ORCID Profile
0000-0003-2465-3818
Current Organisation
University of Rochester Laboratory for Laser Energetics: Rochester, NY, US
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Publisher: AIP Publishing
Date: 09-2011
DOI: 10.1063/1.3640805
Publisher: American Physical Society (APS)
Date: 12-07-2021
Publisher: American Association for the Advancement of Science (AAAS)
Date: 15-05-2020
Abstract: Machine learning–based approach unravels distinct pathological signatures induced by patient-derived α-synuclein seeds in monkeys.
Publisher: American Physical Society (APS)
Date: 13-05-2011
Publisher: Wiley
Date: 18-02-2014
DOI: 10.1002/ANA.24066
Abstract: Mounting evidence suggests that α-synuclein, a major protein component of Lewy bodies (LB), may be responsible for initiating and spreading the pathological process in Parkinson disease (PD). Supporting this concept, intracerebral inoculation of synthetic recombinant α-synuclein fibrils can trigger α-synuclein pathology in mice. However, it remains uncertain whether the pathogenic effects of recombinant synthetic α-synuclein may apply to PD-linked pathological α-synuclein and occur in species closer to humans. Nigral LB-enriched fractions containing pathological α-synuclein were purified from postmortem PD brains by sucrose gradient fractionation and subsequently inoculated into the substantia nigra or striatum of wild-type mice and macaque monkeys. Control animals received non-LB fractions containing soluble α-synuclein derived from the same nigral PD tissue. In both mice and monkeys, intranigral or intrastriatal inoculations of PD-derived LB extracts resulted in progressive nigrostriatal neurodegeneration starting at striatal dopaminergic terminals. No neurodegeneration was observed in animals receiving non-LB fractions from the same patients. In LB-injected animals, exogenous human α-synuclein was quickly internalized within host neurons and triggered the pathological conversion of endogenous α-synuclein. At the onset of LB-induced degeneration, host pathological α-synuclein diffusely accumulated within nigral neurons and anatomically interconnected regions, both anterogradely and retrogradely. LB-induced pathogenic effects required both human α-synuclein present in LB extracts and host expression of α-synuclein. α-Synuclein species contained in PD-derived LB are pathogenic and have the capacity to initiate a PD-like pathological process, including intracellular and presynaptic accumulations of pathological α-synuclein in different brain areas and slowly progressive axon-initiated dopaminergic nigrostriatal neurodegeneration.
Publisher: American Physical Society (APS)
Date: 02-01-2008
Publisher: Cold Spring Harbor Laboratory
Date: 31-10-2019
DOI: 10.1101/825216
Abstract: Dopaminergic neuronal cell death, associated with intracellular α-synuclein (α-syn)-rich protein aggregates (termed ‘Lewy bodies’), is a well-established characteristic of Parkinson’s disease. Much evidence, accumulated from multiple experimental models has suggested that α-syn plays a role in PD pathogenesis, not only as a trigger of pathology but also as a mediator of disease progression through pathological spreading. Here we have used a machine learning-based approach to identify unique signatures of neurodegeneration in monkeys induced by distinct α-syn pathogenic structures derived from PD patients. Unexpectedly, our results show that, in non-human primates, a small amount of singular α-syn aggregates is as toxic as larger amyloid fibrils present in the LBs, thus reinforcing the need for preclinical research in this species. Furthermore, our results provide evidence supporting the true multifactorial nature of PD as multiple causes can induce similar outcome regarding dopaminergic neurodegeneration.
Publisher: Informa UK Limited
Date: 28-12-2017
Publisher: Elsevier BV
Date: 03-2012
Publisher: AIP Publishing
Date: 27-02-2009
DOI: 10.1063/1.3078422
Abstract: A high-performance inertial confinement fusion capsule is compressed by multiple shock waves before it implodes. To minimize the entropy acquired by the fuel, the strength and timing of those shock waves must be accurately controlled. Ignition experiments at the National Ignition Facility (NIF) will employ surrogate targets designed to mimic ignition targets while making it possible to measure the shock velocities inside the capsule. A series of experiments on the OMEGA laser facility [Boehly et al., Opt. Commun. 133, 495 (1997)] validated those targets and the diagnostic techniques proposed. Quartz was selected for the diagnostic window and shock-velocity measurements were demonstrated in Hohlraum targets heated to 180 eV. Cryogenic experiments using targets filled with liquid deuterium further demonstrated the entire timing technique in a Hohlraum environment. Direct-drive cryogenic targets with multiple spherical shocks were used to further validate this technique, including convergence effects at relevant pressures (velocities) and sizes. These results provide confidence that shock velocity and timing can be measured in NIF ignition targets, allowing these critical parameters to be optimized.
Location: Germany
Location: China
Location: United States of America
Location: United States of America
No related grants have been discovered for Suxing Hu.