ORCID Profile
0000-0002-6111-6280
Current Organisation
Victoria University of Wellington
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Publisher: Wiley
Date: 04-04-2012
DOI: 10.1111/J.1742-6723.2012.01550.X
Abstract: Access block (AB) and hospital overcrowding adversely affect ED functionality. ED throughput measures have been described in the literature with positive impacts on key performance indicators (KPIs)--time to first seen, did-not-wait rates, off-stretcher times for ambulances and ED length of stay figures. In this study, we aimed to assess the impact of a new model of care, the Senior Streaming Assessment Further Evaluation after Triage (SAFE-T) zone concept on ED performance indicators and statistical outcomes. We implemented a model of care at our tertiary hospital ED amalgamating multiple ED throughput interventions. These interventions included dynamic transition waiting room concept, early senior ED physician assessment and decision-making, early streaming, acute-care bed quarantining and ED short stay and observation units. The principal intervention was the SAFE-T zone. End-point data were compared for similar periods (77 days) of 2010 and 2011 with and without the new model of care. In total, 11 408 and 11 845 patients were included in the study periods pre- and post-intervention, respectively. Time to physician KPI improved from 72.5% to 84.1%. Did-not-wait rates dropped from 10.7% to 9.6% (P= 0.02) and off-stretcher times for ambulances KPI improved from 74.5% to 79.5% (P < 0.001). ED length of stay dropped most significantly for Australasian Triage Scale categories 3 and 4 (14.3% and 11.8%, P-values <0.001). These results were achieved despite worsened AB and hospital bed-occupancy rates during the intervention period (+3.9% and +6.7%). The SAFE-T zone model of care involving multiple ED throughput measures achieved improvements in ED performance despite AB and hospital overcrowding.
Publisher: Public Library of Science (PLoS)
Date: 31-10-2014
Publisher: IEEE
Date: 05-2014
Publisher: AIP
Date: 2011
DOI: 10.1063/1.3658164
Publisher: Elsevier BV
Date: 12-2013
Publisher: IEEE
Date: 10-2009
Publisher: IEEE
Date: 02-2010
Publisher: Informa UK Limited
Date: 02-09-2013
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 02-2023
Publisher: AIP
Date: 2011
DOI: 10.1063/1.3658163
Publisher: IEEE
Date: 03-2012
Publisher: IOP Publishing
Date: 25-03-2015
Publisher: Public Library of Science (PLoS)
Date: 16-11-2015
Publisher: IEEE
Date: 05-2010
Publisher: Elsevier BV
Date: 2014
Abstract: Cardiac toxicity an uncommon but serious side-effect of some fluoropyrimides. Cardiac toxicity from raltitrexed is rarely reported. With this background, we initiated this study to investigate the incidence of cardiac events in patients who had switched to raltitrexed following cardiac toxicity from fluoropyrimidines (5-fluorouracil or capecitabine). Pharmacy records were used to identify patients receiving raltitrexed from January 2004 till March 2012. Medical records were then reviewed to confirm the use of raltitrexed after cardiac toxicity from 5-fluorouracil or capecitabine. The primary end point was the rate of further cardiac events after commencing raltitrexed. Forty-two patients were identified and the majority had colorectal cancer. Prior regimens included 5-fluorouracil ± leucovorin, capecitabine alone, FOLFOX, FOLFIRI, epirubicin/cisplatin/5-fluorouracil, and capecitabine/oxaliplatin. Seven patients (17%) had bolus 5-fluorouracil regimens, 26 patients (62%) had infusion 5-fluorouracil regimens, and 9 patients (21%) had capecitabine alone or in combination. Angina was the most common cardiac toxicity from 5-fluorouracil or capecitabine and usually occurred in the first or the second cycle. Four patients after their first cardiac event continued with the same 5-fluorouracil or capecitabine regimen with the addition of nitrates and calcium antagonists but still had further cardiac events. After changing to raltitrexed, either as a single agent or a continuing combination regimen, no patients experienced further cardiac toxicity. Raltitrexed is associated with no significant cardiac toxicity in patients who have experienced prior cardiac toxicity from 5-fluorouracil or capecitabine. Raltitrexed, alone or in combination with oxaliplatin or irinotecan, provides a safe option in terms of cardiac toxicity for such patients.
Publisher: Elsevier BV
Date: 10-2012
DOI: 10.1016/J.MEDENGPHY.2012.06.017
Abstract: The Cochlear Microphonic is one of the electrical potentials generated by the ear in response to audible stimuli. It is very difficult to measure the CM non-invasively because it has a very small magnitude (less than 1 μV). A high Common Mode Rejection Ratio (CMRR) and very large bandwidth (5 Hz-20 kHz) biomedical lifier system is presented to measure the signal. The system also uses a driven right leg circuit to increase the CMRR.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2002
Publisher: Springer Science and Business Media LLC
Date: 07-03-2011
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2013
Publisher: Hindawi Limited
Date: 2014
DOI: 10.1155/2014/150637
Abstract: The cochlea plays a crucial role in mammal hearing. The basic function of the cochlea is to map sounds of different frequencies onto corresponding characteristic positions on the basilar membrane (BM). Sounds enter the fluid-filled cochlea and cause deflection of the BM due to pressure differences between the cochlear fluid chambers. These deflections travel along the cochlea, increasing in litude, until a frequency-dependent characteristic position and then decay away rapidly. The hair cells can detect these deflections and encode them as neural signals. Modelling the mechanics of the cochlea is of help in interpreting experimental observations and also can provide predictions of the results of experiments that cannot currently be performed due to technical limitations. This paper focuses on reviewing the numerical modelling of the mechanical and electrical processes in the cochlea, which include fluid coupling, micromechanics, the cochlear lifier, nonlinearity, and electrical coupling.
Publisher: AIP
Date: 2011
DOI: 10.1063/1.3658158
Publisher: IEEE
Date: 10-2009
Publisher: IEEE
Date: 03-2011
DOI: 10.1109/AINA.2011.34
Publisher: IEEE
Date: 12-2011
Publisher: Elsevier BV
Date: 11-2013
DOI: 10.1016/J.EJCA.2013.06.046
Abstract: Anthracycline agents are undermined by their cardiotoxicity. As life expectancy following treatment is greatly improved, techniques that ensure early detection and timely management of cardiotoxicity are essential. The aim of the present study was to evaluate left ventricular (LV) systolic function with LV ejection fraction (LVEF) and two-dimensional myocardial strain up to 12 months after anthracycline chemotherapy, specifically in HER2/neu negative breast cancer patients. Seventy-eight consecutive anthracycline naïve breast cancer patients were studied before and immediately after anthracycline chemotherapy. Fifty HER2/neu negative patients were studied over 12 months with serial echocardiograms at four time points. All patients were treated with standard regimens containing anthracyclines. Global systolic strain was significantly reduced immediately after, and 6 months after anthracyclines (-19.0 ± 2.3% to -17.5 ± 2.3% (P<0.001) and -18.2 ± 2.2% (P=0.01) respectively). A non-uniform reduction in strain was observed each time with relative sparing of the LV apex. LVEF remained largely unchanged at both time points. Global strain normalised by 12 months in the majority of patients. Persistently reduced strain was observed in 16% (n=8) these patients had a greater reduction in strain at 6 months (≤ -17.2%), and had received higher cumulative anthracycline doses. Myocardial strain imaging is more sensitive than LVEF for the early detection and intermediate term monitoring of LV systolic function following anthracycline chemotherapy in HER2/neu negative breast cancer patients, and may aid in the development of improved monitoring protocols.
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2022
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2004
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 02-2007
Publisher: American Medical Association (AMA)
Date: 04-09-2018
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 06-2018
Publisher: IEEE
Date: 04-2015
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 10-2014
DOI: 10.1161/CIRCEP.113.001112
Abstract: Cardiac and respiratory movements cause catheter instability. Lateral catheter sliding over target endocardial surface can lead to poor tissue contact and unpredictable lesion formation. We describe a novel method of overcoming the effects of lateral catheter sliding movements using an electrogram-gated pulsed power ablation. All ablations were performed on a thermochromic gel myocardial phantom. Ablation settings were randomized to conventional (nongated) 30 W versus electrogram-gated at 20% duty cycle (30 W average power) at 0-, 3-, 6-, and 9-mm lateral sliding distances. Forty-eight radiofrequency ablations were performed. Deeper lesions were created in electrogram-gated versus conventional ablations at 3 mm (4.36±0.08 versus 4.05±0.17 mm P =0.009), 6 mm (4.39±0.10 versus 3.44±0.15 mm P .001), and 9 mm (4.41±0.06 versus 2.94±0.16 mm P .001) sliding distances. Electrogram-gated ablations created consistent lesions at a quicker rate of growth in depth when compared with conventional ablations ( P .001). (1) Lesion depth decreases and length increases in conventional ablations with greater degrees of lateral catheter movements (2) electrogram-gated pulsed radiofrequency delivery negated the effects from lateral catheter movement by creating consistently deeper lesions irrespective of the degree of catheter movement and (3) target lesion depths were reached significantly faster in electrogram-gated than in conventional ablations.
Publisher: IEEE
Date: 06-2013
Publisher: Annals of Laboratory Medicine
Date: 2014
Publisher: IEEE
Date: 06-2009
Publisher: AIP Publishing LLC
Date: 2015
DOI: 10.1063/1.4939334
Publisher: Public Library of Science (PLoS)
Date: 30-09-2015
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 12-2015
Publisher: AIP
Date: 2011
DOI: 10.1063/1.3658137
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2021
Publisher: IEEE
Date: 06-2012
Publisher: AIP
Date: 2011
DOI: 10.1063/1.3658090
Publisher: IEEE
Date: 05-2014
Publisher: IEEE
Date: 06-2014
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 2016
Publisher: IEEE
Date: 03-2011
Publisher: IEEE
Date: 09-2013
Publisher: Acoustical Society of America (ASA)
Date: 06-2011
DOI: 10.1121/1.3589481
Abstract: A spherical harmonic expansion for the sound field due to a rotating oscillating point source has recently been derived. This paper provides further confirmation of the expansion results by comparing it with two known numerical approaches to determining the sound field. In the advanced time approach—applicable for Mach numbers below 1—the sound at transmission time determines the field at an observation point from the distance from source to observation point at the transmission time. In the retarded time approach the field at the observation point at the observation time is determined by solving for the retarded transmission times. The results from all three approaches are shown to be in good agreement. Expressions for the far-field instantaneous frequency are also derived and shown to agree with previous work.
Publisher: IEEE
Date: 2012
Publisher: IEEE
Date: 05-2010
Publisher: IEEE
Date: 07-2013
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 11-2014
Publisher: IEEE
Date: 12-2013
Publisher: IEEE
Date: 2013
Publisher: IEEE
Date: 06-2014
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 1998
DOI: 10.1109/22.739297
Publisher: IEEE
Date: 12-2008
Publisher: IEEE
Date: 12-2008
Publisher: Wiley
Date: 14-02-2015
DOI: 10.1111/JCE.12598
Abstract: Steam pop is an explosive rupture of cardiac tissue caused by tissue overheating above 100 °C, resulting in steam formation, predisposing to serious complications associated with radiofrequency (RF) ablations. However, there are currently no reliable techniques to predict the occurrence of steam pops. We propose the utility of acoustic signals emitted during RF ablation as a novel method to predict steam pop formation and potentially prevent serious complications. Radiofrequency generator parameters (power, impedance, and temperature) were temporally recorded during ablations performed in an in vitro bovine myocardial model. The acoustic system consisted of HTI-96-min hydrophone, microphone pre lifier, and sound card connected to a laptop computer. The hydrophone has the frequency range of 2 Hz to 30 kHz and nominal sensitivity in the range -240 to -165 dB. The sound was s led at 96 kHz with 24-bit resolution. Output signal from the hydrophone was fed into the camera audio input to synchronize the video stream. An automated system was developed for the detection and analysis of acoustic events. Nine steam pops were observed. Three distinct sounds were identified as warning signals, each indicating rapid steam formation and its release from tissue. These sounds had a broad frequency range up to 6 kHz with several spectral peaks around 2-3 kHz. Subjectively, these warning signals were perceived as separate loud clicks, a quick succession of clicks, or continuous squeaking noise. Characteristic acoustic signals were identified preceding 80% of pops occurrence. Six cardiologists were able to identify 65% of acoustic signals accurately preceding the pop. An automated system identified the characteristic warning signals in 85% of cases. The mean time from the first acoustic signal to pop occurrence was 46 ± 20 seconds. The automated system had 72.7% sensitivity and 88.9% specificity for predicting pops. Easily identifiable characteristic acoustic emissions predictably occur before imminent steam popping during RF ablations. Such acoustic emissions can be carefully monitored during an ablation and may be useful to prevent serious complications during RF delivery.
Publisher: IEEE
Date: 05-2011
Publisher: BMJ
Date: 2018
Publisher: Elsevier BV
Date: 2014
Publisher: IEEE
Date: 05-2008
Publisher: IEEE
Date: 2010
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 09-2014
Publisher: Wiley
Date: 10-07-2018
DOI: 10.1111/JOSH.12647
Abstract: School-level socioeconomic status (SES) influences on adolescents' lifestyle behaviors is understudied. We examined how school-level SES and sex influence adolescents' health-related lifestyle behaviors and intentions. Grade 8 students aged 13-14 years completed an online questionnaire regarding their sociodemographic characteristics, dietary behaviors, physical activity participation and recreational screen-time, and intentions regarding these behaviors. School-level SES, based on an Index of Community Socio-Educational Advantage (ICSEA), was categorized as low or high. Generalized estimating equations estimated in idual-level summary statistics, adjusted for clustering. Students (N = 2538 response rate = 79%) from 23 high schools (low ICSEA = 16) participated. Compared with low ICSEA students, high ICSEA students were more likely to report eating breakfast daily (OR 1.9 [95% CI 1.5, 2.4]), not drinking sugar-sweetened beverages (SSBs) daily (2.9 [1.9, 4.3]), and were more likely to have intentions to eat breakfast (1.8 [1.3, 2.3]) and ≥ 5 vegetable serves (1.2 [1.0, 1.5]) daily. Boys were more likely than girls to meet recommendations for breakfast eating, vegetable intake, moderate-to-vigorous physical activity and screen-time, but boys were less likely to meet recommendations regarding SSB intake. Students from low ICSEA schools would benefit from additional support to improve dietary-related behaviors and intentions. More research is required to identify what targeted approaches will address sex differences in adolescents' lifestyle behaviors.
Publisher: Wiley
Date: 16-05-2013
Publisher: Elsevier BV
Date: 03-2018
Publisher: IEEE
Date: 11-2015
Publisher: IEEE
Date: 05-2013
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 15-12-2019
Publisher: IEEE
Date: 2016
Publisher: Springer Science and Business Media LLC
Date: 12-2013
Publisher: Springer Netherlands
Date: 20-10-2011
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 05-2019
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 03-2001
DOI: 10.1109/8.918617
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 08-2017
Publisher: AIP Publishing LLC
Date: 2015
DOI: 10.1063/1.4939325
Publisher: IEEE
Date: 04-2015
Publisher: IEEE
Date: 2007
Publisher: Public Library of Science (PLoS)
Date: 05-05-2016
Publisher: IEEE
Date: 06-2014
Publisher: IEEE
Date: 10-2011
Publisher: SPIE
Date: 27-04-2016
DOI: 10.1117/12.2227923
Publisher: IEEE
Date: 06-2014
Publisher: IEEE
Date: 06-2014
Publisher: Acoustical Society of America (ASA)
Date: 10-2016
DOI: 10.1121/1.4964897
Abstract: The operation of each hair cell within the cochlea generates a change in electrical potential at the frequency of the vibrating basilar membrane beneath the hair cell. This electrical potential influences the operation of the cochlea at nearby locations and can also be detected as the cochlear microphonic signal. The effect of such potentials has been proposed as a mechanism for the non-local operation of the cochlear lifier, and the interaction of such potentials has been thought to be the cause of the broadness of cochlea microphonic tuning curves. The spatial extent of influence of these potentials is an important parameter for determining the significance of their effects. Calculations of this extent have typically been based on calculating the longitudinal resistance of each of the scalae from the scala cross sectional area, and the conductivity of the lymph. In this paper, the range of influence of the electrical potential is examined using an electrical finite element model. It is found that the range of influence of the hair cell potential is much shorter than the conventional calculation, but is consistent with recent measurements.
Publisher: Wiley
Date: 16-03-2013
DOI: 10.1111/IBI.12031
Publisher: Springer Science and Business Media LLC
Date: 09-05-2014
DOI: 10.1038/SREP04669
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 02-2019
Publisher: Wiley
Date: 27-06-2014
DOI: 10.1111/JAV.00411
Publisher: Springer Science and Business Media LLC
Date: 28-09-2018
DOI: 10.1038/S41467-018-05564-Z
Abstract: Accurately identifying patients with high-grade serous ovarian carcinoma (HGSOC) who respond to poly(ADP-ribose) polymerase inhibitor (PARPi) therapy is of great clinical importance. Here we show that quantitative BRCA1 methylation analysis provides new insight into PARPi response in preclinical models and ovarian cancer patients. The response of 12 HGSOC patient-derived xenografts (PDX) to the PARPi rucaparib was assessed, with variable dose-dependent responses observed in chemo-naive BRCA1/2 -mutated PDX, and no responses in PDX lacking DNA repair pathway defects. Among BRCA1 -methylated PDX, silencing of all BRCA1 copies predicts rucaparib response, whilst heterozygous methylation is associated with resistance. Analysis of 21 BRCA1- methylated platinum-sensitive recurrent HGSOC (ARIEL2 Part 1 trial) confirmed that homozygous or hemizygous BRCA1 methylation predicts rucaparib clinical response, and that methylation loss can occur after exposure to chemotherapy. Accordingly, quantitative BRCA1 methylation analysis in a pre-treatment biopsy could allow identification of patients most likely to benefit, and facilitate tailoring of PARPi therapy.
Publisher: Informa UK Limited
Date: 25-05-2018
Publisher: IEEE
Date: 2003
Publisher: Oxford University Press (OUP)
Date: 05-06-2012
DOI: 10.1093/CID/CIS529
Abstract: Longer-term morbidity and outcomes of Cryptococcus gattii infection are not described. We analyzed clinical, microbiological, and outcome data in Australian patients followed for 12 months, to identify prognostic determinants. Culture-confirmed C. gattii cases from 2000 to 2007 were retrospectively evaluated. Clinical, microbiological, radiological, and outcome data were recorded at diagnosis and at 6 weeks, 6 months, and 12 months. Clinical and laboratory variables associated with mortality and with death and/or neurological sequelae were determined. Annual C. gattii infection incidence was 0.61 per 10(6) population. Sixty-two of 86 (72%) patients had no immunocompromise 6 of 24 immunocompromised hosts had idiopathic CD4 lymphopenia, and 1 had human immunodeficiency virus/AIDS. Clinical and microbiological characteristics of infection were similar in immunocompromised and healthy hosts. Isolated lung, combined lung and central nervous system (CNS), and CNS only disease was reported in 12%, 51% and 34% of the cases, respectively. Complications in CNS disease included raised intracranial pressure (42%), hydrocephalus (30%), neurological deficits (27% 6% developed during therapy) and immune reconstitutionlike syndrome (11%). Geometric mean serum cryptococcal antigen (CRAG) titers in CNS disease were 563.9 (vs 149.3 in isolated lung infection). Patient immunocompromise was associated with increased mortality risk. An initial cerebrospinal fluid CRAG titer of ≥256 predicted death and/or neurological sequelae (P = .05). Neurological C. gattii disease predominates in the Australian endemic setting. Lumbar puncture and cerebral imaging, especially if serum CRAG titers are ≥512, are essential. Long-term follow up is required to detect late neurological complications. Immune system evaluation is important because host immunocompromise is associated with reduced survival.
Publisher: Elsevier BV
Date: 02-2022
DOI: 10.1016/J.JMR.2021.107124
Abstract: Two dimensional diffusion and transverse (T
Publisher: Elsevier BV
Date: 2012
Publisher: Institute of Electrical and Electronics Engineers (IEEE)
Date: 10-2015
Publisher: Springer Science and Business Media LLC
Date: 08-09-2016
DOI: 10.1038/NCOMMS12731
Abstract: The ‘shock and kill’ approach to cure human immunodeficiency virus (HIV) includes transcriptional induction of latent HIV-1 proviruses using latency-reversing agents (LRAs) with targeted immunotherapy to purge infected cells. The administration of LRAs (panobinostat or vorinostat) to HIV-1-infected in iduals on antiretroviral therapy induces a significant increase in cell-associated unspliced (CA-US) HIV-1 RNA from CD4 + T cells. However, it is important to discern whether the increases in CA-US HIV-1 RNA are due to limited or broad activation of HIV-1 proviruses. Here we use single-genome sequencing to find that the RNA transcripts observed following LRA administration are genetically erse, indicating activation of transcription from an extensive range of proviruses. Defective sequences are more frequently found in CA HIV-1 RNA than in HIV-1 DNA, which has implications for developing an accurate measure of HIV-1 reservoir size. Our findings provide insights into the effects of panobinostat and vorinostat as LRAs for latent HIV-1.
Publisher: AIP Publishing LLC
Date: 2015
DOI: 10.1063/1.4939386
Publisher: Informa UK Limited
Date: 12-2014
DOI: 10.1071/MU13114
Publisher: Oxford University Press (OUP)
Date: 22-05-2013
DOI: 10.1093/CID/CIT341
Abstract: We describe antifungal therapy and management of complications due to Cryptococcus gattii infection in 86 Australian patients followed for at least 12 months. Patient data from culture-confirmed cases (2000-2007) were recorded at diagnosis, 6 weeks, 6 months, and 12 months. Clinical, laboratory, and treatment variables associated with raised intracranial pressure (ICP) and immune reconstitution inflammatory syndrome (IRIS) were determined. Seven of 10 patients with lung infection received hotericin B (AMB) induction therapy (6 with 5-flucytosine [5-FC] for a median of 2 weeks) median duration of therapy including azole eradication therapy was 41 weeks, with a complete artial clinical response in 78%. For neurologic disease, 88% of patients received AMB, 78% with 5-FC, for a median of 6 weeks. The median total course was 18 months. Nine patients receiving fluconazole induction therapy were reinduced with AMB plus 5-FC for clinical failure. Raised ICP (31 patients) was associated with initial abnormal neurology, and neurologic sequelae and/or death at 12 months (both P = .02) cerebrospinal fluid drains/shunts were placed in 58% of patients and in 64% of 22 patients with hydrocephalus. IRIS developed 2-12 months after starting antifungals in 8 patients, who presented with new/enlarging brain lesions. Risk factors included female sex, brain involvement at presentation, and higher median CD4 counts (all P < .05) corticosteroids reduced cryptococcoma-associated edema. Induction AMB plus 5-FC is indicated for C. gattii neurologic cryptococcosis (6 weeks) and when localized to lung (2 weeks). Shunting was often required to control raised ICP. IRIS presents with cerebral manifestations.
Publisher: Acoustical Society of America (ASA)
Date: 04-2010
DOI: 10.1121/1.3336401
Abstract: Previous work has indicated that a limitation on the performance of a circular microphone array for holographic sound field recording at low frequencies is phase mismatch between the microphones in the array. At low frequencies these variations become more significant than at mid-range and high frequencies because the high order phase mode responses at low frequencies are lower in litude. This paper demonstrates the feasibility of a “self-calibration” method. The basis of the calibration is to estimate the location of one or more wide-band sources using mid-range frequencies and to use this source location information to perform correction to the array at low frequencies. In its simplest form the calibration must be performed in an anechoic environment, since multipath effects at widely differing frequencies are uncorrelated. The approach is first demonstrated in such an environment using recordings from an array of high quality microphones. The technique is then extended to an adaptive calibration that can be used in an environment that is somewhat reverberant. The validity of the adaptive approach is demonstrated using recordings from an array of inexpensive microphones.
Publisher: Wiley
Date: 16-03-2016
Abstract: Perceived incivility during ED medical phone consultations is poorly researched. We aimed to determine frequency and factors influencing perceived incivility during ED phone consultations. We conducted a prospective self-reported survey of 40 consecutive phone consultations for 21 ED volunteer doctors. Consultations were classified based on the aim of consultation and deemed as 'positive', 'neutral' or 'negative' based on the perceptions of the consulting doctor. Training levels, time bands and specialty data were collected for both consulting and consulted parties. Fifty-seven of 714 included consultations (7.98%, 95% CI 6.2-10.2%) were reported as negative by ED medical staff. Factors associated with significant incidence of negative grading of consultation involved requests for investigations (19.3% vs 5.3%, P 4 (9.1% vs 3.8%, P < 0.01) and those involving radiology specialty (18% vs 5.32%, P < 0.01). The risk was lower when the consulted professional was a specialist medical practitioner as compared to specialist trainee (4.1% vs 9.4%, P = 0.02). Multiple logistical modelling suggests that female (adjusted OR 2.4, 95% CI 1.1-5.2) medical staff are more likely to report perceived incivility during ED phone consultations. Perceived incivility occurs infrequently during ED phone consultations. ED female medical staff are at an increased risk of perceived incivility during phone consultations with non-ED medical professionals. Health organisations should actively pursue programmes to investigate the occurrence of incivility during healthcare consultations and implement programmes to mitigate the risk of developing a negative workplace culture.
Publisher: Elsevier BV
Date: 06-2010
Publisher: ACM Press
Date: 2012
Publisher: American Physiological Society
Date: 09-2016
DOI: 10.1152/AJPHEART.00254.2016
Abstract: The dynamic regulation of cerebral blood flow (CBF) is thought to involve myogenic and chemoreflex mechanisms, but the extent to which the sympathetic nervous system also plays a role remains debated. Here we sought to identify the role of human sympathetic neurovascular control by examining cerebral pressure-flow relations using linear transfer function analysis and multivariate wavelet decomposition analysis that explicitly accounts for the confounding effects of dynamic end-tidal Pco 2 (Pet CO 2 ) fluctuations. In 18 healthy participants randomly assigned to the α 1 -adrenergic blockade group ( n = 9 oral Prazosin, 0.05 mg/kg) or the placebo group ( n = 9), we recorded blood pressure, middle cerebral blood flow velocity, and breath-to-breath Pet CO 2 . Analyses showed that the placebo administration did not alter wavelet phase synchronization index (PSI) values, whereas sympathetic blockade increased PSI for frequency components ≤0.03 Hz. Additionally, three-way interaction effects were found for PSI change scores, indicating that the treatment response varied as a function of frequency and whether PSI values were Pet CO 2 corrected. In contrast, sympathetic blockade did not affect any linear transfer function parameters. These data show that very-low-frequency CBF dynamics have a composite origin involving, not only nonlinear and nonstationary interactions between BP and Pet CO 2 , but also frequency-dependent interplay with the sympathetic nervous system.
Publisher: Acoustical Society of America (ASA)
Date: 06-2015
DOI: 10.1121/1.4921550
Abstract: Nonlinear models of the cochlea are best implemented in the time domain, but their computational demands usually limit the duration of the simulations that can reasonably be performed. This letter presents a modified state space method and its application to an ex le nonlinear one-dimensional transmission-line cochlear model. The sparsity pattern of the in idual matrices for this alternative formulation allows the use of significantly faster numerical algorithms. Combined with a more efficient implementation of the saturating nonlinearity, the computational speed of this modified state space method is more than 40 times faster than that of the original formulation.
Location: New Zealand
Start Date: 2023
End Date: 2026
Funder: Ministry of Business, Innovation and Employment
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End Date: 2026
Funder: Ministry of Business, Innovation and Employment
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