ORCID Profile
0000-0001-7880-578X
Current Organisation
University of Oxford
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Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SC03218A
Abstract: Surprisingly small structural changes in Donor–Acceptor Stenhouse Adducts (DASAs) result in predictable, robust and effective photochromic switches.
Publisher: Wiley
Date: 22-06-2020
Publisher: Elsevier BV
Date: 03-2018
Publisher: Wiley
Date: 22-06-2020
Publisher: Cold Spring Harbor Laboratory
Date: 08-04-2021
DOI: 10.1101/2021.04.08.438951
Abstract: We introduce dynamic mass photometry, a method for label-free imaging, tracking and mass measurement of membrane-associated proteins. Our method enables quantitative studies of their mobility, membrane affinity and interactions at the single molecule level. Application to the membrane remodelling GTPase dynamin1 reveals heterogeneous mixtures of oligomers suggesting that the fundamental building block for oligomerisation is a dimer, challenging current tetramer-centric models. Dynamic mass photometry has the ability to transform our approach to studying biomolecular mechanisms in and on lipid bilayers.
Publisher: Wiley
Date: 02-04-2020
Publisher: Springer Science and Business Media LLC
Date: 10-2021
DOI: 10.1038/S41592-021-01261-W
Abstract: The quantification of membrane-associated biomolecular interactions is crucial to our understanding of various cellular processes. State-of-the-art single-molecule approaches rely largely on the addition of fluorescent labels, which complicates the quantification of the involved stoichiometries and dynamics because of low temporal resolution and the inherent limitations associated with labeling efficiency, photoblinking and photobleaching. Here, we demonstrate dynamic mass photometry, a method for label-free imaging, tracking and mass measurement of in idual membrane-associated proteins diffusing on supported lipid bilayers. Application of this method to the membrane remodeling GTPase, dynamin-1, reveals heterogeneous mixtures of dimer-based oligomers, oligomer-dependent mobilities, membrane affinities and (dis)association of in idual complexes. These capabilities, together with assay-based advances for studying integral membrane proteins, will enable the elucidation of biomolecular mechanisms in and on lipid bilayers.
Publisher: Wiley
Date: 02-04-2020
Publisher: CSIRO Publishing
Date: 2021
DOI: 10.1071/MF20129
Abstract: We share observations of silver gulls (Chroicocephalus novaehollandiae) harassing humpback whales (Megaptera novaeangliae) in Exmouth Gulf, Western Australia, between August and October in 2018 and 2019. Sixteen events were recorded of gulls pecking at the skin of 16 mothers and 2 calves resting on the surface. Data were collected opportunistically from a research vessel covering 5474.2km (565h). Events were documented through photographs and unmanned aerial vehicle video recordings and persisted for an average minimum time of 20.73min (range 2.50–46.85min). At least one event of a gull consistently gouging in a pre-existing lesion was recorded on a mother. Changes in behavioural activity from the whales, which varied from slipping under the surface to travelling and performing instantaneous behavioural events, were observed in 94% (15/16) of events. These are the first known records of birds attacking humpback whales. The results are comparable to early events of kelp gull (Larus dominicanus) harassment of southern right whales (Eubalaena australis) off Península Valdés, Argentina, where events have escalated over the past 50 years to consistent attacks on the whales’ skin and blubber. Future research is required to monitor the trajectory of these interactions to inform management.
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Eric D.B. Foley.