ORCID Profile
0000-0001-7347-5865
Current Organisation
Shaanxi Normal University
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Publisher: American Chemical Society (ACS)
Date: 29-11-2021
Abstract: The construction of intelligent near-infrared (NIR) fluorophores for high specificity to cancer cells and application in multiple therapeutic modalities is crucial for precise cancer diagnostic and therapy. In this study, an aggregation-induced emission-active NIR fluorophore (TACQ) with mitophagy-modulating activity was synthesized and developed for mitochondrial targeting multimodal cancer theranostics. The strengthened push-pull interaction extended the emission of TACQ into the NIR-II region (>1000 nm). Further, the rotor structure and twisted molecular conformation enables nanoaggregates of TACQ to balance the radiative and nonradiative decays to simultaneously exhibit bright NIR emission, high photothermal conversion efficiency (55%), and efficient generation of reactive oxygen species. The lipocationic property of TACQ allows it to selectively accumulate in the mitochondria of cancer cells. TACQ can induce mitophagy and block mitophagic flux facilitating cancer cell apoptosis. Both
Publisher: American Chemical Society (ACS)
Date: 05-05-2023
Publisher: Elsevier BV
Date: 04-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6SC02875F
Abstract: Organic solid fluorophores based on p -bis(2,2-dicyanovinyl)benzene were designed and synthesized, which displayed a tunable emission color and substituent dependent optical behavior.
Publisher: American Chemical Society (ACS)
Date: 25-06-2018
Abstract: Compared to the many studies that focus on the development of novel molecular frameworks pertaining to functionalized fluorescent materials, there is lesser emphasis on side chains even though they have a significant impact on the properties and applications of fluorescent materials. In this study, a series of pyridinium-functionalized tetraphenylethene salts (TPEPy-1 to TPEPy-4) possessing different alkyl chains are synthesized, and the influence of chain length on their optical performance and applications is thoroughly investigated. By changing the alkyl chain, the fluorogens exhibit opposite emission behavior in aqueous media because of their distinct hydrophobic nature, and their solid-state emission can be fine-tuned from green to red owing to their distinct molecular configuration. In addition, by increasing the chain length, the microstructure of the self-assembled fluorogens converts from microplates to microrods with various emission colors. Moreover, TPEPy-1 exhibits dual-mode fluorescence "turn-on" response toward NO
Publisher: Royal Society of Chemistry (RSC)
Date: 2015
DOI: 10.1039/C5CC04731E
Abstract: In this work, a red emission AIE active mitochondrial probe is developed. It is the first non-self-quenching mitochondria specific probe with membrane potential sensitivity. Its application in sensing the membrane potential differences in mouse sperm cells is demonstrated.
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2CC33780K
Abstract: Melding a benzothiazolium unit with tetraphenylethene generates a new hemicyanine luminogen with aggregation-induced emission characteristics the luminogen exhibits crystochromism and its solid-state emission can be repeatedly tuned from yellow or orange to red by grinding-fuming or grinding-heating processes due to the transformation from the crystalline to the amorphous state and vice versa.
Publisher: American Chemical Society (ACS)
Date: 24-07-2023
Location: No location found
Location: China
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