ORCID Profile
0000-0002-7835-3581
Current Organisation
Defence Science and Technology Laboratory
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Publisher: Springer Science and Business Media LLC
Date: 28-11-2022
DOI: 10.1007/S00705-022-05546-Z
Abstract: In March 2022, following the annual International Committee on Taxonomy of Viruses (ICTV) ratification vote on newly proposed taxa, the phylum Negarnaviricota was amended and emended. The phylum was expanded by two new families (bunyaviral Discoviridae and Tulasviridae), 41 new genera, and 98 new species. Three hundred forty-nine species were renamed and/or moved. The accidentally misspelled names of seven species were corrected. This article presents the updated taxonomy of Negarnaviricota as now accepted by the ICTV.
Publisher: Springer Science and Business Media LLC
Date: 17-11-2021
Publisher: Springer Science and Business Media LLC
Date: 20-01-2019
Publisher: Springer Science and Business Media LLC
Date: 29-01-2013
Publisher: Springer Science and Business Media LLC
Date: 14-05-2019
Publisher: Cold Spring Harbor Laboratory
Date: 18-09-2014
Abstract: Burkholderia pseudomallei (Bp) is the causative agent of the infectious disease melioidosis. To investigate population ersity, recombination, and horizontal gene transfer in closely related Bp isolates, we performed whole-genome sequencing (WGS) on 106 clinical, animal, and environmental strains from a restricted Asian locale. Whole-genome phylogenies resolved multiple genomic clades of Bp, largely congruent with multilocus sequence typing (MLST). We discovered widespread recombination in the Bp core genome, involving hundreds of regions associated with multiple haplotypes. Highly recombinant regions exhibited functional enrichments that may contribute to virulence. We observed clade-specific patterns of recombination and accessory gene exchange, and provide evidence that this is likely due to ongoing recombination between clade members. Reciprocally, interclade exchanges were rarely observed, suggesting mechanisms restricting gene flow between clades. Interrogation of accessory elements revealed that each clade harbored a distinct complement of restriction-modification (RM) systems, predicted to cause clade-specific patterns of DNA methylation. Using methylome sequencing, we confirmed that representative strains from separate clades indeed exhibit distinct methylation profiles. Finally, using an E. coli system, we demonstrate that Bp RM systems can inhibit uptake of non-self DNA. Our data suggest that RM systems borne on mobile elements, besides preventing foreign DNA invasion, may also contribute to limiting exchanges of genetic material between in iduals of the same species. Genomic clades may thus represent functional units of genetic isolation in Bp, modulating intraspecies genetic ersity.
Publisher: Springer Science and Business Media LLC
Date: 23-05-2016
Publisher: Springer Science and Business Media LLC
Date: 04-09-2020
Publisher: Springer Science and Business Media LLC
Date: 23-09-2012
Publisher: Springer Science and Business Media LLC
Date: 07-04-2017
Publisher: Springer Science and Business Media LLC
Date: 11-04-2018
Publisher: Informa UK Limited
Date: 04-05-2015
DOI: 10.3109/17483107.2015.1042077
Abstract: The purpose of this study was to investigate of how assistive cutlery design effects perception of the user. Studies regarding the usage and development of assistive cutlery have primarily focused on the ergonomics, whereas research into the aesthetics of assistive cutlery has been minimal. A method based on Canter's "Room Inference Protocol" from the field of environmental psychology was used to evaluate the aesthetics of the assistive cutlery. A series of images were digitally composited and a survey was deployed online, with an outcome of 562 usable responses. The results demonstrated that the female model with assistive cutlery was perceived to be less attractive, less stylish and less sporty in comparison with the male model that was utilising identical pieces of assistive cutlery. The research contributes to the existing literature in the field, complimenting the study by Torrens and Smith and validating the need for greater aesthetic consideration in addition to an ergonomically acceptable response for assistive cutlery. This in turn highlights the importance of industrial design for the context and adaptations of use, rather than just a design response given to the physical manifestation of a product. Implications for Rehabilitation Reduced grip can be not only physically debilitating but also socially isolating through stigmatisation. Current assistive cutlery may be ergonomically sound, but aesthetically lacking. Large, multinational study demonstrates significant gender effect relating to the perception of women using these devices.
Publisher: Oxford University Press (OUP)
Date: 22-10-2016
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
No related grants have been discovered for Sophie Smither.