ORCID Profile
0000-0002-5779-9090
Current Organisation
University of Pittsburgh School of Medicine
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
In Research Link Australia (RLA), "Research Topics" refer to ANZSRC FOR and SEO codes. These topics are either sourced from ANZSRC FOR and SEO codes listed in researchers' related grants or generated by a large language model (LLM) based on their publications.
Renewable Power and Energy Systems Engineering (excl. Solar Cells) | Electrical and Electronic Engineering | Power and Energy Systems Engineering (excl. Renewable Power) | Database Management | Atmospheric Aerosols |
Solar-Photovoltaic Energy | Atmospheric Processes and Dynamics | Energy Systems Analysis | Information Processing Services (incl. Data Entry and Capture)
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2016
Publisher: Elsevier BV
Date: 12-2019
Publisher: IEEE
Date: 07-2012
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 09-2021
Publisher: IEEE
Date: 07-2012
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2020
Publisher: IEEE
Date: 07-2017
Publisher: IEEE
Date: 11-2018
Publisher: IEEE
Date: 07-2017
Publisher: IEEE
Date: 11-2015
Publisher: Elsevier BV
Date: 05-2022
Publisher: Elsevier BV
Date: 2016
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2012
Publisher: Elsevier BV
Date: 09-2015
Publisher: IEEE
Date: 07-2017
Publisher: Springer Science and Business Media LLC
Date: 08-08-2022
DOI: 10.1038/S41588-022-01152-6
Abstract: The fetal-to-adult switch in hemoglobin production is a model of developmental gene control with relevance to the treatment of hemoglobinopathies. The expression of transcription factor BCL11A, which represses fetal β-type globin (HBG) genes in adult erythroid cells, is predominantly controlled at the transcriptional level but the underlying mechanism is unclear. We identify HIC2 as a repressor of BCL11A transcription. HIC2 and BCL11A are reciprocally expressed during development. Forced expression of HIC2 in adult erythroid cells inhibits BCL11A transcription and induces HBG expression. HIC2 binds to erythroid BCL11A enhancers to reduce chromatin accessibility and binding of transcription factor GATA1, diminishing enhancer activity and enhancer-promoter contacts. DNA-binding and crystallography studies reveal direct steric hindrance as one mechanism by which HIC2 inhibits GATA1 binding at a critical BCL11A enhancer. Conversely, loss of HIC2 in fetal erythroblasts increases enhancer accessibility, GATA1 binding and BCL11A transcription. HIC2 emerges as an evolutionarily conserved regulator of hemoglobin switching via developmental control of BCL11A.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2022
Publisher: IEEE
Date: 07-2014
Publisher: IEEE
Date: 07-2016
Publisher: Power System Technology Press
Date: 08-2019
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 09-2018
Publisher: IEEE
Date: 2013
Publisher: IEEE
Date: 11-2015
Publisher: IEEE
Date: 11-2015
Publisher: IEEE
Date: 07-2011
Publisher: Institution of Engineering and Technology (IET)
Date: 08-2015
Publisher: IEEE
Date: 07-2014
Publisher: IEEE
Date: 08-2018
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2018
Publisher: IEEE
Date: 2013
Publisher: IEEE
Date: 07-2014
Publisher: Institution of Engineering and Technology (IET)
Date: 10-2016
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2013
Publisher: Institution of Engineering and Technology (IET)
Date: 10-2015
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2021
Publisher: IEEE
Date: 07-2015
Publisher: Institution of Engineering and Technology (IET)
Date: 22-06-2016
Publisher: Elsevier BV
Date: 10-2023
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 09-2018
Publisher: Institution of Engineering and Technology (IET)
Date: 07-09-2017
Publisher: IEEE
Date: 12-2017
Publisher: Elsevier BV
Date: 06-2014
Publisher: IEEE
Date: 08-2018
Publisher: IEEE
Date: 09-2014
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2020
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2018
Publisher: IEEE
Date: 07-2014
Publisher: IEEE
Date: 09-2016
Publisher: Institution of Engineering and Technology (IET)
Date: 09-01-2020
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2018
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2022
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 07-2020
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2018
Publisher: Elsevier BV
Date: 07-2022
Publisher: Institution of Engineering and Technology (IET)
Date: 09-2015
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 06-2020
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2023
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2012
Publisher: Institution of Engineering and Technology (IET)
Date: 22-05-2017
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2021
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2018
Publisher: IEEE
Date: 09-2013
Publisher: IEEE
Date: 07-2011
Publisher: Springer Science and Business Media LLC
Date: 31-07-2023
Publisher: IEEE
Date: 12-2014
Publisher: IEEE
Date: 12-2014
Publisher: IEEE
Date: 10-2010
Publisher: Institution of Engineering and Technology (IET)
Date: 03-2016
Publisher: Elsevier BV
Date: 10-2013
Publisher: IEEE
Date: 07-2015
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2020
Location: United States of America
Location: United States of America
Start Date: 2018
End Date: 06-2021
Amount: $314,446.00
Funder: Australian Research Council
View Funded ActivityStart Date: 04-2022
End Date: 12-2023
Amount: $475,000.00
Funder: Australian Research Council
View Funded Activity