ORCID Profile
0000-0002-2692-1524
Current Organisation
Terasaki Institute for Biomedical Innovation
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Publisher: American Association for the Advancement of Science (AAAS)
Date: 04-10-2017
DOI: 10.1126/SCITRANSLMED.AAI7466
Abstract: A highly elastic and adhesive photocrosslinkable surgical sealant using a modified human protein controls liquid leakages without the need for suturing.
Publisher: American Chemical Society (ACS)
Date: 24-05-2019
Abstract: Layer-by-layer (LbL) assembly is a widely used tool for engineering materials and coatings. In this Perspective, dedicated to the memory of ACS Nano associate editor Prof. Dr. Helmuth Möhwald, we discuss the developments and applications that are to come in LbL assembly, focusing on coatings, bulk materials, membranes, nanocomposites, and delivery vehicles.
Publisher: Wiley
Date: 08-10-2019
Abstract: Models of the human gastrointestinal tract (GIT) can be powerful tools for examining the biological interactions of food products and pharmaceuticals. This can be done under normal healthy conditions or using models of disease-many of which have no curative therapy. This report outlines the field of gastrointestinal modeling, with a particular focus on the intestine. Traditional in vivo animal models are compared to a range of in vitro models. In vitro systems are elaborated over time, recently culminating with microfluidic intestines-on-chips (IsOC) and 3D bioengineered models. Macroscale models are also reviewed for their important contribution in the microbiota studies. Lastly, it is discussed how in silico approaches may have utility in predicting and interpreting experimental data. The various advantages and limitations of the different systems are contrasted. It is posited that only through complementary use of these models will salient research questions be able to be addressed.
Publisher: American Chemical Society (ACS)
Date: 29-01-2020
Publisher: IOP Publishing
Date: 12-01-2018
Publisher: American Chemical Society (ACS)
Date: 02-03-2021
Publisher: Wiley
Date: 02-05-2017
Publisher: IOP Publishing
Date: 05-08-2021
Publisher: American Chemical Society (ACS)
Date: 17-10-2010
Publisher: Elsevier BV
Date: 07-2022
DOI: 10.1016/J.GIE.2022.02.022
Abstract: The risk of cancer in large nonpedunculated colorectal polyps ≥20 mm (LNPCPs) in the rectum relative to the remainder of the colon is unknown. We aimed to describe differences between rectal and colonic LNPCPs to better inform treatment decisions. Patients with LNPCPs referred to tertiary centers for endoscopic resection within a prospective, multicenter, observational cohort were evaluated. Data recorded were participant demographics, LNPCP location, morphology, resection modality, and histopathologic data. Multiple logistic regression analysis was used to identify those variables independently associated with rectal versus nonrectal location in the colon. Patients with LNPCPs referred for endoscopic resection between July 2008 and July 2021 were included. Rectal LNPCPs (n = 618) were larger (median size, 40 mm vs 30 mm P < .001) and more likely to be granular (79% vs 50%, P < .001) with a nodular component (53% vs 17%, P < .001) compared with nonrectal LNPCPs (n = 2787). Rectal LNPCPs were more likely to have tubulovillous histopathology (72% vs 47%, P < .001) and contain cancer (15% vs 6%, P < .001). After adjusting for the other features independently associated with location, cancer was more common in the rectum compared with the colon (odds ratio, 1.77 95% confidence interval, 1.25-2.53). This study suggests that compared with LNPCPs in the rest of the colon, rectal LNPCPs are more likely to be larger and contain more advanced pathology. These findings have implications for curative endoscopic resection techniques particularly where early cancer is present. (Clinical trial registration numbers: NCT01368289 and NCT02000141.).
Publisher: Wiley
Date: 03-03-2020
Publisher: American Chemical Society (ACS)
Date: 21-03-2017
Publisher: Wiley
Date: 09-02-2023
Location: United States of America
Location: United States of America
Location: United States of America
Location: United States of America
Start Date: 2020
End Date: 2022
Funder: Australian Research Council
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