ORCID Profile
0000-0002-4797-3569
Current Organisation
University of Newcastle Australia
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Publisher: Elsevier BV
Date: 06-2021
DOI: 10.1093/AJCN/NQAA442
Publisher: Wiley
Date: 06-04-2020
DOI: 10.1002/PPUL.24756
Publisher: MDPI AG
Date: 29-09-2020
DOI: 10.3390/NU12102978
Abstract: Low 25-hydroxyvitamin D (25(OH)D) levels are common in pregnancy and associated with adverse maternal/neonatal outcomes. In pregnant women with asthma, this study examined the association of lifestyle- and asthma-related factors on 25(OH)D levels and maternal/neonatal outcomes by vitamin D status. Serum 25(OH)D was measured at 16 and 35 weeks gestation in women with asthma (n = 103). Body mass index (BMI), gestational weight gain (GWG), smoking status, inhaled corticosteroid (ICS) use, asthma control, airway inflammation, and exacerbations, and maternal/neonatal outcomes were collected. Baseline and change (Δ) in 25(OH)D were modelled separately using backward stepwise regression, adjusted for season and ethnicity. Maternal/neonatal outcomes were compared between low (25(OH)D 75 nmol/L at both time points) and high (≥75 nmol/L at one or both time points) vitamin D status. Fifty-six percent of women had low vitamin D status. Obesity was significantly associated with lower baseline 25(OH)D (Adj-R2 = 0.126, p = 0.008) ICS and airway inflammation were not. Excess GWG and season of baseline s le collection were significantly associated with Δ25(OH)D (Adj-R2 = 0.405, p 0.0001) asthma-related variables were excluded (p 0.2). Preecl sia was more common in the low (8.6%) vs. high (0%) vitamin D group (p 0.05). Obesity and excess GWG may be associated with gestational 25(OH)D levels, highlighting the importance of antenatal weight management.
Publisher: MDPI AG
Date: 18-12-2020
DOI: 10.3390/NU12123872
Abstract: Measurement of vitamin D status has significant use in clinical and research settings, including during pregnancy. We aimed to assess the agreement of total 25-hydroxyvitamin D (25(OH)D) concentration, and its three analytes (25-hydroxyvitamin D3 (25(OH)D3), 25-hydroxyvitamin D2 (25(OH)D2) and Epi-25-hydroxyvitamin D3 (Epi-25(OH)D3)), in plasma and serum s les collected during pregnancy, and to examine the proportion of women who change vitamin D status category based on s le type. Matching s les were collected from n = 114 non-fasting women between 12–25 weeks gestation in a clinical trial in Newcastle, Australia. S les were analysed by liquid chromatography-tandem mass-spectrometry (LC-MS/MS) to quantify total 25(OH)D and its analytes and examined using Bland-Altman plots, Pearson correlation (r), intraclass correlation coefficient and Cohen’s Kappa test. Serum total 25(OH)D ranged from 33.8–169.8 nmol/L and plasma ranged from 28.6–211.2 nmol/L. There was a significant difference for total 25(OH)D based on s le type (measurement bias 7.63 nmol/L for serum vs plasma (95% Confidence Interval (CI) 5.36, 9.90, p ≤ 0.001). The mean difference between serum and plasma concentrations was statistically significant for 25(OH)D3 (7.38 nmol/L 95% CI 5.28, 9.48, p ≤ 0.001) and Epi-25(OH)D3 (0.39 nmol/L 95% CI 0.14, 0.64, p = 0.014). Of 114 participants, 28% were classified as vitamin D deficient ( nmol/L) or insufficient ( nmol/L) based on plasma s le and 36% based on serum s le. Nineteen (16.7%) participants changed vitamin D status category based on s le type. 25-hydroxyvitamin D quantification using LC-MS/MS methodology differed significantly between serum and plasma, yielding a higher value in plasma this influenced vitamin D status based on accepted cut-points, which may have implications in clinical and research settings.
Publisher: Elsevier BV
Date: 11-2022
No related grants have been discovered for Soriah Harvey.