ORCID Profile
0000-0001-7051-3790
Current Organisation
University of New Mexico
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Publisher: American Association for the Advancement of Science (AAAS)
Date: 23-03-2007
Abstract: A hallmark of mammalian immunity is the heterogeneity of cell fate that exists among pathogen-experienced lymphocytes. We show that a iding T lymphocyte initially responding to a microbe exhibits unequal partitioning of proteins that mediate signaling, cell fate specification, and asymmetric cell ision. Asymmetric segregation of determinants appears to be coordinated by prolonged interaction between the T cell and its antigen-presenting cell before ision. Additionally, the first two daughter T cells displayed phenotypic and functional indicators of being differentially fated toward effector and memory lineages. These results suggest a mechanism by which a single lymphocyte can apportion erse cell fates necessary for adaptive immunity.
Publisher: Elsevier BV
Date: 04-2011
Publisher: Informa UK Limited
Date: 09-07-2015
Publisher: Wiley
Date: 27-06-2014
DOI: 10.1111/PCMR.12274
Abstract: Solid cancers are composed of heterogeneous zones containing proliferating and quiescent cells. Despite considerable insight into the molecular mechanisms underlying aberrant cell cycle progression, there is limited understanding of the relationship between the cell cycle on the one side, and melanoma cell motility, invasion, and drug sensitivity on the other side. Utilizing the fluorescent ubiquitination-based cell cycle indicator (FUCCI) to longitudinally monitor proliferation and migration of melanoma cells in 3D culture and in vivo, we found that invading melanoma cells cycle actively, while G1-arrested cells showed decreased invasion. Melanoma cells in a hypoxic environment or treated with mitogen-activated protein kinase pathway inhibitors remained G1-arrested for extended periods of time, with proliferation and invasion resuming after re-exposure to a more favorable environment. We challenge the idea that the invasive and proliferative capacity of melanoma cells are mutually exclusive and further demonstrate that a reversibly G1-arrested subpopulation survives in the presence of targeted therapies.
Publisher: Elsevier BV
Date: 06-2008
Publisher: Springer Science and Business Media LLC
Date: 24-02-2015
DOI: 10.1038/NCOMMS7301
Abstract: The precise pathways of memory T-cell differentiation are incompletely understood. Here we exploit transgenic mice expressing fluorescent cell cycle indicators to longitudinally track the ision dynamics of in idual CD8 + T cells. During influenza virus infection in vivo , naive T cells enter a CD62L intermediate state of fast proliferation, which continues for at least nine generations. At the peak of the anti-viral immune response, a subpopulation of these cells markedly reduces their cycling speed and acquires a CD62L hi central memory cell phenotype. Construction of T-cell family ision trees in vitro reveals two patterns of proliferation dynamics. While cells initially ide rapidly with moderate stochastic variations of cycling times after each generation, a slow-cycling subpopulation displaying a CD62L hi memory phenotype appears after eight isions. Phenotype and cell cycle duration are inherited by the progeny of slow cyclers. We propose that memory precursors cell-intrinsically modulate their proliferative activity to ersify differentiation pathways.
Publisher: Wiley
Date: 02-2008
No related grants have been discovered for Ichiko Kinjyo.