ORCID Profile
0000-0002-2873-5135
Current Organisations
Heidelberg University
,
Heidelberg University Hospital
,
Ruprecht Karls Universität Heidelberg Medizinische Fakultät Heidelberg
,
Universitätsklinikum Erlangen
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Publications
Publisher Correction: Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes
Publisher: Springer Science and Business Media LLC
Date: 26-03-2021
A microRNA expression and regulatory element activity atlas of the mouse immune system
Publisher: Springer Science and Business Media LLC
Date: 07-06-2021
ImmGen at 15
Publisher: Springer Science and Business Media LLC
Date: 23-06-2020
The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments
Publisher: Springer Science and Business Media LLC
Date: 17-05-2021
DOI: 10.1038/S41467-021-22973-9
Abstract: Neutrophils are implicated in multiple homeostatic and pathological processes, but whether functional ersity requires discrete neutrophil subsets is not known. Here, we apply single-cell RNA sequencing to neutrophils from normal and inflamed mouse tissues. Whereas conventional clustering yields multiple alternative organizational structures, diffusion mapping plus RNA velocity discloses a single developmental spectrum, ordered chronologically. Termed here neutrotime, this spectrum extends from immature pre-neutrophils, largely in bone marrow, to mature neutrophils predominantly in blood and spleen. The sharpest increments in neutrotime occur during the transitions from pre-neutrophils to immature neutrophils and from mature marrow neutrophils to those in blood. Human neutrophils exhibit a similar transcriptomic pattern. Neutrophils migrating into inflamed mouse lung, peritoneum and joint maintain the core mature neutrotime signature together with new transcriptional activity that varies with site and stimulus. Together, these data identify a single developmental spectrum as the dominant organizational theme of neutrophil heterogeneity.
Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes
Publisher: Springer Science and Business Media LLC
Date: 18-01-2021
Related Organisations
Ruprecht Karls Universität Heidelberg Medizinische Fakultät Heidelberg
Location: Germany
The Immunological Genome Project Consortium
Location: United States of America
Related Funding Activities
No related grants have been discovered for Professor Dr. med. Ricardo Grieshaber-Bouyer.