ORCID Profile
0000-0001-8644-2827
Current Organisations
University of Minnesota
,
Minneapolis VA Health Care System
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Publications
Biomarkers and Bacterial Pneumonia Risk in Patients with Treated HIV Infection: A Case-Control Study
Publisher: Public Library of Science (PLoS)
Date: 15-02-2013
Pulmonary effects of immediate versus deferred antiretroviral therapy in HIV-positive individuals: a nested substudy within the multicentre, international, randomised, controlled Strategic Timing of Antiretroviral Treatment (START) trial
Publisher: Elsevier BV
Date: 12-2016
Increased Indoleamine-2,3-Dioxygenase Activity Is Associated With Poor Clinical Outcome in Adults Hospitalized With Influenza in the INSIGHT FLU003Plus Study
Publisher: Oxford University Press (OUP)
Date: 25-10-2017
DOI: 10.1093/OFID/OFX228
Abstract: Indoleamine-2,3-dioxygenase (IDO) mediated tryptophan (TRP) depletion has antimicrobial and immuno-regulatory effects. Increased kynurenine (KYN)-to-TRP (KT) ratios, reflecting increased IDO activity, have been associated with poorer outcomes from several infections. We performed a case-control (1:2 age and sex matched) analysis of adults hospitalized with influenza A(H1N1)pdm09 with protocol-defined disease progression (died/transferred to ICU/mechanical ventilation) after enrollment (cases) or survived without progression (controls) over 60 days of follow-up. Conditional logistic regression was used to analyze the relationship between baseline KT ratio and other metabolites and disease progression. We included 32 cases and 64 controls with a median age of 52 years 41% were female, and the median durations of influenza symptoms prior to hospitalization were 8 and 6 days for cases and controls, respectively (P = .04). Median baseline KT ratios were 2-fold higher in cases (0.24 mM/M IQR, 0.13–0.40) than controls (0.12 IQR, 0.09–0.17 P ≤ .001). When ided into tertiles, 59% of cases vs 20% of controls had KT ratios in the highest tertile (0.21–0.84 mM/M). When adjusted for symptom duration, the odds ratio for disease progression for those in the highest vs lowest tertiles of KT ratio was 9.94 (95% CI, 2.25–43.90). High KT ratio was associated with poor outcome in adults hospitalized with influenza A(H1N1)pdm09. The clinical utility of this biomarker in this setting merits further exploration. NCT01056185.
Why START ? Reflections that led to the conduct of this large long‐term strategic HIV trial
Publisher: Wiley
Date: 25-02-2015
DOI: 10.1111/HIV.12227
Current Challenges and Solutions for Clinical Management and Care of People with HIV: Findings from the 12th Annual International HIV and Aging Workshop.
Publisher: Mary Ann Liebert Inc
Date: 2022
Longitudinal Association Between Muscle Loss and Mortality in Ever Smokers
Publisher: Elsevier BV
Date: 04-2022
Anti-influenza hyperimmune intravenous immunoglobulin for adults with influenza A or B infection (FLU-IVIG): a double-blind, randomised, placebo-controlled trial
Publisher: Elsevier BV
Date: 11-2019
Related Organisations
Related Funding Activities
No related grants have been discovered for Ken Kunisaki.