ORCID Profile
0000-0003-3152-8978
Current Organisation
National Cancer Institute
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Publisher: Springer Science and Business Media LLC
Date: 14-07-2021
DOI: 10.1038/S41467-021-24467-0
Abstract: Patients with chronic lung disease (CLD) have an increased risk for severe coronavirus disease-19 (COVID-19) and poor outcomes. Here, we analyze the transcriptomes of 611,398 single cells isolated from healthy and CLD lungs to identify molecular characteristics of lung cells that may account for worse COVID-19 outcomes in patients with chronic lung diseases. We observe a similar cellular distribution and relative expression of SARS-CoV-2 entry factors in control and CLD lungs. CLD AT2 cells express higher levels of genes linked directly to the efficiency of viral replication and the innate immune response. Additionally, we identify basal differences in inflammatory gene expression programs that highlight how CLD alters the inflammatory microenvironment encountered upon viral exposure to the peripheral lung. Our study indicates that CLD is accompanied by changes in cell-type-specific gene expression programs that prime the lung epithelium for and influence the innate and adaptive immune responses to SARS-CoV-2 infection.
Publisher: Springer Science and Business Media LLC
Date: 03-2021
Publisher: American Association for the Advancement of Science (AAAS)
Date: 10-07-2020
Abstract: Single-cell RNA sequencing provides new insights into pathologic epithelial and mesenchymal remodeling in the human lung.
Location: United States of America
Location: United States of America
No related grants have been discovered for Linh Bui.