ORCID Profile
0000-0003-0733-3513
Current Organisation
The University of Edinburgh
Does something not look right? The information on this page has been harvested from data sources that may not be up to date. We continue to work with information providers to improve coverage and quality. To report an issue, use the Feedback Form.
Publisher: American Chemical Society (ACS)
Date: 09-2010
DOI: 10.1021/CM101408N
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C0JM03061A
Publisher: Royal Society of Chemistry (RSC)
Date: 2011
DOI: 10.1039/C1CE05194F
Publisher: Elsevier BV
Date: 03-2010
DOI: 10.1016/J.EJPS.2010.01.011
Abstract: DNA vaccines or proteins are capable of inducing specific immunity however, the translation to the clinic has generally been problematic, primarily due to the reduced magnitude of immune response and poor pharmacokinetics. Herein we demonstrate a composite microsphere formulation, composed of mesoporous silica spheres (MPS) and poly(D,L-lactide-co-glycolide) (PLGA), enables the controlled delivery of a prime-boost vaccine via the encapsulation of plasmid DNA (pDNA) and protein in different compartments. Method with modified dual-concentric-feeding needles attached to a 40 kHz ultrasonic atomizer was studied. These needles focus the flow of two different solutions, which passed through the ultrasonic atomizer. The process synthesis parameters, which are important to the scale-up of composite microspheres, were also studied. These parameters include polymer concentration, feed flowrate, and volumetric ratio of polymer and pDNA-PEI/MPS-BSA. This fabrication technique produced composite microspheres with mean D[4,3] ranging from 6 to 34 microm, depending upon the microsphere preparation. The resultant physical morphology of composite microspheres was largely influenced by the volumetric ratio of pDNA-PEI/MPS-BSA to polymer, and this was due to the precipitation of MPS at the surface of the microspheres. The encapsulation efficiencies were predominantly in the range of 93-98% for pDNA and 46-68% for MPS. In the in vitro studies, the pDNA and protein showed different release kinetics in a 40 day time frame. The dual-concentric-feeding in ultrasonic atomization was shown to have excellent reproducibility. It was concluded that this fabrication technique is an effective method to prepare formulations containing a heterologous prime-boost vaccine in a single delivery system.
Publisher: IEEE
Date: 02-2010
Publisher: Elsevier BV
Date: 2009
Publisher: Elsevier BV
Date: 02-2010
Publisher: Royal Society of Chemistry (RSC)
Date: 2012
DOI: 10.1039/C2CC17378F
Abstract: Growth of silicalite with graphene oxide (GO) nanosheets occurred via attachment of GO onto the silicalite surface, and entrapment of GO nanosheets inside single crystals. Electrically conductive composites were produced by calcination in nitrogen whereas silicalite crystals with slit-like mesopores of sizes 20-25 Å were obtained after GO burn-off.
Publisher: Royal Society of Chemistry (RSC)
Date: 2009
DOI: 10.1039/B900874H
Publisher: Elsevier BV
Date: 12-2008
Publisher: Wiley
Date: 21-11-2012
DOI: 10.1002/APP.35356
Publisher: Royal Society of Chemistry (RSC)
Date: 2010
DOI: 10.1039/C0JM01003K
Location: United Kingdom of Great Britain and Northern Ireland
Location: United States of America
No related grants have been discovered for Yi Huang.