing between these CD90+ SC subpopulations in human LNs allows for further study of their respective impact on T-cell responses to tumor antigens and clinical outcomes.
Publisher: American Association for Cancer Research (AACR)
Date: 04-04-2023
DOI: 10.1158/2326-6066.C.6550291
Abstract: Abstract Metastasis of human tumors to lymph nodes (LN) is a universally negative prognostic factor. LN stromal cells (SC) play a crucial role in enabling T-cell responses, and because tumor metastases modulate their structure and function, this interaction may suppress immune responses to tumor antigens. The SC subpopulations that respond to infiltration of malignant cells into human LNs have not been defined. Here, we identify distinctive subpopulations of CD90 sup + /sup SCs present in melanoma-infiltrated LNs and compare them with their counterparts in normal LNs. The first population (CD90 sup + /sup podoplanin sup + /sup CD105 sup + /sup CD146 sup + /sup CD271 sup + /sup VCAM-1 sup + /sup ICAM-1 sup + /sup α-SMA sup + /sup ) corresponds to fibroblastic reticular cells that express various T-cell modulating cytokines, chemokines, and adhesion molecules. The second (CD90 sup + /sup CD34 sup + /sup CD105 sup + /sup CD271 sup + /sup ) represents a novel population of CD34 sup + /sup SCs embedded in collagenous structures, such as the capsule and trabeculae, that predominantly produce extracellular matrix. We also demonstrated that these two SC subpopulations are distinct from two subsets of human LN pericytes, CD90 sup + /sup CD146 sup + /sup CD36 sup + /sup NG2 sup − /sup pericytes in the walls of high endothelial venules and other small vessels, and CD90 sup + /sup CD146 sup + /sup NG2 sup + /sup CD36 sup − /sup pericytes in the walls of larger vessels. Distinguishing between these CD90 sup + /sup SC subpopulations in human LNs allows for further study of their respective impact on T-cell responses to tumor antigens and clinical outcomes. /
Publisher: American Association for Cancer Research (AACR)
Date: 04-04-2023
DOI: 10.1158/2326-6066.22543495
Abstract: Supplementary Figures 1-6 and Tables 1-7
Location: United States of America
No related grants have been discovered for Joanna Mathy.