ORCID Profile
0000-0002-5559-3822
Current Organisations
University of Southern Denmark
,
SDU
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Publisher: Wiley
Date: 22-01-2022
Abstract: Boronic acids are Lewis acids that exist in equilibrium with boronate forms in aqueous solution. Here we experimentally and computationally investigated the Lewis acidity of 2,6‐diarylphenylboronic acids specially designed phenylboronic acids that possess two flanking aromatic rings with tunable aromatic character. Hammett analysis of 2,6‐diarylphenylboronic acids reveals that their Lewis acidity remains unchanged upon the introduction of EWG/EDG at the distant para position of the flanking aromatic rings. Structural and computational studies demonstrate that polar‐π interactions and solvation effects contribute to the stabilization of boronic acids and boronate forms by aromatic rings. Our physical‐organic chemistry work highlights that boronic acids and boronates can be stabilized by aromatic systems, leading to an important molecular knowledge for rational design and development of boronic acid‐based catalysts and inhibitors of biomedically important proteins.
Publisher: Wiley
Date: 03-06-2020
Publisher: Wiley
Date: 03-06-2020
Publisher: Elsevier BV
Date: 08-2007
Publisher: Elsevier BV
Date: 09-2009
Publisher: American Chemical Society (ACS)
Date: 29-09-2020
Publisher: American Chemical Society (ACS)
Date: 26-04-2022
Abstract: Arene-arene interactions are fundamentally important in molecular recognition. To precisely probe arene-arene interactions in cyclophanes, we designed and synthesized (2,6-phenol)paracyclophanes and (2,6-aniline)paracyclophanes that possess two aromatic rings in close proximity. Fine-tuning the aromatic character of one aromatic ring by fluorine substituents enables investigations on the intramolecular interactions between the electron-rich phenol and aniline with tetra-H- and tetra-F-substituted benzene. p
Publisher: Wiley
Date: 08-05-2020
Publisher: Wiley
Date: 03-03-2021
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8CC00387D
Abstract: The binding of prolyl-hydroxylated HIF-α to PHD2 is hindered by prior 2OG binding likely, leading to the inhibition of HIF-α degradation under limiting 2OG conditions.
No related grants have been discovered for Jasmin Mecinovic.