ORCID Profile
0000-0001-9882-5948
Current Organisation
Julius-Maximilians-Universität Würzburg Biozentrum
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Publisher: S. Karger AG
Date: 2005
DOI: 10.1159/000084205
Publisher: Springer Science and Business Media LLC
Date: 03-1999
DOI: 10.1038/6769
Publisher: Springer Science and Business Media LLC
Date: 19-10-2023
Publisher: Springer Science and Business Media LLC
Date: 04-2013
DOI: 10.1038/NATURE12027
Publisher: S. Karger AG
Date: 2002
DOI: 10.1159/000071591
Abstract: Sex chromosomes of birds and mammals are highly differentiated and share several cytological features. However, comparative gene mapping reveals extensive conserved synteny between the chicken Z sex chromosome and human chromosome 9 but not the human X sex chromosome, implying an independent origin of avian and mammalian sex chromosomes. To better understand the evolution of the avian Z chromosome we analysed the synteny of chicken Z-linked genes in zebrafish, which is the best-mapped teleost genome so far. Existing zebrafish maps do not support the existence of an ancestral Z linkage group in the zebrafish genome, whereas mammalian X-linked genes show at least some degree of synteny conservation. This is consistent with in situ hybridisation mapping data in the freshwater pufferfish, i Tetraodon nigroviridis /i where mammalian X-linked genes show a much higher degree of conserved synteny than human chromosome 9 or the avian Z chromosome. Collectively, these data argue in favour of a more recent evolution of the avian Z chromosome, compared with the mammalian X.
Publisher: Public Library of Science (PLoS)
Date: 23-02-2015
Publisher: Wiley
Date: 17-09-2016
DOI: 10.1002/ECE3.2396
Publisher: Springer Science and Business Media LLC
Date: 11-05-2011
DOI: 10.1007/S00427-011-0363-7
Abstract: AGO proteins are universal effectors of eukaryotic small RNA-directed regulatory pathways. In this study, we used a comparative genomics approach to explore the AGO sub-family in the teleost clade. We identified five Ago homologues in teleost genomes, one more than encoded in other vertebrate clades. The additional teleost homologue was preserved most likely due to the differential retention of regulatory elements following the fish-specific genome duplication event that occurred approximately 350 million years ago. Analysis of all five Ago genomic loci in teleosts revealed that orthologues contain specific, conserved sequence elements in non-coding regions indicating that the teleost Ago paralogues are differentially regulated. This was supported by qRT-PCR analysis that showed differential expression of the zebrafish homologues across development and between adult tissues indicating stage and tissue-specific function of in idual AGO proteins. Multiple sequence alignments showed not only that all teleost homologues possess critical residues for AGO function, but also that teleost homologues contain multiple orthologue-specific features, indicative of structural ersification. Notably, these are retained throughout the vertebrate lineage arguing these may be important for orthologue-specific functions.
No related grants have been discovered for Manfred Schartl.