ORCID Profile
0000-0002-0110-0244
Current Organisations
Bionics Institute
,
UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill
,
National University of Singapore
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Publisher: American Chemical Society (ACS)
Date: 07-09-2018
Abstract: Supraparticles (SPs) composed of smaller colloidal particles provide a platform for the long-term, controlled release of therapeutics in biomedical applications. However, current synthesis methods used to achieve high drug loading and those involving biocompatible materials are often tedious and low throughput, thereby limiting the translation of SPs to erse applications. Herein, we present a simple, effective, and automatable alginate-mediated electrospray technique for the assembly of robust spherical silica SPs (Si-SPs) for long-term (>4 months) drug delivery. The Si-SPs are composed of either porous or nonporous primary Si particles within a decomposable alginate matrix. The size and shape of the Si-SPs can be tailored by controlling the concentrations of alginate and silica primary particles used and key electrospraying parameters, such as flow rate, voltage, and collector distance. Furthermore, the performance (including drug loading kinetics, loading capacity, loading efficiency, and drug release) of the Si-SPs can be tuned by changing the porosity of the primary particles and through the retention or removal (via calcination) of the alginate matrix. The structure and morphology of the Si-SPs were characterized by electron microscopy, dynamic light scattering, N
Publisher: Elsevier BV
Date: 02-2023
DOI: 10.1016/J.CARBPOL.2022.120323
Abstract: Innovative food packaging techniques provide extrinsic systems for ensuring the quality and safety of food products. Recent research has focused on the development of multifunctional nanocomposites towards emerging active and sustainable food packaging (ASFP) systems. Specifically, erse biomass-derived nanocomposite films (BNFs) are engineered via incorporating functional nanomaterials into the naturally-occurring biopolymers (e.g., polysaccharides and proteins). Such BNFs lead to minimum environmental risks compared to petroleum-derived materials, while exhibit improved physicochemical properties and functionalities, demonstrating great potential for ASFP. This review provides a summary of state-of-art BNFs based on their composition and application. We also highlight the advantages of BNFs for agricultural products. Particularly, the interactions between the biomass matrix and the nanomaterials are discussed to provide insightful rationales for designing high-performance BNFs. We envision that BNFs will not only be emerged as the dominant food packaging materials, but also contribute to the international trade and addressing the global food crisis.
Publisher: American Chemical Society (ACS)
Date: 14-08-2019
DOI: 10.1021/ACS.BIOMAC.9B00710
Abstract: Supraparticles (SPs) assembled from smaller colloidal nanoparticles can serve as depots of therapeutic compounds and are of interest for long-term, sustained drug release in biomedical applications. However, a key challenge to achieving temporal control of drug release from SPs is the occurrence of an initial rapid release of the loaded drug (i.e., "burst" release) that limits sustained release and potentially causes burst release-associated drug toxicity. Herein, a biocoating strategy is presented for silica-SPs (Si-SPs) to reduce the extent of burst release of the loaded model protein lysozyme. Specifically, Si-SPs were coated with a fibrin film, formed by enzymatic conversion of fibrinogen into fibrin. The fibrin-coated Si-SPs,
Publisher: Elsevier BV
Date: 09-2023
Publisher: Elsevier BV
Date: 08-2019
Publisher: American Chemical Society (ACS)
Date: 11-07-2023
Publisher: American Chemical Society (ACS)
Date: 30-09-2020
Publisher: American Chemical Society (ACS)
Date: 09-2023
DOI: 10.1021/JACS.3C05574
Publisher: American Chemical Society (ACS)
Date: 15-05-2023
DOI: 10.1021/JACS.3C02584
Publisher: Elsevier BV
Date: 2020
Publisher: Wiley
Date: 21-04-2023
Abstract: Even though lipid nanoparticles (LNPs) can deliver messenger RNA (mRNA) payloads into cells, their efficiency is often limited by endosomal trapping which prevents RNA payloads from acting therapeutically. Improving the percentage of RNA LNPs that can escape from endosomes and enter the cytoplasm is therefore an area of active research interest that could lead to improved safety profiles and reduced manufacturing costs of mRNA drugs. Here, tannic acid mRNA LNPs [TA(+) mRNA LNPs] are reported as an effective delivery platform for the delivery of mRNA payloads. The formulation, characterization, and stability of TA(+) mRNA LNPs are described two different approaches via confocal microscopy are then utilized to quantify the endosomal escape of the TA(+) mRNA LNPs and lastly, the biodistribution and tolerability of the TA(+) mRNA LNPs are evaluated in mice following intravenous and intramuscular dosing regimens. To isolate the effect that TA imparts on each of these properties, mRNA LNPs that do not contain TA [TA(−) mRNA LNPs] are evaluated side‐by‐side in each of these studies. A collective analysis of these results suggests that TA(+) mRNA LNPs are effective carriers for mRNA payloads and that the incorporation of TA within each formulation improves the endosomal escape of mRNA LNPs.
Publisher: Wiley
Date: 06-08-2020
Publisher: World Scientific Pub Co Pte Lt
Date: 28-11-2013
DOI: 10.1142/S0217979213501968
Abstract: This paper offers two different attacks on a freshly proposed image encryption based on chaotic logistic map. The cryptosystem under study first uses a secret key of 80-bit and employed two chaotic logistic maps. We derived the initial conditions of the logistic maps from using the secret key by providing different weights to all its bits. Additionally, in this paper eight different types of procedures are used to encrypt the pixels of an image in the proposed encryption process of which one of them will be used for a certain pixel which is determined by the product of the logistic map. The secret key is revised after encrypting each block which consisted of 16 pixels of the image. The encrypting process have weakness, worst of which is that every byte of plaintext is independent when substituted, so the cipher text of the byte will not change even the other bytes have changed. As a result of weakness, a chosen plaintext attack and a chosen cipher text attack can be completed without any knowledge of the key value to recuperate the ciphered image.
Publisher: Elsevier BV
Date: 09-2023
Publisher: American Chemical Society (ACS)
Date: 21-09-2018
Abstract: Hybrid conformal coatings, such as metal-phenolic networks (MPNs) that are constructed from the coordination-driven assembly of natural phenolic ligands, are of interest in areas including biomedicine, separations, and energy. To date, most MPN coatings have been prepared by immersing substrates in solutions containing the phenolic ligands and metal ions, which is a suitable method for coating small or flexible objects. In contrast, more industrially relevant methods for coating and patterning large substrates, such as spray assembly, have been explored to a lesser extent toward the fabrication of MPNs, particularly regarding the effect of process variables on MPN growth. Herein, a spray assembly method was used to fabricate MPN coatings with various phenolic building blocks and metal ions and their formation and patterning were explored for different applications. Different process parameters including solvent, pH, and metal-ligand pair allowed for control over the film properties such as thickness and roughness. On the basis of these investigations, a potential route for the formation of spray-assembled MPN films was proposed. Conditions favoring the formation of bis complexes could produce thicker coatings than those favoring the formation of mono or tris complexes. Finally, the spray-assembled MPNs were used to generate superhydrophilic membranes for oil-water separation and colorless films for UV shielding. The present study provides insights into the chemistry of MPN assembly and holds promise for advancing the fabrication of multifunctional hybrid materials.
Publisher: World Scientific Pub Co Pte Ltd
Date: 28-11-2013
DOI: 10.1142/S0217979213502019
Abstract: Aiming at the drawbacks of the chaotic masking scheme, this paper optimizes this conventional scheme by using improved state observer method and system-alternating method, proposes a new secure communication scheme which can improve these drawbacks of chaotic method: (1) Restriction that the power of useful signal must be smaller than that of chaotic signal. (2) Low security. In addition, the model of this whole communication system is constructed under the system simulation environment of Simulink.
Publisher: Elsevier BV
Date: 02-2022
DOI: 10.1016/J.JCONREL.2021.12.037
Abstract: Hearing loss is the most prevalent sensory disorder affecting nearly half a billion people worldwide. Aside from devices to assist hearing, such as hearing aids and cochlear implants, a drug treatment for hearing loss has yet to be developed. The neurotrophin family of growth factors has long been established as a potential therapy, however delivery of these factors into the inner ear at therapeutic levels over a sustained period of time has remained a challenge restricting clinical translation. We previously demonstrated that direct delivery of exogenous neurotrophin-3 (NT3) in the guinea pig cochleae via a bolus injection was rapidly cleared from the inner ear, with almost complete elimination 3 days post-treatment. Here, we explored the potential of suprapaticles (SPs) for NT3 delivery to the inner ear to achieve sustained delivery over time. SPs are porous spheroid structures comprised of smaller colloidal silica nanoparticles that provide a platform for long-term controlled release of therapeutics. This study aimed to assess the pharmacokinetics and biodistribution of SP-delivered NT3. We used a radioactive tracer (iodine 125:
Publisher: American Chemical Society (ACS)
Date: 18-12-2020
DOI: 10.1021/JACS.9B10835
Abstract: Mesoporous metal-organic networks have attracted widespread interest owing to their potential applications in erse fields including gas storage, separations, catalysis, and drug delivery. Despite recent advances, the synthesis of metal-organic networks with large and ordered mesochannels (>20 nm), which are important for loading, separating, and releasing macromolecules, remains a challenge. Herein, we report a templating strategy using sacrificial double cubic network polymer cubosomes (
Location: No location found
Location: United States of America
No related grants have been discovered for Yutian Ma.