ORCID Profile
0000-0003-0819-8325
Current Organisation
Nanyang Technological University
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Publisher: Wiley
Date: 19-12-2016
Publisher: Wiley
Date: 14-09-2015
Abstract: We proposed a side channel photonic crystal fiber (SC-PCF) based Surface enhanced Raman spectroscopy (SERS) platform which is able to accurately monitor lipid peroxidation derived protein modifications in cells. This platform incorporates linoleamide alkyne (LAA), which is oxidized and subsequently modifies proteins in cells with alkyne functional group upon lipid peroxidation. By loading the side channel of SC-PCF with a mixture of gold nanoparticles and LAA treated cells, and subsequently measuring the interference-free alkyne Raman peak from these proteins in cells, strong SERS signal was obtained. The platform provides a method for the rapid monitoring of lipid peroxidation derived protein modification in cells.
Publisher: Wiley
Date: 09-2023
Publisher: Elsevier BV
Date: 05-2020
Publisher: Elsevier BV
Date: 04-2018
Publisher: American Physical Society (APS)
Date: 24-01-2019
Publisher: The Optical Society
Date: 12-10-2009
DOI: 10.1364/OE.17.019356
Publisher: Wiley
Date: 08-08-2019
Location: United States of America
No related grants have been discovered for Lei Wei.