ORCID Profile
0000-0002-5443-3640
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Publisher: American Astronomical Society
Date: 05-01-2023
Abstract: Convergent disk migration has long been suspected to be responsible for forming planetary systems with a chain of mean-motion resonances (MMRs). Dynamical evolution over time could disrupt the delicate resonant configuration. We present TOI-1136, a 700 ± 150 Myr old G star hosting at least six transiting planets between ∼2 and 5 R ⊕ . The orbital period ratios deviate from exact commensurability by only 10 −4 , smaller than the ∼10 −2 deviations seen in typical Kepler near-resonant systems. A transit-timing analysis measured the masses of the planets (3–8 M ⊕ ) and demonstrated that the planets in TOI-1136 are in true resonances with librating resonant angles. Based on a Rossiter–McLaughlin measurement of planet d, the star’s rotation appears to be aligned with the planetary orbital planes. The well-aligned planetary system and the lack of a detected binary companion together suggest that TOI-1136's resonant chain formed in an isolated, quiescent disk with no stellar flyby, disk warp, or significant axial asymmetry. With period ratios near 3:2, 2:1, 3:2, 7:5, and 3:2, TOI-1136 is the first known resonant chain involving a second-order MMR (7:5) between two first-order MMRs. The formation of the delicate 7:5 resonance places strong constraints on the system’s migration history. Short-scale (starting from ∼0.1 au) Type-I migration with an inner disk edge is most consistent with the formation of TOI-1136. A low disk surface density (Σ 1 au ≲ 10 3 g cm −2 lower than the minimum-mass solar nebula) and the resultant slower migration rate likely facilitated the formation of the 7:5 second-order MMR.
Publisher: Springer Science and Business Media LLC
Date: 06-1989
DOI: 10.1007/BF00441521
Abstract: Guggulsterone is a plant polyphenol traditionally used to treat obesity, diabetes, hyperlipidemia, atherosclerosis, and osteoarthritis, possibly through an anti-inflammatory mechanism. Whether this steroid has any role in cancer is not known. In this study, we found that guggulsterone inhibits the proliferation of wide variety of human tumor cell types including leukemia, head and neck carcinoma, multiple myeloma, lung carcinoma, melanoma, breast carcinoma, and ovarian carcinoma. Guggulsterone also inhibited the proliferation of drug-resistant cancer cells (e.g., gleevac-resistant leukemia, dexamethasone-resistant multiple myeloma, and doxorubicin-resistant breast cancer cells). Guggulsterone suppressed the proliferation of cells through inhibition of DNA synthesis, producing cell cycle arrest in S-phase, and this arrest correlated with a decrease in the levels of cyclin D1 and cdc2 and a concomitant increase in the levels of cyclin-dependent kinase inhibitor p21 and p27. Guggulsterone-induced apoptosis as indicated by increase in the number of Annexin V- and TUNEL-positive cells, through the downregulation of anti-apoptototic products. The apoptosis induced by guggulsterone was also indicated by the activation of caspase-8, bid cleavage, cytochrome c release, caspase-9 activation, caspase-3 activation, and PARP cleavage. The apoptotic effects of guggulsterone were preceded by activation of JNK and downregulation of Akt activity. JNK was needed for guggulsterone-induced apoptosis, inasmuch as inhibition of JNK by pharmacological inhibitors or by genetic deletion of MKK4 (activator of JNK) abolished the activity. Overall, our results indicate that guggulsterone can inhibit cell proliferation and induce apoptosis through the activation of JNK, suppression of Akt, and downregulation of antiapoptotic protein expression.
Publisher: American Astronomical Society
Date: 23-11-2021
Abstract: We report the discovery of an ultrahot Jupiter with an extremely short orbital period of 0.67247414 ± 0.00000028 days (∼16 hr). The 1.347 ± 0.047 R Jup planet, initially identified by the Transiting Exoplanet Survey Satellite (TESS) mission, orbits TOI-2109 (TIC 392476080)—a T eff ∼ 6500 K F-type star with a mass of 1.447 ± 0.077 M ☉ , a radius of 1.698 ± 0.060 R ☉ , and a rotational velocity of v sin i * = 81.9 ± 1.7 km s −1 . The planetary nature of TOI-2109b was confirmed through radial-velocity measurements, which yielded a planet mass of 5.02 ± 0.75 M Jup . Analysis of the Doppler shadow in spectroscopic transit observations indicates a well-aligned system, with a sky-projected obliquity of λ = 1.°7 ± 1.°7. From the TESS full-orbit light curve, we measured a secondary eclipse depth of 731 ± 46 ppm, as well as phase-curve variations from the planet’s longitudinal brightness modulation and ellipsoidal distortion of the host star. Combining the TESS-band occultation measurement with a K s -band secondary eclipse depth (2012 ± 80 ppm) derived from ground-based observations, we find that the dayside emission of TOI-2109b is consistent with a brightness temperature of 3631 ± 69 K, making it the second hottest exoplanet hitherto discovered. By virtue of its extreme irradiation and strong planet–star gravitational interaction, TOI-2109b is an exceptionally promising target for intensive follow-up studies using current and near-future telescope facilities to probe for orbital decay, detect tidally driven atmospheric escape, and assess the impacts of H 2 dissociation and recombination on the global heat transport.
Publisher: Ovid Technologies (Wolters Kluwer Health)
Date: 03-1996
DOI: 10.1097/00003246-199603000-00006
Abstract: The aims of this study were: a) to evaluate plasma concentrations of cytokines and their soluble receptors, as well as antioxidant substances in patients at high risk of developing multiple organ failure b) to investigate early change: and c) to examine the possible prognostic value of these elements. Prospective analysis. Surgical intensive care unit (ICU) of a university hospital. sixteen patients at risk for multiple organ failure. Ten patients developed multiple organ failure and five of them died. Whereas tumor necrosis factor-alpha (TNF-alpha) plasma concentrations were only borderline higher in patients developing multiple organ failure, TNF-soluble receptors 55 and 75 were significantly increased during all ICU days compared with patients not going into organ failure. Interleukin-6 plasma concentrations were higher in patients developing multiple organ failure during the first 2 days after ICU admission. The antioxidant vitamin C was significantly decreased in patients going into multiple organ failure during all ICU days. Other biochemical markers of antioxidant activity, such as vitamin E, copper, and zinc plasma concentrations, did not differ between the two groups. Our data suggest that there is a marked increase in anti-TNF activity and a decrease of antioxidant defense in patients at risk of developing multiple organ failure. The predictive value of plasma concentrations of circulating TNF-soluble receptors and vitamin C in this type of patient needs further evaluation.
Publisher: Massachusetts Medical Society
Date: 18-08-1988
DOI: 10.1056/NEJM198808183190703
Abstract: Diagnosis of esophageal squamous cell carcinoma (SCC) may improve with early diagnosis. Currently it is difficult to diagnose SCC in the early stage because there is a limited number of tumor markers available. Fifty-two esophageal SCC SEREX antigens were identified by SEREX (serological identification of antigens by recombinant cDNA expression cloning) using a cDNA phage library and sera of patients with esophageal SCC. Sequence analysis revealed that three of these antigens were similar in amino acid sequences, and they were designated as ECSA (esophageal carcinoma SEREX antigen)-1, -2 and -3. The ECSA family was also similar to an EST clone, hepatocellular carcinoma-associated antigen 25a (HCA25a). Serum antibody levels to ECSA-1, -2 and -3 were significantly higher in patients with esophageal SCC than in healthy donors. Based on the conserved amino acid sequences, three peptides were synthesized and used for enzyme-linked immunosorbent assays (ELISA). The serum antibody levels against one of these peptides were significantly higher in patients with esophageal SCC. This peptide sequence was also conserved in FAM119A, GOSR1 and BBS5, suggesting that these are also ECSA family members. Reverse transcription followed by quantitative PCR analysis showed that the mRNA expression levels of ECSA-1, -2 and -3 and FAM119A but not of HCA25a, GOSR1 and BBS5 were frequently elevated in esophageal SCC tissues. We have identified a new gene family designated ECSA. Serum antibodies against the conserved domain of the ECSA family may be a promising tumor marker for esophageal SCC.
Publisher: Elsevier BV
Date: 09-1995
Abstract: Mesangial cells (MC) are one cellular source of tumor necrosis factor alpha (TNF) within the kidney as shown by experimental stimulation with endotoxin. TNF was shown to increase MC synthesis of prostaglandins E2 (PGE2) which down regulate MC proliferation. The involvement of endogenous TNF as an autocrine factor to control MC proliferation is unknown. This role was evaluated in vitro by addition of anti-TNF immunoglobulins and soluble TNF receptor-I (sTNF-RI) on rat MC. Anti-TNF immunoglobulins and sTNF-RI induced a dose-dependent increase of cell proliferation when the cells were quiescent in 0.5% FCS P = 0.002). No effect was found when the cells were growing in 10% FCS (P = 0.113). Incubation of MC with anti-TNF immunoglobulins resulted in a dose-dependent decrease of PGE2 release. In order to investigate if the effect of TNF on MC proliferation was mediated by the decrease of PGE2 release, PGE2 was added to the culture medium at concentrations of 0.1 to 10 micrograms/ml in conjunction with anti-TNF immunoglobulins. PGE2 did not modify the proliferation induced by anti-TNF immunoglobulins. We conclude that anti-TNF immunoglobulins and sTNF-RI promoted MC DNA synthesis and influenced their PGE2 release by blocking the endogenous TNF. The mechanism of action on DNA synthesis was not mediated by PGE2. This indicates that endogenous TNF has a substantial role in the control of resting mesangial cells.
Publisher: American Astronomical Society
Date: 27-07-2022
Abstract: Hot Jupiters—short-period giant planets—were the first extrasolar planets to be discovered, but many questions about their origin remain. NASA’s Transiting Exoplanet Survey Satellite (TESS), an all-sky search for transiting planets, presents an opportunity to address these questions by constructing a uniform s le of hot Jupiters for demographic study through new detections and unifying the work of previous ground-based transit surveys. As the first results of an effort to build this large s le of planets, we report here the discovery of 10 new hot Jupiters (TOI-2193A b, TOI-2207b, TOI-2236b, TOI-2421b, TOI-2567b, TOI-2570b, TOI-3331b, TOI-3540A b, TOI-3693b, TOI-4137b). All of the planets were identified as planet candidates based on periodic flux dips observed by TESS, and were subsequently confirmed using ground-based time-series photometry, high-angular-resolution imaging, and high-resolution spectroscopy coordinated with the TESS Follow-up Observing Program. The 10 newly discovered planets orbit relatively bright F and G stars ( G 12.5, T eff between 4800 and 6200 K). The planets’ orbital periods range from 2 to 10 days, and their masses range from 0.2 to 2.2 Jupiter masses. TOI-2421b is notable for being a Saturn-mass planet and TOI-2567b for being a “sub-Saturn,” with masses of 0.322 ± 0.073 and 0.195 ± 0.030 Jupiter masses, respectively. We also measured a detectably eccentric orbit ( e = 0.17 ± 0.05) for TOI-2207b, a planet on an 8 day orbit, while placing an upper limit of e 0.052 for TOI-3693b, which has a 9 day orbital period. The 10 planets described here represent an important step toward using TESS to create a large and statistically useful s le of hot Jupiters.
Publisher: American Astronomical Society
Date: 16-12-2022
Abstract: We present an estimate of the occurrence rate of hot Jupiters (7 R ⊕ ≤ R p ≤ 2 R J , 0.8 ≤ P b ≤ 10 days) around early-type M dwarfs based on stars observed by the Transiting Exoplanet Survey Satellite (TESS) during its primary mission. We adopt stellar parameters from the TESS Input Catalog and construct a s le of 60,819 M dwarfs with 10.5 ≤ T mag ≤ 13.5, effective temperatures 2900 ≤ T eff ≤ 4000 K, and stellar masses 0.45 ≤ M * ≤ 0.65 M ⊙ . We conduct a uninformed transit search using a detection pipeline based on the box least square search and characterize the searching completeness through an injection and recovery experiment. We combine a series of vetting steps including light centroid measurement, odd/even and secondary eclipse analysis, rotation and transit period synchronization tests as well as inspecting the ground-based photometric, spectroscopic, and imaging observations. Finally, we find a total of nine planet candidates, all of which are known TESS objects of interest. We obtain an occurrence rate of 0.27% ± 0.09% for hot Jupiters around early-type M dwarfs that satisfy our selection criteria. Compared with previous studies, the occurrence rate of hot Jupiters around early-type M dwarfs is smaller than all measurements for FGK stars, although they are consistent within 1 σ –2 σ . There is a trend that the occurrence rate of hot Jupiters has a peak at G dwarfs and falls toward both hotter and cooler stars. Combining results from transit, radial velocity, and microlensing surveys, we find that hot Jupiters around early-type M dwarfs possibly show a steeper decrease in the occurrence rate per logarithmic semimajor axis bin ( dN / d log 10 a ) when compared with FGK stars.
Publisher: American Astronomical Society
Date: 11-04-2022
Abstract: Astronomers do not have a complete picture of the effects of wide-binary companions (semimajor axes greater than 100 au) on the formation and evolution of exoplanets. We investigate these effects using new data from Gaia Early Data Release 3 and the Transiting Exoplanet Survey Satellite mission to characterize wide-binary systems with transiting exoplanets. We identify a s le of 67 systems of transiting exoplanet candidates (with well-determined, edge-on orbital inclinations) that reside in wide visual binary systems. We derive limits on orbital parameters for the wide-binary systems and measure the minimum difference in orbital inclination between the binary and planet orbits. We determine that there is statistically significant difference in the inclination distribution of wide-binary systems with transiting planets compared to a control s le, with the probability that the two distributions are the same being 0.0037. This implies that there is an overabundance of planets in binary systems whose orbits are aligned with those of the binary. The overabundance of aligned systems appears to primarily have semimajor axes less than 700 au. We investigate some effects that could cause the alignment and conclude that a torque caused by a misaligned binary companion on the protoplanetary disk is the most promising explanation.
Publisher: Springer Science and Business Media LLC
Date: 06-1990
DOI: 10.1007/BF02034754
Publisher: American Astronomical Society
Date: 30-07-2021
Publisher: American Astronomical Society
Date: 28-01-2022
Abstract: The James Webb Space Telescope will be able to probe the atmospheres and surface properties of hot, terrestrial planets via emission spectroscopy. We identify 18 potentially terrestrial planet candidates detected by the Transiting Exoplanet Survey Satellite (TESS) that would make ideal targets for these observations. These planet candidates cover a broad range of planet radii ( R p ∼ 0.6–2.0 R ⊕ ) and orbit stars of various magnitudes ( K s = 5.78–10.78, V = 8.4–15.69) and effective temperatures ( T eff ∼ 3000–6000 K). We use ground-based observations collected through the TESS Follow-up Observing Program (TFOP) and two vetting tools— DAVE and TRICERATOPS —to assess the reliabilities of these candidates as planets. We validate 13 planets: TOI-206 b, TOI-500 b, TOI-544 b, TOI-833 b, TOI-1075 b, TOI-1411 b, TOI-1442 b, TOI-1693 b, TOI-1860 b, TOI-2260 b, TOI-2411 b, TOI-2427 b, and TOI-2445 b. Seven of these planets (TOI-206 b, TOI-500 b, TOI-1075 b, TOI-1442 b, TOI-2260 b, TOI-2411 b, and TOI-2445 b) are ultra-short-period planets. TOI-1860 is the youngest (133 ± 26 Myr) solar twin with a known planet to date. TOI-2260 is a young (321 ± 96 Myr) G dwarf that is among the most metal-rich ([Fe/H] = 0.22 ± 0.06 dex) stars to host an ultra-short-period planet. With an estimated equilibrium temperature of ∼2600 K, TOI-2260 b is also the fourth hottest known planet with R p 2 R ⊕ .
Location: United States of America
No related grants have been discovered for Eric Girardin.