ORCID Profile
0000-0001-5137-0771
Current Organisation
Shenzhen University
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Publisher: Wiley
Date: 02-03-2021
Abstract: Bacteria infected cells acting as “Trojan horses” not only protect bacteria from antibiotic therapies and immune clearance, but also increase the dissemination of pathogens from the initial sites of infection. Antibiotics are hard and insufficient to treat such hidden internalized bacteria, especially multidrug‐resistant (MDR) bacteria. Herein, aggregation‐induced emission luminogens (AIEgens) such as N , N ‐diphenyl‐4‐(7‐(pyridin‐4‐yl) benzo [ c ] [1,2,5] thiadiazol‐4‐yl) aniline functionalized with 1‐bromoethane (TBP‐1) and (3‐bromopropyl) trimethylammonium bromide (TBP‐2) (TBPs) show potent broad‐spectrum bactericidal activity against both extracellular and internalized Gram‐positive pathogens. TBPs trigger reactive oxygen species (ROS)‐mediated membrane damage to kill bacteria, regardless of light irradiation. TBPs effectively kill bacteria without the development of resistance. Additionally, such AIEgens activate mitochondria dependent autophagy to eliminate internalized bacteria in host cells. Compared to the routinely used vancomycin in clinic, TBPs demonstrate comparable efficacy against methicillin‐resistant Staphylococcus aureus (MRSA) in vivo. The studies suggest that AIEgens are promising new agents for the treatment of MDR bacteria associated infections.
Publisher: Wiley
Date: 06-08-2020
Publisher: American Chemical Society (ACS)
Date: 12-08-2022
Abstract: Supramolecular toroids have attracted continuous attention because of their fascinating topological structure and important role in biological systems. However, it still remains a great challenge to construct supramolecular functional toroids and clarify the formation mechanism. Herein, we develop a strategy to prepare supramolecular helical fluorescent nanotoroids by cooperative self-assembly of an amino acid and a dendritic hiphile (AIE-den-1) with aggregation-induced emission characteristics. Mechanistic investigation on the basis of fluorescence and circular dichroism analyses suggests that the toroid formation can be driven by the interactions of AIE-den-1 with amino acid and goes through a topological morphology transformation from nanofibers to left-handed nanotoroids by means of a twist-fused-loop process.
Publisher: Wiley
Date: 22-12-2022
Abstract: Photoactivatable agent is a powerful tool in biomedicine studies due to high‐precision spatiotemporal control of light. However, those previously reported agents generally suffer from short wavelength, fluorescence self‐quenching effect, and the lack of photosensitizing property, which severely restrict their practical applications. To address these issues, molecular engineering of 1,4‐dihydropyridine derivatives is conducted to obtain an optimized agent, namely TPA‐DHPy‐Py, which exhibits low oxidation potential, high photoactivation efficiency, and excellent type I/II combined photodynamic activity. Concurrently, its photoactivated counterpart is featured by aggregation‐induced near‐infrared emission and remarkable reactive oxygen species (ROS) production efficiency. Upon photoactivation, TPA‐DHPy‐Py is capable of precisely identifying cancer cells from co‐culturing cancer cells and normal cells without the assistance of any extra targeting units, and in situ monitoring lipid droplets and endoplasmic reticulum alteration under ROS stress, as well as achieving fluorescent visualization of tumor in vivo with supremely high imaging contrast. Furthermore, the unprecedented performance on photodynamic cancer therapy is demonstrated by the significant inhibition of tumor growth. Therefore, the photoactivatable TPA‐DHPy‐Py with dual‐organelle‐targeted and excellent photodynamic activity associated with self‐monitoring ability is highly promising for cancer theranostics in clinical trials.
Publisher: Wiley
Date: 18-09-2021
Abstract: The ingenious construction of versatile cancer phototheranostics involving fluorescence imaging (FLI) and photodynamic and photothermal therapies (PDT, PTT) concurrently has attracted great interest. By virtue of their inherent twisted structures and plentiful motion moieties, aggregation‐induced emission luminogens (AIEgens) have been proven to be perfect templates for the development of multimodal phototheranostic systems as their erse energy consumption pathways can be flexibly regulated through tuning the intramolecular motions. Side‐chain engineering is generally accepted as a useful regulation strategy for intramolecular motions through altering the side‐chain structure of the molecule, but has rarely been reported for the construction of AIE‐active multimodal phototheranostics. Herein, by taking full advantage of the side‐chain engineering strategy, an AIE‐active multifunctional phototheranostic system (TBFT2 nanoparticles) is successfully constructed by intentionally manipulating the length of side chains. Bearing the longest alkyl chain, all of those three energy dissipation pathways including radiative decay, nonradiative thermal deactivation, and intersystem crossing process of TBFT2 are retained simultaneously and controllably in the aggregate state. In vitro and in vivo evaluations verify that TBFT2 nanoparticles perform well in terms of FLI‐guided PDT and PTT synergistic cancer therapy. This study thus provides new insight into the exploration of superior versatile phototheranostics through side‐chain engineering.
Publisher: American Chemical Society (ACS)
Date: 28-12-2018
DOI: 10.1021/ACS.ANALCHEM.8B04736
Abstract: Facile, efficient, and mass production of aggregation-induced emission (AIE) luminogens (AIEgens) with excited-state intramolecular proton transfer (ESIPT) characteristics was achieved by a one-step condensation reaction of 2-(hydrazonomethyl)phenol with benzaldehydes. The function of as-prepared AIEgens could be tuned easily by varying the functional group being carried on the phenyl ring of benzaldehyde just like a Swiss knife handle. The suitable distance and angle of the intramolecular hydrogen bond in these AIEgens endowed them with ESIPT properties, intense solid-state luminescence, and large Stokes shifts (155-169 nm). These AIEgens could not only serve as biological probes showing specific targeting to lipid droplets, endoplasmic reticulum, and lysosomes, respectively, but also generate reactive oxygen species upon visible light irradiation to make them promise for photodynamic therapy.
Publisher: Wiley
Date: 07-08-2021
Abstract: The lysosome is a prominent and crucial target for actualizing anticancer therapy due to the outstanding therapeutic effect of lysosomal cell death on apoptosis‐ and drug‐resistance cancer. Exploration of multifunctional materials involving lysosome‐targeting drugs for achieving efficient cancer treatment is definitely appealing, yet a significantly challenging task. Herein, a versatile nanotheranostic system allowing all cancer cell‐targeting, tumor microenvironment stimuli‐responsive, fluorescence imaging, lysosome‐targeting chemotherapy and nucleus‐targeting chemotherapy functions was tactfully designed and constructed, by encapsulating both doxorubicin and a lysosome‐specific targeting drug with aggregation‐induced emission features in functional hiphilic polymers. Both in vitro and in vivo studies revealed that the presented nanotheranostic system exhibited synergistic anticancer therapy effects, negligible systemic toxicity, and remarkable inhibition of drug‐resistant cancer cells. This study thus brings a new insight into the development of a superior effective protocol for practical cancer treatment.
Publisher: Elsevier BV
Date: 08-2021
Publisher: Wiley
Date: 22-08-2021
Abstract: The development of multifunctional nanoplatforms has been recognized as a promising strategy for potent photodynamic theranostics. Aggregation‐induced emission (AIE) photosensitizers undergoing Type‐I reactive oxygen species (ROS) generation pathway appear as potential candidates due to their capability of hypoxia‐tolerance, efficient ROS production, and fluorescence imaging navigation. To further improve their performance, a facile and universal method of constructing a type of glutathione (GSH)‐depleting and near‐infrared (NIR)‐regulated nanoplatform for dual‐modal imaging‐guided photodynamic therapy (PDT) is presented. The nanoplatforms are obtained through the coprecipitation process involving upconversion nanoparticles (UCNPs) and AIE‐active photosensitizers, followed by in situ generation of MnO 2 as the outer shell. The introduction of UCNPs actualizes the NIR‐activation of AIE‐active photosensitizers to produce ·OH as a Type‐I ROS. Intracellular upregulated GSH‐responsive decomposition of the MnO 2 shell to Mn 2+ realizes GSH‐depletion, which is a distinctive approach for elevating intracellular ·OH. Meanwhile, the generated Mn 2+ can implement T 1 ‐weighted magnetic resonance imaging (MRI) in specific tumor sites, and mediate the conversion of intracellular H 2 O 2 to ·OH. These outputs reveal a triple‐jump ·OH production, and this approach brings about distinguished performance in FLI‐MRI‐guided PDT with high‐efficacy, which presents great potential for future clinical translations.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1BM00044F
Abstract: With the morphological transformation of fluorescent self-assembled nanostructures, their functions can be varied simultaneously.
Publisher: American Chemical Society (ACS)
Date: 24-07-2023
Publisher: Wiley
Date: 15-12-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1SC03932F
Abstract: As two important subcellular organelles in eukaryotic cells, the Golgi apparatus (GA) and endoplasmic reticulum (ER) have recently captivated much interest due to their considerable importance in many biofunctions and role as critical biomarkers for various diseases.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9CS00495E
Abstract: This review presents comprehensive discussions on the recent development in supramolecular materials based on luminogens with aggregation-induced emission (AIE) characteristics.
Publisher: Wiley
Date: 25-01-2022
Abstract: Molecular motions are ubiquitous in nature and they immutably play intrinsic roles in all actions. However, exploring appropriate models to decipher molecular motions is an extremely important but very challenging task for researchers. Considering aggregation‐induced emission (AIE) luminogens possess their unique merits to visualize molecular motions, it is particularly fascinating to construct new AIE systems as models to study molecular motion. Herein, a novel quinolizine (QLZ) AIE system was constructed based on the restriction intramolecular vibration (RIV) mechanism. It was demonstrated that QLZ could act as an ideal model to visualize single‐molecule motion and macroscopic molecular motion via fluorescence change. Additionally, further elaborate tailoring of this impressive core achieved highly efficient reactive oxygen species production and realized fluorescence imaging‐guided photodynamic therapy applications, which confirms the great application potential of this new AIE‐active QLZ core. Therefore, this work not only provides an ideal model to visualize molecular motion but also opens a new way for the application of AIEgens.
Publisher: Wiley
Date: 16-11-2021
Abstract: Owing to their versatile functionality and tunable energy dissipation, aggregation‐induced emission luminogens (AIEgens) have emerged as a potential platform for multimodal theranostics. Nevertheless, the construction of AIE‐active phototheranostic agents in the second near‐infrared window (NIR‐II, 1000–1700 nm), which allows superior resolution and minimized photodamage, is still a formidable challenge. Herein, benzo[ c ]thiophene serves as an electron‐rich and bulky donor (D)/π‐bridge, which can enlarge the conjugation length and distort the backbone of an AIEgen. By precise D/π‐bridge engineering, highly stable NIR‐II AIEgen DPBTA‐DPTQ nanoparticles are obtained with acceptable NIR‐II fluorescence quantum yield and excellent photothermal conversion efficiency. In addition, the spatial conformation of DPBTA‐DPTQ is determined for the first time by X‐ray single crystal diffraction and theoretical simulations. DPBTA‐DPTQ NPs have good biocompatibility and show efficient photothermal therapeutic effects in in vitro tests. Furthermore, DPBTA‐DPTQ NPs were used in fluorescence‐photoacoustic‐photothermal trimodal imaging‐guided photothermal eradication of tumors in HepG2 and B16‐F10 tumor‐xenografted mice.
Publisher: American Chemical Society (ACS)
Date: 06-09-2020
Publisher: American Chemical Society (ACS)
Date: 14-05-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1QM00328C
Abstract: A versatile red/near-infrared AIE probe, TTPy-H2O2 , was developed for the specific visualization of H 2 O 2 with mitochondria targeting ability, meanwhile achieving efficient photodynamic therapy for cancer cells.
Publisher: Elsevier BV
Date: 03-2021
Publisher: American Chemical Society (ACS)
Date: 02-06-2202
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C8SC05805A
Abstract: Facile synthesis and bio-applications of a series of AIEgens with widely tunable emissions ranging from violet to near-infrared are reported.
Publisher: American Chemical Society (ACS)
Date: 02-06-2022
Abstract: Developing effective intelligent nanotheranostics is highly desirable for cancer treatment but remains challenging. In this study, an acidic tumor microenvironment-activated organosilica nanosystem, namely AD-Cu-DOX-HA, is straightforwardly constructed, which is composed of aggregation-induced emission (AIE)-active photosensitizer, copper ion-engineered aminosilica, direct coordination polymer of doxorubicin (DOX), and targeting component hyaluronic acid (HA). AD-Cu-DOX-HA is able to accurately distinguish cancer cells over normal cells meanwhile, it simultaneously exhibits selective accumulation and copper ion-mediated rapid disassembly and turn-on fluorescence in tumor tissue, consequently achieving efficient tumor diagnosis and tumor-growth inhibition through fluorescence imaging-navigated synergetic photodynamic therapy, copper ion-mediated chemodynamic therapy, and DOX-enabled chemotherapy. This work thus brings fresh insight into the exploration of versatile theranostics and presents a momentous advance for potential clinical cancer treatment.
Publisher: American Chemical Society (ACS)
Date: 18-07-2022
Publisher: Wiley
Date: 15-09-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM00995D
Abstract: An easily available ratiometric fluorescent probe (TCFPB-HNO) with aggregation-induced emission (AIE) characteristics was developed for the first time for the detection and visualization of nitroxyl (HNO) in vitro and in vivo .
Publisher: Wiley
Date: 09-02-2021
Abstract: As a consequence of their intrinsic advantageous properties, luminogens that show aggregation‐induced emission (AIEgens) have received increasing global interest for a wide range of applications. Whereas general synthetic methods towards AIEgens largely rely on tedious procedures and limited reaction types, various innovative synthetic methods have now emerged as complementary, and even alternative, strategies. In this Review, we systematically highlight advancements made in metal‐catalyzed functionalization and metal‐free‐promoted pathways for the construction of AIEgens over the past five years, and briefly illustrate new perspectives in this area. The development of innovative synthetic procedures will enable the facile synthesis of AIEgens with great structural ersity for multifunctional applications.
Publisher: American Chemical Society (ACS)
Date: 25-10-2021
Publisher: American Chemical Society (ACS)
Date: 27-12-2022
DOI: 10.1021/JACS.2C10076
Publisher: American Chemical Society (ACS)
Date: 31-05-2023
Publisher: American Chemical Society (ACS)
Date: 10-02-2023
DOI: 10.1021/JACS.2C12654
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D1QM00420D
Abstract: A natural AIE-active PS (PaH) is utilized to bind into DNA-T for cancer theranostics. The constructed PaH@DNA-T exhibits highly boosted fluorescence intensity and ROS generation, as well as much higher cell uptake efficiency.
Publisher: Wiley
Date: 18-03-2021
Abstract: Supramolecular approaches have opened up vast possibilities to construct versatile materials, especially those with stimuli‐responsiveness and integrated functionalities of multi‐modal diagnosis and synergistic therapeutics. In this study, a hybrid theranostic nanosystem named TTPY‐Py⊂CP5@AuNR is constructed via facile host–guest interactions, where TTPY‐Py is a photosensitizer with aggregation‐induced emission and CP5@AuNR represents the carboxylatopillar[5]arene (CP5)‐modified Au nanorods. TTPY‐Py⊂CP5@AuNR integrates the respective advantages of TTPY‐Py and CP5@AuNR such as the high performance of reactive oxygen species generation and photothermal conversion, and meanwhile shows fluorescence responses to both temperature and pH stimuli. The successful modification of CP5 macrocycles on AuNRs surfaces can eliminate the cytotoxicity of AuNRs and enable them to serve as the nanocarrier of TTPY‐Py for further theranostic applications. Significantly, in vitro and in vivo evaluations demonstrate that this supramolecular nanotheranostic system possesses multiple modalities including intensive fluorescence imaging (FLI), photoacoustic imaging (PAI), efficient photodynamic therapy (PDT), and photothermal therapy (PTT), indicating its great potential for FLI‐PAI imaging‐guided synergistic PDT‐PTT therapy. Moreover, TTPY‐Py can be released upon activation by the acidic environment of lysosomes and then specifically light up mitochondria. This study demonstrates a new strategy for the design of versatile nanotheranostics for accurate tumor imaging and cancer therapies.
Publisher: American Chemical Society (ACS)
Date: 22-08-2019
DOI: 10.1021/ACS.ACCOUNTS.9B00305
Abstract: Fluorescent sensing has emerged as a powerful tool for detecting various analytes and visualizing numerous biological processes by virtue of its superb sensitivity, rapidness, excellent temporal resolution, easy operation, and low cost. Of particular interest is activity-based sensing (ABS), a burgeoning sensing approach that is actualized on the basis of dynamic molecular reactivity rather than conventional lock-and-key molecular recognition. ABS has been recognized to possess some distinct advantages, such as high specificity, extraordinary sensitivity, and accurate signal outputs. A majority of ABS sensors are constructed by modifying conventional fluorogens, which are strongly emissive when molecularly dissolved in solvents but experience emission quenching upon aggregate formation or concentration increase. The aggregation-caused quenching (ACQ) phenomenon leads to a limited amount of labeling of the analyte with the sensor and low photobleaching resistance, which could impede practical applications of the ABS protocol. As an anti-ACQ phenomenon, aggregation-induced emission (AIE) provides a straightforward solution to the ACQ problem. Thanks to their intrinsic advantages, including high photobleaching threshold, high signal-to-noise ratio, fluorescence turn-on nature, and large Stokes shift, AIE-active luminogens (AIEgens) represent a class of extraordinary fluorogen alternatives for the ABS protocol. The use of AIEgen-involved ABS can integrate the advantages of AIEgens and ABS, and additionally, the AIE process offers some unique properties to the ABS approach. For instance, in some cases of water-soluble AIEgen-involved ABS, chemical reaction not only leads to a chang in the emission color of the AIEgens but also causes solubility variations, which could result in specific "light-up" signaling. In this Account, the basic concepts and mechanistic insights of the ABS approach involving the AIE principle are briefly summarized, and then we highlight the new breakthroughs, seminal studies, and trends in the area that have been most recently reported by our group. This emerging sensing protocol has been successfully utilized for detecting an array of targets including ions, small molecules, biomacromolecules, and microenvironments, all of which closely relate to human health, medical, and public concerns. These detections are smoothly achieved on the basis of various reactions (e.g., hydrolysis, boronate cleavage, dephosphorylation, addition, cyclization, and rearrangement reactions) through different sensing principles. In these studies, the AIEgen-involved ABS strategy generally shows good biocompatibility, high selectivity, excellent reliability and high signal contrast, strongly indicating its great potential for high-tech innovations in the sensing field, among which bioprobing is of particular interest. With this Account, we hope to spark new ideas and inspire new endeavors in this emerging research area, further promoting state-of-the-art developments in the field of sensing.
Publisher: American Chemical Society (ACS)
Date: 18-08-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D1MH01829A
Abstract: We present a facile strategy to activate ultralong RTP emissions of organic phosphors doped into H-bond crosslinked PVA films. The longest RTP lifetime of 1.74 s is obtained by tailoring the electrostatic and dispersion interactions.
Publisher: American Chemical Society (ACS)
Date: 09-10-2023
DOI: 10.1021/JACS.3C08627
Publisher: Wiley
Date: 21-07-2020
Publisher: Wiley
Date: 24-03-2020
Publisher: Wiley
Date: 06-2021
Abstract: Organic phosphors exhibiting room‐temperature phosphorescence (RTP) in amorphous phase are good candidates for optoelectronic and biomedical applications. In this proof‐of‐concept work, a rational strategy to activate wide‐color ranged and persistent RTP from amorphous films by embedding electron‐rich organic phosphor into electron‐deficient matrix polyacrylonitrile (PAN) is presented. Through tailoring noncovalent interactions between the electron‐deficient PAN matrix and electron‐rich organic phosphors, an ultralong lifetime of 968.1 ms is obtained for doped film TBB‐6OMe@PAN. Control experiments conducted on the polymers polymethyl methacrylate (PMMA) and polystyrene (PS) without electron‐withdrawing groups, and organic phosphors containing electron‐withdrawing groups indicate that the persistent RTP of doped films may be triggered by strong electrostatic interactions between electron‐deficient PAN and electron‐rich organic phosphor. Further theoretical calculations including electrostatic potential distributions, binding energies, and energy decomposing analysis demonstrate that both electrostatic and dispersion interactions between electron‐deficient PAN and electron‐rich organic phosphor are responsible for the activation of persistent RTP of doped films. In addition, the doped film TBB‐6OMe@PAN still maintains brightness even after soaking in water for 12 weeks. This excellent water resistance not only is favorable for future applications but also demonstrates an advantage of electrostatic and dispersion interactions over hydrogen bonding interactions.
Publisher: Wiley
Date: 29-05-2021
Abstract: In order to endow quasi‐2D organic‐inorganic hybrid metal halide perovskites (quasi‐2D‐PVK) with superior performance, an aromatic organic ligand with aggregation‐induced emission (AIE) features is rationally designed and utilized for constructing distinctive quasi‐2D‐PVK materials. This AIE‐active ligand, TTPy‐NH 2 , well fits into the lattices of quasi‐2D‐PVK and leaves hydrophobic tails surrounding PVK layers, making the presented TTPy‐NH 2 /PVK film extraordinary in terms of both luminescence and stability. Benefiting from the prominent sensitization function and AIE tendency of TTPy‐NH 2 , the presented TTPy‐NH 2 /PVK film exhibits a high quantum yield of 62.2%, unique blue‐red dual‐emission property of both blue and red, high stability with the remnant of more than 94% fluorescence intensity remnant after 21 days. As a result, TTPy‐NH 2 /PVK film is capable of constituting high‐performance white light‐emitting diodes, with its color gamut reaching 138% of the National Television System Committee (NTSC) standard and the maximum efficiency is 105 lm W −1 at 20 mA. Evidently, a win‐win effect is achieved by the integration of AIE‐active ligands and quasi‐2D‐PVK, which are two of the most reputable solid‐state luminogens. This developed protocol thus opens up a new avenue for exploring the next generation of luminescent devices.
Publisher: Wiley
Date: 26-07-2021
Abstract: Solar‐driven interfacial steam generation (SISG) has been recognized as a promising strategy to solve water shortages in an eco‐friendly and low‐cost way. However, the practical application of SISG is vitally restricted by some inherent limits, especially for finite evaporation rate and insufficient working life of evaporator. Herein, a novel SISG system involving an all‐fiber porous cylinder‐like foam 3D evaporator, side area‐assisted evaporation protocol, and aggregation‐induced‐emission‐active solar absorber with “one stone two birds” function is explored. The solar absorber exhibits efficient photothermal conversion, endowing the side area‐assisted evaporator with as high as 3.6 kg m −2 h −1 of solar evaporation rate, which is highly desirable for SISG under 1 sun of irradiation. Moreover, the solar absorber is capable of powerfully producing reactive oxygen species upon sunlight irradiation, which results in extraordinary photodynamic killing of bacteria nearby the fiber to prevent biofouling, consequently improving the working life of evaporator.
Publisher: Royal Society of Chemistry (RSC)
Date: 2023
DOI: 10.1039/D2SC05960F
Abstract: A catalyst-free multicomponent polymerization method was developed toward fluorescent polyoxadiazoles with ersified topological structures and applications in the facile formation and morphology visualization of microporous films and cell imaging.
Publisher: Wiley
Date: 20-03-2019
Publisher: American Chemical Society (ACS)
Date: 23-06-2022
DOI: 10.1021/JACS.2C04032
Abstract: The development of straightforward and efficient synthetic methods toward ring-fused heteroaromatic polymers with attractive functionalities has great significance in both chemistry and materials science. Herein, we develop a facile cascade C-H-activated polyannulation route that can in situ generate multiple ring-fused aza-heteroaromatic polymers from readily available monomers in an atom-economical manner. A series of complex polybenzimidazole derivatives with high absolute molecular weights of up to 24 000 are efficiently produced in high yields within 2 h. Benefiting from their unique imidazole-containing ring-fused structures with multiple aryl pendants, the obtained polymers show excellent thermal and morphological stability, good solution processability, high refractive index, small chromic dispersion, as well as remarkable acid-base-responsive fluorescence. Taking advantage of the ratiometric fluorescence response of the triphenylamine-substituted heteroaromatic polymer to pH variations, we successfully apply it as a sensitive fluorescence probe for the mapping and quantitative analysis of intracellular pH in live cells. Furthermore, through the simple
Publisher: American Chemical Society (ACS)
Date: 16-11-2202
Abstract: Utilizing nonplanar conjugated molecules as building blocks facilitates the development of self-assembly but is fundamentally challenging. To study the self-assembly behavior, we herein demonstrate the self-assembly process of a nonplanar conjugated molecule with aggregation-induced emission (AIE) feature from an isolated molecule to an irregular cluster to a well-defined vesicle driven by hiphiles. The superhigh aggregation-sensitive emission affords more precise and detailed information about the self-assembly process than traditional dyes. Meanwhile, the arrangements of the AIE-active molecule change from disordered to well-organized forms by reducing the twisted configuration during the transformation process, and the strong hydrophobicity of hiphiles is crucial for such configuration and morphology transformations. Owing to the thermophilic bacteria-mimetic membranes, the obtained vesicles exhibit a property of superhigh thermal stability. They also display promising light-harvesting applications. This work not only deciphers the self-assembly of AIE molecules but also provides a strategy for nonplanar molecules to build well-organized self-assemblies.
Publisher: Wiley
Date: 17-09-2020
Publisher: Wiley
Date: 06-10-2020
Publisher: American Chemical Society (ACS)
Date: 25-09-2019
DOI: 10.1021/JACS.9B07162
Abstract: Bacterial infectious diseases, especially those caused by Gram-positive bacteria, have been seriously threatening human health. Preparation of a multifunctional system bearing both rapid bacterial differentiation and effective antibacterial effects is highly in demand, but remains a severe challenge. Herein, we rationally designed and successfully developed a sequence of aggregation-induced emission luminogens (AIEgens) with orderly enhanced D-A strength. Evaluation of structure-function relationships reveals that AIEgens having intrinsic positive charge and proper ClogP value are able to stain Gram-positive bacteria. Meanwhile, one of the presented AIEgens (TTPy) can generate reactive oxygen species (ROS) in extraordinarily high efficiency under white light irradiation due to the smaller singlet-triplet energy gap. Thanks to the NIR emission, excellent specificity to Gram-positive bacteria, and effective ROS generation efficiency, TTPy has been proved to perform well in selective photodynamic killing of Gram-positive bacteria
Publisher: Elsevier BV
Date: 10-2021
Publisher: American Chemical Society (ACS)
Date: 26-05-2022
Publisher: Springer Science and Business Media LLC
Date: 11-01-2010
Publisher: American Chemical Society (ACS)
Date: 27-07-2021
Abstract: Personal protective equipment (PPE) is vital for the prevention and control of SARS-CoV-2. However, conventional PPEs lack virucidal capabilities and arbitrarily discarding used PPEs may cause a high risk for cross-contamination and environmental pollution. Recently reported photothermal or photodynamic-mediated self-sterilizing masks show bactericidal-virucidal abilities but have some inherent disadvantages, such as generating unbearable heat during the photothermal process or requiring additional ultraviolet light irradiation to inactivate pathogens, which limit their practical applications. Here, we report the fabrication of a series of fabrics (derived from various PPEs) with real-time self-antiviral capabilities, on the basis of a highly efficient aggregation-induced emission photosensitizer (namely, ASCP-TPA). ASCP-TPA possesses facile synthesis, excellent biocompatibility, and extremely high reactive oxygen species generation capacity, which significantly outperforms the traditional photosensitizers. Meanwhile, the ASCP-TPA-attached fabrics (ATaFs) show tremendous photodynamic inactivation effects against MHV-A59, a surrogate coronavirus of SARS-CoV-2. Upon ultralow-power white light irradiation (3.0 mW cm -2 ), .999% virions (5 log) on the ATaFs are eliminated within 10 min. Such ultralow-power requirement and rapid virus-killing ability enable ATaFs-based PPEs to provide real-time protection for the wearers under indoor light irradiation. ATaFs' virucidal abilities are retained after 100 washings or continuous exposure to office light for 2 weeks, which offers the benefits of reusability and long-term usability. Furthermore, ATaFs show no toxicity to normal skin, even upon continuous high-power light illumination. This self-antiviral ATaFs-based strategy may also be applied to fight against other airborne pathogens and holds huge potential to alleviate global PPE supply shortages.
Publisher: Wiley
Date: 21-05-2021
Abstract: Photodynamic therapy (PDT) has long been recognized to be a promising approach for cancer treatment. However, the high oxygen dependency of conventional PDT dramatically impairs its overall therapeutic efficacy, especially in hypoxic solid tumors. Exploration of distinctive PDT strategy involving both high‐performance less‐oxygen‐dependent photosensitizers (PSs) and prominent drug delivery system is an appealing yet significantly challenging task. Herein, a precise nuclear targeting PDT protocol based on type‐I PSs with aggregation‐induced emission (AIE) characteristics is fabricated for the first time. Of the two synthesized AIE PSs, TTFMN is demonstrated to exhibit superior AIE property and stronger type‐I reactive oxygen species (ROS) generation efficiency owing to the introduction of tetraphenylethylene and smaller singlet–triplet energy gap, respectively. With the aid of a lysosomal acid‐activated TAT‐peptide‐modified hiphilic polymer poly(lactic acid)12k–poly(ethylene glycol)5k–succinic anhydride‐modified TAT, the corresponding TTFMN‐loaded nanoparticles accompanied with acid‐triggered nuclear targeting peculiarity can quickly accumulate in the tumor site, effectively generate type‐I ROS in the nuclear region and significantly suppress the tumor growth under white light irradiation with minimized systematic toxicity. This delicate “Good Steel Used in the Blade” tactic significantly maximizes the PDT efficacy and offers a conceptual while practical paradigm for optimized cancer treatment in further translational medicine.
Publisher: Wiley
Date: 15-12-2020
Publisher: American Chemical Society (ACS)
Date: 13-07-2022
Abstract: The intense metabolism of cancer cells leads to hypoxia and lack of crucial nutrients in the tumor microenvironment, which hinders the function of immune cells. We designed a biomimetic immune metabolic nanoplatform, in which a type I aggregation-induced emission photosensitizer and a glutamine antagonist are encapsulated into a cancer cell membrane for achieving specific delivery
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2SC01260J
Abstract: A membrane-targeting photosensitizer TBMPEI with AIE properties was synthesized via a new acceptor, and it was utilized as a necroptosis inducer during imaging-guided photodynamic therapy.
Publisher: Wiley
Date: 11-10-2017
Publisher: American Chemical Society (ACS)
Date: 05-07-2202
DOI: 10.1021/JACS.2C03895
Abstract: The construction of supramolecular coordination complexes (SCCs) featuring prominent cancer theranostic functions is an appealing yet significantly challenging task. In this study, we rationally designed and facilely constructed a prism-like metallacage C-DTTP with efficient fluorescence emission in the second near-infrared (NIR-II) region through the assembly of an aggregation-induced emission-active four-arm ligand with 90° Pt acceptors Pt(PEt
Publisher: Wiley
Date: 20-03-2019
Abstract: The efficient utilization of energy dissipating from non-radiative excited-state decay of fluorophores was only rarely reported. Herein, we demonstrate how to boost the energy generation of non-radiative decay and use it for cancer theranostics. A novel compound (TFM) was synthesized which possesses a rotor-like twisted structure, strong absorption in the far red/near-infrared region, and it shows aggregation-induced emission (AIE). Molecular dynamics simulations reveal that the TFM aggregate is in an amorphous form consisting of disordered molecules in a loose packing state, which allows efficient intramolecular motions, and consequently elevates energy dissipation from the pathway of thermal deactivation. These intrinsic features enable TFM nanoparticles (NPs) to display a high photothermal conversion efficiency (51.2 %), an excellent photoacoustic (PA) effect, and effective reactive oxygen species (ROS) generation. In vivo evaluation shows that the TFM NPs are excellent candidates for PA imaging-guided phototherapy.
Publisher: Wiley
Date: 04-11-2020
Publisher: American Chemical Society (ACS)
Date: 26-06-2023
Publisher: Wiley
Date: 15-10-2018
Abstract: Aggregation-induced emission (AIE) luminogens (AIEgens) with red/near-infrared (NIR) emissions are appealing for applications in optoelectronics and biomedical engineering owing to their intrinsic advantages of efficient solid-state emission, low background, and deep tissue penetration. In this context, an AIEgen with long-wavelength emission is synthesized by introducing tetraphenylethene (TPE) to the periphery of electron-deficient spiro-benzo[d]imidazole-2,1'-cyclohexane (BI). The resulting AIEgen, abbreviated as 2TPE-BI, adopts a donor-acceptor structure and shows bathochromic absorption and emission with a larger Stokes shift of 157 nm in acetonitrile than that based on benzo[c][1,2,5]thiadiazole. It also exhibits a high solid-state fluorescence quantum yield of 56.6%. By further insertion of thiophene to its molecular structure generates 2TPE-2T-BI with higher conjugation and NIR emission. 2TPE-2T-BI can be fabricated into AIE dots for in vivo metabolic labeling through bio-orthogonal click chemistry. These results open a new approach for facile construction of long-wavelength emissive AIEgens based on the BI core.
Publisher: American Chemical Society (ACS)
Date: 13-01-2022
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9MH00906J
Abstract: Using a multiscale molecular modeling protocol, we proposed a design strategy of fluorescent probes to selectively target the cell membrane or mitochondria.
Publisher: American Chemical Society (ACS)
Date: 18-06-2020
Publisher: Wiley
Date: 10-07-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM00914H
Abstract: A near-infrared AIE probe was developed for super-resolution imaging and nuclear lipid droplets dynamic study with good biocompatibility and high photostability.
Publisher: Wiley
Date: 03-08-2021
Abstract: Phototheranostics based on luminogens with aggregation‐induced emission (AIE) characteristics is captivating increasing research interest nowadays. However, AIE luminogens are inherently featured by inferior absorption coefficients (ε) resulting from the distorted molecular geometry. Besides, molecular innovation of long‐wavelength light‐excitable AIE luminogens with highly efficient phototheranostic outputs is an appealing yet significantly challenging task. Herein, on the basis of a fused‐ring electron acceptor–donator–acceptor (A–D–A) type molecule (IDT) with aggregation‐caused quenching (ACQ) properties, molecular engineering smoothly proceeds and successfully yields a novel AIE luminogen (IDT‐TPE) via simply modifying tetraphenylethene (TPE) moieties on the sides of IDT backbone. The AIE tendency endows IDT‐TPE nanoparticles with enhanced fluorescence brightness and far superior fluorescence imaging performance to IDT nanoparticles for mice tumors. Moreover, IDT‐TPE nanoparticles exhibit near‐infrared light‐excitable features with a high ε of 8.9 × 10 4 m −1 cm −1 , which is roughly an order of magnitude higher than that of most previously reported AIE luminogens. Combining with their reactive oxygen species generation capability and extremely high photothermal conversion efficiency (59.7%), IDT‐TPE nanoparticles actualize unprecedented performance in multimodal phototheranostics. This study thus brings useful insights into the development of versatile phototheranostic materials with great potential for practical cancer theranostics.
Publisher: Wiley
Date: 22-08-2018
Abstract: Fluorescence-imaging-guided photodynamic therapy has emerged as a promising protocol for cancer theranostics. However, facile preparation of such a theranostic material for simultaneously achieving bright emission with long wavelength, high-performance reactive oxygen species (ROS) generation, and good targeting-specificity of cancer cells, is highly desirable but remains challenging. In this study, a novel type of far-red/near-infrared-emissive fluorescent molecules with aggregation-induced emission (AIE) characteristics is synthesized through a few steps reaction. These AIE luminogens (AIEgens) possess simple structures, excellent photostabilities, large Stokes shifts, bright emission, and good biocompatibilities. Meanwhile, their ROS generation is extremely efficient with up to 90.7% of ROS quantum yield, which is far superior to that of some popularly used photosensitizers. Importantly, these AIEgens are able to selectively target and ablate cancer cells over normal cells without the aid of any extra targeting ligands. Rather than using laser light, one of the presented AIEgens (MeTTPy) shows a remarkable tumor-targeting photodynamic therapeutic effect by using an ultralow-power l light (18 mW cm
Publisher: American Chemical Society (ACS)
Date: 30-10-2023
Publisher: American Chemical Society (ACS)
Date: 28-07-2022
DOI: 10.1021/JACS.2C06111
Abstract: Conducting crystallization-assisted self-assembly in living biosystems to obtain large-size nanoparticles and achieve a specific physiological purpose remains an appealing yet significantly challenging task. In this study, we designed Au(I)-disulfide nanosheets containing an aggregation-induced emission photosensitizer, namely, NSs@TTVP, which exhibited pH-responsive crystallization-driven self-assembly capability in lysosomes of cancer cells and tumor tissues of mice. The crystallization process endowed NSs@TTVP with a microscale morphology, stronger fluorescence output, and highly enhanced reactive oxygen species production efficiency. The
Publisher: Wiley
Date: 12-2020
DOI: 10.1002/AGT2.7
Abstract: Theranostics referring to the ingenious integration of diagnostics and therapeutics has garnered tremendous attention in these years as it provides a promising opportunity for modern personalized and precision medicine. By virtue of the good biocompatibility, outstanding fluorescence property, easy processability and functionalization, promoted photosensitizing efficiency, as well as facile construction of multi‐modality theranostics, fluorophores with aggregation‐induced emission (AIE) characteristics exhibit inexhaustible and vigorous vitality in the field of theranostics. Numerous significant breakthroughs and state‐of‐the‐art progression have been witnessed in the past few years. This review highlights the tremendous aggregation‐enhanced superiorities of AIE luminogens (AIEgens) in disease theranostics mainly involving diagnostic imaging (fluorescence and room temperature phosphorescence), therapeutic intervention (photodynamic therapy), and feasibility in construction of multi‐modality theranostics based on the experimental measurements and theoretical simulations. Additionally, the latest and advanced developments of AIEgens in disease theranostics in the aspect of corresponding strategies to design highly effective AIE‐active theranostics through triggering aggregation formation are comprehensively summarized. Moreover, a brief conclusion with the discussion of current challenges and future perspectives in this area is further presented.
Publisher: American Chemical Society (ACS)
Date: 20-02-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2022
DOI: 10.1039/D2TC01857H
Abstract: A facile strategy to achieve simple organic isomers featuring ersified emissive behaviors of AIE, TADF, RTP, dual-RTP, and ML via a subtle variation in the substitution position is presented for the first time.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0SC01843K
Abstract: The water-stable and pH-responsive Au( i )-disulfide NPs serve as a luminescent probe for monitoring intragastric acidity in an acid-suppressed therapy.
Publisher: American Chemical Society (ACS)
Date: 24-02-2023
Publisher: American Chemical Society (ACS)
Date: 20-07-2020
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9QM00242A
Abstract: Berberine chloride, an AIE-active natural product, can be utilized as a highly efficient theranostic agent for cancer and bacteria.
Publisher: Wiley
Date: 23-09-2020
Publisher: American Chemical Society (ACS)
Date: 02-04-2021
Publisher: Wiley
Date: 24-06-2021
Abstract: Graphene oxide (GO)‐based fluorescent DNA aptasensors are promising nanomaterials in bioassays owing to the fluorescent ultrasensitivity and target identification ability. However, their in vivo application remains an appealing yet significantly challenging task. In this contribution, for the first time, a nanomaterial for in vivo diagnosis and therapy of liver tumors is demonstrated. A DNA nanomaterial consisting of DNA tetrahedron and aptamers, aggregation‐induced emission luminogens, and antitumor drug doxorubicin, is fabricated and attached on the GO surface. This developed hybrid with good biocompatibility exhibits high selectivity to target liver cancer cells, and performs well in in vitro and in vivo liver tumor fluorescence imaging diagnosis and chemotherapy. Additionally, a GO‐based fluorescent DNA nanodevice is also constructed by using microfluidic chips for liver tumor cell screening.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C7SC04963C
Abstract: The first water-soluble NIR AIEgen was synthesized and used for ultrafast wash-free cellular imaging and photodynamic cancer cell ablation.
Publisher: Wiley
Date: 09-11-2020
Publisher: Wiley
Date: 19-12-2021
Abstract: Multidrug resistance (MDR) bacteria pose a serious threat to human health. The development of alternative treatment modalities and therapeutic agents for treating MDR bacteria‐caused infections remains a global challenge. Herein, a series of near‐infrared (NIR) anion– π + photosensitizers featuring aggregation‐induced emission (AIE‐PSs) are rationally designed and successfully developed for broad‐spectrum MDR bacteria eradication. Due to the strong intramolecular charge transfer (ICT) and enhanced highly efficient intersystem crossing (ISC), these electron‐rich anion– π + AIE‐PSs show boosted type I reactive oxygen species (ROS) generation capability involving hydroxyl radicals and superoxide anion radicals, and up to 99% photodynamic killing efficacy is achieved for both Methicillin‐resistant Staphylococcus aureus (MRSA) and multidrug resistant Escherichia coli (MDR E. coli ) under a low dose white light irradiation (16 mW cm −2 ). In vivo experiments confirm that one of these AIE‐PSs exhibit excellent therapeutic performance in curing MRSA or MDR E. coli ‐infected wounds with negligible side‐effects. The study would thus provide useful guidance for the rational design of high‐performance type I AIE‐PSs to overcome antibiotic resistance.
No related grants have been discovered for Dong Wang.