ORCID Profile
0000-0001-8071-8079
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Publisher: Wiley
Date: 17-02-2016
Abstract: Anionic surfactants are widely used in daily life and industries, but their residues can cause serious damage to the environment. The current detection methods for anionic surfactants suffer from various limitations and a new detection strategy is highly desirable. Based on 2-(2-hydroxyphenyl)benzothiazole fluorogen with aggregation-induced emission characteristics, we have developed a fluorescent probe HBT-C18 for selective and sensitive detection of anionic surfactants. By in situ formation of catanionic aggregates or micelles with anionic surfactants, the emission intensity of the HBT-C18 probe can increase with increasing keto/enol emission ratio through restriction of intramolecular motion and excited-state intramolecular proton-transfer mechanisms. The probe can also be used for wash-free imaging of bacteria enveloped by a negatively charged outer membrane. The results of this study provide a new strategy for sensitive detection of anionic surfactants and wash-free bacterial imaging.
Publisher: Wiley
Date: 08-08-2022
Abstract: Immunogenic cell death (ICD) can activate the anticancer immune response and is highly attractive to improve cancer treatment efficacy. ICD is closely related to endoplasmic reticulum (ER) stress, and a series of ICD inducers has recently been reported based on ER‐targeted photodynamic hotothermal agents or metal complexes. However, these ER‐targeted ICD inducers suffer from complicated synthesis and heavy‐metal cytotoxicity. Inspired by the promising clinical potential of small organic molecules, herein, an ER‐targeted fluorescent self‐reporting ICD inducer, SA‐Cbl, is developed by simple conjugation of the chemotherapeutic drug chlorambucil (Cbl) with salicylaldehyde (SA). SA‐Cbl can selectively accumulate in the ER to induce rapid ROS generation and an unfolded protein response process, which leads to a fast release of damage‐associated molecular patterns and efficient dendritic cells maturation. Meanwhile, the ER‐targeted accumulation and ER‐stress‐inducing process can be in situ monitored based on the turn‐on fluorescence of SA‐Cbl, which is highly pH‐ and polarity‐sensitive and can selectively interact with ER proteins. Compared with the traditional chemotherapy drug doxorubicin, the superior anticancer immunity effect of SA‐Cbl is verified via an in vivo tumor model. This study thus provides a new strategy for developing fluorescent self‐reporting ICD inducers by decoration of chemotherapeutic drugs with pH and polarity‐sensitive organic fluorophores.
Publisher: American Chemical Society (ACS)
Date: 21-11-2022
DOI: 10.1021/ACS.JMEDCHEM.2C01262
Abstract: Cancer therapies usually suffer from poor targeting ability and serious side effects. Photoactivatable cancer therapy has the significant advantage of a high spatiotemporal resolution, but most photoactivatable prodrugs require decoration with stoichiometric photocleavable groups, which are only responsive to ultraviolet irradiation and suffer from low reaction efficiency. To tackle these challenges, we herein propose a photoactivation strategy with biogenic riboflavin as the photosensitizer to promote the in situ transformation of noncytotoxic dihydroalkaloid prodrugs dihydrochelerythrine (DHCHE), dihydrosanguinarine (DHSAN), and dihydronitidine (DHNIT) into anticancer alkaloid drugs chelerythrine (CHE), sanguinarine (SAN), and nitidine (NIT), respectively, which can efficiently kill cancer cells and inhibit in vivo tumor growth. Meanwhile, the photoactivatable transformation can be in situ monitored by green-to-red fluorescence conversion, which will contribute to easy controlling of the therapeutic dose. The proposed photoactivatable transformation mechanism was also explored by density functional theory (DFT) calculations. We believe this riboflavin-promoted and imaging-guided photoactivation strategy is promising for precise cancer therapy.
Publisher: Wiley
Date: 13-11-2019
Abstract: Two-photon photodynamic therapy (TP-PDT) is emerging as a powerful strategy for stereotactic targeting of diseased areas, but ideal photosensitizers (PSs) are currently lacking. This work reports a smart PS with aggregation-induced emission (AIE) feature, namely DPASP, for TP-PDT with excellent performances. DPASP exhibits high affinity to mitochondria, superior photostability, large two-photon absorption cross section as well as efficient reactive oxygen species generation, enabling it to achieve photosensitization both in vitro and in vivo under two-photon excitation. Moreover, its capability of stereotactic ablation of targeted cells with high-precision is also successfully demonstrated. All these merits make DPASP a promising TP-PDT candidate for accurate ablation of abnormal tissues with minimal damages to surrounding areas in the treatment of various diseases.
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2CC33780K
Abstract: Melding a benzothiazolium unit with tetraphenylethene generates a new hemicyanine luminogen with aggregation-induced emission characteristics the luminogen exhibits crystochromism and its solid-state emission can be repeatedly tuned from yellow or orange to red by grinding-fuming or grinding-heating processes due to the transformation from the crystalline to the amorphous state and vice versa.
Publisher: American Chemical Society (ACS)
Date: 24-07-2023
Publisher: American Chemical Society (ACS)
Date: 19-04-2018
Abstract: The fluorescent probe for the detection of calcium ions is an indispensable tool in the biomedical field. The millimolar order of Ca(II) ions is associated with many physiological processes and diseases, such as hypercalcemia, soft tissue calcification, and bone microcracks. However, the conventional fluorescent probes are only suitable for imaging Ca(II) ions in the nanomolar to micromolar range, which can be because of their high affinities toward Ca(II) ions and aggregation-caused quenching drawbacks. To tackle this challenge, we herein develop an aggregation-induced emission (AIE) probe SA-4CO
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/C9QM00732F
Abstract: A smart AIEgen has been developed to rapidly (5 minutes) and precisely differentiate fungal viability in a wash-free manner.
Publisher: American Chemical Society (ACS)
Date: 25-09-2017
DOI: 10.1021/ACSSENSORS.7B00551
Abstract: Fluorescent sensors with advantages of excellent sensitivity, rapid response, and easy operation are emerging as powerful tools in environmental monitoring, biological research, and disease diagnosis. However, conventional fluorophores featured with π-planar structures usually suffer from serious self-quenching in the aggregated state, poor photostability, and small Stokes' shift. In contrast to conventional aggregation-caused quenching (ACQ) fluorophores, the newly emerged aggregation-induced emission fluorogens (AIEgens) are featured with high emission efficiency in the aggregated state, which provide unique opportunities for various sensing applications with advantages of high signal-to-noise ratio, strong photostability, and large Stokes' shift. In this review, we will first briefly give an introduction of the AIE concept and the turn-on sensing principles. Then, we will discuss the recent ex les of AIE sensors according to types of analytes. Finally, we will give a perspective on the future developments of AIE sensors. We hope this review will inspire more endeavors to devote to this emerging world.
Publisher: American Chemical Society (ACS)
Date: 22-03-2018
Abstract: Multidrug resistant bacterial infection has become one of the most serious threats to human health. Antimicrobial peptides (AMPs) have been identified as potential alternatives to antibiotics owing to their excellent bactericidal activity. However, the complicated bactericidal mechanism of AMPs is still poorly understood. Fluorescence imaging has many advantages in terms of dynamic monitoring, easy operation, and high sensitivity. In this study, we developed an aggregation-induced emission (AIE)-active probe AMP-2HBT by decorating the antimicrobial peptide HHC36 (KRWWKWWRR) with an AIEgen of 2-(2-hydroxyphenyl)benzothiazole (HBT). This AIE-active probe exhibited an excellent light-up fluorescence after binding with bacteria, enabling a real-time monitoring of the binding process. Moreover, a similar time-dependent bactericidal kinetics was observed for the AIE-active probe and HHC36 peptide, which indicated that the bactericidal activity of the peptide was not compromised by decorating with the AIEgen. The bactericidal mechanism of HHC36 peptide was further investigated by super-resolution fluorescence microscopy, transmission electron microscopy (TEM), and scanning electron microscopy (SEM), which suggested that the probe tended to accumulate on the bacterial membrane and efficiently disrupt the membrane structure to kill both Gram-positive and -negative bacteria. This AIE-active probe thus provided a convenient tool to investigate the bactericidal mechanism of AMPs.
Publisher: Royal Society of Chemistry (RSC)
Date: 2018
DOI: 10.1039/C8SC01887A
Abstract: Photoactivatable fluorescent probes are ideal tools for organelle study with a significant advantage of high spatiotemporal resolution.
Publisher: Wiley
Date: 17-04-2020
Publisher: Wiley
Date: 04-03-2023
Publisher: Royal Society of Chemistry (RSC)
Date: 2017
DOI: 10.1039/C6SC04842K
Abstract: Photoactivatable probes for lipid droplets (LDs)-specific live-cell imaging are powerful tools for investigating their biological functions through precise spatial and temporal control.
Publisher: Royal Society of Chemistry (RSC)
Date: 2021
DOI: 10.1039/D0QM00947D
Abstract: A photo-triggered Zn 2+ release system was developed based on HBTH–Zn–TAT NPs, which showed an excellent light-dependent “on–off” performance for Zn 2+ release and the precise regulation of extra- and intracellular zinc enzyme activities.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9CC02782C
Abstract: We develop a dual detection strategy for bioaccumulated Hg 2+ based on turn-off of the bioluminescence of P. phosphoreum bacteria by disrupting the quorum sensing system and turn-on of the photoluminescence of an aggregation-induced emission (AIE) probe by forming aggregates with Hg 2+ inside the bacteria.
Publisher: Royal Society of Chemistry (RSC)
Date: 2019
DOI: 10.1039/C9TB00121B
Abstract: An AIE-active probe of Cur-N-BF 2 is developed for light-up detection of Aβ fibrils and plaques, inhibition of Aβ fibrillation, disassembly of preformed Aβ fibrils, and protection of neuronal cells.
Publisher: Royal Society of Chemistry (RSC)
Date: 2020
DOI: 10.1039/D0MH00931H
Abstract: A photoactivatable strategy is proposed for precise cancer therapy based on photooxidative dehydrogenation reaction, which is demonstrated with the natural dihydroalkaloids of DHCHE and DHSAN as an ex le.
Publisher: Wiley
Date: 11-02-2013
Abstract: Chitosan with tetraphenylethene pendants (TPE-CS) are synthesized by reaction between amine and isothiocyanate groups of chitosan and tetraphenylethene (TPE), respectively. Nanoparticles of TPE-CS (TPE-CS NPs) are fabricated by ionic gelation method. The NPs are uniform in size, spherical in shape, monodispersed, and positive in surface charge. The suspension of TPE-CS NPs emits strong blue fluorescence under photoexcitation due to the aggregation-induced emission characteristics of the TPE moieties. The NPs can be internalized into cytoplasm through endocytosis pathway and retain inside the live cells to image the cells. Cytotoxicity assay reveals that TPE-CS NPs are cytocompatible and thus can be used for long-term live cell imaging.
No related grants have been discovered for Meng Gao.