ORCID Profile
0000-0002-9586-1596
Current Organisation
Pathwest Laboratory Medicine
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Publisher: Nepal Journals Online (JOL)
Date: 10-03-2013
Abstract: NOTE: The first author (Reena K. Mukhiya) was omitted as an author of this paper in the table of contents for this issue and on the webpage. This was an error. Reena Mukhiya was always included as the first author on the PDF of the article. 11 December 2014.Present study was conducted to determine the prevalence of nosocomial pathogen methicillin resistant Staphylococcus aureus in hospital environment s les (surface swabs and air, n=188) and health care workers (nose and hand, n=162) of hospitals located in Kathmandu valley. The s les were studied following the standard protocols. Of the 61 S. aureus, 20.9% and 14.3% were isolated from health personnel and hospital environment respectively. Of 20.9% S. aureus in hospital environment, 6.6% were isolated from OPD and 17.9% from wards. Similarly, in HCWs 28.3% and 13.5% were hand and nasal carrier respectively. In total, 45.9% were MRSA. Among MRSA isolates, 50% were from HCWs whereas, 40.7% from hospital environment. The most effective antibiotic for all isolates was vancomycin with 100% efficacy. The isolates had relatively high rate of resistance to cefixime (44.0%), followed by co-trimoxazole (28.0%), erythromycin (23.0%), gentamicin (18.0%), tetracycline (16.0%) and ofloxacin (8.0%). Since MRSA prevalence was not reduced, so indicates regular surveillance of nosocomial infection, hand hygiene improvement strategies and monitoring of antimicrobial susceptibility pattern. Nepal Journal of Science and Technology Vol. 13, No. 2 (2012) 185-190 DOI: 0.3126/njst.v13i2.7734
Publisher: MDPI AG
Date: 24-01-2022
DOI: 10.3390/V14020219
Abstract: The transmission of dengue and other medically important mosquito-borne viruses in the westernmost region of Indonesia is not well described. We assessed dengue and Zika virus seroprevalence in Aceh province, the westernmost area of the Indonesian archipelago. Serum s les collected from 199 randomly s led healthy residents of Aceh Jaya in 2017 were analyzed for neutralizing antibodies by plaque reduction neutralization test (PRNT). Almost all study participants (198/199 99.5%) presented with multitypic profiles of neutralizing antibodies to two or more DENV serotypes, indicating transmission of multiple DENV in the region prior to 2017. All residents were exposed to one or more DENV serotypes by the age of 30 years. The highest geometric mean titers were measured for DENV-4, followed by DENV-1, DENV-2 and DENV-3. Among a subset of 116 sera, 27 neutralized ZIKV with a high stringency (20 with PRNT90 10 and 7 with PRNT90 40). This study showed that DENV is hyperendemic in the westernmost region of the Indonesian archipelago and suggested that ZIKV may have circulated prior to 2017.
Publisher: Nepal Journals Online (JOL)
Date: 10-03-2013
Abstract: Cross infection through hospital environment has been a major challenge to control nosocomial infection. This has been worse with the emergence of multidrug resistant strains. The present study was conducted to study the pattern of antibiotic resistant group of Acinetobacter spp. in hospital environment to understand possibility of nosocomial infection. The study was conducted for a period of six months during which Acinetobacter spp. from 269 s les of hospital environment (air s le, surface swab and hand swab from healthcare workers) were identified by conventional microbiological method and antibiogram was performed by Kirby-Bauer disc diffusion method and NCCLS guidelines. Bacterial isolates obtained from both s les were tested for their relatedness based on their resistivity pattern among the tested antibiotics. Of the total environmental s les 212 s les were found to be positive and a total of 183 gram negative isolates were obtained. Of the total gram negative isolates, 84.2% (154/183) Acinetobacter spp. were isolated. Analysis of MDR isolates revealed 70.8% (109/154) Acinetobacter spp. which was MDR. A total of 12 different antibiogram patterns were found with five different antibiotic groups tested. Nepal Journal of Science and Technology Vol. 13, No. 2 (2012) 203-208 DOI: 0.3126/njst.v13i2.7737
Publisher: AME Publishing Company
Date: 02-2022
DOI: 10.21037/AJO-21-40
Publisher: MDPI AG
Date: 06-01-2022
DOI: 10.3390/V14010099
Abstract: Dengue is a mosquito-borne disease of public health concern affecting tropical and subtropical countries, including Indonesia. Although studies on dengue epidemiology have been undertaken in Indonesia, data are lacking in many areas of the country. The aim of this study was to determine dengue virus (DENV) and chikungunya virus (CHIKV) molecular epidemiology in western regions of the Indonesian archipelago. A one-year prospective study was conducted in Aceh and Jambi in 2015 and 2016, respectively, where patients with dengue-like illness were enrolled. Of 205 patients recruited, 29 and 27 were confirmed with dengue in Aceh and Jambi, respectively, and three from Jambi were confirmed with chikungunya. DENV-1 was the predominant serotype identified in Aceh while DENV-2 was predominant in Jambi. All DENV-1 and DENV-2 from both regions were classified as Genotype I and Cosmopolitan genotype, respectively, and all DENV-3 viruses from Jambi were Genotype I. Some viruses, in particular DENV-1, displayed a distinct lineage distribution, where two DENV-1 lineages from Aceh were more closely related to viruses from China instead of Jambi highlighting the role of travel and flight patterns on DENV transmission in the region. DENV-2 from both Aceh and Jambi and DENV-3 from Jambi were all closely related to Indonesian local strains. All three CHIKV belonged to Asian genotype and clustered closely with Indonesian CHIKV strains including those previously circulating in Jambi in 2015, confirming continuous and sustainable transmission of CHIKV in the region. The study results emphasize the importance of continuous epidemiological surveillance of arboviruses in Indonesia and simultaneous testing for CHIKV among dengue-suspected patients.
Location: Nepal
Location: Australia
No related grants have been discovered for Kritu Panta.