ORCID Profile
0000-0002-3043-8949
Current Organisation
Canberra Hospital
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Publisher: Medip Academy
Date: 24-11-2018
DOI: 10.18203/2319-2003.IJBCP20184865
Abstract: Lithium is an effective first-line mood stabiliser for bipolar disorder, treatment-refractory depression and suicide prevention. Studies have demonstrated its ability to produce neuroprotective benefits. Despite this, Lithium can cause neurotoxicity, cardiotoxicity and endocrine derangement resulting in severe (and potentially permanent) side effects. Lithium toxicity can be precipitated by illness, salt restriction diets, dehydration, nephrogenic diabetes insipidus, impaired creatinine clearance, concomitant drugs. This is particularly true in older patients with altered pharmacodynamics and pharmacokinetics. We present a 52-year-old female who presented with prolonged signs of lithium toxicity post-diarrhoea. Lack of monitoring due to her nomadic life-style resulted in the combination of long-lasting neurotoxicity and thyroid dysfunction. Our patient displayed neurotoxicity that was not present on imaging. This highlights the importance of regular monitoring of renal function, lithium serum levels and neuro-endocrine function to reduce complications associated with lithium toxicity.
Publisher: Springer Science and Business Media LLC
Date: 14-07-2020
Publisher: Wiley
Date: 22-01-2020
DOI: 10.1111/AJD.13241
Publisher: Wiley
Date: 17-04-2020
DOI: 10.1111/IJD.14874
Publisher: Springer Science and Business Media LLC
Date: 08-08-2019
Publisher: Wiley
Date: 06-04-2020
DOI: 10.1111/AJD.13282
Publisher: EDP Sciences
Date: 12-2014
Publisher: Wiley
Date: 2020
DOI: 10.1111/JPC.14716
Publisher: Springer Science and Business Media LLC
Date: 08-07-2020
Publisher: Springer Science and Business Media LLC
Date: 22-06-2019
DOI: 10.1007/S12551-019-00556-9
Abstract: Knowledge of when to actively modify outdoor sun protective behaviour is crucial for sun safety and should be based upon personal susceptibility to sunburn and the intensity of the ultraviolet radiation dose during outdoor exposure. To facilitate measurements of dose and exposure, non-scientific and research-grade instruments measuring different exposure parameters of solar radiation are commercially available. These devices have been marketed as weather stations, purpose-built UVI display stations, portable dosimeters, handheld solarmeters, watches, and even stickers that can be worn. According to their measurements, the public can be educated and reminded to adopt appropriate sun safety practices such as limiting midday sun exposure, seeking shade, wearing protective clothing such as a broad-brimmed hat, and regularly applying and reapplying broad-spectrum sunscreen. There are many different commercial devices and smart phone applications (apps) that allow the public to be informed about current ultraviolet radiation levels in their immediate area, but each aims to enable the public to practise good sun safety behaviour. Naturally, each device is not without its various limitations and unique advantages. This study explores the ways in which ultraviolet radiation sensors can provide an accurate and highly convenient way of practising good sun safety behaviour in various contexts of high sun exposure such as playgrounds, tourist attractions, workplaces, and swimming pools. However, the author advises caution on the use of personal meters that have not been validated for their reliability and accuracy as public health tools.
Publisher: Wiley
Date: 04-05-2020
DOI: 10.1111/PHP.13251
Publisher: Wiley
Date: 21-11-2020
DOI: 10.1111/EVE.13230
Publisher: Springer Science and Business Media LLC
Date: 18-09-2018
Publisher: Wiley
Date: 11-12-2020
DOI: 10.1111/AJD.13219
Publisher: Wiley
Date: 23-05-2011
DOI: 10.1002/ETC.568
Abstract: Chemical toxicants, particularly metal ions, are a major contaminant in global waterways. Live-organism bioassays used to monitor chemical toxicants commonly involve measurements of activity or survival of a freshwater cladoceran (Ceriodaphnia dubia) or light emitted by the marine bacterium Vibrio fischeri, used in the commercial Microtox® bioassay. Here we describe a novel molecule-based assay system employing DNA as the chemical biosensor. Metals bind to DNA, causing structural changes that expel a bound (intercalated) fluorescent reporter dye. Analyses of test data using 48 wastewater s les potentially contaminated by metal ions show that the DNA-dye assay results correlate with those from C. dubia and Microtox bioassays. All three assays exhibit additive, antagonistic, and synergistic responses that cannot be predicted by knowing in idual metal concentrations. Analyses of metals in these s les imply the presence of chemical toxicants other than metal ions. The DNA-dye assay is robust, has a 12-month shelf life, and is only slightly affected by s le pH in the range 4 to 9. The assay is completed in a matter of minutes, and its portability makes it well suited as a screening assay for use in the field. We conclude that the DNA-dye test is a surrogate bioassay suitable for screening chemical toxicity.
Publisher: Springer Science and Business Media LLC
Date: 17-09-2018
Publisher: Wiley
Date: 24-01-2020
DOI: 10.1111/AJD.13237
No related grants have been discovered for Vangelis Kanellis.