ORCID Profile
0000-0002-2733-1972
Current Organisation
Institut Cochin
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Publisher: Springer Science and Business Media LLC
Date: 23-06-2020
Publisher: Springer Science and Business Media LLC
Date: 04-07-2014
DOI: 10.1038/NRI3714
Publisher: Springer Science and Business Media LLC
Date: 15-07-2012
DOI: 10.1038/NI.2370
Publisher: Springer Science and Business Media LLC
Date: 30-09-2012
DOI: 10.1038/NI.2419
Publisher: Springer Science and Business Media LLC
Date: 07-09-2012
DOI: 10.1038/NRI3300
Abstract: Although the field has a long collaborative tradition, immunology has made less use than genetics of 'consortium biology', wherein groups of investigators together tackle large integrated questions or problems. However, immunology is naturally suited to large-scale integrative and systems-level approaches, owing to the multicellular and adaptive nature of the cells it encompasses. Here, we discuss the value and drawbacks of this organization of research, in the context of the long-running 'big science' debate, and consider the opportunities that may exist for the immunology community. We position this analysis in light of our own experience, both positive and negative, as participants of the Immunological Genome Project.
Publisher: The American Association of Immunologists
Date: 03-2011
Abstract: T and B lymphocytes are developmentally and functionally related cells of the immune system, representing the two major branches of adaptive immunity. Although originating from a common precursor, they play very different roles: T cells contribute to and drive cell-mediated immunity, whereas B cells secrete Abs. Because of their functional importance and well-characterized differentiation pathways, T and B lymphocytes are ideal cell types with which to understand how functional differences are encoded at the transcriptional level. Although there has been a great deal of interest in defining regulatory factors that distinguish T and B cells, a truly genomewide view of the transcriptional differences between these two cells types has not yet been taken. To obtain a more global perspective of the transcriptional differences underlying T and B cells, we exploited the statistical power of combinatorial profiling on different microarray platforms, and the breadth of the Immunological Genome Project gene expression database, to generate robust differential signatures. We find that differential expression in T and B cells is pervasive, with the majority of transcripts showing statistically significant differences. These distinguishing characteristics are acquired gradually, through all stages of B and T differentiation. In contrast, very few T versus B signature genes are uniquely expressed in these lineages, but are shared throughout immune cells.
Publisher: Elsevier BV
Date: 09-2009
Location: United Kingdom of Great Britain and Northern Ireland
Location: United States of America
No related grants have been discovered for Julie Helft.