ORCID Profile
0000-0001-5987-2426
Current Organisation
Uppsala University
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Publisher: Georg Thieme Verlag KG
Date: 29-10-2020
DOI: 10.1055/A-1028-7786
Abstract: Three new (1–3) and 2 known (4–5) bis-indole alkaloids were identified from the bark of Flindersia pimenteliana (Rutaceae). The structures of 1–3 were elucidated on the basis of their (+)-HRESESIMS and 2D NMR spectroscopic data. Antiplasmodial activity for 1–3 against chloroquine sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum is also reported, with IC50 values ranging from 0.96 to 2.41 µg/mL. These results expand our knowledge of the structure-activity relationships of potently antiplasmodial isoborreverine-type alkaloids, the bioactivity of which have recently attracted significant attention in the literature.
Publisher: Elsevier BV
Date: 08-2018
DOI: 10.1016/J.PHYTOCHEM.2018.04.011
Abstract: The genus Flindersia (Rutaceae) comprises 17 species of mostly Australian endemic trees. Although most species are restricted to rainforests, four have evolved to grow in semi-arid and arid environments. In this study, the leaf alkaloid ersity of rainforest and semi-arid/arid zone adapted Australian Flindersia were compared by LC/MS-MS and NMR spectroscopy. Contrary to expectations, Flindersia alkaloid ersity was strongly correlated with environmental aridity, where species predominating in drier regions produced more alkaloids than their wet rainforest congenerics. Rainforest species were also more chemically similar to each other than were the four semi-arid/arid zone species. There was a significant relationship between the presence of alkaloid structural classes and phylogenetic distance, suggesting that alkaloid profiles are influenced by both genetic and environmental factors. The results suggest that the radiation of Flindersia species out of the rainforest and into drier environments has promoted the evolution of unique alkaloid ersity. Plants growing in arid and semi-arid regions of Australia may represent an untapped source of undescribed specialised metabolites.
Publisher: Elsevier BV
Date: 09-2019
Publisher: CSIRO Publishing
Date: 2021
DOI: 10.1071/CH20125
Abstract: One new furoquinoline alkaloid, leptanoine D (1) and nine known alkaloids 2–10 were isolated from Pitaviaster haplophyllus. Leptanoine D (1) contains a typically unstable vinyl ether moiety and was structurally elucidated based on 2D NMR, (+)-HR-ESI-MS, and ECD data. The structures of the known furoquinoline alkaloids leptanoine A (11) and B (12) have also been revised. Compounds 1–10 were screened against three species of bacteria (Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli), however they showed no activity at the highest dose tested (32µg mL−1). The compounds were also evaluated for anti-proliferative action against PC-3 and WPMY-1 cells, with 7–9 displaying weak activity at 100μM.
Publisher: Wiley
Date: 26-03-2018
DOI: 10.1111/AEN.12338
Publisher: American Chemical Society (ACS)
Date: 13-03-2019
DOI: 10.1021/ACS.JNATPROD.8B00956
Abstract: A new oxidized xanthene, acrotrione (1), and two known acetophenones (2 and 3) were isolated from a methanol extract of the roots of Acronychia pubescens. The structure of 1 was elucidated on the basis of its (+)-HRESIMS, 2D NMR, and ECD data. Acritrione (1) contains an unusual oxidized furo[2,3- c]xanthene moiety that has not been previously reported. Moderate antiplasmodial activity for these natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum was determined with IC
Publisher: American Chemical Society (ACS)
Date: 24-11-2020
Publisher: American Chemical Society (ACS)
Date: 13-12-2017
DOI: 10.1021/ACS.JNATPROD.7B00587
Abstract: Three members of a new class of ascorbic acid-adduct indole alkaloids (1-3), a new prenylated indole alkaloid (4), and five known compounds (5-9) were isolated from the leaves of Flindersia pimenteliana. The structures of 1-4 were elucidated on the basis of their (+)-HRESIMS and 2D NMR spectroscopic data. Antiplasmodial activity was also reported for the natural products against chloroquine-sensitive (3D7) and chloroquine-resistant (Dd2) Plasmodium falciparum with IC
Publisher: American Chemical Society (ACS)
Date: 22-08-2019
DOI: 10.1021/ACS.JNATPROD.9B00551
Abstract: A library of 500 Australian marine invertebrate extracts was screened for anti-prion activity using a yeast-based assay, and this resulted in an extract from the ascidian
Publisher: American Chemical Society (ACS)
Date: 20-01-2022
DOI: 10.1021/ACS.JNATPROD.1C01172
Abstract: Seven new polyaromatic bis-spiroketal-containing butenolides, the prunolides D-I (
Publisher: American Chemical Society (ACS)
Date: 15-07-2019
DOI: 10.1021/ACS.JNATPROD.9B00493
Abstract: Six new lamellarin sulfates (
Publisher: American Chemical Society (ACS)
Date: 06-11-2018
DOI: 10.1021/ACS.JNATPROD.8B00494
Abstract: Four new β-triketone monoterpene hybrids, intermediones A-D (1-4), have been identified from the flowers of the Australian eucalypt tree Corymbia intermedia. Intermediones A-D are β-triketones that incorporate a pinene moiety attached via a benzyl group to a syncarpic acid. The structures of 1-4, including relative configurations, were elucidated from the analysis of 1D/2D NMR and MS data. The absolute configurations of intermediones A and B were determined by comparison of experimental and predicted ECD spectra. Intermedione D possesses a tetracyclic ring system that is related to that found in the meroterpenes, guadials B and C. Low to moderate antiplasmodial activity toward the chloroquine-sensitive (3D7) strain of Plasmodium falciparum, with IC
Publisher: MDPI AG
Date: 30-05-2018
DOI: 10.3390/MD16060189
Publisher: American Chemical Society (ACS)
Date: 30-08-2023
Publisher: American Chemical Society (ACS)
Date: 15-12-2021
Publisher: American Chemical Society (ACS)
Date: 25-03-2020
No related grants have been discovered for Luke Robertson.