ORCID Profile
0000-0001-9733-7088
Current Organisation
National Council of Research (CNR)
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Publisher: Elsevier BV
Date: 03-2008
Publisher: Elsevier BV
Date: 12-2020
Publisher: Elsevier BV
Date: 10-2021
DOI: 10.1016/J.IJBIOMAC.2021.08.069
Abstract: The design of powerful in vitro cell culture platforms to support precision medicine can contribute to predict therapeutic success of cancer patients. Electrospun nanofibers applied to cell culture can mimic extracellular matrix and improve in vitro cell behavior. Here, we describe biocompatible blended polyvinyl-alcohol (PVA)/gum arabic (GA) extracellular matrix (ECM)-like nanofibers for in vitro cell cultures capable of delivering nanocomposite for desired biomedical application. Therefore, PVA/GA ECM-like electrospun nanofibers were developed and characterized. Heat treatment was used to crosslink the nanofibers and biocompatibility was evaluated, which demonstrated the ability of developed platform to provide a cell culture-friendly environment. Previous work demonstrated that GA-gold nanoparticles (GA-AuNPs) in non-cytotoxic concentrations can reduce key metastatic cellular events such as invasion and colony formation of metastatic melanoma cells. Thus, crosslinked nanofibers were functionalized with GA-AuNPs and its cellular delivery was evaluated. GA-AuNPs were efficiently adsorbed onto the PVA/GA nanofibers surface and the system effectively delivered the nanocomposites to metastatic melanoma cells. In conclusion, the described biocompatible system could be prospected as a valuable in vitro tool for precision medicine.
Publisher: American Chemical Society (ACS)
Date: 31-08-2017
Publisher: American Vacuum Society
Date: 11-2006
DOI: 10.1116/1.2366606
Abstract: The authors report a highly controlled approach, based on electron-beam lithography, to interconnect in idual nano-objects for transport experiments. The process is based on a three-step procedure, consisting of fabrication of four alignment markers, localization of the nano-object after its immobilization onto functionalized surfaces, and interconnection of the single nanostructure by patterning two nanoelectrodes on its sides. The approach is highly reproducible and widely applicable and allows an alignment accuracy of 15–20nm. Here they demonstrate the reliability of such technique by using a thin triangular gold nanoprism as the active element and show the I-V characteristics of the single nanostructure.
Location: Italy
Location: Italy
No related grants have been discovered for Loretta L. del Mercato.