ORCID Profile
0000-0001-7266-6547
Current Organisations
University of Liverpool
,
National Institute for Health Research (NIHR) Health Protection Research Unit in Emerging and Zoonotic Infections
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Publisher: WHO Press
Date: 19-04-2010
Publisher: Public Library of Science (PLoS)
Date: 11-03-2015
Publisher: Oxford University Press (OUP)
Date: 15-01-2001
DOI: 10.1086/318479
Abstract: Dengue hemorrhagic fever is an important cause of morbidity among Asian children, and the more severe dengue shock syndrome (DSS) causes a significant number of childhood deaths. DSS is characterized by a massive increase in systemic capillary permeability with consequent hypovolemia. Fluid resuscitation is critical, but as yet there have been no large trials to determine the optimal fluid regimen. We undertook a randomized blinded comparison of 4 fluids (dextran, gelatin, lactated Ringer's, and "normal" saline) for initial resuscitation of 230 Vietnamese children with DSS. All the children survived, and there was no clear advantage to using any of the 4 fluids, but the longest recovery times occurred in the lactated Ringer's group. The most significant factor determining clinical response was the pulse pressure at presentation. A comparison of the colloid and crystalloid groups suggested benefits in children presenting with lower pulse pressures who received one of the colloids. Further large-scale studies, stratified for admission pulse pressure, are indicated.
Publisher: BMJ
Date: 24-10-2014
DOI: 10.1136/BMJ.G6443
Publisher: Informa UK Limited
Date: 2019
Publisher: Informa UK Limited
Date: 10-2006
Publisher: Frontiers Media SA
Date: 13-10-2017
Publisher: Springer Science and Business Media LLC
Date: 19-05-2023
Publisher: Elsevier BV
Date: 04-2008
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Location: United Kingdom of Great Britain and Northern Ireland
Start Date: 2017
End Date: 2021
Funder: Biotechnology and Biological Sciences Research Council
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