ORCID Profile
0000-0002-6630-5515
Current Organisation
UNSW Sydney
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Publisher: MDPI AG
Date: 17-02-2021
DOI: 10.3390/PR9020368
Abstract: Gold nanoparticles (GNP) aided hyperthermia has demonstrated promising results in the treatment of cancer. However, most existing investigations focus only on the extinction spectra of GNP solutions, few reported the actual heat generation capability of these solutions to estimate their real potential in in-situ hyperthermia treatment. In this study, the impact of GNP clustering on the optical properties and heating capability of GNP aggregates in acidic solutions have been investigated. It was found that localized heat generation could be significantly enhanced (to up to 60.0 °C) when acidic solutions were illuminated by a near infrared light source at 1.7 W/cm2. In addition, infrared thermography imaging can only detect the surface temperature during thermal treatment, leaving the localized temperature distribution inside the tissues unknown. To overcome this limitation, in this study, the absorbed energy during NIR irradiation in GNP solutions was obtained computationally by coupling the P1 approximation with the DDA calculation to predict the localized temperature change in the solutions. It was demonstrated that due to the accumulation and dissipation of heat, some local areas showed higher temperature increase with the hot spots being connected and merged over time.
Publisher: Informa UK Limited
Date: 16-02-2021
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 09-2017
Publisher: AIP Publishing
Date: 03-2023
DOI: 10.1063/5.0138484
Abstract: The acoustic radiation force has been proven as an effective mechanism for displacing particles and bubbles, but it has been mainly applied in a standing wave mode in microfluidics. Alternatively, the use of pulsed traveling acoustic waves could enable new options, but its transient dynamic, which entails the additional complexities of pulse timing, reflections, and the type of waveform, has not yet been fully investigated. To better understand these transient effects, a transient numerical solution and an experimental testbed were developed to gain insights into the displacement of microbubbles when exposed to on- and off-periods of pulsed traveling waves. In this study, a practical sinusoid tone burst excitation at a driving frequency of 0.5 MHz is investigated. Our numerical and experimental results were found to be in good agreement, with only a 13% deviation in the acoustically driven velocity. With greater detail from the numerical solution at a s ling rate of 1 GHz, the fundamental mechanism for the bubble translation was revealed. It was found that the added mass force, gained through the on-period of the pulse, continued to drive the bubble throughout the off-period, enabling a large total displacement, even in the case of low duty-cycle (2%) pulsing. In addition, the results showed greater translational velocity is possible with a lower number of cycles for the same input acoustic energy (constant duty cycle and acoustic pressure litude). Overall, this study proposes a new, practical, and scalable approach for the acoustic manipulation of microbubbles for scientific, biomedical, and industrial applications.
Publisher: Begellhouse
Date: 2018
Publisher: Elsevier BV
Date: 12-2017
Publisher: American Chemical Society (ACS)
Date: 04-08-2018
DOI: 10.1021/ACS.LANGMUIR.8B01457
Abstract: Gold nanoparticle (GNP) aggregation has a strong influence on the plasmonic resonance and hence the effectiveness in various photothermal applications. In relation to this, a comprehensive numerical model is developed to simulate and characterize the GNP aggregation process at various particle volume fractions and base fluid pH levels. Computational fluid dynamics techniques are utilized to model the base fluid, whereas discrete phase modeling is adopted in determining the nanoparticle trajectories. Two-way coupling is implemented to handle the particle-fluid interactions. Discrete dipole approximation approach is utilized to further examine the absorption and scattering efficiency of various GNP aggregate structures. At lower particle volume fraction, short chain-like structures are formed in the particle aggregation process, with a more complex interconnected "particle network" structure formed at higher particle volume fractions. With the three base fluid pH levels investigated, GNP aggregates are more compact with larger fractal dimensions and higher mean coordination numbers at pH = 3.5, whereas a more "loose" structure formed at pH = 6.7 and 9.4 because of larger electrostatic repulsive forces as a result of changes in the zeta potential and Debye length of the GNPs. Among the typical GNP aggregate structures characterized in this paper, the chain-like tetramer demonstrates the highest absorption efficiency of 1.83 at 700 nm wavelength-comparable to the plasmonic resonance of a nanorod-which lies in the optical window of biological tissue. Predictions of GNP optical properties are found to be in good agreement with the published experimental data.
Publisher: IEEE
Date: 10-2016
Publisher: Springer Science and Business Media LLC
Date: 06-2022
Publisher: MDPI AG
Date: 08-10-2019
DOI: 10.3390/APP9194189
Abstract: Magnetorheological (MR) fluid is a smart material fabricated by mixing magnetic-responsive particles with non-magnetic-responsive carrier fluids. MR fluid d ers are able to provide rapid and reversible changes to their d ing coefficient. To optimize the efficiency and effectiveness of such devices, a computational model is developed and presented where the flow field is simulated using the computational fluid dynamics approach, coupled with the magnetohydrodynamics model. Three different inlet pressure profiles were designed to replicate real loading conditions are examined, namely a constant pressure, a sinusoidal pressure profile, and a pressure profile mimicking the 1994 Northbridge earthquake. When the MR fluid d er was in its off-state, a linear pressure drop between the inlet and the outlet was observed. When a uniform perpendicular external magnetic field was applied to the annular orifice of the MR d er, a significantly larger pressure drop was observed across the annular orifice for all three inlet pressure profiles. It was shown that the fluid velocity within the magnetized annular orifice decreased proportionally with respect to the strength of the applied magnetic field until saturation was reached. Therefore, it was clearly demonstrated that the present model was capable of accurately capturing the d ing characteristics of MR fluid d ers.
Publisher: Elsevier BV
Date: 12-2021
DOI: 10.1016/J.JBIOMECH.2021.110755
Abstract: Coronary bifurcations have complex flow patterns including secondary flow zones and helical flow, which directly affect pathophysiological mechanisms such as the development of atherosclerosis. The objective of this study was to generate insights into the effects of curvature, bifurcation angle and the presence of stents on flow patterns and resulting haemodynamics in coronary left main bifurcations. The blood flow and associated metrics were modelled in both idealised and patient-specific bifurcations with varying curvature and bifurcation angles with and without stents, resulting in a total of 128 geometries considered. The results showed that larger curvature of bifurcating vessels has a significant influence on secondary flow, especially with distance to the bifurcation region, causing a skew, spin and asymmetry of Dean vortices, an increase in helical flow intensity with symmetry loss, and a decrease in adversely low time-average wall shear stress (TAWSS). Generally, asymmetric flow patterns coincided with adversely low TAWSS regions. In identical stented geometries, the presence of the stents induced local recirculation immediately adjacent to the stent struts, thus generating adversely low TAWSS in these areas, with some effect on the overall secondary flow. Overall, the effect of stents outweighed the effect of curvature and BA. This new knowledge contributes to a better understanding of the joint effects of curvature, bifurcation angle, and stents on flow patterns and haemodynamics in coronary bifurcations.
No related grants have been discovered for Darson Li.