ORCID Profile
0000-0002-2323-338X
Current Organisations
James Cook University
,
Royal Brisbane and Women's Hospital
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Publisher: Informa UK Limited
Date: 03-03-2020
Publisher: Wiley
Date: 24-04-2021
Publisher: Springer Science and Business Media LLC
Date: 22-07-2112
Publisher: Elsevier BV
Date: 09-2020
Publisher: Springer Science and Business Media LLC
Date: 31-01-2017
DOI: 10.1038/SREP41760
Abstract: First Nations people globally have a higher incidence of mental disorders and non-communicable diseases. These health inequalities are partially attributed to a complex network of social and environmental factors which likely converge on chronic psychosocial stress. We hypothesized that alterations in stress processing and the regulation of the hypothalamic-pituitary-adrenal axis might underlie health disparities in First Nations people. We assessed the cortisol awakening response and the dynamic response to a laboratory induced psychosocial stress of young Indigenous tertiary students (n = 11, mean age 23.82 years) and non-Indigenous students (n = 11) matched for age and gender. Indigenous participants had a blunted cortisol awakening response (27.40 (SD 35.00) vs. 95.24 (SD 55.23), p = 0.002), which was differentially associated with chronic experience of stress in Indigenous (r = −0.641, p = 0.046) and non-Indigenous (r = 0.652, p = 0.03) participants. The cortisol response to the laboratory induced psychosocial stress did not differ between groups. Self-reported racial discrimination was strongly associated with flattened cortisol response to stress (r = −0676, p = 0.022) and with heart rate variability (r = 0.654, p = 0.040). Our findings provide insight into potential biological factors underlying health discrepancies in ethnic minority groups.
Publisher: Elsevier BV
Date: 10-2016
Publisher: Sri Lanka Journals Online (JOL)
Date: 19-08-2019
DOI: 10.4038/JMJ.V31I1.63
Abstract: It is unfortunate that over the last 65 years many factors have contributed to the sporadic publication of the Jaffna Medical Journal (JMJ). To sustain publication as a regular periodical, it is important to explore avenues to increase the number of submissions of high-quality manuscripts. One untapped source that could significantly enhance the number of submissions to JMJ are manuscripts arising from research undertaken by undergraduate students. To enable such students to produce high quality manuscripts from the work they carry out, students have to be adequately trained and mentored. We are of the view that if appropriate training is provided for undergraduates it will not only help JMJ in the short-term but also nurture the aspirations of future clinicians and researchers who have an interest in inquiry. Moreover, such an investment in student training and capacity building will ensure the future continuity of the Journal.
Publisher: SAGE Publications
Date: 18-10-2020
Abstract: To discuss challenges with the diagnosis of autoimmune psychosis (AP) in people with chronic psychotic disorders. We present a case of a 23-year-old man with an exacerbation of treatment-refractory psychosis after receiving intravenous immunoglobulin (IVIG) for suspected AP, diagnosed 4 years after the onset of psychosis. We highlight the diagnostic and management challenges in such cases. The diagnosis of AP in people with long-standing illness relies on the interpretation of non-specific clinical and laboratory findings in in iduals with psychosocial problems and challenges of acceptance and adherence to complex medical investigations and treatments. Equivocal results from investigations undertaken without logical clinical reasoning can lead to inappropriate interventions that are costly and can cause iatrogenic harm. Psychiatrists should restrict screening for antineuronal antibodies in people with chronic psychosis to those with higher risk features such as persistent treatment refractory symptoms with concurrent neurological signs and symptoms. Further research informing the clinical circumstances for antineuronal antibody testing is needed.
Publisher: Frontiers Media SA
Date: 19-10-2020
No related grants have been discovered for Sarangan Ketheesan.