ORCID Profile
0000-0002-3939-1585
Current Organisations
University of Queensland
,
University of Technology Sydney
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Publisher: Springer Science and Business Media LLC
Date: 09-01-2017
Abstract: Topical application of pathogen-specific double-stranded RNA (dsRNA) for virus resistance in plants represents an attractive alternative to transgenic RNA interference (RNAi). However, the instability of naked dsRNA sprayed on plants has been a major challenge towards its practical application. We demonstrate that dsRNA can be loaded on designer, non-toxic, degradable, layered double hydroxide (LDH) clay nanosheets. Once loaded on LDH, the dsRNA does not wash off, shows sustained release and can be detected on sprayed leaves even 30 days after application. We provide evidence for the degradation of LDH, dsRNA uptake in plant cells and silencing of homologous RNA on topical application. Significantly, a single spray of dsRNA loaded on LDH (BioClay) afforded virus protection for at least 20 days when challenged on sprayed and newly emerged unsprayed leaves. This innovation translates nanotechnology developed for delivery of RNAi for human therapeutics to use in crop protection as an environmentally sustainable and easy to adopt topical spray.
Publisher: Royal Society of Chemistry (RSC)
Date: 2016
DOI: 10.1039/C6RA09428G
Abstract: New generation foliar fertilizers are expected to be sheet-like nanocrystals and provide a sustainable supply of metal ions at a suitable concentration.
Publisher: American Chemical Society (ACS)
Date: 27-04-2012
DOI: 10.1021/JP300045U
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D3GC02995F
Publisher: Elsevier BV
Date: 08-2020
Publisher: Oxford University Press (OUP)
Date: 09-07-2021
Abstract: Topical application of double-stranded RNA (dsRNA) can induce RNA interference (RNAi) and modify traits in plants without genetic modification. However, delivering dsRNA into plant cells remains challenging. Using developing tomato (Solanum lycopersicum) pollen as a model plant cell system, we demonstrate that layered double hydroxide (LDH) nanoparticles up to 50 nm in diameter are readily internalized, particularly by early bicellular pollen, in both energy-dependent and energy-independent manners and without physical or chemical aids. More importantly, these LDH nanoparticles efficiently deliver dsRNA into tomato pollen within 2–4 h of incubation, resulting in an 89% decrease in transgene reporter mRNA levels in early bicellular pollen 3-d post-treatment, compared with a 37% decrease induced by the same dose of naked dsRNA. The target gene silencing is dependent on the LDH particle size, the dsRNA dose, the LDH–dsRNA complexing ratio, and the treatment time. Our findings indicate that LDH nanoparticles are an effective nonviral vector for the effective delivery of dsRNA and other biomolecules into plant cells.
Publisher: Springer Science and Business Media LLC
Date: 09-10-2014
Publisher: Springer Science and Business Media LLC
Date: 04-2023
DOI: 10.1038/S41591-023-02271-1
Abstract: Autism omics research has historically been reductionist and diagnosis centric, with little attention paid to common co-occurring conditions (for ex le, sleep and feeding disorders) and the complex interplay between molecular profiles and neurodevelopment, genetics, environmental factors and health. Here we explored the plasma lipidome (783 lipid species) in 765 children (485 diagnosed with autism spectrum disorder (ASD)) within the Australian Autism Biobank. We identified lipids associated with ASD diagnosis ( n = 8), sleep disturbances ( n = 20) and cognitive function ( n = 8) and found that long-chain polyunsaturated fatty acids may causally contribute to sleep disturbances mediated by the FADS gene cluster. We explored the interplay of environmental factors with neurodevelopment and the lipidome, finding that sleep disturbances and unhealthy diet have a convergent lipidome profile (with potential mediation by the microbiome) that is also independently associated with poorer adaptive function. In contrast, ASD lipidome differences were accounted for by dietary differences and sleep disturbances. We identified a large chr19p13.2 copy number variant genetic deletion spanning the LDLR gene and two high-confidence ASD genes ( ELAVL3 and SMARCA4 ) in one child with an ASD diagnosis and widespread low-density lipoprotein-related lipidome derangements. Lipidomics captures the complexity of neurodevelopment, as well as the biological effects of conditions that commonly affect quality of life among autistic people.
Publisher: Elsevier BV
Date: 04-2020
Publisher: Elsevier BV
Date: 03-2019
Publisher: Wiley
Date: 09-08-2021
DOI: 10.1002/EOM2.12132
Abstract: The agrochemical is often applied to enhance the agricultural production. Nanotechnology has advanced agricultural biotechnology in the new “agri‐tech revolution.” Eco‐friendly nanoparticles as carriers can essentially actualize the application of biomolecules as sustainable agrochemicals to increase their biological performance and reduce deterioration of the ecosystem. Particularly, these nanocarrier‐biomolecule hybrids will be ideal for topical applications to enhance the crop yield and quality. This review summarizes the current efforts in developing nanoparticles as carriers of biomolecules for topical delivery. First, the applicable biomolecules for plant growth regulation and the pathogen control are briefly introduced. The criteria and strategies for research and industrial development of nanocarrier‐biomolecule hybrids are then proposed, which better involves both researchers and manufacturers in the beginning for an efficient R& D process. The review further discusses several typical nanoparticle‐biomolecule hybrids as the candidates of next‐generation agrochemicals with advanced scientific merits and high perspectives of industrialization as the conclusion. image
Publisher: Informa UK Limited
Date: 26-02-2016
Publisher: Springer Science and Business Media LLC
Date: 10-02-2021
DOI: 10.1186/S13229-020-00407-5
Abstract: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition whose biological basis is yet to be elucidated. The Australian Autism Biobank (AAB) is an initiative of the Cooperative Research Centre for Living with Autism (Autism CRC) to establish an Australian resource of biospecimens, phenotypes and genomic data for research on autism. Genome-wide single-nucleotide polymorphism genotypes were available for 2,477 in iduals (after quality control) from 546 families (436 complete), including 886 participants aged 2 to 17 years with diagnosed ( n = 871) or suspected ( n = 15) ASD, 218 siblings without ASD, 1,256 parents, and 117 unrelated children without an ASD diagnosis. The genetic data were used to confirm familial relationships and assign ancestry, which was majority European ( n = 1,964 European in iduals). We generated polygenic scores (PGS) for ASD, IQ, chronotype and height in the subset of Europeans, and in 3,490 unrelated ancestry-matched participants from the UK Biobank. We tested for group differences for each PGS, and performed prediction analyses for related phenotypes in the AAB. We called copy-number variants (CNVs) in all participants, and intersected these with high-confidence ASD- and intellectual disability (ID)-associated CNVs and genes from the public domain. The ASD ( p = 6.1e−13), sibling ( p = 4.9e−3) and unrelated ( p = 3.0e−3) groups had significantly higher ASD PGS than UK Biobank controls, whereas this was not the case for height—a control trait. The IQ PGS was a significant predictor of measured IQ in undiagnosed children ( r = 0.24, p = 2.1e−3) and parents ( r = 0.17, p = 8.0e−7 4.0% of variance), but not the ASD group. Chronotype PGS predicted sleep disturbances within the ASD group ( r = 0.13, p = 1.9e−3 1.3% of variance). In the CNV analysis, we identified 13 in iduals with CNVs overlapping ASD/ID-associated CNVs, and 12 with CNVs overlapping ASD/ID/developmental delay-associated genes identified on the basis of de novo variants. This dataset is modest in size, and the publicly-available genome-wide-association-study (GWAS) summary statistics used to calculate PGS for ASD and other traits are relatively underpowered. We report on common genetic variation and rare CNVs within the AAB. Prediction analyses using currently available GWAS summary statistics are largely consistent with expected relationships based on published studies. As the size of publicly-available GWAS summary statistics grows, the phenotypic depth of the AAB dataset will provide many opportunities for analyses of autism profiles and co-occurring conditions, including when integrated with other omics datasets generated from AAB biospecimens (blood, urine, stool, hair).
Publisher: Elsevier BV
Date: 2023
Publisher: Springer Science and Business Media LLC
Date: 09-05-2019
DOI: 10.1007/S11356-019-05295-8
Abstract: As a commonly used surfactant, sodium dodecyl sulfate (SDS) usually coexists with inorganic anions in the industrial wastewater. These anions have a significant influence on SDS removal, indirectly threatening the environment. It is important to understand the relationship between the adsorption of SDS and inorganic anions. In this study, calcium-based layered double hydroxide (CaAl-LDH-Cl) as an efficient adsorbent was synthesized for investigating the effect of SO
Publisher: Elsevier BV
Date: 06-2019
Publisher: Oxford University Press (OUP)
Date: 14-11-2015
DOI: 10.1093/AOB/MCU212
Publisher: Wiley
Date: 19-08-2013
Publisher: Frontiers Media SA
Date: 11-04-2018
Publisher: Springer Science and Business Media LLC
Date: 27-08-2018
Publisher: Informa UK Limited
Date: 08-03-2016
Publisher: Springer Science and Business Media LLC
Date: 11-09-2020
Publisher: American Chemical Society (ACS)
Date: 30-09-2019
DOI: 10.1021/ACS.LANGMUIR.9B02465
Abstract: Surfactants have proven a suitable template agent for the construction of organic three-dimensional layered double hydroxide (O3D-LDH) due to the excellent self-assembled property and ready operation. Although the morphology and growth of O3D-LDH are affected by various factors (initial surfactant concentration, Mg/Al molar ratio, hydrothermal temperature, urea concentration, hydrothermal time, etc.), little is known about the key role of surfactants in the growth behavior and mechanism. In this study, sodium dodecyl sulfate (SDS) was chosen to identify the behavior of the surfactant on the evolution of O3D-LDH with various factors. The as-grown procedure was investigated by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and Brunauer-Emmett-Teller analysis. The results demonstrated that the ideal 3D roselike hierarchical structure was obtained at a Mg/Al/urea molar ratio of 2:1:10 and SDS concentration of 0.1 mol L
Publisher: Wiley
Date: 30-07-2015
Publisher: Elsevier BV
Date: 11-2021
DOI: 10.1016/J.CELL.2021.10.015
Abstract: There is increasing interest in the potential contribution of the gut microbiome to autism spectrum disorder (ASD). However, previous studies have been underpowered and have not been designed to address potential confounding factors in a comprehensive way. We performed a large autism stool metagenomics study (n = 247) based on participants from the Australian Autism Biobank and the Queensland Twin Adolescent Brain project. We found negligible direct associations between ASD diagnosis and the gut microbiome. Instead, our data support a model whereby ASD-related restricted interests are associated with less- erse diet, and in turn reduced microbial taxonomic ersity and looser stool consistency. In contrast to ASD diagnosis, our dataset was well powered to detect microbiome associations with traits such as age, dietary intake, and stool consistency. Overall, microbiome differences in ASD may reflect dietary preferences that relate to diagnostic features, and we caution against claims that the microbiome has a driving role in ASD.
Publisher: Elsevier BV
Date: 10-2020
Publisher: Elsevier BV
Date: 02-2020
Publisher: Wiley
Date: 06-06-2022
DOI: 10.1002/AUR.2762
Abstract: Sensory modulation symptoms form a diagnostic criterion for autism spectrum disorder and are associated with significant daily functional limitations. Utilizing caregiver report on Short Sensory Profile‐2 (SSP‐2) for 919 autistic children (3–14.11 years), we examined the expression of sensory modulation symptoms by age and sex and investigated the existence of specific sensory modulation subtypes. Sensory modulation symptoms appeared to peak in frequency during middle childhood, particularly in sensory sensitivity and avoidance. Symptoms associated with sensory hypo‐reactivity and seeking tended not differ between age cohorts. Males and females demonstrated similar overall sensory modulation profiles, however, females showed elevated symptoms relating to sensory sensitivity. Model‐based cluster analysis revealed five interpretable sensory modulation subtypes which related to symptom severity (low, mid‐range, high). Subtypes demonstrating mid‐range symptom severity differed in focus on sensory hyper‐reactivity or seeking symptoms. The findings of this study report for the first time that age‐related differences in sensory modulation symptoms may be associated with sensory hyper‐reactivity only. The subtyping results also suggest that sensory modulation symptom severity is a reliable means of classifying variance within autistic children, however, consideration of differences in the behavioral strategies employed by in iduals to manage sensory modulation symptoms may inform tailored supportive strategies. We studied sensory symptoms such as over‐responding, under‐responding and sensation seeking behaviors in 919 autistic children and adolescents. We found that 6–12‐year‐olds and females displayed the most sensory over‐responding symptoms. Autistic children could be grouped into mild, moderate, and severe levels of sensory symptoms, however, children differed in the type of strategies used to cope with their sensory symptoms meaning that they may require different intervention approaches.
Publisher: Springer Science and Business Media LLC
Date: 11-2016
Publisher: Elsevier BV
Date: 04-2021
Publisher: Springer Science and Business Media LLC
Date: 16-05-2022
DOI: 10.1038/S41477-022-01152-8
Abstract: Whitefly (Bemisia tabaci) is a phloem-feeding global agricultural pest belonging to the order Hemiptera. Foliar application of double-stranded RNA (dsRNA) represents an attractive avenue for pest control however, limited uptake and phloem availability of the dsRNA has restricted the development of RNA interference (RNAi)-based biopesticides against sap-sucking insects. Following high-throughput single and combinational target gene identification for additive effects, we report here that foliar application of dsRNA loaded onto layered double hydroxide (LDH), termed BioClay, can effectively disrupt multiple whitefly developmental stages in planta. Adjuvants were shown to enhance uptake and movement of foliar-applied dsRNA to vascular bundles and into the whitefly. Notably, delivering the dsRNA as a BioClay spray instead of as naked dsRNA improved protection against immature insect stages, demonstrating the platform's potential to extend the benefits offered by RNA insecticides towards complete life cycle control of whitefly and potentially other pests.
Publisher: MDPI AG
Date: 24-08-2022
DOI: 10.3390/MA15175832
Abstract: Antibiotic contamination in water bodies poses ecological risks to aquatic organisms and humans and is a global environmental issue. Persulfate-based advanced oxidation processes (PS-AOPs) are efficient for the removal of antibiotics. Sustainable biochar materials have emerged as potential candidates as persulfates (Peroxymonosulfate (PMS) and Peroxydisulfate (PDS)) activation catalysts to degrade antibiotics. In this review, the feasibility of pristine biochar and modified biochar (non-metal heteroatom-doped biochar and metal-loaded biochar) for the removal of antibiotics in PS-AOPs is evaluated through a critical analysis of recent research. The removal performances of biochar materials, the underlying mechanisms, and active sites involved in the reactions are studied. Lastly, sustainability considerations for future biochar research, including Sustainable Development Goals, technical feasibility, toxicity assessment, economic and life cycle assessment, are discussed to promote the large-scale application of biochar/PS technology. This is in line with the global trends in ensuring sustainable production.
Publisher: Elsevier BV
Date: 2019
DOI: 10.1016/J.JCIS.2018.09.019
Abstract: The effects of co-existing anions (NO
No related grants have been discovered for Peng Li.