ORCID Profile
0000-0002-9847-2051
Current Organisations
Geneva University
,
University of Oxford
,
Technology Centre for Offshore and Marine, Singapore
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Publisher: Springer Science and Business Media LLC
Date: 23-01-2018
Publisher: American Society of Mechanical Engineers
Date: 09-06-2013
Abstract: This paper, a product of an intensive eight-week Lloyd’s Register Educational Trust (LRET) Collegium held during July – September 2012 in South ton, UK, presents an innovative engineering system concept design for manganese nodule recovery. Issues associated with environmental impacts, such as insufficient or lack of transparent impact studies of any potential full-scale seabed mining, are identified as the key obstacles which could lead to public protest, thus prevent the mining project from taking place. Hence, the proposed system introduces an environmentally friendly solution with the innovative concept of a black box, which performs in-situ nodule-sediment separation and waste discharge, and allows recirculation of waste water. The use of a modularised mining system with small, active hydraulic, crawler-type collectors is proposed to minimise environmental footprint and increase system redundancy. This yields a comparable estimated sediment-to-dry nodule ratio with previous studies in sediment plume impact assessment. The proposed system is a big leap towards a more environmentally friendly solution for achieving (the first) full-scale manganese nodule recovery. Together with the intended small production scale of 0.5 millions dry nodules per year, the proposed system can also be considered as a full-scale experiment or field measurement: a platform for full-scale research concurrently, particularly in the area of environmental impacts. The proposed system, intended to spur more interest in environmental impact studies and to be more transparent to the public, could benefit both industry and research institutes, for the benefit of everybody.
Publisher: Elsevier BV
Date: 09-2022
Publisher: Public Library of Science (PLoS)
Date: 08-11-2021
DOI: 10.1371/JOURNAL.PGEN.1009873
Abstract: Transcription of the human mitochondrial genome and correct processing of the two long polycistronic transcripts are crucial for oxidative phosphorylation. According to the tRNA punctuation model, nucleolytic processing of these large precursor transcripts occurs mainly through the excision of the tRNAs that flank most rRNAs and mRNAs. However, some mRNAs are not punctuated by tRNAs, and it remains largely unknown how these non-canonical junctions are resolved. The FASTK family proteins are emerging as key players in non-canonical RNA processing. Here, we have generated human cell lines carrying single or combined knockouts of several FASTK family members to investigate their roles in non-canonical RNA processing. The most striking phenotypes were obtained with loss of FASTKD4 and FASTKD5 and with their combined double knockout. Comprehensive mitochondrial transcriptome analyses of these cell lines revealed a defect in processing at several canonical and non-canonical RNA junctions, accompanied by an increase in specific antisense transcripts. Loss of FASTKD5 led to the most severe phenotype with marked defects in mitochondrial translation of key components of the electron transport chain complexes and in oxidative phosphorylation. We reveal that the FASTK protein family members are crucial regulators of non-canonical junction and non-coding mitochondrial RNA processing.
Publisher: Wiley
Date: 03-06-2002
DOI: 10.1016/S0014-5793(02)02871-5
Abstract: Pro-apoptotic members of the Bcl-2 family can be sub ided in two classes according to their structure: a group including Bax, Bak, and Bok that display Bcl-2 homology (BH) 1, BH2 and BH3 domains and a second group including Bid (BH3 interacting domain death agonist), Bad, Bim (Bcl-2 interacting mediator of cell death) and several others that contain only a BH3 domain, the BH3-only proteins. The BH3-only proteins have been proposed to activate pro-apoptotic members of the Bax subfamily to trigger a mitochondrial pathway that leads to the release of cytochrome c and other apoptogenic factors. Here we report that the mechanism of action of Bim is different from that of Bid. Although overexpression of Bid or Bim in cells leads to cytochrome c release, only Bid is able to trigger the release of cytochrome c through Bax activation when added directly to isolated mitochondria. Bim(L), although unable to activate Bax, can directly inhibit Bcl-2 or Bcl-x(L). Our data suggest two functional classes of BH3-only proteins: those such as Bid which directly activate Bax-like proteins leading to mitochondrial membrane permeability and apoptosis and those such as Bim which inhibit anti-apoptotic proteins and render the cells more susceptible to apoptogenic stimuli.
Publisher: Elsevier BV
Date: 03-2019
Location: United Kingdom of Great Britain and Northern Ireland
Location: Singapore
No related grants have been discovered for Jean-claude martinou.