ORCID Profile
0000-0001-8302-9893
Current Organisation
The University of Edinburgh
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Publisher: Springer Science and Business Media LLC
Date: 31-05-2016
Publisher: Elsevier BV
Date: 12-2007
Publisher: Springer Science and Business Media LLC
Date: 22-10-2015
DOI: 10.1038/NCOMMS9772
Abstract: Nature Communications 5: Article number: 5488 (2014) Published: 25 November 2014 Updated: 22 October 2015. The affiliation details for Mark Blaxter are incorrect in this Article. The correct affiliation details for this author are given below: Centre for Immunity, Infection and Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3FL, UK.
Publisher: Proceedings of the National Academy of Sciences
Date: 06-05-2015
Abstract: Plant roots function as an interface between plants and the complex soil environment. Root systems of higher plants consist of different root types (RTs) that maximize their adaptive potential in heterogenous soil for nutrient uptake and anchorage. This study pioneers the molecular examination of in idual RTs of adult rice root systems. The global signature of the transcriptional activity of each RT reveals significant quantitative and qualitative differences that predict functional ersity and specialization. Interaction with naturally prevalent beneficial mycorrhizal fungi profoundly modulated the relationship across the RTs such that the crown root transcriptome resembled that of lateral roots. The alteration of secondary cell wall synthesis in colonized roots is consistent with previously reported changes in root system architecture of mycorrhizal plants.
Publisher: Rockefeller University Press
Date: 06-10-2014
DOI: 10.1084/JEM.20140338
Abstract: A single microRNA (miRNA) can regulate the expression of many genes, though the level of repression imparted on any given target is generally low. How then is the selective pressure for a single miRNA/target interaction maintained across long evolutionary distances? We addressed this problem by disrupting in vivo the interaction between miR-155 and PU.1 in mice. Remarkably, this interaction proved to be key to promoting optimal T cell–dependent B cell responses, a previously unrecognized role for PU.1. Mechanistically, miR-155 inhibits PU.1 expression, leading to Pax5 down-regulation and the initiation of the plasma cell differentiation pathway. Additional PU.1 targets include a network of genes whose products are involved in adhesion, with direct links to B–T cell interactions. We conclude that the evolutionary adaptive selection of the miR-155–PU.1 interaction is exercised through the effectiveness of terminal B cell differentiation.
Publisher: Springer Science and Business Media LLC
Date: 25-11-2014
DOI: 10.1038/NCOMMS6488
Abstract: In mammalian systems RNA can move between cells via vesicles. Here we demonstrate that the gastrointestinal nematode Heligmosomoides polygyrus , which infects mice, secretes vesicles containing microRNAs (miRNAs) and Y RNAs as well as a nematode Argonaute protein. These vesicles are of intestinal origin and are enriched for homologues of mammalian exosome proteins. Administration of the nematode exosomes to mice suppresses Type 2 innate responses and eosinophilia induced by the allergen Alternaria. Microarray analysis of mouse cells incubated with nematode exosomes in vitro identifies Il33r and Dusp1 as suppressed genes, and Dusp1 can be repressed by nematode miRNAs based on a reporter assay. We further identify miRNAs from the filarial nematode Litomosoides sigmodontis in the serum of infected mice, suggesting that miRNA secretion into host tissues is conserved among parasitic nematodes. These results reveal exosomes as another mechanism by which helminths manipulate their hosts and provide a mechanistic framework for RNA transfer between animal species.
Publisher: Elsevier BV
Date: 03-2014
Publisher: Frontiers Media SA
Date: 19-05-2015
Location: United Kingdom of Great Britain and Northern Ireland
Location: Mexico
No related grants have been discovered for Cei Abreu-Goodger.