ARDC Research Link Australia

ORCID Profile
Orcid icon. 0009-0007-8443-6934

Current Organisations
Rutgers The State University of New Jersey , University of Freiburg , Barnard College

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Publications

Publication

LOXL2 induces aberrant acinar morphogenesis via ErbB2 signaling

Publisher: Springer Science and Business Media LLC

Date: 08-2013

DOI: 10.1186/BCR3461

Publication

The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells

Publisher: Informa UK Limited

Date: 02-2014

DOI: 10.1128/MCB.00644-12

Publication

Basement membrane stiffness determines metastases formation

Publisher: Springer Science and Business Media LLC

Date: 25-01-2021

DOI: 10.1038/S41563-020-00894-0

Publication

LOXL2-Mediated Matrix Remodeling in Metastasis and Mammary Gland Involution

Publisher: American Association for Cancer Research (AACR)

Date: 03-2011

DOI: 10.1158/0008-5472.CAN-10-2868

Abstract: More than 90% of cancer patient mortality is attributed to metastasis. In this study, we investigated a role for the lysyl oxidase-related enzyme lysyl oxidase-like 2 (LOXL2) in breast cancer metastasis, in both patient s les and in vivo models. Analysis of a published microarray data set revealed that LOXL2 expression is correlated with metastasis and decreased survival in patients with aggressive breast cancer. In immunocompetent or immunocompromised orthotopic and transgenic breast cancer models we showed that genetic, chemical or antibody-mediated inhibition of LOXL2 resulted in decreased metastasis. Mechanistic investigations revealed that LOXL2 promotes invasion by regulating the expression and activity of the extracellular proteins tissue inhibitor of metalloproteinase-1 (TIMP1) and matrix metalloproteinase-9 (MMP9). We found that LOXL2, TIMP1, and MMP9 are coexpressed during mammary gland involution, suggesting they function together in glandular remodeling after weaning. Finally, we found that LOXL2 is highly expressed in the basal/myoepithelial mammary cell lineage, like many other genes that are upregulated in basal-like breast cancers. Our findings highlight the importance of LOXL2 in breast cancer progression and support the development of anti-LOXL2 therapeutics for the treatment of metastatic breast cancer. Cancer Res 71(5) 1561–72. ©2011 AACR.

Publication