ORCID Profile
0000-0002-4547-7457
Current Organisations
Amsterdam UMC Location VUmc
,
Australian National University
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In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Economic Development and Growth | Environment and Resource Economics | Applied Economics | Economic History | Time-Series Analysis |
Energy Conservation and Efficiency not elsewhere classified | Climate Change Mitigation Strategies | Expanding Knowledge in Economics | Technological and Organisational Innovation
Publisher: Elsevier BV
Date: 11-2016
Publisher: Wiley
Date: 18-12-2012
Publisher: Elsevier BV
Date: 02-2005
Publisher: Springer Science and Business Media LLC
Date: 12-03-2016
Publisher: Elsevier BV
Date: 10-2004
Publisher: Elsevier BV
Date: 03-2016
Publisher: Elsevier BV
Date: 11-2006
Publisher: Springer Science and Business Media LLC
Date: 10-07-2015
Publisher: Elsevier BV
Date: 11-2010
Publisher: International Association for Energy Economics (IAEE)
Date: 04-2016
Publisher: Informa UK Limited
Date: 03-1992
Publisher: Elsevier BV
Date: 05-2021
Publisher: Elsevier BV
Date: 07-2008
Publisher: Elsevier BV
Date: 09-2013
Publisher: Wiley
Date: 04-2021
DOI: 10.1111/ECIN.12994
Abstract: The Euclidean length of a citation list is “depth relevant”: the metric increases when citations are transferred from less to more cited papers. We introduce “breadth relevance,” which favors consistent achievers over one‐hit wonders. The exponent of the CES aggregator then is less than unity rather than greater than unity, as for depth relevance. Using two datasets on citations of economists for the top 50 US and global universities, simply counting citations maximizes the correlation between the citation metrics of researchers and the peer‐reviewed rank of their department. However, citation depth may explain the allocation of researchers across lower‐ranked departments.
Publisher: Cambridge University Press (CUP)
Date: 27-04-2017
DOI: 10.1017/S1355770X17000109
Abstract: The authors adopt a new approach to modeling the relationship between emissions and income using long-run per capita growth rates. This approach allows them to test multiple hypotheses about the drivers of per capita emissions in a single framework and avoid several of the econometric issues that have plagued the environmental Kuznets curve literature. They estimate models for carbon and sulfur dioxide emissions. They can reject restricted models that omit either growth or beta convergence effects. Although the term representing the environmental Kuznets effect is statistically significant for per capita carbon and sulfur dioxide emissions, the estimated income per capita turning points are out of the s le for the full data set.
Publisher: Elsevier BV
Date: 07-1996
Publisher: Elsevier BV
Date: 12-1999
Publisher: Springer Science and Business Media LLC
Date: 09-1993
DOI: 10.1007/BF01581662
Publisher: Elsevier BV
Date: 2016
Publisher: Elsevier BV
Date: 09-2010
Publisher: Wiley
Date: 02-2011
DOI: 10.1111/J.1749-6632.2010.05921.X
Abstract: This paper reviews the mainstream, resource economics, and ecological economics models of growth. A possible synthesis of energy-based and mainstream models is presented. This shows that when energy is scarce it imposes a strong constraint on the growth of the economy however, when energy is abundant, its effect on economic growth is much reduced. The industrial revolution released the constraints on economic growth by the development of new methods of using coal and the discovery of new fossil fuel resources. Time-series analysis shows that energy and GDP cointegrate, and energy use Granger causes GDP when capital and other production inputs are included in the vector autoregression model. However, various mechanisms can weaken the links between energy and growth. Energy used per unit of economic output has declined in developed and some developing countries, owing to both technological change and a shift from poorer quality fuels, such as coal, to the use of higher quality fuels, especially electricity. Substitution of other inputs for energy and sectoral shifts in economic activity play smaller roles.
Publisher: Springer Science and Business Media LLC
Date: 30-03-2017
Publisher: Springer Science and Business Media LLC
Date: 12-2002
DOI: 10.1038/420628A
Publisher: Informa UK Limited
Date: 05-1995
Publisher: Elsevier BV
Date: 11-2017
Publisher: Elsevier BV
Date: 08-2002
Publisher: Edward Elgar Publishing
Date: 29-07-2003
Publisher: Elsevier BV
Date: 07-1996
Publisher: Elsevier BV
Date: 09-2020
Publisher: Wiley
Date: 07-10-2010
Publisher: Elsevier BV
Date: 11-2014
Publisher: Springer Science and Business Media LLC
Date: 02-2002
DOI: 10.1038/415905A
Publisher: Elsevier BV
Date: 12-2020
Publisher: Elsevier BV
Date: 11-2014
Publisher: Informa UK Limited
Date: 02-2000
Publisher: Springer Science and Business Media LLC
Date: 23-05-2016
Publisher: Springer Science and Business Media LLC
Date: 11-03-2012
DOI: 10.1038/NCLIMATE1450
Publisher: Elsevier BV
Date: 07-2015
Publisher: Elsevier BV
Date: 02-2000
Publisher: Now Publishers
Date: 06-11-2018
DOI: 10.1561/101.00000101
Publisher: The Company of Biologists
Date: 2020
DOI: 10.1242/JCS.248849
Abstract: A mother's ability to produce a nutritionally-complete neonatal food source has provided a powerful evolutionary advantage to mammals. Milk production by mammary epithelial cells is adaptive, its release is exquisitely-timed and its own glandular stagnation with the permanent cessation of suckling triggers the cell death and tissue remodeling that enables female mammals to nurse successive progeny. Both chemical and mechanical signals play a role in this process. Despite this duality of input, however, much remains unknown about the nature and function of mechanical forces in this organ. Here, we characterize the force landscape in the functionally-mature gland and the capacity of luminal and basal cells to experience and exert force. We explore molecular instruments for force-sensing, in particular channel-mediated mechanotransduction, revealing increased expression of Piezo1 in mammary tissue in lactation and confirming functional expression in luminal cells. We also reveal, however, that lactation and involution proceed normally in mice with luminal-specific Piezo1 deletion. These findings support a multifaceted system of chemical and mechanical sensing in the mammary gland, and a protective redundancy that ensures continued lactational competence and offspring survival.
Publisher: Elsevier BV
Date: 2005
DOI: 10.1016/J.CHEMOSPHERE.2004.08.022
Abstract: The ASL database provides continuous time-series of sulfur emissions for most countries in the World from 1850 to 1990, but academic and official estimates for the 1990s either do not cover all years or countries. This paper develops continuous time series of sulfur emissions by country for the period 1850-2000 with a particular focus on developments in the 1990s. Global estimates for 1996-2000 are the first that are based on actual observed data. Raw estimates are obtained in two ways. For countries and years with existing published data I compile and integrate that data. Previously published data covers the majority of emissions and almost all countries have published emissions for at least 1995. For the remaining countries and for missing years for countries with some published data, I interpolate or extrapolate estimates using either an econometric emissions frontier model, an environmental Kuznets curve model, or a simple extrapolation, depending on the availability of data. Finally, I discuss the main movements in global and regional emissions in the 1990s and earlier decades and compare the results to other studies. Global emissions peaked in 1989 and declined rapidly thereafter. The locus of emissions shifted towards East and South Asia, but even this region peaked in 1996. My estimates for the 1990s show a much more rapid decline than other global studies, reflecting the view that technological progress in reducing sulfur based pollution has been rapid and is beginning to diffuse worldwide.
Publisher: Elsevier BV
Date: 1990
Publisher: Elsevier BV
Date: 09-2012
Publisher: Springer Science and Business Media LLC
Date: 31-12-2010
Publisher: Elsevier BV
Date: 08-1999
Publisher: Elsevier BV
Date: 11-2012
Publisher: Wiley
Date: 2021
DOI: 10.1002/APP5.323
Abstract: This article presents the first‐ever ranking of public policy schools in the Asia‐Pacific region based on their research publication output. We used Scopus as our bibliographic database to assess the publication output of 45 schools between 2014 and 2018, based on affiliations listed on the publications rather than current faculty. The results show substantial variation in terms of research output elite research schools are located in China, Australia, and Singapore. Ranking by total citations, three schools stand out—the Crawford School of Public Policy at the Australian National University, the Lee Kuan Yew School at the National University of Singapore, and the School of Public Policy & Management at Tsinghua University in China. Ranking by impact factor shows that the School of Government at Peking University and the Melbourne School of Government at Melbourne University are the two top‐ranked schools, but because of their relatively small research output in this period, their true rank is very uncertain.
Publisher: Wiley
Date: 08-1998
Publisher: Springer Science and Business Media LLC
Date: 07-1997
DOI: 10.1038/40332
Publisher: Elsevier BV
Date: 06-2022
Publisher: Elsevier BV
Date: 05-2008
Publisher: Elsevier BV
Date: 2020
Publisher: Elsevier BV
Date: 2014
Publisher: SAGE Publications
Date: 03-2005
Abstract: The environmental Kuznets curve (EKC) has been extensively criticized on theoretical and empirical grounds. In this article, the EKC is reformulated as the best practice technology frontier—countries’ distances from the frontier reflect the degree to which they have adopted the best practice technology in emissions abatement. The Kalman filter is used to model the state of sulfur emissions abatement technology in a panel of 15 mainly developed countries. The results are used to determine whether and how fast countries are converging to best practice throughout time and what variables affect the level of technology adopted. The results show that with the exception of Australia, countries are converging toward the frontier but have settled into low pollution abatement and high pollution abatement groups. Preabatement levels of pollution, income per capita, population density, and perhaps cultural factors might partly explain the level of abatement adopted.
Publisher: Elsevier BV
Date: 11-1999
Publisher: Emerald
Date: 04-2004
Publisher: International Association for Energy Economics (IAEE)
Date: 09-2018
Publisher: Elsevier BV
Date: 08-2019
Publisher: International Association for Energy Economics (IAEE)
Date: 10-2014
Publisher: Elsevier BV
Date: 12-2002
DOI: 10.1016/S1471-4922(02)02374-7
Abstract: Climate has a significant impact on malaria incidence and we have predicted that forecast climate changes might cause some modifications to the present global distribution of malaria close to its present boundaries. However, it is quite another matter to attribute recent resurgences of malaria in the highlands of East Africa to climate change. Analyses of malaria time-series at such sites have shown that malaria incidence has increased in the absence of co-varying changes in climate. We find the widespread increase in resistance of the malaria parasite to drugs and the decrease in vector control activities to be more likely driving forces behind the malaria resurgence.
Publisher: Routledge
Date: 20-08-2015
Publisher: Elsevier BV
Date: 06-1997
Publisher: Springer Science and Business Media LLC
Date: 2000
Publisher: Springer Science and Business Media LLC
Date: 06-1994
DOI: 10.1007/BF01581769
Publisher: Springer Science and Business Media LLC
Date: 04-06-2018
Publisher: Elsevier BV
Date: 08-2004
Publisher: Springer Science and Business Media LLC
Date: 20-11-2013
Publisher: Springer Science and Business Media LLC
Date: 04-09-2017
Publisher: Elsevier BV
Date: 04-2000
Publisher: Elsevier BV
Date: 09-2015
Publisher: American Society for Microbiology
Date: 15-03-2018
DOI: 10.1128/JVI.01774-17
Abstract: The innate immune response plays a pivotal role during human cytomegalovirus (HCMV) primary infection. Indeed, HCMV infection of primary fibroblasts rapidly triggers strong induction of type I interferons (IFN-I), accompanied by proinflammatory cytokine release. Here, we show that primary human foreskin fibroblasts (HFFs) infected with a mutant HCMV TB40/E strain unable to express UL83-encoded pp65 (v65Stop) produce significantly higher IFN-β levels than HFFs infected with the wild-type TB40/E strain or the pp65 revertant (v65Rev), suggesting that the tegument protein pp65 may d en IFN-β production. To clarify the mechanisms through which pp65 inhibits IFN-β production, we analyzed the activation of the cGAS/STING/IRF3 axis in HFFs infected with either the wild type, the revertant v65Rev, or the pp65-deficient mutant v65Stop. We found that pp65 selectively binds to cGAS and prevents its interaction with STING, thus inactivating the signaling pathway through the cGAS/STING/IRF3 axis. Consistently, addition of exogenous cGAMP to v65Rev-infected cells triggered the production of IFN-β levels similar to those observed with v65Stop-infected cells, confirming that pp65 inactivation of IFN-β production occurs at the cGAS level. Notably, within the first 24 h of HCMV infection, STING undergoes proteasome degradation independently of the presence or absence of pp65. Collectively, our data provide mechanistic insights into the interplay between HCMV pp65 and cGAS, leading to subsequent immune evasion by this prominent DNA virus. IMPORTANCE Primary human foreskin fibroblasts (HFFs) produce type I IFN (IFN-I) when infected with HCMV. However, we observed significantly higher IFN-β levels when HFFs were infected with HCMV that was unable to express UL83-encoded pp65 (v65Stop), suggesting that pp65 (pUL83) may constitute a viral evasion factor. This study demonstrates that the HCMV tegument protein pp65 inhibits IFN-β production by binding and inactivating cGAS early during infection. In addition, this inhibitory activity specifically targets cGAS, since it can be bypassed via the addition of exogenous cGAMP, even in the presence of pp65. Notably, STING proteasome-mediated degradation was observed in both the presence and absence of pp65. Collectively, our data underscore the important role of the tegument protein pp65 as a critical molecular hub in HCMV's evasion strategy against the innate immune response.
Publisher: Elsevier BV
Date: 03-2022
Publisher: MDPI AG
Date: 03-07-2020
Abstract: The guidelines for metastatic colorectal cancer crudely state that the best local treatment should be selected from a ‘toolbox’ of techniques according to patient- and treatment-related factors. We created an interdisciplinary, consensus-based algorithm with specific resectability and ablatability criteria for the treatment of colorectal liver metastases (CRLM). To pursue consensus, members of the multidisciplinary COLLISION and COLDFIRE trial expert panel employed the RAND appropriateness method (RAM). Statements regarding patient, disease, tumor and treatment characteristics were categorized as appropriate, equipoise or inappropriate. Patients with ECOG≤2, ASA≤3 and Charlson comorbidity index ≤8 should be considered fit for curative-intent local therapy. When easily resectable and/or ablatable (stage IVa), (neo)adjuvant systemic therapy is not indicated. When requiring major hepatectomy (stage IVb), neo-adjuvant systemic therapy is appropriate for early metachronous disease and to reduce procedural risk. To downstage patients (stage IVc), downsizing induction systemic therapy and/or future remnant augmentation is advised. Disease can only be deemed permanently unsuitable for local therapy if downstaging failed (stage IVd). Liver resection remains the gold standard. Thermal ablation is reserved for unresectable CRLM, deep-seated resectable CRLM and can be considered when patients are in poor health. Irreversible electroporation and stereotactic body radiotherapy can be considered for unresectable perihilar and perivascular CRLM 0-5cm. This consensus document provides per-patient and per-tumor resectability and ablatability criteria for the treatment of CRLM. These criteria are intended to aid tumor board discussions, improve consistency when designing prospective trials and advance intersociety communications. Areas where consensus is lacking warrant future comparative studies.
Publisher: Edward Elgar Publishing
Date: 29-07-2003
Publisher: Wiley
Date: 05-2007
Publisher: Public Library of Science (PLoS)
Date: 15-09-2011
Publisher: Springer Science and Business Media LLC
Date: 20-06-2017
Publisher: Public Library of Science (PLoS)
Date: 12-11-2014
Publisher: Informa UK Limited
Date: 10-1994
Publisher: Springer Science and Business Media LLC
Date: 09-01-2017
Publisher: Elsevier BV
Date: 11-2020
Publisher: Wiley
Date: 12-07-2011
Publisher: Springer Science and Business Media LLC
Date: 2000
Publisher: Elsevier BV
Date: 09-2010
Publisher: Elsevier BV
Date: 03-2001
Publisher: Elsevier BV
Date: 04-2016
Publisher: Elsevier BV
Date: 05-2006
Publisher: IOP Publishing
Date: 07-2020
Abstract: Many countries committed to climate action by adopting the Paris Agreement and Sustainable Development Goals in 2015. This study synthesizes 40 years of scientific evidence of what may be an important benefit of these commitments: the non-use value of bio ersity conservation. The synthesis investigates whether bio ersity values can be integrated into climate change damage estimates based on non-use valuation studies of different threats to bio ersity. In the absence of estimates of public willingness to pay (WTP) to avoid the adverse impacts of anthropogenic climate change on bio ersity, we synthesize non-use values for bio ersity conservation from stated preference studies that account for a heterogeneous set of bio ersity threats. We test whether bio ersity non-use values are affected by the threats that policies aim to address, be it human activities or other threats. We estimate meta-regression models in which we explain the variation in these non-use values by accounting for the observed heterogeneity in good, methodology, s le, and context characteristics. We estimate meta-regression models using 159 observations from 62 publications. The models suggest that non-use values for bio ersity conservation addressing human impacts may be larger than those addressing other threats. We also find that non-use values are generally not sensitive to which bio ersity indicators, habitat types, or taxonomic groups are valued. We predict that the mean annual WTP for avoiding human-caused bio ersity losses ranges from 0.2 to 0.4% of GDP per capita. Our findings suggest that state-of-the-art climate change damage functions in integrated assessment models may underestimate actual damage costs because they do not incorporate the premium that the public is willing to pay to avoid human-caused bio ersity losses.
Publisher: Elsevier BV
Date: 06-2006
Publisher: Elsevier BV
Date: 03-2010
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Start Date: 04-2016
End Date: 12-2018
Amount: $273,000.00
Funder: Australian Research Council
View Funded ActivityStart Date: 03-2012
End Date: 02-2015
Amount: $240,000.00
Funder: Australian Research Council
View Funded Activity